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Fitness Landscape of the Immune Compromised Favors the Emergence of Antibiotic Resistance.

Abstract：

:Antibiotic resistance can come at a high cost, both in terms of fitness for the pathogen and poorer outcomes for patients. The fitness landscape encountered by bacterial pathogens varies greatly throughout patient populations in terms of host immunity as well as the duration and spectrum of antibiotics encountered. Severely immunocompromised patients present a favorable environment for antibiotic resistance to emerge due to lack of immune-mediated competition and increased opportunities to evolve both on-target and compensatory mutations. Such patients may present unique pathways for antibiotic resistance to emerge.

journal_name

ACS Infect Dis

journal_title

ACS infectious diseases

authors

Margolis E,Rosch JW

doi

10.1021/acsinfecdis.8b00158

subject

Has Abstract

pub_date

2018-09-14 00:00:00

pages

1275-1277

issue

9

issn

2373-8227

journal_volume

4

pub_type

杂志文章

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