From Inflammasome to Exosome-Does Extracellular Vesicle Secretion Constitute an Inflammasome-Dependent Immune Response?

abstract：:Leishmaniasis is the third most important vector-borne disease worldwide. Visceral leishmaniasis (VL) is a severe and frequently lethal protozoan disease of increasing incidence and severity due to infected human and dog migration, new geographical distribution of the insect due to global warming, coinfection with imm...

journal_title：Frontiers in immunology

authors： Palatnik-de-Sousa CB

更新日期：2012-04-17 00:00:00

abstract：:A common feature of many acute and chronic oral diseases is microbial-induced inflammation. Innate immune responses are the first line of defense against pathogenic microorganisms and are initiated by pattern recognition receptors (PRRs) that specifically recognize pathogen-associated molecular patterns and danger-ass...

journal_title：Frontiers in immunology

authors： Wang L,Sun L,Byrd KM,Ko CC,Zhao Z,Fang J

更新日期：2020-08-13 00:00:00

abstract：:Systemic Sclerosis (SSc) is a complex auto-immune connective tissue disease combining inflammatory, vasculopathic and fibrotic manifestations. Skin effectively recapitulates the main pathogenic processes and therefore is a good organ to decipher the disease pathophysiology, which remains unclear. However, culturing pr...

journal_title：Frontiers in immunology

authors： Henrot P,Laurent P,Levionnois E,Leleu D,Pain C,Truchetet ME,Cario M

更新日期：2020-10-07 00:00:00

abstract：:Clematichinenoside AR (C-AR) is a triterpene saponin isolated from the root of Clematis manshurica Rupr., which is a herbal medicine used in traditional Chinese medicine for the treatment of arthritis. C-AR exerts anti-inflammatory and immunosuppressive properties, but little is known about its action in the suppressi...

journal_title：Frontiers in immunology

authors： Li Y,Zheng JY,Liu JQ,Yang J,Liu Y,Wang C,Ma XN,Liu BL,Xin GZ,Liu LF

更新日期：2016-12-07 00:00:00

abstract：:Bone is a highly dynamic organ that is continuously being remodeled by the reciprocal interactions between bone and immune cells. We have originally established an advanced imaging system for visualizing the in vivo behavior of osteoclasts and their precursors in the bone marrow cavity using two-photon microscopy. Usi...

journal_title：Frontiers in immunology

authors： Hasegawa T,Kikuta J,Ishii M

更新日期：2019-03-26 00:00:00

abstract：:Dietary carbohydrate fibers are known to prevent immunological diseases common in Western countries such as allergy and asthma but the underlying mechanisms are largely unknown. Until now beneficial effects of dietary fibers are mainly attributed to fermentation products of the fibers such as anti-inflammatory short-c...

journal_title：Frontiers in immunology

authors： Sahasrabudhe NM,Beukema M,Tian L,Troost B,Scholte J,Bruininx E,Bruggeman G,van den Berg M,Scheurink A,Schols HA,Faas MM,de Vos P

更新日期：2018-03-01 00:00:00

abstract：:Defensins represents an integral part of the innate immune system serving to ward off potential pathogens and to protect the intestinal barrier from microbial encroachment. In addition to their antimicrobial activities, defensins in general, and human β-defensin 2 (hBD2) in particular, also exhibit immunomodulatory ca...

journal_title：Frontiers in immunology

authors： Koeninger L,Armbruster NS,Brinch KS,Kjaerulf S,Andersen B,Langnau C,Autenrieth SE,Schneidawind D,Stange EF,Malek NP,Nordkild P,Jensen BAH,Wehkamp J

更新日期：2020-01-31 00:00:00

abstract：:In early human immunodeficiency virus (HIV) infection, the virus population escapes from multiple CD8(+) cell responses. The later an escape mutation emerges, the slower it outgrows its competition, i.e., the escape rate is lower. This pattern could indicate that the strength of the CD8(+) cell responses is waning, or...

journal_title：Frontiers in immunology

authors： Garcia V,Regoes RR

更新日期：2015-01-13 00:00:00

abstract：:H7N9 viruses pose a threat to human health and they are no less harmful to the poultry industry than the H5N1 avian influenza viruses. However, the pathogenesis, transmissibility, and the host immune response of the H7N9 virus in chickens and mice remain unclear. In this study, we found that H7N9 viruses replicated in...

journal_title：Frontiers in immunology

authors： Jiao P,Song Y,Huang J,Xiang C,Cui J,Wu S,Qu N,Wang N,Ouyang G,Liao M

更新日期：2018-04-13 00:00:00

abstract：:Immune checkpoint inhibition has been shown to successfully reactivate endogenous T cell responses directed against tumor-associated antigens, resulting in significantly prolonged overall survival in patients with various tumor entities. For malignancies with low endogenous immune responses, this approach has not show...

journal_title：Frontiers in immunology

authors： Lichtenegger FS,Rothe M,Schnorfeil FM,Deiser K,Krupka C,Augsberger C,Schlüter M,Neitz J,Subklewe M

