Cytokine-Based Generation of CD49a+Eomes-/+ Natural Killer Cell Subsets.

abstract：:Responsiveness of maturing natural killer (NK) cells to chemotactic molecules directly affect their retention and relocation in selected bone marrow (BM) microenvironment during development, as well as their localization at sites of immune response during inflammatory diseases. BM is the main site of NK cell generatio...

journal_title：Frontiers in immunology

authors： Bernardini G,Sciumè G,Santoni A

更新日期：2013-01-30 00:00:00

abstract：:Proximal tubular epithelial cells are particularly sensitive to damage. In search of a biomarker, this study evaluated the potential of different cell activation models (hypoxia/replenishment and protein overload) to lead to a release of trefoil factor 3 (TFF3). Surprisingly, we found disparity in the ability of the d...

journal_title：Frontiers in immunology

authors： Zwaini Z,Alammari D,Byrne S,Stover C

更新日期：2016-03-30 00:00:00

abstract：:Dendritic cells (DCs), Langerhans cells (LCs), and macrophages are innate immune cells that reside in genital and intestinal mucosal tissues susceptible to HIV-1 infection. These innate cells play distinct roles in initiation of HIV-1 infection and induction of anti-viral immunity. DCs are potent migratory cells that ...

journal_title：Frontiers in immunology

authors： Mesman AW,Geijtenbeek TB

更新日期：2012-03-26 00:00:00

abstract：Background:Interleukin-9 (IL9) plays a critical role in immunity and the pathogenesis of endometrial cancer (EC), especially endometrioid EC (EEC). This study aimed to identify the IL9+ immune cell subsets and their pleiotropic functions and establish an optimized prognostic nomogram towards the promotion of personaliz...

journal_title：Frontiers in immunology

authors： Tong H,Feng H,Hu X,Wang MF,Song YF,Wen XL,Li YR,Wan XP

更新日期：2020-11-19 00:00:00

abstract：:Common variable immunodeficiency (CVID) is one of the most common and clinically important primary immune deficiencies. CVID patients have poor humoral immunity, resulting in recurrent infections of the gastrointestinal and upper respiratory tracts, as well as increased incidence of some forms of cancers and autoimmun...

journal_title：Frontiers in immunology

authors： Paquin-Proulx D,Sandberg JK

更新日期：2014-12-16 00:00:00

abstract：:Guava Psidium guajava L (Pg) and bhumi amla Phyllanthus amarus Schum. et Thonn (Pa) are well-known plants in traditional medicine. However, the capacity of these plants for improving the immune system of aquatic species has received less attention so far. This study aimed to investigate the effects of single supply or...

journal_title：Frontiers in immunology

authors： Nhu TQ,Bich Hang BT,Cornet V,Oger M,Bach LT,Anh Dao NL,Thanh Huong DT,Quetin-Leclercq J,Scippo ML,Phuong NT,Kestemont P

更新日期：2020-05-05 00:00:00

abstract：:Natural killer (NK) cells are effector lymphocytes of the innate immune system that are able to mount a multifaceted antiviral response within hours following infection. This is achieved through an array of cell surface receptors surveilling host cells for alterations in human leukocyte antigen class I (HLA-I) express...

journal_title：Frontiers in immunology

authors： Hölzemer A,Garcia-Beltran WF,Altfeld M

更新日期：2017-11-14 00:00:00

abstract：:Fungal bioaerosols are ubiquitous in the environment and human exposure can result in a variety of health effects ranging from systemic, subcutaneous, and cutaneous infections to respiratory morbidity including allergy, asthma, and hypersensitivity pneumonitis. Recent research has focused on the role of microRNAs (miR...

journal_title：Frontiers in immunology

authors： Croston TL,Lemons AR,Beezhold DH,Green BJ

更新日期：2018-02-07 00:00:00

abstract：:Dyslipidemia is a central component of atherosclerosis and metabolic syndrome linked to chronic inflammation and immune dysfunction. Previously, we showed that hypercholesterolemic apolipoprotein E knock out (apoE-/-) mice exhibit systemic effects including skin inflammation and hypertrophic lymph nodes (LNs). However...

journal_title：Frontiers in immunology

authors： Tay MHD,Lim SYJ,Leong YFI,Thiam CH,Tan KW,Torta FT,Narayanaswamy P,Wenk M,Angeli V

更新日期：2019-03-27 00:00:00

abstract：:Cystic fibrosis (CF) patients frequently acquire Pseudomonas aeruginosa infections that have been associated with a bad prognosis and an increased rate of pulmonary exacerbations. Respiratory viruses can cause exacerbations in chronic pulmonary diseases including COPD or asthma and have been suggested to contribute to...

