Solenoidal Micromagnetic Stimulation Enables Activation of Axons With Specific Orientation.

Abstract:

:Electrical stimulation of the central and peripheral nervous systems - such as deep brain stimulation, spinal cord stimulation, and epidural cortical stimulation are common therapeutic options increasingly used to treat a large variety of neurological and psychiatric conditions. Despite their remarkable success, there are limitations which if overcome, could enhance outcomes and potentially reduce common side-effects. Micromagnetic stimulation (μMS) was introduced to address some of these limitations. One of the most remarkable properties is that μMS is theoretically capable of activating neurons with specific axonal orientations. Here, we used computational electromagnetic models of the μMS coils adjacent to neuronal tissue combined with axon cable models to investigate μMS orientation-specific properties. We found a 20-fold reduction in the stimulation threshold of the preferred axonal orientation compared to the orthogonal direction. We also studied the directional specificity of μMS coils by recording the responses evoked in the inferior colliculus of rodents when a pulsed magnetic stimulus was applied to the surface of the dorsal cochlear nucleus. The results confirmed that the neuronal responses were highly sensitive to changes in the μMS coil orientation. Accordingly, our results suggest that μMS has the potential of stimulating target nuclei in the brain without affecting the surrounding white matter tracts.

journal_name

Front Physiol

journal_title

Frontiers in physiology

authors

Golestanirad L,Gale JT,Manzoor NF,Park HJ,Glait L,Haer F,Kaltenbach JA,Bonmassar G

doi

10.3389/fphys.2018.00724

subject

Has Abstract

pub_date

2018-07-27 00:00:00

pages

724

issn

1664-042X

journal_volume

9

pub_type

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