Impaired Control of Epstein-Barr Virus Infection in B-Cell Expansion with NF-κB and T-Cell Anergy Disease.

abstract：:The adaptive immune response begins when CD4+ T cells recognize antigenic peptides bound to class II molecules of the Major Histocompatibility Complex (MHCII). The interaction between peptides and MHCII has been historically interpreted as a rigid docking event. However, this model has been challenged by the evidence ...

journal_title：Frontiers in immunology

authors： Ferrante A

更新日期：2013-10-01 00:00:00

abstract：:Rationale: Caspase-1 is a zymogen whose activation predominantly depends upon the assembly of ASC monomers into insoluble prion-like polymers (specks). ASC polymers support caspase-1 dimer formation inducing a proximity mediated auto-activation of caspase-1. Therefore, the amount and nature of ASC monomers and polymer...

journal_title：Frontiers in immunology

authors： Gavrilin MA,McAndrew CC,Prather ER,Tsai M,Spitzer CR,Song MA,Mitra S,Sarkar A,Shields PG,Diaz PT,Wewers MD

更新日期：2020-03-19 00:00:00

abstract：:CD4(+) CD25(+) Foxp3(+) regulatory T (Treg) cells are essential to the balance between pro- and anti-inflammatory responses. There are two major subsets of Treg cells, "natural" Treg (nTreg) cells that develop in the thymus, and "induced" Treg (iTreg) cells that arise in the periphery from CD4(+) Foxp3(-) conventional...

journal_title：Frontiers in immunology

authors： Schmitt EG,Williams CB

更新日期：2013-06-19 00:00:00

abstract：:Dysregulation of macrophage has been demonstrated to contribute to aberrant immune responses and inflammatory diseases. CD11b, expressed on macrophages, plays a critical role in regulating pathogen recognition, phagocytosis, and cell survival. In the present study, we explored the effect of leukadherin-1 (LA1), an ago...

journal_title：Frontiers in immunology

authors： Yao X,Dong G,Zhu Y,Yan F,Zhang H,Ma Q,Fu X,Li X,Zhang Q,Zhang J,Shi H,Ning Z,Dai J,Li Z,Li C,Wang B,Ming J,Yang Y,Hong F,Meng X,Xiong H,Si C

更新日期：2019-02-12 00:00:00

abstract：:Understanding affinity maturation of antibodies that can target many variants of HIV-1 is important for vaccine development. While the antigen-binding site of antibodies is known to mutate throughout the co-evolution of antibodies and viruses in infected individuals, the roles of the mutations in the antibody framewor...

journal_title：Frontiers in immunology

authors： Zhou JO,Zaidi HA,Ton T,Fera D

更新日期：2020-07-17 00:00:00

abstract：:Of all the microbial infections relevant to mammals the relationship between parasitic worms and what constitutes and regulates a host protective immune response is perhaps the most complex and evolved. Nippostrongylus brasiliensis is a tissue migrating parasitic roundworm of rodents that exemplifies many of the salie...

journal_title：Frontiers in immunology

authors： Harvie M,Camberis M,Le Gros G

更新日期：2013-03-20 00:00:00

abstract：:Moraxella catarrhalis is a human-specific commensal of the respiratory tract and an opportunistic pathogen. It is one of the leading cause of otitis media in children and of acute exacerbations in patients with chronic obstructive pulmonary disease, resulting in significant morbidity and economic burden. Vaccines and ...

journal_title：Frontiers in immunology

authors： Laabei M,Colineau L,Bettoni S,Maziarz K,Ermert D,Riesbeck K,Ram S,Blom AM

更新日期：2020-09-02 00:00:00

abstract：:Bullous pemphigoid (BP) is an autoimmune blistering disease characterized by autoantibodies targeting cellular adhesion molecules. While IgE autoantibodies are occasionally reported in other autoimmune blistering diseases, BP is unique in that most BP patients develop an IgE autoantibody response. It is not known why ...

journal_title：Frontiers in immunology

authors： Messingham KN,Crowe TP,Fairley JA

更新日期：2019-10-04 00:00:00

abstract：:Assembly of the CARD11/CARMA1-BCL10-MALT1 (CBM) signaling complex upon T or B cell antigen receptor (TCR or BCR) engagement drives lymphocyte activation. Recruitment of pre-assembled BCL10-MALT1 complexes to CARD11 fosters activation of the MALT1 protease and canonical NF-κB signaling. Structural data and in vitro ass...

journal_title：Frontiers in immunology

authors： Seeholzer T,Kurz S,Schlauderer F,Woods S,Gehring T,Widmann S,Lammens K,Krappmann D

更新日期：2018-11-20 00:00:00

abstract：:Chimeric antigen receptor (CAR)-engineered T cells represent a breakthrough in personalized medicine. In this strategy, a patient's own T lymphocytes are genetically reprogrammed to encode a synthetic receptor that binds a tumor antigen, allowing T cells to recognize and kill antigen-expressing cancer cells. As a resu...

journal_title：Frontiers in immunology

authors： Long KB,Young RM,Boesteanu AC,Davis MM,Melenhorst JJ,Lacey SF,DeGaramo DA,Levine BL,Fraietta JA

