Abstract：
PURPOSE:Joint pain is the most common symptom of osteoarthritis (OA); however, its mechanism remains unclarified. The present study investigated hindlimb motion during locomotion on the treadmill using a three-dimensional (3D) motion analysis system with high-speed cameras to evaluate whether this method can be used as an indication of joint pain in a mouse model of surgically induced OA. METHODS:We resected the medial meniscus and medial collateral ligament in 8-week old C57BL/6 male mice and performed locomotion recording 6 months post-operatively. Additionally, we performed the same recording after oral administration of the selective cyclooxygenase-2 inhibitor to determine whether alteration of the parameters were associated with joint pain. RESULTS:OA development, characterized by cartilage degeneration and osteophyte formation, was markedly enhanced in the OA group. There was no significant difference between the sham and OA groups in basic gait parameters, including stance duration, swing duration and gait cycle. However, when we divided the gait cycle into four phases and calculated the joint ranges of motion in each phase, the range of motion of the knee joint during the stepping-in phase and the swing duration were significantly decreased in the OA group. These significant differences between the sham and OA groups were diminished by the oral administration of a selective cyclooxygenase-2 inhibitor to the OA group. CONCLUSION:The present method may be useful to evaluate joint pain in experimental mice and contribute to elucidating the molecular mechanisms of pain in the OA knee joint in combination with genetically modified mice.
journal_name
J Orthop Surg (Hong Kong)journal_title
Journal of orthopaedic surgery (Hong Kong)authors
Makii Y,Asaka M,Setogawa S,Fujiki S,Hosaka Y,Yano F,Oka H,Tanaka S,Fukui N,Yanagihara D,Saito Tdoi
10.1177/2309499018768017subject
Has Abstractpub_date
2018-05-01 00:00:00pages
2309499018768017issue
2eissn
1022-5536issn
2309-4990journal_volume
26pub_type
杂志文章abstract：PURPOSE:To compare early outcome of transforaminal lumbar interbody fusion (TLIF) for lytic versus degenerative spondylolisthesis. METHODS:14 women and 8 men aged 20 to 60 (mean, 36) years underwent TLIF for lytic (n=15) or degenerative (n=7) spondylolisthesis. Of the 15 patients with lytic spondylolisthesis, 9 involv...
journal_title：Journal of orthopaedic surgery (Hong Kong)
pub_type： 杂志文章
doi：10.1177/230949901202000323
更新日期：2012-12-01 00:00:00
abstract：BACKGROUND:Juvenile hallux valgus (JHV) frequently results in an impaired quality of life because of pain and deformity. We used a validated clinical score to investigate the efficacy of lateral hemiepiphysiodesis of the first metatarsal base as a treatment for JHV. METHODS:We conducted a prospective, nonrandomized, s...
journal_title：Journal of orthopaedic surgery (Hong Kong)
pub_type： 临床试验,杂志文章
doi：10.1177/2309499018801135
更新日期：2018-05-01 00:00:00
abstract：PURPOSE:To assess the compression and flexural strength of bone cement mixed with 0 ml, 1 ml, or 2 ml of blood. METHODS:High viscosity polymethyl methacrylate (PMMA) loaded with or without gentamicin was used. Blood was collected from total knee arthroplasty patients. In the same operating room, one pack of cement eac...
journal_title：Journal of orthopaedic surgery (Hong Kong)
pub_type： 杂志文章
doi：10.1177/1602400223
更新日期：2016-08-01 00:00:00
abstract：PURPOSE:To review the functional outcome and local recurrence rate of 29 patients who underwent segmental excision or intralesional curettage with adjuvant therapy for giant cell tumour (GCT) of bone. METHODS:Records of 17 men and 12 women (mean age, 30.17 years) who underwent segmental excision (n=18) or intralesiona...
journal_title：Journal of orthopaedic surgery (Hong Kong)
pub_type： 杂志文章
doi：10.1177/230949901602400120
更新日期：2016-04-01 00:00:00
abstract：PURPOSE:Fingertip replantation is a challenging and technically demanding procedure. A variety of venous drainage techniques have been attempted for successful fingertip replantation. We present a new venous drainage technique, known as serial multifocal incision for fingertip replantation. METHODS:Between 2006 and 20...
