Fisetin suppresses malignant proliferation in human oral squamous cell carcinoma through inhibition of Met/Src signaling pathways.

Abstract:

:Fisetin (3,7,3',4'-tetrahydroxyflavone) is a dietary flavonoid and has been indicated as a novel anti-cancer agent in several types of cancer cells. However, the mechanisms underlying the effect of fisetin in human oral squamous cell carcinoma (OSCC) remain unclear. Here, we report that fisetin significantly inhibits tumor cell proliferation and induces apoptosis in OSCC (UM-SCC-23 and Tca-8113) cancer cell lines. Further analysis demonstrates that fisetin also inhibits Met/Src signaling pathways using the PathScan® receptor tyrosine kinases (RTK) Signaling Antibody Array Kit. Fisetin resulted in decreased basal expression of Met and Src protein in UM-SCC-23 cancer cell lines, which validated by western blot. A student's t-test (two-tailed) was used to compare differences between groups. Furthermore, fisetin significantly inhibited the expression of a disintegrin and metalloproteinase 9 (ADAM9) protein in OSCC cells. Taken together, these results provide novel insights into the mechanism of fisetin and suggest potential therapeutic strategies for human OSCC by blocking the Met/Src signaling pathways.

journal_name

Am J Transl Res

authors

Li YS,Qin XJ,Dai W

subject

Has Abstract

pub_date

2017-12-15 00:00:00

pages

5678-5683

issue

12

issn

1943-8141

journal_volume

9

pub_type

杂志文章
  • Fn14 is regulated via the RhoA pathway and mediates nuclear factor-kappaB activation by Angiotensin II.

    abstract::Angiotesin II (Ang II) plays an important role in cardiac remodeling. Fibroblast growth factor inducible-14 (Fn14) is the smallest member of the tumor necrosis factor superfamily of receptors. Currently, little is known about the functional role of Fn14 in the heart. Chiefly, we observe the up-regulation of extracellu...

    journal_title:American journal of translational research

    pub_type: 杂志文章

    doi:

    authors: Li Z,Shen Z,Du L,He J,Chen S,Zhang J,Luan Y,Fu G

    更新日期:2016-12-15 00:00:00

  • The effect of the surgical microscope on the outcome of root scaling.

    abstract::The benefits of using a surgical microscope in periodontal therapy were mainly based on subjective statements made by patients or periodontists. We aimed to provide laboratory evidence for the advantages of using a surgical microscope during root scaling on periodontitis teeth. In the present study, the extracted teet...

    journal_title:American journal of translational research

    pub_type: 杂志文章

    doi:

    authors: Liao H,Zhang H,Xiang J,Chen G,Cao Z

    更新日期:2020-11-15 00:00:00

  • Circular RNA: a novel biomarker for progressive laryngeal cancer.

    abstract::Circular RNAs (circRNAs), a class of endogenous RNAs, are characterized by covalently closed continuous loop without 5' to 3' polarity and polyadenylated tail. Recent studies indicated that circRNAs might play an important role in cancer. However, the function of circRNA in laryngeal squamous cell cancer tissues (LSCC...

    journal_title:American journal of translational research

    pub_type: 杂志文章

    doi:

    authors: Xuan L,Qu L,Zhou H,Wang P,Yu H,Wu T,Wang X,Li Q,Tian L,Liu M,Sun Y

    更新日期:2016-02-15 00:00:00

  • Tomographic analysis of the temporomandibular joint in patients with arthritis: a case of disease translation in Yucatan, Mexico.

    abstract::Computed tomography imaging of the temporomandibular joint was carried out in 22 previously-diagnosed arthritis patients (3 men, 19 women). This descriptive, cross-sectional observational, qualitative study allowed to characterize the type of condylar morphology condition, the space between temporomandibular joint, th...

    journal_title:American journal of translational research

    pub_type: 杂志文章

    doi:

    authors: Mendiburu-Zavala C,Camargo-Riqué ME,Peñaloza-Cuevas R,Cárdenas-Erosa R,Lara-Flores M,Castaño VM

    更新日期:2019-01-15 00:00:00

  • Intravenous administration of atorvastatin-pretreated mesenchymal stem cells improves cardiac performance after acute myocardial infarction: role of CXCR4.

    abstract:BACKGROUND:The interaction between stromal cell-derived factor 1 (SDF-1) and its receptor CXC chemokine receptor 4 (CXCR4) plays an important role in mesenchymal stem cells (MSCs) migration and engraftment. Statins can increase the survival of MSCs. However, whether statins could enhance MSCs migration and engraftment ...