更新日期：2018-12-03 00:00:00

abstract：:Over the last decade, the acceleration in the clinical use of mesenchymal stromal cells (MSCs) has been nothing short of spectacular. Perhaps most surprising is how little we know about the "MSC product." Although MSCs are being delivered to patients at an alarming rate, the regulatory requirements for MSC therapies (...

journal_title：Frontiers in immunology

authors： Wilson A,Hodgson-Garms M,Frith JE,Genever P

更新日期：2019-05-16 00:00:00

abstract：:Adenosine, a purine nucleoside generated by the dephosphorylation of adenine nucleotides, is a potent endogenous physiologic and pharmacologic regulator of many functions. Adenosine was first reported to inhibit the inflammatory actions of neutrophils nearly 30 years ago and since then the role of adenosine and its re...

journal_title：Frontiers in immunology

authors： Haskó G,Cronstein B

更新日期：2013-04-08 00:00:00

abstract：:Low vitamin D and insufficient sun exposure are additive independent risk factors for the development of multiple sclerosis (MS). The usual measure of vitamin D status, serum 25-hydroxy vitamin D [25(OH)D], is also a marker of recent exposure to the UVB rays of sunshine. The main evidence for a protective effect for M...

journal_title：Frontiers in immunology

authors： Hart PH,Lucas RM,Booth DR,Carroll WM,Nolan D,Cole JM,Jones AP,Kermode AG

更新日期：2017-01-24 00:00:00

abstract：:Follicular regulatory T cells (Tfr) are a unique subset of CD4 T cells that control and impact adaptive immune responses in the lymphoid follicles and germinal centers (GC). Since their relatively recent discovery, several studies have revealed that Tfr interact with other cells within this niche and shape ensuing res...

journal_title：Frontiers in immunology

authors： Miles B,Connick E

更新日期：2018-11-20 00:00:00

abstract：:Despite its excellent efficacy in controlling T cell mediated acute rejection, lymphocyte depletion may promote a humoral response. While T cell repopulation after depletion has been evaluated in many aspects, the B cell response has not been fully elucidated. We tested the hypothesis that the mechanisms also involve ...

journal_title：Frontiers in immunology

authors： Kwun J,Park J,Yi JS,Farris AB,Kirk AD,Knechtle SJ

更新日期：2018-10-15 00:00:00

abstract：:Nephritic factors comprise a heterogeneous group of autoantibodies against neoepitopes generated in the C3 and C5 convertases of the complement system, causing its dysregulation. Classification of these autoantibodies can be clustered according to their stabilization of different convertases either from the classical ...

journal_title：Frontiers in immunology

authors： Corvillo F,Okrój M,Nozal P,Melgosa M,Sánchez-Corral P,López-Trascasa M

更新日期：2019-04-24 00:00:00

abstract：:Multiple sclerosis is a chronic auto-inflammatory disease of the central nervous system affecting patients worldwide. Neuroinflammation in multiple sclerosis is mainly driven by peripheral immune cells which invade the central nervous system and cause neurodegenerative inflammation. To enter the target tissue, immune ...

journal_title：Frontiers in immunology

authors： Zondler L,Herich S,Kotte P,Körner K,Schneider-Hohendorf T,Wiendl H,Schwab N,Zarbock A

更新日期：2020-12-14 00:00:00

abstract：:Adults exposed to childhood maltreatment have increased stress reactivity. This profile is associated with dysregulation of the immune system, including enhanced inflammatory reactions and accelerated senescence. Subjects exposed to ear stress have increased risk for several age-related diseases, including cardiovascu...

journal_title：Frontiers in immunology

authors： Trintinaglia L,Bandinelli LP,Grassi-Oliveira R,Petersen LE,Anzolin M,Correa BL,Schuch JB,Bauer ME

更新日期：2018-07-16 00:00:00

abstract：:Therapy with Tyrosine Kinase Inhibitors (TKI) aiming stable deep molecular response is the gold standard to treat Chronic Myeloid Leukemia (CML). NKT-like cells (CD3+CD56+) combine characteristics of T and NK cells. The physiopathological role of these cells remains unknown although the literature refers their associa...

journal_title：Frontiers in immunology

authors： Almeida JS,Couceiro P,López-Sejas N,Alves V,Růžičková L,Tarazona R,Solana R,Freitas-Tavares P,Santos-Rosa M,Rodrigues-Santos P

更新日期：2019-10-22 00:00:00

abstract：:Advances in the understanding of leishmaniasis progression indicate that cellular interactions more complex than the Th1/Th2 paradigm define the course of infection. Th17 cells are a crucial modulator of adaptive immunity against Leishmania parasites acting mainly on neutrophil recruitment and playing a dual role at t...

journal_title：Frontiers in immunology

authors： Gonçalves-de-Albuquerque SDC,Pessoa-E-Silva R,Trajano-Silva LAM,de Goes TC,de Morais RCS,da C Oliveira CN,de Lorena VMB,de Paiva-Cavalcanti M