journal_title：Frontiers in immunology

authors： Sörensen M,Kantorek J,Byrnes L,Boutin S,Mall MA,Lasitschka F,Zabeck H,Nguyen D,Dalpke AH

更新日期：2020-02-04 00:00:00

abstract：:Natural Killer (NK) cells are characterized by their potential to kill tumor cells by different means without previous sensitization and have, therefore, become a valuable tool in cancer immunotherapy. However, their efficacy against solid tumors is still poor and further studies are required to improve it. One of the...

journal_title：Frontiers in immunology

authors： Terrén I,Orrantia A,Vitallé J,Zenarruzabeitia O,Borrego F

更新日期：2019-09-24 00:00:00

abstract：:Acrylamide is a toxic chemical substance produced when starch-rich foods are fried at high temperatures. Asthma is a chronic and complicated respiratory disease, of which genetic and environmental factors are the main triggers. Orally-received components may have an effect on asthma pathophysiology. The aim of this st...

journal_title：Frontiers in immunology

authors： Hajimohammadi B,Athari SM,Abdollahi M,Vahedi G,Athari SS

更新日期：2020-10-09 00:00:00

abstract：:Implantation of the fertilized egg into the maternal uterus is a crucial step in pregnancy establishment. Increasing evidence suggests that its success depends on various cell types of the innate immune system and on the fine balance between inflammatory and anti-inflammatory processes. In addition, it has recently be...

journal_title：Frontiers in immunology

authors： Zenclussen AC,Hämmerling GJ

更新日期：2015-06-17 00:00:00

abstract：:T cells play a vital role in eliminating pathogenic infections. To activate, naïve T cells search lymph nodes (LNs) for dendritic cells (DCs). Positioning and movement of T cells in LNs is influenced by chemokines including CCL21 as well as multiple cell types and structures in the LNs. Previous studies have suggested...

journal_title：Frontiers in immunology

authors： Tasnim H,Fricke GM,Byrum JR,Sotiris JO,Cannon JL,Moses ME

更新日期：2018-07-26 00:00:00

abstract：:Gestational age-dependent immune intolerance at the maternal-fetal interface might be a contributing factor to placental pathology and adverse pregnancy outcomes. Although the intrauterine setting is highly choreographed and considered to be a protective environment for the fetus, unscheduled inflammation might overwh...

journal_title：Frontiers in immunology

authors： Kamity R,Sharma S,Hanna N

更新日期：2019-04-05 00:00:00

abstract：:Sensing of microbe-associated molecular patterns or danger signals by innate immune receptors drives a complex exchange of information. Innate receptor signaling not only triggers transcriptional events but also induces profound changes in metabolic fluxes, redox balance, and metabolite abundance thereby influencing i...

journal_title：Frontiers in immunology

authors： Sancho D,Enamorado M,Garaude J

更新日期：2017-05-08 00:00:00

abstract：:Primary immunodeficiencies (PIDs) are genetic disorders impairing host immunity, leading to life-threatening infections, autoimmunity, and/or malignancies. Genomic technologies have been critical for expediting the discovery of novel genetic defects underlying PIDs, expanding our knowledge of the complex clinical phen...

journal_title：Frontiers in immunology

authors： Seleman M,Hoyos-Bachiloglu R,Geha RS,Chou J

更新日期：2017-07-24 00:00:00

abstract：:Skeletal health is maintained by bone remodeling, a process in which microscopic sites of effete or damaged bone are degraded on bone surfaces by osteoclasts and subsequently replaced by new bone, which is laid down by osteoblasts. This normal process can be disturbed in a variety of pathologic processes, including lo...

journal_title：Frontiers in immunology

authors： Boyce BF,Li J,Xing L,Yao Z

更新日期：2018-09-28 00:00:00

abstract：:Recent genome-wide association studies have identified over 230 genetic risk loci for multiple sclerosis. Current experimental autoimmune encephalomyelitis (EAE) models requiring active induction of disease may not be optimally suited for the characterization of the function of these genes. We have thus used gene expr...

journal_title：Frontiers in immunology

authors： Faber H,Kurtoic D,Krishnamoorthy G,Weber P,Pütz B,Müller-Myhsok B,Weber F,Andlauer TFM

更新日期：2020-09-18 00:00:00

abstract：:The cytosolic adhesion and degranulation-promoting adapter protein ADAP is expressed in various hematopoietic cells including T cells, NK cells, myeloid cells, and platelets but absent in mature B cells. The role of ADAP in T cell activation, proliferation and integrin activation is well-accepted. We previously demons...

journal_title：Frontiers in immunology

authors： Rudolph J,Meinke C,Voss M,Guttek K,Kliche S,Reinhold D,Schraven B,Reinhold A