    journal_title:American journal of translational research

    pub_type: 杂志文章

    doi:

    authors: Li N,Yang YJ,Qian HY,Li Q,Zhang Q,Li XD,Dong QT,Xu H,Song L,Zhang H

    更新日期:2015-06-15 00:00:00

  • VNN1 overexpression is associated with poor response to preoperative chemoradiotherapy and adverse prognosis in patients with rectal cancers.

    abstract:BACKGROUND:Colorectal cancer is prevalent worldwide and it is also the fourth most common cause of cancer mortality. For rectal cancer, neoadjuvant concurrent chemoradiotherapy (CCRT) followed by radical proctectomy is gold standard treatment for patients with stage II/III rectal cancer. By data mining a public dataset...

    journal_title:American journal of translational research

    pub_type: 杂志文章

    doi:

    authors: Chai CY,Zhang Y,Song J,Lin SC,Sun S,Chang IW

    更新日期:2016-10-15 00:00:00

  • Bone marrow derived mesenchymal stem cells alleviated brain injury via down-regulation of interleukin-1β in focal cerebral ischemic rats.

    abstract::Interleukin-1β (IL-1β) plays an important role in brain injury after focal ischemia, and bone marrow-derived mesenchymal stem cells (BMSCs) are capable of reducing the expression of IL-1β, we investigated the effects of BMSCs transplantation on brain edema and cerebral infarction as well as the underlying mechanisms v...

    journal_title:American journal of translational research

    pub_type: 杂志文章

    doi:

    authors: Zhao Y,Wang X,Dong P,Xu Q,Ma Z,Mu Q,Sun X,Jiang Z,Wang X

    更新日期:2016-03-15 00:00:00

  • Activation of spinal MrgC-Gi-NR2B-nNOS signaling pathway by Mas oncogene-related gene C receptor agonist bovine adrenal medulla 8-22 attenuates bone cancer pain in mice.

    abstract:OBJECTIVES:In the present study, we investigate the effects of Mas oncogene-related gene (Mrg) C receptors (MrgC) on the expression and activation of spinal Gi protein, N-methyl-D-aspartate receptor subunit 2B (NR2B), and neuronal nitric oxide synthase (nNOS) in mouse model of bone cancer pain. METHODS:The number of s...

    journal_title:American journal of translational research

    pub_type: 杂志文章

    doi:

    authors: Sun Y,Zhang J,Lei Y,Lu C,Hou B,Ma Z,Gu X

    更新日期:2016-02-15 00:00:00

  • VSIG4 is highly expressed and correlated with poor prognosis of high-grade glioma patients.

    abstract::The high-grade glioma (HGG) remains as the greatest challenge for cancer management worldwide. Identification of novel therapeutics and diagnostic method is in urgent need. The V-set and immunoglobulin domain-containing protein 4 (VSIG4) is a complement receptor for C3b/iC3b and inhibits cytotoxic T lymphocytes activa...

    journal_title:American journal of translational research

    pub_type: 杂志文章

    doi:

    authors: Xu T,Jiang Y,Yan Y,Wang H,Lu C,Xu H,Li W,Fu D,Lu Y,Chen J

    更新日期:2015-06-15 00:00:00

  • Dexmedetomidine mitigates CLP-stimulated acute lung injury via restraining the RAGE pathway.

    abstract:OBJECTIVE:RAGE pathway plays crucial effects in causing acute lung injury (ALI). Dexmedetomidine (DEX) is showed to mitigate sepsis-stimulated ALI. However, its mechanisms have not been verified. The study was to evaluate whether the RAGE pathway participated in the actions of DEX on sepsis-stimulated ALI in rats. MET...

    journal_title:American journal of translational research

    pub_type: 杂志文章

    doi:

    authors: Hu H,Shi D,Hu C,Yuan X,Zhang J,Sun H

    更新日期:2017-12-15 00:00:00

  • MicroRNA-130a-3p suppresses cell viability, proliferation and invasion in nasopharyngeal carcinoma by inhibiting CXCL12.

    abstract::Incidence of nasopharyngeal carcinoma (NPC) has remained high worldwide, posing a serious health problem. MicroRNAs (miRNAs) are a family of about 20-23 nucleotides small non-coding molecules, which play a significant role in NPC. In this study, we explored the molecular mechanisms of miR-130a-3p in inhibiting viabili...

