Lateral Habenula Gone Awry in Depression: Bridging Cellular Adaptations With Therapeutics.

Abstract:

:Depression is a highly heterogeneous disease characterized by symptoms spanning from anhedonia and behavioral despair to social withdrawal and learning deficit. Such diversity of behavioral phenotypes suggests that discrete neural circuits may underlie precise aspects of the disease, rendering its treatment an unmet challenge for modern neuroscience. Evidence from humans and animal models indicate that the lateral habenula (LHb), an epithalamic center devoted to processing aversive stimuli, is aberrantly affected during depression. This raises the hypothesis that rescuing maladaptations within this nucleus may be a potential way to, at least partially, treat aspects of mood disorders. In this review article, we will discuss pre-clinical and clinical evidence highlighting the role of LHb and its cellular adaptations in depression. We will then describe interventional approaches aiming to rescue LHb dysfunction and ultimately ameliorate depressive symptoms. Altogether, we aim to merge the mechanistic-, circuit-, and behavioral-level knowledge obtained about LHb maladaptations in depression to build a general framework that might prove valuable for potential therapeutic interventions.

journal_name

Front Neurosci

authors

Nuno-Perez A,Tchenio A,Mameli M,Lecca S

doi

10.3389/fnins.2018.00485

subject

Has Abstract

pub_date

2018-07-23 00:00:00

pages

485

eissn

1662-4548

issn

1662-453X

journal_volume

12

pub_type

杂志文章,评审
  • Active Time-Restricted Feeding Improved Sleep-Wake Cycle in db/db Mice.

    abstract::People with diabetes are more likely to experience sleep disturbance than those without. Sleep disturbance can cause daytime sleepiness in diabetic patients, which may impair their daytime performance or even lead to workplace injuries. Therefore, restoring the normal sleep-wake cycle is critical for diabetic patients...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.00969

    authors: Hou T,Wang C,Joshi S,O'Hara BF,Gong MC,Guo Z

    更新日期:2019-09-20 00:00:00

  • A Mathematical Approach to Correlating Objective Spectro-Temporal Features of Non-linguistic Sounds With Their Subjective Perceptions in Humans.

    abstract::Non-linguistic sounds (NLSs) are a core feature of our everyday life and many evoke powerful cognitive and emotional outcomes. The subjective perception of NLSs by humans has occasionally been defined for single percepts, e.g., their pleasantness, whereas many NLSs evoke multiple perceptions. There has also been very ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.00794

    authors: Burns T,Rajan R

    更新日期:2019-07-31 00:00:00

  • Nutrient Sensing Systems in Fish: Impact on Food Intake Regulation and Energy Homeostasis.

    abstract::Evidence obtained in recent years in a few species, especially rainbow trout, supports the presence in fish of nutrient sensing mechanisms. Glucosensing capacity is present in central (hypothalamus and hindbrain) and peripheral [liver, Brockmann bodies (BB, main accumulation of pancreatic endocrine cells in several fi...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2016.00603

    authors: Conde-Sieira M,Soengas JL

    更新日期:2017-01-05 00:00:00

  • Exercise Attenuates Anabolic Steroids-Induced Anxiety via Hippocampal NPY and MC4 Receptor in Rats.

    abstract::The aim of our study was to evaluate the effects of chronic administration of nandrolone-decanoate (ND) or testosterone-enanthate (TE) in supraphysiological doses and a prolonged swimming protocol, alone and in combination with ND or TE, on anxiety-like behavior in rats. We investigated the immunohistochemical alterat...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.00172

    authors: Joksimovic J,Selakovic D,Jovicic N,Mitrovic S,Mihailovic V,Katanic J,Milovanovic D,Rosic G

    更新日期:2019-02-26 00:00:00

  • Pyneal: Open Source Real-Time fMRI Software.

    abstract::Increasingly, neuroimaging researchers are exploring the use of real-time functional magnetic resonance imaging (rt-fMRI) as a way to access a participant's ongoing brain function throughout a scan. This approach presents novel and exciting experimental applications ranging from monitoring data quality in real time, t...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.00900

    authors: MacInnes JJ,Adcock RA,Stocco A,Prat CS,Rao RPN,Dickerson KC

    更新日期:2020-09-15 00:00:00

  • Endocannabinoid System and Migraine Pain: An Update.

