DeCoST: A New Approach in Drug Repurposing From Control System Theory.

abstract：:Background: The gastrointestinal system hosts roughly 1,800 distinct phyla and about 40,000 bacterial classes, which are known as microbiota, and which are able to influence the brain. For instance, microbiota can also influence the immune response through the activation of the immune system or through the release of ...

journal_title：Frontiers in pharmacology

authors： Cuomo A,Maina G,Rosso G,Beccarini Crescenzi B,Bolognesi S,Di Muro A,Giordano N,Goracci A,Neal SM,Nitti M,Pieraccini F,Fagiolini A

更新日期：2018-10-15 00:00:00

abstract：:Particulate matter poses health risk to developing organisms. To investigate particulate matters with a diameter smaller than 2.5 um (PM2.5)-induced developmental cardiotoxicity, fertile chicken eggs were exposed to PM2.5 via air cell injection at doses of 0.05, 0.2, 0.5, 2, and 5 mg/egg kg. Morphological changes in t...

journal_title：Frontiers in pharmacology

authors： Jiang Q,Zhang C,Chen S,Shi L,Li DC,Lv N,Cui L,Chen Y,Zheng Y

更新日期：2020-06-05 00:00:00

abstract：:Field independence (FI) has been found to correlate with a wide range of cognitive processes requiring cognitive restructuring. Cognitive restructuring, that is going beyond the information given by the setting, is pivotal in creating stable mental representations of the environment, the so-called "cognitive maps," an...

journal_title：Frontiers in pharmacology

authors： Boccia M,Vecchione F,Piccardi L,Guariglia C

更新日期：2017-07-25 00:00:00

abstract：:The skin is the main barrier that protects us against environmental stressors (physical, chemical, and biological). These stressors, combined with internal factors, are responsible for cutaneous aging. Furthermore, they negatively affect the skin and increase the risk of cutaneous diseases, particularly skin cancer. T...

journal_title：Frontiers in pharmacology

authors： Parrado C,Mercado-Saenz S,Perez-Davo A,Gilaberte Y,Gonzalez S,Juarranz A

更新日期：2019-07-09 00:00:00

abstract：:Hippocampal theta activity is related to spatial information processing, and high-frequency theta activity, in particular, has been linked to efficient spatial memory performance. Theta activity is regulated by the synchronizing ascending system (SAS), which includes mesencephalic and diencephalic relays. The supramam...

journal_title：Frontiers in pharmacology

authors： Hernández-Pérez JJ,Gutiérrez-Guzmán BE,López-Vázquez MÁ,Olvera-Cortés ME

更新日期：2015-10-29 00:00:00

abstract：:Pulmonary fibrosis is closely associated with the recruitment of fibroblasts from capillary vessels with damaged endothelial cells, the epithelial mesenchymal transition (EMT) of type II alveolar epithelial cells, and the transformation of fibroblasts to myofibroblasts. Recent studies suggest that EMT is a key factor ...

journal_title：Frontiers in pharmacology

authors： Xie L,Zeng Y

更新日期：2020-12-04 00:00:00

abstract：:Digoxin is widely used to treat heart failure. Epidemiological studies suggested it might be used as an anticancer drug or sensitizing agent for cancer therapy. Adriamycin is a well-known anticancer drug, but often causes cardiotoxicity which limits its use. We recently investigated the anticancer effects of digoxin a...

journal_title：Frontiers in pharmacology

authors： Wang Y,Ma Q,Zhang S,Liu H,Zhao B,Du B,Wang W,Lin P,Zhang Z,Zhong Y,Kong D

更新日期：2020-02-28 00:00:00

abstract：:Many ion channels are involved in tumor development, promoting cancer cell proliferation, migration, invasion, and survival. Accordingly, some of them have been suggested as tumor markers and novel targets for cancer therapy. Some sex steroid hormones (SSH), including estrogens and androgens, favor cancer progression....

journal_title：Frontiers in pharmacology

authors： Restrepo-Angulo I,Bañuelos C,Camacho J

更新日期：2020-02-28 00:00:00

abstract：:Several reports have shown that the periventricular region of the brain, including the paraventricular nucleus (PVN), is critical to sensing and responding to changes in plasma osmolality. Further studies also implicate the transient receptor potential ion channel, type V4 (TRPV4) channel in this homeostatic behavior....

journal_title：Frontiers in pharmacology

authors： Feetham CH,Nunn N,Barrett-Jolley R

更新日期：2015-04-23 00:00:00

abstract：:Fertility issues are common amongst women with rheumatoid arthritis (RA). Interleukin 6 (IL-6) and tumor necrosis factor alpha (TNFα), known key players in RA pathogenesis, have been associated with reproductive disorders. This study investigates the role of these cytokines in decreased fertility in women with active ...