    journal_title:American journal of translational research

    pub_type: 杂志文章

    doi:

    authors: Qu R,Sun Y,Li Y,Hu C,Shi G,Tang Y,Guo D

    更新日期:2017-08-15 00:00:00

  • Epithelial and stromal expression of miRNAs during prostate cancer progression.

    abstract::Global microRNA (miRNA) profile may predict prostate cancer (PCa) behaviors. In this study, we examined global miRNA expression by miRNA profiling as well as specific miRNA expression levels in PCa epithelium and stroma by in situ hybridization (ISH) and correlated with various clinicopathological features. We first p...

    journal_title:American journal of translational research

    pub_type: 杂志文章

    doi:

    authors: Ren Q,Liang J,Wei J,Basturk O,Wang J,Daniels G,Gellert LL,Li Y,Shen Y,Osman I,Zhao J,Melamed J,Lee P

    更新日期:2014-07-18 00:00:00

  • FGF-16 protects against adverse cardiac remodeling in the infarct diabetic heart.

    abstract::Till now, no functional studies for FGF-16 in diabetic heart have been reported. Therefore, this study aims to evaluate the potential function of FGF-16 in inhibiting adverse cardiac remodeling in post myocardial infarction (MI) of diabetic heart. We investigated the role of fibroblast growth factor-16 (FGF-16) in pos...

    journal_title:American journal of translational research

    pub_type: 杂志文章

    doi:

    authors: Hu Y,Li L,Shen L,Gao H,Yu F,Yin W,Liu W

    更新日期:2017-04-15 00:00:00

  • Association between acute severe mercury poisoning and multiple organ failure.

    abstract::Acute mercury poisoning, involving a number of organs, leads to severe dysfunctions, such as acute renal failure (ARF), and even threatens patients' lives. A case of acute severe mercuric chloride (HgCl2) poisoning with multiple organ failure was reported in this study. A 38-year-old woman orally took about 50 g HgCl2...

    journal_title:American journal of translational research

    pub_type: 杂志文章

    doi:

    authors: Bai L,Peng X,Liu Y,Sun Y,Zheng L,Liu Z,Wan K,Wang J,Zhao J,Qiu Z

    更新日期:2020-08-15 00:00:00

  • Angiotensin II type i receptor agonistic autoantibodies induces apoptosis of cardiomyocytes by downregulating miR21 in preeclampsia: a mechanism study.

    abstract::Angiotensin II type I receptor agonistic autoantibodies (AT1-AA) in the plasma of preeclampsia patients can induce apoptosis of cardiomyocytes, and microRNA-21 (miR-21) can exert a protective effect on cardiomyocytes. But whether the pro-apoptotic effect of AT1-AA is associated with miR-21 is unclear. The objective of...

    journal_title:American journal of translational research

    pub_type: 杂志文章

    doi:

    authors: Wang J,Yue J,Xia Q,Jiao X,Zhi J

    更新日期:2019-04-15 00:00:00

  • Circ_0039569 promotes renal cell carcinoma growth and metastasis by regulating miR-34a-5p/CCL22.

    abstract::Circular RNAs (circRNAs) belong to non-coding RNAs and are known as key regulators in gene regulation. CircRNAs involve in the various biological processes of cancer. However, the functions of circRNAs in renal cell carcinoma (RCC) are still not clear. In this study, the circRNA expression profile was performed in the...

    journal_title:American journal of translational research

    pub_type: 杂志文章

    doi:

    authors: Jin C,Shi L,Li Z,Liu W,Zhao B,Qiu Y,Zhao Y,Li K,Li Y,Zhu Q

    更新日期:2019-08-15 00:00:00

  • Differential expression of miR-21 and miR-75 in esophageal carcinoma patients and its clinical implication.

    abstract::In Xinjiang, China, esophageal carcinoma has a high incidence in Kazak and Uighur populations. MicroRNA (miR)-21 and miR-375 are related to esophageal carcinoma. This study thus investigated their potencials in early diagnosis and prognosis in Kazak and Uighur populations, to provide evidences for serum markers of eso...

    journal_title:American journal of translational research

    pub_type: 杂志文章

    doi:

    authors: Lv H,He Z,Wang H,Du T,Pang Z

    更新日期:2016-07-15 00:00:00

  • Human induced pluripotent stem cell-derived mesenchymal stem cell therapy effectively reduced brain infarct volume and preserved neurological function in rat after acute intracranial hemorrhage.