    abstract::The trigeminovascular system (TS) activation and the vasoactive release from trigeminal endings, in proximity of the meningeal vessels, are considered two of the main effector mechanisms of migraine attacks. Several other structures and mediators are involved, however, both upstream and alongside the TS. Among these, ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2018.00172

    authors: Greco R,Demartini C,Zanaboni AM,Piomelli D,Tassorelli C

    更新日期:2018-03-19 00:00:00

  • The Profiles of Non-stationarity and Non-linearity in the Time Series of Resting-State Brain Networks.

    abstract::The linearity and stationarity of fMRI time series need to be understood due to their important roles in the choice of approach for brain network analysis. In this paper, we investigated the stationarity and linearity of resting-state fMRI (rs-fMRI) time-series data from the Midnight Scan Club datasets. The degree of ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.00493

    authors: Guan S,Jiang R,Bian H,Yuan J,Xu P,Meng C,Biswal B

    更新日期:2020-06-11 00:00:00

  • Cholinergic Deficit Induced by Central Administration of 192IgG-Saporin Is Associated With Activation of Microglia and Cell Loss in the Dorsal Hippocampus of Rats.

    abstract::Alzheimer's disease (AD) is associated with degeneration of cholinergic neurons in the basal forebrain. Administration of the immunotoxin 192IgG-saporin to rats, an animal model of AD, leads to degeneration of cholinergic neurons in the medial septal area. In the present study, cholinergic cell death was induced by in...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.00146

    authors: Dobryakova YV,Volobueva MN,Manolova AO,Medvedeva TM,Kvichansky AA,Gulyaeva NV,Markevich VA,Stepanichev MY,Bolshakov AP

    更新日期:2019-03-12 00:00:00

  • Comparison of IVA and GIG-ICA in Brain Functional Network Estimation Using fMRI Data.

    abstract::Spatial group independent component analysis (GICA) methods decompose multiple-subject functional magnetic resonance imaging (fMRI) data into a linear mixture of spatially independent components (ICs), some of which are subsequently characterized as brain functional networks. Group information guided independent compo...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2017.00267

    authors: Du Y,Lin D,Yu Q,Sui J,Chen J,Rachakonda S,Adali T,Calhoun VD

    更新日期:2017-05-19 00:00:00

  • Effects of Light and Sound on the Prefrontal Cortex Activation and Emotional Function: A Functional Near-Infrared Spectroscopy Study.

    abstract::We constructed a near infrared spectroscopy-based real-time feedback system to estimate the subjects' emotional states using the changes in oxygenated hemoglobin concentration [Δ(oxy-Hb)] in the prefrontal cortex (PFC). Using this system, we investigated the influences of continual mild and equivocal stimuli consistin...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2017.00321

    authors: Hori S,Mori K,Mashimo T,Seiyama A

    更新日期:2017-06-09 00:00:00

  • Glycine-Histidine-Lysine (GHK) Alleviates Astrocytes Injury of Intracerebral Hemorrhage via the Akt/miR-146a-3p/AQP4 Pathway.

    abstract::Intracerebral hemorrhage (ICH) is a major type of cerebrovascular disease with poor prognosis. Recent studies have shown that Glycyl-l-histidyl-l-lysine (GHK) is a kind of natural human tripeptide which could inhibit inflammation and against neurodegenerative diseases, but neither its role nor the mechanisms in ICH ha...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.576389

    authors: Zhang H,Wang Y,Lian L,Zhang C,He Z

    更新日期:2020-10-28 00:00:00

  • The Role of MicroRNA in the Modulation of the Melanocortinergic System.

    abstract::The central control of energy balance involves a highly regulated neuronal network within the hypothalamus and the dorsal vagal complex. In these structures, pro-opiomelanocortin (POMC) neurons are known to reduce meal size and to increase energy expenditure. In addition, leptin, a peripheral signal that relays inform...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2017.00181

    authors: Derghal A,Djelloul M,Trouslard J,Mounien L

    更新日期:2017-04-05 00:00:00

  • Explaining Individual Differences in Motor Behavior by Intrinsic Functional Connectivity and Corticospinal Excitability.

    abstract::Motor performance varies substantially between individuals. This variance is rooted in individuals' innate motor abilities, and should thus have a neural signature underlying these differences in behavior. Could these individual differences be detectable with neural measurements acquired at rest? Here, we tested the h...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.00076

    authors: Herszage J,Dayan E,Sharon H,Censor N

    更新日期:2020-02-05 00:00:00

  • Role of central vagal 5-HT3 receptors in gastrointestinal physiology and pathophysiology.

