Abstract:
PURPOSE:This study assessed the levels of soluble tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and matrix metalloproteinase 1 (MMP-1) in the synovial fluid from osteoarthritic knees to determine their role as well as the relationship between these levels and the severity of osteoarthritis (OA). METHODS:Synovial fluid was obtained from 44 knees of 40 patients. The Kellgren-Lawrence (KL) grade was measured using radiograph. The concentration of TWEAK and MMP-1 in the synovial fluid was assessed by enzyme-linked immunosorbent assay. The underlying inflammatory factors (erythrocyte sedimentation rate and C-reactive protein) were also measured. We analyzed the correlation between the factors measured. In addition, the samples were subdivided into three groups according to OA severity using the KL grade, and the differences in TWEAK and MMP-1 levels between groups were analyzed. RESULTS:The TWEAK and MMP-1 levels in the synovial fluid showed a positive correlation with each other. The TWEAK and MMP-1 levels were compared between the three groups according to the KL grade, and the levels showed a significant difference. A post hoc test demonstrated that the group with advanced OA showed a lower concentration of both factors when compared to groups with early OA. CONCLUSION:The concentration of TWEAK and MMP-1 in the synovial fluid were relatively high in the early stage of OA, and the levels decreased as the OA progressed.
journal_name
J Orthop Surg (Hong Kong)journal_title
Journal of orthopaedic surgery (Hong Kong)authors
Hwang IY,Youm YS,Cho SD,Choi SW,Bae MH,Park SJ,Kim HWdoi
10.1177/2309499018760112subject
Has Abstractpub_date
2018-01-01 00:00:00pages
2309499018760112issue
1eissn
1022-5536issn
2309-4990journal_volume
26pub_type
杂志文章abstract:PURPOSE:Reconstruction of the anterior cruciate ligament (ACL) is the most frequently performed reconstructive surgery in the knee. Biomechanical studies have shown that double bundle (DB) reconstruction is better than single bundle (SB) reconstruction with regard to rotational stability. It is postulated that resectio...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章
doi:10.1177/2309499018773124
更新日期:2018-05-01 00:00:00
abstract::The incidence of anterior cruciate ligament reconstruction (ACLR) is continuously increasing. As a result so has the need for revision ACLR, which unfortunately has worse functional outcomes and rate of return to sport. Revision ACLR can be performed as a single stage or in two stages. The latter is recommended in the...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章
doi:10.1177/2309499019857736
更新日期:2019-05-01 00:00:00
abstract:PURPOSE:Osteochondral impaction grafting to manage isolated chondral defects in femoral condyles usually uses a metal punch to impact the grafts into predrilled cavities. Damage to the chondrocytes during impaction is a concern, however, and new methods are being sought to minimise the damage. We studied if impaction w...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章
doi:10.1177/230949900201000211
更新日期:2002-12-01 00:00:00
abstract:PURPOSE:To report the outcome of fusion of the first metatarsophalangeal joint (MTPJ) using the Fyxis plate and compression screws. METHODS:Medical records of 12 men and 39 women (54 feet) aged 28 to 74 (mean, 58) years who underwent primary fusion of the first MTPJ using the Fyxis plate and compression screws for hal...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章
doi:10.1177/230949901402200110
更新日期:2014-04-01 00:00:00
abstract:PURPOSE:Reconstruction of the lateral collateral ligament (LCL) and biceps femoris tendon following proximal fibula resection is controversial. Postoperative knee instability and peroneal nerve dysfunction affect outcome. This study aimed to determine functional, clinical, and radiological outcomes of patients who unde...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章
doi:10.1177/2309499019837411
更新日期:2019-05-01 00:00:00
abstract:PURPOSE:This study analysed the accuracy and safety of the fluoroscopic guided percutaneous screws in the upper thoracic vertebrae (T1-T6). METHODS:Computed tomography scans from 74 patients were retrospectively evaluated between January 2008 and December 2012. Pedicle perforations were classified by two types of grad...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章
doi:10.1177/2309499017722438
更新日期:2017-05-01 00:00:00
abstract:PURPOSE:To evaluate the correlation between survival and tumour characteristics in 23 patients with chondrosarcoma. METHODS:Records of 15 men and 8 women aged 14 to 66 (mean, 37) years who were diagnosed with primary (n=19) or secondary (n=4) chondrosarcoma of the axial skeleton (n=8), proximal extremity (n=9), or dis...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章
doi:10.1177/230949901502300323
更新日期:2015-12-01 00:00:00
abstract:PURPOSE:To evaluate the incidence and risk factors of periprosthetic joint infection (PJI) in patients undergoing total knee arthroplasty (TKA) in a high-volume hospital. METHODS:Records of 1133 primary TKAs were reviewed. Correlation between surgery volume and infection rate was determined. Risk factors for PJI were ...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章
doi:10.1177/230949901502300303
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Juvenile hallux valgus (JHV) frequently results in an impaired quality of life because of pain and deformity. We used a validated clinical score to investigate the efficacy of lateral hemiepiphysiodesis of the first metatarsal base as a treatment for JHV. METHODS:We conducted a prospective, nonrandomized, s...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 临床试验,杂志文章