journal_title：Frontiers in pharmacology

authors： Bongenaar M,Smeele HTW,Lubberts E,Dolhain RJEM

更新日期：2020-12-10 00:00:00

abstract：:Cholesterol is essential for development, growth, and maintenance of organisms. Mutations in cholesterol biosynthetic genes are embryonic lethal and few polymorphisms have been so far associated with pathologies in humans. Previous analyses show that lanosterol 14α-demethylase (CYP51A1) from the late part of cholester...

journal_title：Frontiers in pharmacology

authors： Režen T,Ogris I,Sever M,Merzel F,Golic Grdadolnik S,Rozman D

更新日期：2017-06-30 00:00:00

abstract：:Inwardly rectifying potassium (Kir) channel subunits Kir4.1 are specifically expressed in astrocytes and regulate neuronal excitability by mediating spatial potassium buffering. In addition, it is now known that astrocytic Kir4.1 channels are closely involved in the pathogenesis of epilepsy. Here, to explore the role ...

journal_title：Frontiers in pharmacology

authors： Mukai T,Kinboshi M,Nagao Y,Shimizu S,Ono A,Sakagami Y,Okuda A,Fujimoto M,Ito H,Ikeda A,Ohno Y

更新日期：2018-08-06 00:00:00

abstract：:[This corrects the article on p. 161 in vol. 3, PMID: 22993507.]. ...

journal_title：Frontiers in pharmacology

authors： Villalba-Galea CA

更新日期：2015-05-29 00:00:00

abstract：:Nanoparticle-based antibiotic constructs have become a popular area of investigation in the biomedical sciences. Much of this work has pertained to human diseases, largely in the cancer therapy arena. However, considerable research has also been devoted to the nanochemistry for controlling infectious diseases. Among t...

journal_title：Frontiers in pharmacology

authors： Labruère R,Sona AJ,Turos E

更新日期：2019-10-04 00:00:00

abstract：:Acute Respiratory Distress Syndrome (ARDS) is a life-threatening complication that can ensue following Staphylococcus aureus infection. The enterotoxin produced by these bacteria (SEB) acts as a superantigen thereby activating a large proportion of T cells leading to cytokine storm and severe lung injury. Δ9Tetrahydro...

journal_title：Frontiers in pharmacology

authors： Mohammed A,Alghetaa H,Sultan M,Singh NP,Nagarkatti P,Nagarkatti M

更新日期：2020-06-16 00:00:00

abstract：:Background: Alzheimer's disease (AD), is a progressive neurodegenerative disease that is characterized by cognitive loss. Most researchers believe that aggregation and accumulation of β-amyloid peptides (Aβ) in brain cells are the central pathological hallmark of this disease. Methods: Based on the amyloid hypothesis,...

journal_title：Frontiers in pharmacology

authors： Liu W,Sun F,Wan M,Jiang F,Bo X,Lin L,Tang H,Xu S

更新日期：2018-01-08 00:00:00

abstract：:At present there is no effective treatment of pathologies associated with the death of neurons and glial cells which take place as a result of physical trauma or ischemic lesions of the nervous system. Thus, researchers have high hopes for a treatment based on the use of stem cells (SC), which are potentially able to ...

journal_title：Frontiers in pharmacology

authors： Galieva LR,Mukhamedshina YO,Arkhipova SS,Rizvanov AA

更新日期：2017-09-08 00:00:00

abstract：:Oncogenic activation of the KRAS gene via point mutations occurs in 20-30% of patients with non-small cell lung cancer (NSCLC). The RAS-RAF-ERK and RAS-PI3K-AKT pathways are the major hyper-activated downstream pathways in RAS mutation, which promotes the unlimited lifecycle of cancer cells and their metastasis in hum...

journal_title：Frontiers in pharmacology

authors： Lai H,Wang Y,Duan F,Li Y,Jiang Z,Luo L,Liu L,Leung ELH,Yao X

更新日期：2018-08-22 00:00:00

abstract：:Gamithromycin is approved for the treatment and prevention of bovine respiratory disease (BRD), which is caused mainly by Mannheimia haemolytica, Pasteurella multocida, Histophilus somni, and Mycoplasma species. In this study, multiple dosage regimens were administered to the neutropenic mouse lung infection model in ...

journal_title：Frontiers in pharmacology

authors： Yang Q,Liu X,Zhang C,Yong K,Clifton AC,Ding H,Liu Y

更新日期：2019-09-24 00:00:00

abstract：:Diabetes is affecting the social and economic developments in developing countries like Sri Lanka. Siddha Medicine (Tamil Medicine) is mostly practiced in the Eastern and Northern Provinces of Sri Lanka. Our recent review of Sri Lankan Siddha historical documents identified 171 plant species used to prepare anti-diabe...

journal_title：Frontiers in pharmacology

authors： Sathasivampillai SV,Rajamanoharan PRS,Heinrich M

更新日期：2018-10-10 00:00:00

abstract：:Random-pattern skin flap replantation is commonly used to repair skin defects during plastic and reconstructive surgery. However, flap necrosis due to ischemia and ischemia-reperfusion injury limits clinical applications. Betulinic acid, a plant-derived pentacyclic triterpene, may facilitate flap survival. In the pres...