更新日期：2017-10-30 00:00:00

abstract：:Over the past few decades, we have witnessed a decline in the rates of acute rejection without significant improvement in chronic rejection. Current treatment strategies principally target the adaptive immune response and not the innate response. Therefore, better understanding of innate immunity in transplantation an...

journal_title：Frontiers in immunology

authors： Zhao D,Abou-Daya KI,Dai H,Oberbarnscheidt MH,Li XC,Lakkis FG

更新日期：2020-05-28 00:00:00

abstract：:Cytokines are known to shape the tumor microenvironment and although progress has been made in understanding their role in carcinogenesis, much remains to learn regarding their role in tumor growth and progression. We have identified granulocyte colony-stimulating factor (G-CSF) as one such cytokine, showing that G-CS...

journal_title：Frontiers in immunology

authors： Karagiannidis I,Jerman SJ,Jacenik D,Phinney BB,Yao R,Prossnitz ER,Beswick EJ

更新日期：2020-09-15 00:00:00

abstract：:Currently, liver transplantation is the most effective treatment for end-stage liver disease. Immunosuppressive agents are required to be taken after the operations, which have significantly reduced rejection rates and improved the short-term (<1 year) survival rates. However, post-transplant complications related to ...

journal_title：Frontiers in immunology

authors： Huang H,Lu Y,Zhou T,Gu G,Xia Q

更新日期：2018-11-09 00:00:00

abstract：:During the course of Chagas disease, infectious forms of Trypanosoma cruzi are occasionally liberated from parasitized heart cells. Studies performed with tissue culture trypomastigotes (TCTs, Dm28c strain) demonstrated that these parasites evoke neutrophil/CXCR2-dependent microvascular leakage by activating innate se...

journal_title：Frontiers in immunology

authors： Nascimento CR,Andrade D,Carvalho-Pinto CE,Serra RR,Vellasco L,Brasil G,Ramos-Junior ES,da Mota JB,Almeida LN,Andrade MV,Correia Soeiro MN,Juliano L,Alvarenga PH,Oliveira AC,Sicuro FL,de Carvalho ACC,Svensjö E,Scharfstei

更新日期：2017-08-02 00:00:00

abstract：:Breast cancer is characterized by cellular and molecular heterogeneity. Several molecular events are involved in controlling malignant cell process. In this sense, the importance of studying multiple cell alterations in this pathology is overriding. A well-identified fact on immune response is that it can vary depend ...

journal_title：Frontiers in immunology

authors： Segovia-Mendoza M,Morales-Montor J

更新日期：2019-03-01 00:00:00

abstract：:The induction and modulation of the immune response to vaccination can be rationally designed by combining different vaccine formulations for priming and boosting. Here, we investigated the impact of heterologous prime-boost approaches on the vaccine-specific cellular and humoral responses specific for a mycobacterial...

journal_title：Frontiers in immunology

authors： Ciabattini A,Pettini E,Fiorino F,Lucchesi S,Pastore G,Brunetti J,Santoro F,Andersen P,Bracci L,Pozzi G,Medaglini D

更新日期：2018-03-12 00:00:00

abstract：:As cutaneous melanoma (CM) currently remains with a bleak prognosis, thorough investigation of new treatment options are of utmost relevance. In the phase II/III randomized clinical trial (CASVAC-0401), the repeated immunization of stages IIB-III CM patients with the irradiated, allogeneic cellular CSF-470 vaccine plu...

journal_title：Frontiers in immunology

authors： Pampena MB,Cartar HC,Cueto GR,Levy EM,Blanco PA,Barrio MM,Mordoh J

更新日期：2018-11-02 00:00:00

abstract：:Antibody production and function represent an essential part of the immune response, particularly in fighting bacterial and viral infections. Multiple immunological phenotypes can result in dysregulation of the immune system humoral compartment, including class-switch recombination (CSR) defects associated with hyper-...

journal_title：Frontiers in immunology

authors： Jhamnani RD,Nunes-Santos CJ,Bergerson J,Rosenzweig SD

更新日期：2018-09-26 00:00:00

abstract：:Interleukin-10 plays important, yet contrasting, roles in host protection against bacterial infections and in the septic response. To determine the role of IL-10 in the host defense against Acinetobacter baumannii infection, wild-type (WT) and IL-10-deficient mice were infected intranasally with the bacteria. IL-10-de...

journal_title：Frontiers in immunology

authors： Kang MJ,Jang AR,Park JY,Ahn JH,Lee TS,Kim DY,Lee MS,Hwang S,Jeong YJ,Park JH

更新日期：2020-02-21 00:00:00

abstract：:Secretion of extracellular vesicles (EVs) is a ubiquitous mechanism of intercellular communication based on the exchange of effector molecules, such as growth factors, cytokines, and nucleic acids. Recent studies identified tumor-derived EVs as central players in tumor progression and the establishment of the tumor mi...

journal_title：Frontiers in immunology

authors： Dörsam B,Bösl T,Reiners KS,Barnert S,Schubert R,Shatnyeva O,Zigrino P,Engert A,Hansen HP,von Strandmann EP

更新日期：2018-06-18 00:00:00