doi:10.1177/2309499018801135
更新日期:2018-05-01 00:00:00
abstract:PURPOSE:Sacropelvic fixation continues to present challenges when involved in the adult spinal deformity correction. The S2 alar iliac (S2AI) fixation is commonly used in sacropelvic fixation. Several techniques, including intraoperative navigation and freehand technique, were used for S2AI screws placement. The aim of...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章
doi:10.1177/2309499020967110
更新日期:2020-09-01 00:00:00
abstract::Paediatric musculoskeletal infection remains an important cause of morbidity. Methicillin sensitive Staphylococcus aureus is still the most common organism although the incidence of methicillin resistant S. aureus in the community is rising. Osteomyelitis and septic arthritis due to Haemophilus influenzae is decreasin...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章
doi:10.1177/230949900100900116
更新日期:2001-06-01 00:00:00
abstract::We report a case of thigh emphysema resulting from perforated appendicitis. The patient was an 83-year-old man who had no apparent abdominal signs and was initially misdiagnosed as having psoas abscess. Magnetic resonance imaging of the pelvis revealed appendicitis, and a barium enema showed a leakage of enhanced cont...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章
doi:10.1177/230949900501300118
更新日期:2005-04-01 00:00:00
abstract::To clarify the effect of CTLA4-lg on immune rejection of bone grafts, we observed the effect of CTLA4-lg on lymphocyte proliferation of BALB/C mice stimulated by lymphocytes and bone supernatant of C57BL/6 mice. The splenic lymphocytes and bone supernatant of C57BL/6 mice, as the stimulator cells and stimulator antige...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章
doi:10.1177/230949900000800114
更新日期:2000-06-01 00:00:00
abstract::Due to accurate preoperative imaging techniques, early diagnosis and effective chemotherapy, many tumors arising in the metaphyseo-diaphyseal regions of long bones can be segmentally resected with joint preservation. The intercalary resection of malignant bone tumor results in a bone defect which can represent a chall...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章,评审
doi:10.1177/2309499019832970
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:To report the clinical, functional, and magnetic resonance imaging (MRI)-based outcomes of a novel autologous-made matrix consisting of hyaline cartilage chips combined with mixed plasma poor rich in platelets clot and plasma rich in growth factors (PRGF) for the treatment of knee full-thickness cartilage or os...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章
doi:10.1177/2309499019887547
更新日期:2020-01-01 00:00:00
abstract:PURPOSE:Interleukin 6 (IL-6) and the acute phase C-reactive protein (CRP) blood concentrations after lumbar spine fusion may be affected by age. The purpose of this prospective observational study was to assess postoperative serum levels of pro-inflammatory IL-6 and CRP after instrumented lumbar spine fusion surgery. W...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章
doi:10.1177/2309499019826406
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:Tibial bowing in valgus knees with arthritis can lead to component malplacement during total knee arthroplasty (TKA). Incidence of valgus knees with medial tibial bowing, its effect on tibial component placement during primary TKA and methods to improve accuracy of the component placement were studied. METHODS...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章
doi:10.1177/2309499019867006
更新日期:2019-09-01 00:00:00
abstract:PURPOSE:This study aimed to use MRI to evaluate the fibula and talus position difference in functional and mechanical ankle stability patients. METHODS:61 and 68 patients with functional and mechanical instability, and 60 healthy volunteers were involved. Based on the axial MRI images, the rotation of the talus was id...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章
doi:10.1177/2309499020984575
更新日期:2021-01-01 00:00:00
abstract:PURPOSE:To review the outcome of retrograde locked nailing for aseptic supracondylar femoral nonunions following failed locked plating. METHODS:Records of 20 men and 4 women aged 20 to 57 (mean, 39) years who underwent retrograde locked intramedullary nailing for aseptic supracondylar femoral nonunion following failed...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章
doi:10.1177/230949901502300207
更新日期:2015-08-01 00:00:00
abstract:PURPOSE:Maintaining independence after hip fracture repair is important for geriatric patients and general welfare. We investigated the effects of anesthetic methods on postoperative activities of daily living (ADLs) following hip fracture surgery in elderly patients. METHODS:The medical records of 12,342 patients age...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章,多中心研究
doi:10.1177/2309499017754106
更新日期:2018-01-01 00:00:00
abstract::Open reduction and internal fixation for unstable fractures of the lateral end of the clavicle (Neer type II) is not complication-free. Most clavicle fractures can be successfully treated by conservative methods. Neer type II fractures have a reportedly high rate of nonunion, therefore internal fixation is recommended...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章
doi:10.1177/230949900601400320
更新日期:2006-12-01 00:00:00
abstract:PURPOSE:Hoffa fractures are uncommon intra-articular fractures of femoral condyle in coronal plane. The purpose of our study is to assess radiologic and functional outcome in operatively treated Hoffa fractures. METHODS:We retrospectively reviewed 32 patients of isolated Hoffa fracture from January 2010 to March 2015....