journal_title：Journal of orthopaedic surgery (Hong Kong)
pub_type： 杂志文章
doi：10.1177/2309499019831480
更新日期：2019-01-01 00:00:00
abstract：:Paediatric musculoskeletal infection remains an important cause of morbidity. Methicillin sensitive Staphylococcus aureus is still the most common organism although the incidence of methicillin resistant S. aureus in the community is rising. Osteomyelitis and septic arthritis due to Haemophilus influenzae is decreasin...
journal_title：Journal of orthopaedic surgery (Hong Kong)
pub_type： 杂志文章
doi：10.1177/230949900100900116
更新日期：2001-06-01 00:00:00
abstract：PURPOSE:To evaluate the tibial articular cartilage and histology of the posterior cruciate ligament (PCL) in osteoarthritic knees so as to determine predictors of PCL degeneration. METHODS:23 advanced osteoarthritic knees (mean patient age, 61 years) treated with total knee arthroplasty (TKA) were prospectively studie...
journal_title：Journal of orthopaedic surgery (Hong Kong)
pub_type： 杂志文章
doi：10.1177/230949901302100106
更新日期：2013-04-01 00:00:00
abstract：PURPOSE:This study analysed the accuracy and safety of the fluoroscopic guided percutaneous screws in the upper thoracic vertebrae (T1-T6). METHODS:Computed tomography scans from 74 patients were retrospectively evaluated between January 2008 and December 2012. Pedicle perforations were classified by two types of grad...
journal_title：Journal of orthopaedic surgery (Hong Kong)
pub_type： 杂志文章
doi：10.1177/2309499017722438
更新日期：2017-05-01 00:00:00
abstract：:An 11-year-old girl presented with a progressive swelling of the right elbow after a contusion. Radiography and magnetic resonance imaging showed a densely calcified lesion with no periosteal reaction or fracture. The underlying bone and muscles had normal signal intensity. A bone scan revealed increased uptake over t...
journal_title：Journal of orthopaedic surgery (Hong Kong)
pub_type： 杂志文章
doi：10.1177/230949901101900125
更新日期：2011-04-01 00:00:00
abstract：:Cervical cancer patients may experience hip problems related to the cancer itself or therapeutic management for the cancer. Septic arthritis should be one of the possibilities but there have been no reports on this. Here we present three patients who developed hip problems more than two years after radiotherapy with o...
journal_title：Journal of orthopaedic surgery (Hong Kong)
pub_type： 杂志文章
doi：10.1177/230949900100900209
更新日期：2001-12-01 00:00:00
abstract：:The failure rate of rotator cuff repair is high. Regenerative techniques using material scaffolds, stem cells, and growth factors help augment repair and regenerate tissue. We reviewed the literature of various regenerative techniques in terms of (1) enhancing the repair process, (2) tissue regeneration, (3) mechanica...
journal_title：Journal of orthopaedic surgery (Hong Kong)
pub_type： 杂志文章,评审
doi：10.1177/230949901302100223
更新日期：2013-08-01 00:00:00
abstract：BACKGROUND:Navigation is associated with improved accuracy in alignment. However, its influence on clinical outcome is inconclusive. The aim of this study was to compare the component alignment and functional outcome in patients undergoing navigation-assisted and conventional total knee replacement (TKR). MATERIALS AN...
journal_title：Journal of orthopaedic surgery (Hong Kong)
pub_type： 杂志文章
doi：10.1177/2309499019848079
更新日期：2019-05-01 00:00:00
abstract：PURPOSE:To determine correlation between metal hypersensitivity and long-term foot and ankle function and pain after internal fixation using stainless steel implants. METHODS:60 men and 46 women (mean age, 47 years) who underwent internal fixation for ankle fractures completed a questionnaire 13 to 38 (mean, 26) month...