更新日期：2018-02-27 00:00:00

abstract：:The intestinal barrier provides the host with a strong defense line against the external environment playing also a pivotal role in the crosstalk between the gut microbiota and the immune system. Notably, increasing lines of evidence concerning autoimmune disorders such as Multiple Sclerosis (MS) report an imbalance i...

journal_title：Frontiers in immunology

authors： Antonini M,Lo Conte M,Sorini C,Falcone M

更新日期：2019-08-16 00:00:00

abstract：:Background: Infection with HIV-2, a retrovirus that is closely related to HIV-1, is characterized by slower disease progression and transmission, longer latency period and low or undetectable viremia. Host immunity, including production of potent neutralizing antibodies, may be one of the possible contributors to the ...

journal_title：Frontiers in immunology

authors： Vidyavijayan KK,Cheedarala N,Babu H,Precilla LK,Sathyamurthi P,Chandrasekaran P,Murugavel KG,Swaminathan S,Tripathy SP,Hanna LE

更新日期：2018-12-17 00:00:00

abstract：:During gestation, Toxoplasma gondii infection produces a series of complications including stillbirths, abortions, and congenital malformations. The inhibitory receptor, LILRB4, which is mainly expressed by professional antigen-presenting cells (especially macrophages and dendritic cells) may play an important immune-...

journal_title：Frontiers in immunology

authors： Li Z,Zhao M,Li T,Zheng J,Liu X,Jiang Y,Zhang H,Hu X

更新日期：2017-08-24 00:00:00

abstract：:A key aspect to finding an efficacious human immunodeficiency virus (HIV) vaccine is the optimization of vaccine schedules that can mediate the efficient maturation of protective immune responses. In the present study, we investigated the effect of alternate booster regimens on the immune responses to a candidate HIV-...

journal_title：Frontiers in immunology

authors： Kratochvil S,McKay PF,Kopycinski JT,Bishop C,Hayes PJ,Muir L,Pinder CL,Cizmeci D,King D,Aldon Y,Wines BD,Hogarth PM,Chung AW,Kent SJ,Held K,Geldmacher C,Dally L,Santos NS,Cole T,Gilmour J,Fidler S,Shattock RJ

更新日期：2017-05-24 00:00:00

abstract：:Delayed graft function (DGF) occurs in a significant proportion of deceased donor kidney transplant recipients and was associated with graft injury and inferior clinical outcome. The aim of the present multi-center study was to identify the immunological and non-immunological predictors of DGF and to determine its inf...

journal_title：Frontiers in immunology

authors： Morath C,Döhler B,Kälble F,Pego da Silva L,Echterdiek F,Schwenger V,Živčić-Ćosić S,Katalinić N,Kuypers D,Benöhr P,Haubitz M,Ziemann M,Nitschke M,Emmerich F,Pisarski P,Karakizlis H,Weimer R,Ruhenstroth A,Scherer S,Tr

更新日期：2020-08-26 00:00:00

abstract：:Retinoic acid inducible gene I (RIG-I) is associated to the DExD/H box RNA helicases. It is a pattern recognition receptor (PRR), playing a crucial role in the system and is a germ line encoded host sensor to perceive pathogen-associated molecular patterns (PAMPs). So far, reports are available for the role of RIG-I i...

journal_title：Frontiers in immunology

authors： Banerjee S,Pal A,Pal A,Mandal SC,Chatterjee PN,Chatterjee JK

更新日期：2021-01-08 00:00:00

abstract：:Enhanced susceptibility to bacterial infection in the days following an acute virus infection such as flu is a major clinical problem. Mouse models have provided major advances in understanding viral-bacterial superinfections, yet interactions of the anti-viral and anti-bacterial responses remain elusive. Here, we hav...

journal_title：Frontiers in immunology

authors： Boucontet L,Passoni G,Thiry V,Maggi L,Herbomel P,Levraud JP,Colucci-Guyon E

更新日期：2018-05-24 00:00:00

abstract：:FcγRIIa is an activating FcγR, unique to humans and non-human primates. It induces antibody-dependent proinflammatory responses and exists predominantly as FcγRIIa1. A unique splice variant, we designated FcγRIIa3, has been reported to be associated with anaphylactic reactions to intravenous immunoglobulins (IVIg) the...

journal_title：Frontiers in immunology

authors： Anania JC,Trist HM,Palmer CS,Tan PS,Kouskousis BP,Chenoweth AM,Kent SJ,Mackay GA,Hoi A,Koelmeyer R,Slade C,Bryant VL,Hodgkin PD,Aui PM,van Zelm MC,Wines BD,Hogarth PM

更新日期：2018-08-20 00:00:00

abstract：:Immune checkpoint inhibitors (ICIs) are a novel class of immunotherapy drugs that have improved the treatment of a broad spectrum of cancers as metastatic melanoma, non-small lung cancer or renal cell carcinoma. These humanized monoclonal antibodies target inhibitory receptors (e.g. CTLA-4, PD-1, LAG-3, TIM-3) and lig...

journal_title：Frontiers in immunology

authors： Franzin R,Netti GS,Spadaccino F,Porta C,Gesualdo L,Stallone G,Castellano G,Ranieri E