    abstract::We tested the hypothesis that human induced pluripotent stem cell-derived mesenchymal stem cell (iPSC-MSC) therapy could effectively reduce brain-infarct volume (BIV) and improve neurological function in rat after acute intracranial hemorrhage (ICH) induced by a weight-drop device. Adult-male SD rats (n=40) were equal...

    journal_title:American journal of translational research

    pub_type: 杂志文章

    doi:

    authors: Chen KH,Lin KC,Wallace CG,Li YC,Shao PL,Chiang JY,Sung PH,Yip HK

    更新日期:2019-09-15 00:00:00

  • GRK2 deletion improves the function of skin flap following ischemia-reperfusion injury by regulating Drp1.

    abstract::Skin flap ischemia-reperfusion (IR) injury is the key factor to the success rate of skin transplantation, the molecular mechanism of flap IR injury needs to be continuously explored to provide new ideas for its clinical treatment. G protein-coupled receptor kinase 2 (GRK2) was reported to be involved in regulating mit...

    journal_title:American journal of translational research

    pub_type: 杂志文章

    doi:

    authors: Wang Y,Wu Y,Zhou M,Wang P,Luo J,Rui Y

    更新日期:2021-01-15 00:00:00

  • Biomechanical analysis of cervical range of motion and facet contact force after a novel artificial cervical disc replacement.

    abstract::An ideal implantation of artificial cervical disc replacement (ACDR) prosthesis should preserve the cervical biomechanics and maintain normal cervical biomechanics. In this study, we designed a novel prosthesis based on the physiological curvature of the cervical endplate, and conducted an in vitro test with cadaveric...

    journal_title:American journal of translational research

    pub_type: 杂志文章

    doi:

    authors: Zhao X,Yuan W

    更新日期:2019-05-15 00:00:00

  • Expression, purification and characterization of Der f 27, a new allergen from dermatophagoides farinae.

    abstract::The house dust mite (HDM), Dermatophagoidesfarinae (D. farina), is one of the most important indoor allergen sources and a major elicitor of allergic asthma; itscharacterization is important in the diagnosis and immunotherapy of mite allergen-relevant diseases. This study aims to characterize a novel allergen, the D. ...

    journal_title:American journal of translational research

    pub_type: 杂志文章

    doi:

    authors: Lin J,Li M,Liu Y,Jiang C,Wu Y,Wang Y,Gao A,Liu Z,Yang P,Liu X

    更新日期:2015-07-15 00:00:00

  • Activated protein C: a potential cardioprotective factor against ischemic injury during ischemia/reperfusion.

    abstract::Activated protein C (APC) is a vitamin-K dependent natural anticoagulant protein. With its function in blood clotting reaction, APC can reduce the risk of venous thrombosis to prevent ischemic disease. A number of in vivo and in vitro studies over the past few decades have revealed that APC also exerted cytoprotective...

    journal_title:American journal of translational research

    pub_type: 杂志文章

    doi:

    authors: Wang J,Li J

    更新日期:2009-07-15 00:00:00

  • Combined therapy with atorvastatin and atorvastatin-pretreated mesenchymal stem cells enhances cardiac performance after acute myocardial infarction by activating SDF-1/CXCR4 axis.

    abstract::The SDF-1/CXCR4 signaling plays a critical role in the trafficking of mesenchymal stem cells (MSCs) to the sites of tissue damage. Our recent study demonstrated that atorvastatin (ATV) treatment improved the survival of MSCs, and ATV pretreated MSCs (ATV-MSCs) exhibited enhanced engraftment to injured myocardium. In t...

    journal_title:American journal of translational research

    pub_type: 杂志文章

    doi:

    authors: Tian XQ,Yang YJ,Li Q,Xu J,Huang PS,Xiong YY,Li XD,Jin C,Qi K,Jiang LP,Chen GH,Qian L,Liu J,Geng YJ

    更新日期:2019-07-15 00:00:00

  • Probiotics enhance the effect of allergy immunotherapy on regulating antigen specific B cell activity in asthma patients.

    abstract::Immune regulatory system dysfunction plays a role in the pathogenesis of asthma. The therapeutic effect of allergic asthma is to be improved. The immune regulatory function of probiotics has been recognized. This study tests a hypothesis that Clostridium butyricum (CB) enhances the effect of allergen specific immunoth...

    journal_title:American journal of translational research

    pub_type: 杂志文章

    doi:

    authors: Liu J,Chen FH,Qiu SQ,Yang LT,Zhang HP,Liu JQ,Geng XR,Yang G,Liu ZQ,Li J,Liu ZG,Li HB,Yang PC