    abstract::Vagal neurocircuits are vitally important in the co-ordination and modulation of GI reflexes and homeostatic functions. 5-hydroxytryptamine (5-HT; serotonin) is critically important in the regulation of several of these autonomic gastrointestinal (GI) functions including motility, secretion and visceral sensitivity. W...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2015.00413

    authors: Browning KN

    更新日期:2015-10-29 00:00:00

  • MicroRNA Let-7i Is a Promising Serum Biomarker for Post-stroke Cognitive Impairment and Alleviated OGD-Induced Cell Damage in vitro by Regulating Bcl-2.

    abstract:Background:The mechanism of post-stroke cognitive impairment (PSCI) has not been explained. We aimed to investigate whether miR-let-7i participates in the PSCI and illuminates its underlying role in oxygen-glucose deprivation (OGD)-induced cell apoptosis. Methods:Blood samples from 36 subjects with PSCI and 38 with po...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.00215

    authors: Wang ZQ,Li K,Huang J,Huo TT,Lv PY

    更新日期:2020-03-24 00:00:00

  • New Vision for Visual Prostheses.

    abstract::Developments of new strategies to restore vision and improving on current strategies by harnessing new advancements in material and electrical sciences, and biological and genetic-based technologies are of upmost health priorities around the world. Federal and private entities are spending billions of dollars on visua...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2020.00036

    authors: Farnum A,Pelled G

    更新日期:2020-02-18 00:00:00

  • Finding a roadmap to achieve large neuromorphic hardware systems.

    abstract::Neuromorphic systems are gaining increasing importance in an era where CMOS digital computing techniques are reaching physical limits. These silicon systems mimic extremely energy efficient neural computing structures, potentially both for solving engineering applications as well as understanding neural computation. T...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2013.00118

    authors: Hasler J,Marr B

    更新日期:2013-09-10 00:00:00

  • Event-Related Potential Responses to Task Switching Are Sensitive to Choice of Spatial Filter.

    abstract::Event-related potential (ERP) studies using the task-switching paradigm show that multiple ERP components are modulated by activation of proactive control processes involved in preparing to repeat or switch task and reactive control processes involved in implementation of the current or new task. Our understanding of ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2018.00143

    authors: Wong ASW,Cooper PS,Conley AC,McKewen M,Fulham WR,Michie PT,Karayanidis F

    更新日期:2018-03-08 00:00:00

  • Gastrocnemius Myoelectric Control of a Robotic Hip Exoskeleton Can Reduce the User's Lower-Limb Muscle Activities at Push Off.

    abstract::We present a novel assistive control strategy for a robotic hip exoskeleton for assisting hip flexion/extension, based on a proportional Electromyography (EMG) strategy. The novelty of the proposed controller relies on the use of the Gastrocnemius Medialis (GM) EMG signal instead of a hip flexor muscle, to control the...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2018.00071

    authors: Grazi L,Crea S,Parri A,Molino Lova R,Micera S,Vitiello N

    更新日期:2018-02-14 00:00:00

  • Integration of Descending Command Systems for the Generation of Context-Specific Locomotor Behaviors.

    abstract::Over the past decade there has been a renaissance in our understanding of spinal cord circuits; new technologies are beginning to provide key insights into descending circuits which project onto spinal cord central pattern generators. By integrating work from both the locomotor and animal behavioral fields, we can now...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2017.00581

    authors: Kim LH,Sharma S,Sharples SA,Mayr KA,Kwok CHT,Whelan PJ

    更新日期:2017-10-18 00:00:00

  • A Hypothesis of the Co-evolution of Cooperation and Responses to Inequity.

    abstract::Recent evidence demonstrates that humans are not the only species to respond negatively to inequitable outcomes which are to their disadvantage. Several species respond negatively if they subsequently receive a less good reward than a social partner for completing the same task. While these studies suggest that the ne...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2011.00043

    authors: Brosnan SF

    更新日期:2011-04-05 00:00:00

  • Convolutional Networks Outperform Linear Decoders in Predicting EMG From Spinal Cord Signals.

    abstract::Advanced algorithms are required to reveal the complex relations between neural and behavioral data. In this study, forelimb electromyography (EMG) signals were reconstructed from multi-unit neural signals recorded with multiple electrode arrays (MEAs) from the corticospinal tract (CST) in rats. A six-layer convolutio...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2018.00689

    authors: Guo Y,Gok S,Sahin M

    更新日期:2018-10-17 00:00:00

  • Ambiguity aversion in rhesus macaques.

