Abstract:
:Early diagnosis in Alzheimer's disease (AD), prior to the appearance of marked clinical symptoms, is critical to prevent irreversible neuronal damage and neural malfunction that lead to dementia and death. Therefore, there is an urgent need to generate new contrast agents which reveal by a noninvasive method the presence of some of the pathological signs of AD. In the present study, we demonstrate for the first time a new nanoconjugate composed of magnetic nanoparticles bound to an antiferritin antibody, which has been developed based on the existence of iron deposits and high levels of the ferritin protein present in areas with a high accumulation of amyloid plaques (particularly the subiculum in the hippocampal area) in the brain of a transgenic mouse model with five familial AD mutations. Both in vitro and after intravenous injection, functionalized magnetic nanoparticles were able to recognize and bind specifically to the ferritin protein accumulated in the subiculum area of the AD transgenic mice.
journal_name
ACS Chem Neuroscijournal_title
ACS chemical neuroscienceauthors
Fernández T,Martínez-Serrano A,Cussó L,Desco M,Ramos-Gómez Mdoi
10.1021/acschemneuro.7b00260subject
Has Abstractpub_date
2018-05-16 00:00:00pages
912-924issue
5issn
1948-7193journal_volume
9pub_type
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