    更新日期:2016-12-15 00:00:00

  • Long-term effect of extracorporeal shock wave therapy on attenuating radiation-induced chronic cystitis in rat.

    abstract:BACKGROUND:This study tested the long-term effect of extracorporeal shock wave (ECSW) therapy on ameliorating radiotherapy-induced chronic cystitis (CC) in rat. METHODS AND RESULTS:Adult-female SD rats (n = 24) were equally categorized into group 1 (normal control), group 2 (CC induced by radiotherapy with 450 cGy twi...

    journal_title:American journal of translational research

    pub_type: 杂志文章

    doi:

    authors: Chen YT,Yang CC,Sung PH,Lin KC,Chiang JY,Huang CR,Huang KH,Chuang FC,Chu YC,Huang EY,Yip HK

    更新日期:2020-03-15 00:00:00

  • Molecular simulation studies on B-cell lymphoma/leukaemia 11A (BCL11A).

    abstract::B-cell lymphoma/leukaemia 11A (BCL11A) is a modulator of foetal-to-adult globin switching and is involved in brain development and normal lymphopoiesis. The three-dimensional structure of BCL11A and its structural domains had not yet been completely determined; hence, this study aimed to elucidate the structural domai...

    journal_title:American journal of translational research

    pub_type: 杂志文章

    doi:

    authors: Abdulazeez S

    更新日期:2019-06-15 00:00:00

  • Green Tea-EGCG reduces GFAP associated neuronal loss in HIV-1 Tat transgenic mice.

    abstract::In the current era of antiretroviral treatment, the prevalence of HIV-associated dementia is on the rise. Many past works have associated inflammation and neuronal loss with cognitive deficits inherent to the syndrome. Importantly, HIV-1 induced astrogliosis has been shown to play a central role in this process. Here ...

    journal_title:American journal of translational research

    pub_type: 杂志文章

    doi:

    authors: Rrapo E,Zhu Y,Tian J,Hou H,Smith A,Fernandez F,Tan J,Giunta B

    更新日期:2009-01-01 00:00:00

  • Differential regulation of Streptococcus pneumoniae-induced human MUC5AC mucin expression through distinct MAPK pathways.

    abstract::Human epithelial mucin, the major glycoprotein component of mucus, plays a critical role in host innate defense response against invading microbes by facilitating the mucociliary clearance. Excess mucin production, however, overwhelms the mucociliary clearance, resulting in not only defective mucosal defense but also ...

    journal_title:American journal of translational research

    pub_type: 杂志文章

    doi:

    authors: Lim JH,Kim HJ,Komatsu K,Ha U,Huang Y,Jono H,Kweon SM,Lee J,Xu X,Zhang GS,Shen H,Kai H,Zhang W,Xu H,Li JD

    更新日期:2009-05-08 00:00:00

  • MicroRNA-410 promotes chondrogenic differentiation of human bone marrow mesenchymal stem cells through down-regulating Wnt3a.

    abstract:BACKGROUND:Chondrogenic differentiation of mesenchymal stem cells (MSCs) is important for osteoarthritis (OA) treatment. However, the specific mechanisms involved are undefined. MicroRNAs (miRNAs) downregulate protein synthesis by binding to the 3'UTR of target mRNA. METHODS:Bone marrow aspirates were obtained from OA...

    journal_title:American journal of translational research

    pub_type: 杂志文章

    doi:

    authors: Zhang Y,Huang X,Yuan Y

    更新日期:2017-01-15 00:00:00

  • HaloTag as a reporter gene: positron emission tomography imaging with (64)Cu-labeled second generation HaloTag ligands.

    abstract::THE GOAL OF THIS STUDY IS TO EMPLOY THE HALOTAG TECHNOLOGY FOR POSITRON EMISSION TOMOGRAPHY (PET), WHICH INVOLVES TWO COMPONENTS: the HaloTag protein (a modified hydrolase which covalently binds to synthetic ligands) and HaloTag ligands (HTLs). 4T1 murine breast cancer cells were stably transfected to express HaloTag ...

    journal_title:American journal of translational research

    pub_type: 杂志文章

    doi:

    authors: Hong H,Benink HA,Uyeda HT,Valdovinos HF,Zhang Y,Meisenheimer P,Barnhart TE,Fan F,Cai W

    更新日期:2013-04-19 00:00:00