更新日期：2020-10-08 00:00:00

abstract：:Amyotrophic Lateral Sclerosis (ALS) is a group of neurodegenerative disorders that featured with the death of motor neurons, which leads to loss of voluntary control on muscles. The etiologies vary among different subtypes of ALS, and no effective management or medication could be provided to the patients, with the un...

journal_title：Frontiers in immunology

authors： Liu Z,Li H,Hong C,Chen M,Yue T,Chen C,Wang Z,You Q,Li C,Weng Q,Xie H,Hu R

更新日期：2018-11-14 00:00:00

abstract：:Innate inflammatory responses are crucial for induction and regulation of T cell and antibody responses. Mast cell (MC)-deficient Kit mutant mice showed impaired adaptive immunity, suggesting that MCs provide essential adjuvant activities, and pharmacological MC activation was proposed as a new adjuvant principle. How...

journal_title：Frontiers in immunology

authors： Schubert N,Lisenko K,Auerbach C,Weitzmann A,Ghouse SM,Muhandes L,Haase C,Häring T,Schulze L,Voehringer D,Gunzer F,Müller W,Feyerabend TB,Rodewald HR,Dudeck A,Roers A

更新日期：2018-08-28 00:00:00

abstract：:Gastrointestinal (GI) cancers, especially gastric cancer and colorectal cancer (CRC), represent a major global health burden. A large population of microorganisms residing in the GI tract regulate physiological processes, such as the immune response, metabolic balance, and homeostasis. Accumulating evidence has reveal...

journal_title：Frontiers in immunology

authors： Peng C,Ouyang Y,Lu N,Li N

更新日期：2020-06-30 00:00:00

abstract：:The conceptualization of immunological self is amongst the most important theories of modern biology, representing a sort of theoretical guideline for experimental immunologists, in order to understand how host constituents are ignored by the immune system (IS). A consistent advancement in this field has been represen...

journal_title：Frontiers in immunology

authors： Grignolio A,Mishto M,Faria AM,Garagnani P,Franceschi C,Tieri P

更新日期：2014-04-09 00:00:00

abstract：:Endometriosis is an estrogen-dependent disease with symptoms of dysmenorrhea, chronic pain, and infertility that affects 6-10% of women of reproductive age. Medical or surgical therapy, such as administration of an anti-gonadotropin or ovarian cystectomy, provide effective pain relief. However, neither therapy can be ...

journal_title：Frontiers in immunology

authors： Kato T,Yasuda K,Matsushita K,Ishii KJ,Hirota S,Yoshimoto T,Shibahara H

更新日期：2019-08-22 00:00:00

abstract：:COVID-19 is a global pandemic currently in an acute phase of rapid expansion. While public health measures remain the most effective protection strategy at this stage, when the peak passes, it will leave in its wake important health problems. Historically, very few viruses have ever been eradicated. Instead, the virus...

journal_title：Frontiers in immunology

authors： Sviridov D,Miller YI,Ballout RA,Remaley AT,Bukrinsky M

更新日期：2020-09-29 00:00:00

abstract：:In response to the global burden of liver disease there has been a commensurate increase in the demand for liver transplantation. However, due to a paucity of donor organs many centers have moved toward the routine use of marginal allografts, which can be associated with a greater risk of complications and poorer clin...

journal_title：Frontiers in immunology

authors： Owen A,Newsome PN

更新日期：2020-06-19 00:00:00

abstract：:Cancer neoantigens derived from random somatic mutations in tumor tissue represent an attractive type of targets for the cancer immunotherapies including cancer vaccine. Vaccination against the tumor-specific neoantigens minimizes the potential induction of central and peripheral tolerance as well as the risk of autoi...

journal_title：Frontiers in immunology

authors： Guo Y,Lei K,Tang L

更新日期：2018-07-02 00:00:00

abstract：:M2 macrophage (Mφ) promotes pathologic angiogenesis through a release of pro-angiogenic mediators or the direct cell-cell interaction with endothelium in the micromilieu of several chronic inflammatory diseases, including rheumatoid arthritis and cancer, where interleukin (IL)-18 also contributes to excessive angiogen...

journal_title：Frontiers in immunology

authors： Kobori T,Hamasaki S,Kitaura A,Yamazaki Y,Nishinaka T,Niwa A,Nakao S,Wake H,Mori S,Yoshino T,Nishibori M,Takahashi H

更新日期：2018-03-06 00:00:00

abstract：:The fitness gains resulting from development of the adaptive immune system (AIS) during evolution are still the subject of hot debate. A large random repertoire of antigenic receptors is costly to develop and could be the source of autoimmune reactions. And yet, despite their drawbacks, AIS-like systems seem to have b...

journal_title：Frontiers in immunology

authors： Muraille E

更新日期：2014-05-13 00:00:00

abstract：:The inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are chronic inflammatory disorders of the intestine. The prevalence in the United States is greater than 200 cases per 100,000, with the total number of IBD patients between 1 and 1.5 million. CD may affect all parts of ...

journal_title：Frontiers in immunology

authors： Rubin DC,Shaker A,Levin MS

更新日期：2012-05-08 00:00:00