journal_title：Journal of orthopaedic surgery (Hong Kong)
pub_type： 杂志文章
doi：10.1177/230949901101900309
更新日期：2011-12-01 00:00:00
abstract：PURPOSE:To evaluate the condition of the tendons and neurovascular bundles after percutaneous release for trigger finger of the middle, ring, and little fingers. METHODS:30 women and 13 men aged 20 to 55 (mean, 40) years underwent percutaneous release of the A1 pulley using a 18-gauge needle for 43 trigger fingers of ...
journal_title：Journal of orthopaedic surgery (Hong Kong)
pub_type： 杂志文章
doi：10.1177/230949901502300227
更新日期：2015-08-01 00:00:00
abstract：:We report on a 30-year-old haemophilic man with a pelvic pseudotumour compressing adjacent structures causing pain and swelling and destruction of surrounding soft tissues and bones. He underwent evacuation of the pseudotumour, acetabular reconstruction using the Harrington procedure, and total hip arthroplasty. ...
journal_title：Journal of orthopaedic surgery (Hong Kong)
pub_type： 杂志文章
doi：10.1177/230949901402200232
更新日期：2014-08-01 00:00:00
abstract：:Tumours and metastases of the spine are extremely stressful for patients, especially for elderly multimorbid patients. The modern cavity/coblation method offers a very good therapeutic alternative for such patients. The goal of this article was to evaluate and present the characteristics, significance, opportunities, ...
journal_title：Journal of orthopaedic surgery (Hong Kong)
pub_type： 杂志文章
doi：10.1177/2309499016684505
更新日期：2017-01-01 00:00:00
abstract：PURPOSES:To examine radiographically the component motion in a bipolar prosthesis and to determine whether the self-centering mechanism really works in vivo. METHODS:38 patients with 41 bipolar hip endoprostheses (30 for coxarthrosis and 11 for osteonecrosis of femoral head) were included in this study. Two radiograph...
journal_title：Journal of orthopaedic surgery (Hong Kong)
pub_type： 杂志文章
doi：10.1177/230949900501300108
更新日期：2005-04-01 00:00:00
abstract：:We report on a 41-year-old man with multiple epithelioid hemangioendothelioma of the left foot and ankle. The patient was treated with curettage and fixation with 2 separate plates, but later developed local infection. Owing to the potential for malignancy, below-knee amputation was suggested, but the patient declined...
journal_title：Journal of orthopaedic surgery (Hong Kong)
pub_type： 杂志文章
doi：10.1177/230949901402200130
更新日期：2014-04-01 00:00:00
abstract：:The incidence of anterior cruciate ligament reconstruction (ACLR) is continuously increasing. As a result so has the need for revision ACLR, which unfortunately has worse functional outcomes and rate of return to sport. Revision ACLR can be performed as a single stage or in two stages. The latter is recommended in the...
journal_title：Journal of orthopaedic surgery (Hong Kong)
pub_type： 杂志文章
doi：10.1177/2309499019857736
更新日期：2019-05-01 00:00:00
abstract：PURPOSE:To evaluate the correlation between survival and tumour characteristics in 23 patients with chondrosarcoma. METHODS:Records of 15 men and 8 women aged 14 to 66 (mean, 37) years who were diagnosed with primary (n=19) or secondary (n=4) chondrosarcoma of the axial skeleton (n=8), proximal extremity (n=9), or dis...
journal_title：Journal of orthopaedic surgery (Hong Kong)
pub_type： 杂志文章
doi：10.1177/230949901502300323
更新日期：2015-12-01 00:00:00
abstract：PURPOSE:To determine risk factors of venous thromboembolism (VTE) in Indian patients undergoing surgery for pelvic-acetabular fractures. METHODS:48 men and 8 women aged 17 to 61 (mean, 36) years who underwent open reduction and internal fixation for pelvic-acetabular fractures were evaluated for VTE in the postoperati...
journal_title：Journal of orthopaedic surgery (Hong Kong)
pub_type： 杂志文章
doi：10.1177/230949901101900105
更新日期：2011-04-01 00:00:00
abstract：PURPOSE:We have analyzed the surgical outcomes of primary total knee arthroplasty (TKA) using computer-assisted (CA) navigation in terms of postoperative coronal alignment depending on preoperative lateral femoral bowing. METHODS:We conducted a retrospective study of patients who have undergone navigated primary TKA f...
