Abstract:
:Serial measurements of coronary plaque volume have been used to evaluate drug efficacy in atherosclerotic progression. However, the usefulness of computed tomography for this purpose is unknown. We investigated whether the change in total plaque volume on coronary computed tomographic angiography is associated with the change in segment plaque volume on intravascular ultrasound. We prospectively enrolled 11 consecutive patients (mean age, 56.3 ± 5 yr; 6 men) who were to undergo serial invasive coronary angiographic examinations with use of grayscale intravascular ultrasound and coronary computed tomography, performed <180 days apart at baseline and from 1 to 2 years later. Subjects underwent 186 serial measurements of total plaque volume on coronary computed tomography and 22 of segmental plaque volume on intravascular ultrasound. We used semiautomated software to examine percentage relationships and changes between total plaque and segmental plaque volumes. No significant correlations were found between percentages of total coronary and segment coronary plaque volume, nor between normalized coronary plaque volume. However, in the per-patient analysis, there were strong correlations between the imaging methods for changes in total coronary and segment coronary plaque volume (r=0.62; P=0.04), as well as normalized plaque volume (r=0.82; P=0.002). Per-patient change in plaque volume on coronary computed tomography is significantly associated with that on intravascular ultrasound. Computed tomographic angiography may be safer and more widely available than intravascular ultrasound for evaluating atherosclerotic progression in coronary arteries. Larger studies are warranted.
journal_name
Tex Heart Inst Jjournal_title
Texas Heart Institute journalauthors
Nakanishi R,Alani A,Matsumoto S,Li D,Fahmy M,Abraham J,Dailing C,Broersen A,Kitslaar PH,Nasir K,Min JK,Budoff MJdoi
10.14503/THIJ-15-5212subject
Has Abstractpub_date
2018-04-07 00:00:00pages
84-91issue
2eissn
0730-2347issn
1526-6702journal_volume
45pub_type
杂志文章abstract::Using continuous-wave Doppler echocardiography, we evaluated the mitral flow velocity pattern in 30 ventricular septal defect patients, 11 of whom had severe pulmonary vascular obstructive disease (Group I); 10 of whom had severe pulmonary hypertension without pulmonary vascular obstructive disease (Group II); and 9 o...
journal_title:Texas Heart Institute journal
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journal_title:Texas Heart Institute journal
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journal_title:Texas Heart Institute journal
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pub_type: 杂志文章
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journal_title:Texas Heart Institute journal
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pub_type: 临床试验,杂志文章
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更新日期:2004-01-01 00:00:00
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journal_title:Texas Heart Institute journal
pub_type: 杂志文章
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journal_title:Texas Heart Institute journal
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