Abstract:
:This study was undertaken to investigate the associations between chronic exposure to particulate matter of medium aerodynamic diameter ≤10 or ≤2.5 µm (PM10 or PM2.5) and nitrogen dioxide (NO₂) levels and lung function and to examine a possible change in these relationships by demographic and lifestyle factors. Chronic obstructive pulmonary disease (COPD) was defined using the Global Initiative for COPD criteria (forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) of <70%). Associations of lung function and COPD with PM10 or PM2.5 or NO₂ were examined using linear and logistic regression analyses among 1264 Korean adults. The highest tertiles of PM2.5 (≥37.1 μg/m³) and NO₂ (≥53.8 μg/m³) exposure were significantly associated with COPD (highest versus lowest tertile of PM2.5: adjusted odds ratio (OR) = 1.79, 95% CI: 1.02-3.13; highest versus lowest tertile of NO₂: adjusted OR = 1.83, 95% CI: 1.04-3.21). A 10 μg/m³ increase in PM10 concentration was associated with a 1.85 L (95% CI -3.65 to -0.05) decrease in FEV1 and a 1.73 L (95% CI -3.35 to -0.12) decrease in FVC, with the strongest negative association among older people and those with less education. Reduced lung function was associated with PM2.5 exposure in subjects with no physical activity. This study provides evidence that exposure to ambient air pollution has adverse effects on lung function in adults.
journal_name
Int J Environ Res Public Healthauthors
Lamichhane DK,Leem JH,Kim HCdoi
10.3390/ijerph15020363subject
Has Abstractpub_date
2018-02-19 00:00:00issue
2eissn
1661-7827issn
1660-4601pii
ijerph15020363journal_volume
15pub_type
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pub_type: 杂志文章,随机对照试验
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