journal_title：Journal of orthopaedic surgery (Hong Kong)
pub_type： 杂志文章
doi：10.1177/2309499020965679
更新日期：2020-09-01 00:00:00
abstract：:A subcapital femoral neck fracture complicating a healed trochanteric fracture is rare. Such cases are managed in a rather heterogeneous manner, i.e. there exists a mixture of cases treated by either fixed angle devices or dynamic compression screws. We describe 5 patients who developed subcapital femoral neck fractur...
journal_title：Journal of orthopaedic surgery (Hong Kong)
pub_type： 杂志文章
doi：10.1177/230949900701500224
更新日期：2007-08-01 00:00:00
abstract：PURPOSE:The aim of this study was to evaluate short-term clinical and radiological results of extensor carpi radialis longus (ECRL) tendon ball arthroplasty for treatment of late-stage Kienböck's disease. METHODS:We retrospectively reviewed data of 19 patients suffering from Kienböck's treated with ECRL tendon ball ar...
journal_title：Journal of orthopaedic surgery (Hong Kong)
pub_type： 杂志文章
doi：10.1177/2309499018802514
更新日期：2018-05-01 00:00:00
abstract：PURPOSE:To review nutritional status and outcome of 90 patients who underwent total hip arthroplasty (THA) or hemiarthroplasty. METHODS:Records of 51 women and 39 men aged 26 to 96 (median, 71) years who underwent elective THA (n=48) for osteoarthritis, or trauma-related THA (n=10) or hemiarthroplasty (n=32) for subca...
journal_title：Journal of orthopaedic surgery (Hong Kong)
pub_type： 杂志文章
doi：10.1177/230949901202000313
更新日期：2012-12-01 00:00:00
abstract：PURPOSE:To report outcomes in 6 patients with the terrible triad of the elbow treated with our modified protocol. METHODS:6 men aged 26 to 54 years underwent surgery for the terrible triad of the elbow by a single surgeon. All the patients had a displaced comminuted fracture of the radius, posterior dislocation of the...
journal_title：Journal of orthopaedic surgery (Hong Kong)
pub_type： 杂志文章
doi：10.1177/230949900901700108
更新日期：2009-04-01 00:00:00
abstract：PURPOSE:To examine the effectiveness of a multidisciplinary rehabilitation programme for patients with chronic low back pain in Hong Kong, and to identify factors associated with work resumption. METHODS:57 men and 8 women aged 20 to 56 (mean, 39) years who had a more than 3-month history of low back pain and were unr...
journal_title：Journal of orthopaedic surgery (Hong Kong)
pub_type： 杂志文章
doi：10.1177/230949901001800201
更新日期：2010-08-01 00:00:00
abstract：:Osteoarthritis (OA) is an extremely common form of chronic joint disease which can affect the knees and other joints of older adults, leading to debilitating disability in the knee and consequent reduction in quality of life. Intra-articular platelet-rich plasma (PRP) or hyaluronic acid (HA) injections are effective f...
journal_title：Journal of orthopaedic surgery (Hong Kong)
pub_type： 杂志文章,meta分析,评审
doi：10.1177/2309499019887660
更新日期：2020-01-01 00:00:00
abstract：:Cervical endoscopic spinal surgery (CESS) is now regularly performed in some centres in the Far East, yet rarely in Europe and the United States. This review describes the application of CESS through anterior and posterior approaches with analysis of the available evidence supporting current techniques. An electronic ...
journal_title：Journal of orthopaedic surgery (Hong Kong)
pub_type： 杂志文章,评审
doi：10.1177/2309499018758520
更新日期：2018-01-01 00:00:00
abstract：:Spondylolysis is a major cause of back pain in children and adolescents. The prevalence of spondylolysis depends on the sex, race, and congenital abnormality. These biases suggest hereditary predisposition as an etiology of spondylolysis. However, no conclusive evidence still exists regarding the inheritance for spond...
journal_title：Journal of orthopaedic surgery (Hong Kong)
pub_type： 杂志文章
doi：10.1177/2309499017713917
更新日期：2017-05-01 00:00:00