更新日期：2019-10-01 00:00:00

abstract：:Microvilli are finger-like membrane protrusions, supported by the actin cytoskeleton, and found on almost all cell types. A growing body of evidence suggests that the dynamic lymphocyte microvilli, with their highly curved membranes, play an important role in signal transduction leading to immune responses. Neverthele...

journal_title：Frontiers in immunology

authors： Orbach R,Su X

更新日期：2020-09-11 00:00:00

abstract：:Short-chain fatty acids (SCFAs), such as acetate, butyrate, and propionate, modulate immune responses in the gut. However, the effect of SCFAs on mucosal vaccine-induced immune cell migration is poorly understood. Here, we investigated whether SCFAs modulate chemokine expression induced by the killed whole-cell oral c...

journal_title：Frontiers in immunology

authors： Sim JR,Kang SS,Lee D,Yun CH,Han SH

更新日期：2018-01-29 00:00:00

abstract：:The apparition of adaptive immunity in Gnathostomata correlates with the expansion of the E-protein family to encompass E2-2, HEB, and E2A. Within the family, E2-2 and HEB are more closely evolutionarily related but their concerted action in hematopoiesis remains to be explored. Here we show that the combined disrupti...

journal_title：Frontiers in immunology

authors： Bouderlique T,Peña-Pérez L,Kharazi S,Hils M,Li X,Krstic A,De Paepe A,Schachtrup C,Gustafsson C,Holmberg D,Schachtrup K,Månsson R

更新日期：2019-03-18 00:00:00

abstract：:Human regulatory CD4+ T cells (Tregs) are potent immunosuppressive lymphocytes responsible for immune tolerance and homeostasis. Since the seminal reports identifying Tregs, vast research has been channeled into understanding their genesis, signature molecular markers, mechanisms of suppression, and role in disease. T...

journal_title：Frontiers in immunology

authors： Adair PR,Kim YC,Zhang AH,Yoon J,Scott DW

更新日期：2017-09-21 00:00:00

abstract：:Red blood cell (RBC) alloimmunization can make it difficult to procure compatible RBCs for future transfusion, directly leading to increased morbidity and mortality in transfusion-dependent patients. However, the factors that regulate RBC alloimmunization remain incompletely understood. As complement has been shown to...

journal_title：Frontiers in immunology

authors： Mener A,Arthur CM,Patel SR,Liu J,Hendrickson JE,Stowell SR

更新日期：2018-06-11 00:00:00

abstract：:The axonal guidance molecules, semaphorins, have been described to function both physiologically and pathologically outside of the nervous system. In this review, we focus on the vertebrate semaphorins found in classes 3 through 7 and their roles in vascular development and autoimmune diseases. Recent studies indicate...

journal_title：Frontiers in immunology

authors： Iragavarapu-Charyulu V,Wojcikiewicz E,Urdaneta A

更新日期：2020-03-05 00:00:00

abstract：:The receptor for advanced glycation endproducts (RAGE) can engage a diverse class of ligands and contribute to the immune and inflammatory response to infection and injury. It is known to be a pathogenic receptor in many inflammatory diseases, including ischemia/reperfusion (IR) injuries in several tissues; however, i...

journal_title：Frontiers in immunology

authors： Wu MC,Gilmour TD,Mantovani S,Woodruff TM

更新日期：2015-12-07 00:00:00

abstract：:Unlike mice and humans, porcine γδ T cells represent a prominent subset of T cells in blood and secondary lymphatic organs. GATA-3, T-bet and Eomesodermin (Eomes) are transcription factors with crucial functions in T-cell development and functional differentiation, but their expression has not been investigated in por...

journal_title：Frontiers in immunology

authors： Rodríguez-Gómez IM,Talker SC,Käser T,Stadler M,Reiter L,Ladinig A,Milburn JV,Hammer SE,Mair KH,Saalmüller A,Gerner W

更新日期：2019-03-11 00:00:00

abstract：:Toll-like receptor 9 (TLR9) belongs to the group of endosomal receptors of the innate immune system with the ability to recognize hypomethylated CpG sequences from DNA. There is scarce information about TLR9 expression and its association with the circadian cycle (CC). Different patterns of TLR9 expression are regulat...

journal_title：Frontiers in immunology

authors： Martínez-García EA,Zavala-Cerna MG,Lujano-Benítez AV,Sánchez-Hernández PE,Martín-Márquez BT,Sandoval-García F,Vázquez-Del Mercado M

更新日期：2018-07-06 00:00:00

abstract：:We are living through an unprecedented accumulation of data on gene expression by macrophages, reflecting their origin, distribution, and localization within all organs of the body. While the extensive heterogeneity of the cells of the mononuclear phagocyte system is evident, the functional significance of their diver...

journal_title：Frontiers in immunology

authors： Gordon S,Plüddemann A

更新日期：2019-08-09 00:00:00