journal_title：Frontiers in pharmacology

authors： Li J,Bao G,ALyafeai E,Ding J,Li S,Sheng S,Shen Z,Jia Z,Lin C,Zhang C,Lou Z,Xu H,Gao W,Zhou K

更新日期：2019-09-13 00:00:00

abstract：:Rapidly progressive interstitial lung disease is typically associated with clinically amyopathic dermatomyositis and the anti-melanoma differentiation associated gene 5 antibody, a condition with high mortality and resistance to classic immunosuppression. Recent reports have described the efficacy of the Janus kinase ...

journal_title：Frontiers in pharmacology

authors： Conca W,Weheba I,Abouzied ME,Abdelsayed A,Aleyouni Y,Al-Mutairy E,Bakshi N,Khalid M

更新日期：2020-12-15 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic autoimmune disease that is primarily characterized by synovial inflammation. In this study, we found that a traditional Chinese decoction, Juanbi-Tang (JBT), JBT attenuated the symptoms of collagen-induced arthritis (CIA) mice and in tumor necrosis factor transgenic (TNF-Tg) mice...

journal_title：Frontiers in pharmacology

authors： Wang T,Jia Q,Chen T,Yin H,Tian X,Lin X,Liu Y,Zhao Y,Wang Y,Shi Q,Huang C,Xu H,Liang Q

更新日期：2020-02-14 00:00:00

abstract：:Aim: Little is known regarding the relationship between use of oral corticosteroids and hip fracture in the elderly in Taiwan. The aim of the study was to examine this issue. Methods: A retrospective population-based case-control study using the database of the Taiwan National Health Insurance Program (2000-2013) was ...

journal_title：Frontiers in pharmacology

authors： Lai SW,Lin CL,Liao KF

更新日期：2017-09-11 00:00:00

abstract：:The Health Improvement Network UK primary care database was used to identify a cohort of 38 077 individuals aged 50-84 years with a first prescription of low-dose acetylsalicylic acid (ASA; 75-300 mg/day) for secondary prevention of cardiovascular or cerebrovascular events during 2000-2007. From this cohort, 169 incid...

journal_title：Frontiers in pharmacology

authors： Cea Soriano L,Rodríguez LA

更新日期：2010-10-14 00:00:00

abstract：:The skin is the first line of defense against pathogen and other environmental pollutant. The body is constantly exposed to reactive oxygen species (ROS) that stimulates inflammatory process in the skin. Many studies have linked ROS to various inflammatory skin diseases. Patients with skin diseases face various challe...

journal_title：Frontiers in pharmacology

authors： Choo WT,Teoh ML,Phang SM,Convey P,Yap WH,Goh BH,Beardall J

更新日期：2020-07-31 00:00:00

abstract：:Accumulating evidence suggests that Astragaloside IV (AS-IV) improves cardiac function and protects the cardiovascular system. However, the molecular targets involved remain ambiguous. In this work, we report research suggesting that AS-IV can antagonize arrhythmias and reduce the cardiac damage induced by aconitine i...

journal_title：Frontiers in pharmacology

authors： Wang M,Shi Y,Yao L,Li Q,Wang Y,Li J,Fu D

更新日期：2020-06-24 00:00:00

abstract：:Peritoneal dialysis (PD)-associated peritoneal fibrosis is a chronic progress which induces ultrafiltration failure. It remains a challenge to prevent the progression of PD-associated fibrosis in clinic practice. Wnt/β-catenin pathway plays important role in many severe fibrotic diseases, here we investigated its cont...

journal_title：Frontiers in pharmacology

authors： Guo Y,Sun L,Xiao L,Gou R,Fang Y,Liang Y,Wang R,Li N,Liu F,Tang L

更新日期：2017-10-30 00:00:00

abstract：:Since the introduction of antibiotics, they have been used freely, with their prescription occurring almost always when they were not necessary. The other major form of contact between humans and antibiotics, now unintentionally, is with the large amount of these drugs in the environment and in our food. The relations...

journal_title：Frontiers in pharmacology

authors： Del Fiol FS,Balcão VM,Barberato-Fillho S,Lopes LC,Bergamaschi CC

更新日期：2018-12-03 00:00:00

abstract：:Choroid plexus carcinomas (CPCs) are rare, aggressive pediatric brain tumors with no established curative therapy for relapsed disease, and poor survival rates. TP53 Mutation or dysfunction correlates with poor or no survival outcome in CPCs. Here, we report the case of a 4 month-old female who presented with dissemin...

journal_title：Frontiers in pharmacology

authors： Cornelius A,Foley J,Bond J,Nagulapally AB,Steinbrecher J,Hendricks WPD,Rich M,Yendrembam S,Bergendahl G,Trent JM,Sholler GS

更新日期：2017-09-25 00:00:00