    abstract::People generally prefer risky options, which have fully specified outcome probabilities, to ambiguous options, which have unspecified probabilities. This preference, formalized in economics, is strong enough that people will reliably prefer a risky option to an ambiguous option with a greater expected value. Explanati...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2010.00166

    authors: Hayden BY,Heilbronner SR,Platt ML

    更新日期:2010-09-17 00:00:00

  • The Experimental Oxime K027-A Promising Protector From Organophosphate Pesticide Poisoning. A Review Comparing K027, K048, Pralidoxime, and Obidoxime.

    abstract::Poisoning with organophosphorus compounds (OPCs) is a major problem worldwide. Standard therapy with atropine and established oxime-type enzyme reactivators (pralidoxime, obidoxime) is unsatisfactory. In search of more efficacious broad-spectrum oximes, new bispyridinium (K-) oximes have been synthesized, with K027 be...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2019.00427

    authors: Lorke DE,Petroianu GA

    更新日期:2019-05-22 00:00:00

  • How Sensitive Are Conventional MEG Functional Connectivity Metrics With Sliding Windows to Detect Genuine Fluctuations in Dynamic Functional Connectivity?

    abstract::Despite advances in the field of dynamic connectivity, fixed sliding window approaches for the detection of fluctuations in functional connectivity are still widely used. The use of conventional connectivity metrics in conjunction with a fixed sliding window comes with the arbitrariness of the chosen window lengths. I...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.00797

    authors: Liuzzi L,Quinn AJ,O'Neill GC,Woolrich MW,Brookes MJ,Hillebrand A,Tewarie P

    更新日期:2019-08-02 00:00:00

  • Development of Performance and ERPs in a Flanker Task in Children and Adolescents with Tourette Syndrome-A Follow-Up Study.

    abstract::Background: Tourette Syndrome (TS) is a neurodevelopmental disorder with childhood-onset, with a typical decline in tic severity, as well as an increasing ability to suppress tics in late childhood and adolescence. These processes develop in parallel with general improvement of self-regulatory abilities, and performan...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2017.00305

    authors: Eichele H,Eichele T,Marquardt L,Adolfsdottir S,Hugdahl K,Sørensen L,Plessen KJ

    更新日期:2017-06-12 00:00:00

  • Partial Least Squares Regression Performs Well in MRI-Based Individualized Estimations.

    abstract::Estimation of individuals' cognitive, behavioral and demographic (CBD) variables based on MRI has attracted much research interest in the past decade, and effective machine learning techniques are of great importance for these estimations. Partial least squares regression (PLSR) is an attractive machine learning techn...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.01282

    authors: Chen C,Cao X,Tian L

    更新日期:2019-11-27 00:00:00

  • The Dual Role of AQP4 in Cytotoxic and Vasogenic Edema Following Spinal Cord Contusion and Its Possible Association With Energy Metabolism via COX5A.

    abstract::Spinal cord edema, mainly including vasogenic and cytotoxic edema, influences neurological outcome after spinal cord contusion (SCC). Aquaporin 4 (AQP4) is the most ubiquitous water channel in the central nervous system (CNS), which is a rate-limiting factor in vasogenic edema expressing in brain injury, and it contri...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.00584

    authors: Huang Y,Li SN,Zhou XY,Zhang LX,Chen GX,Wang TH,Xia QJ,Liang N,Zhang X

    更新日期:2019-06-14 00:00:00

  • Molecular and neural bases underlying roles of BDNF in the control of body weight.

    abstract::Brain-derived neurotrophic factor (BDNF) is a potent regulator of neuronal development and synaptic plasticity that is fundamental to neural circuit formation and cognition. It is also involved in the control of appetite and body weight, with mutations in the genes for BDNF and its receptor, TrkB, resulting in remarka...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2013.00037

    authors: Vanevski F,Xu B

    更新日期:2013-03-21 00:00:00

  • Walking the Tightrope: A Proposed Model of Chronic Pain and Stress.

    abstract::Pain and stress are both phenomena that challenge an individual's homeostasis and have significant overlap in conceptual and physiological processes. Allostasis is the ability to adapt to pain and stress and maintain homeostasis; however, if either process becomes chronic, it may result in negative long-term outcomes....

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2020.00270

    authors: Lunde CE,Sieberg CB

    更新日期:2020-03-26 00:00:00