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章
doi:10.1177/2309499017718928
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND:In vivo three-dimensional (3D) kinematics of the scapula after reverse total shoulder arthroplasty (rTSA) have been sparsely investigated. The aim of this study was to analyze static and dynamic kinematic alterations of the scapula after rTSA in vivo with the use of computer-aided 3D reconstruction program. ...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章
doi:10.1177/2309499020921979
更新日期:2020-01-01 00:00:00
abstract:PURPOSE:To evaluate the operative findings and postoperative results of one-stage repair on patients with acromioclavicular joint dislocation complicated by rotator cuff tear. METHODS:Between 1992 and 1999, one-stage repair was performed on 5 patients with acromioclavicular joint dislocation complicated by rotator cuf...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章
doi:10.1177/230949900401200118
更新日期:2004-06-01 00:00:00
abstract:PURPOSE:In this study, we asked the question of whether non-invasive (NI) extendible bone tumour implants are as reliable and reduce infection when compared with patients who received a minimally invasive (MI) extendible implant. METHODS:Forty-two NI extendible bone tumour implants were investigated at a mean follow-u...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章
doi:10.1177/2309499019833403
更新日期:2019-01-01 00:00:00
abstract::A 7-year-old girl presented with a 2-day history of acute neck pain without any preceding injury. The pain was around the left posterior paraspinal muscle and was aggravated by neck movement. There was no neurological abnormality; white cell count and inflammatory markers were slightly elevated. Radiology of the cervi...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章
doi:10.1177/1602400331
更新日期:2016-12-01 00:00:00
abstract:PURPOSE:To review the outcome of acetabular revision with bone grafting and cementation for aseptic loosening after primary Charnley low-friction hip arthroplasty with structural bulk autografts in 15 patients. METHODS:Records were reviewed for 3 men and 12 women aged 31 to 72 (mean, 53) years who underwent acetabular...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章
doi:10.1177/1602400311
更新日期:2016-12-01 00:00:00
abstract:PURPOSE:To evaluate radiological and clinical outcome of minimally invasive plate osteosynthesis (MIPO) for tibial plateau fractures. METHODS:35 men and 6 women aged 19 to 75 (mean, 40; standard deviation [SD], 14) years underwent MIPO for displaced tibial plateau fractures. According to the Schatzker system, the tibi...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章
doi:10.1177/230949901202000109
更新日期:2012-04-01 00:00:00
abstract::We report on a 30-year-old haemophilic man with a pelvic pseudotumour compressing adjacent structures causing pain and swelling and destruction of surrounding soft tissues and bones. He underwent evacuation of the pseudotumour, acetabular reconstruction using the Harrington procedure, and total hip arthroplasty. ...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章
doi:10.1177/230949901402200232
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to evaluate clinical and radiological outcomes and to analyze the histological findings of repaired cartilage in patients more than 50 years old with underwent fibrin-matrix autologous chondrocyte implantation (ACI). METHODS:From January 2013 to February 2014, a prospective stu...
journal_title:Journal of orthopaedic surgery (Hong Kong)
pub_type: 杂志文章
doi:10.1177/2309499019893509
更新日期:2020-01-01 00:00:00