A Comprehensive Strategy to Evaluate Compatible Stability of Chinese Medicine Injection and Infusion Solutions Based on Chemical Analysis and Bioactivity Assay.

abstract：:Dizocilpine (MK-801) is a non-competitive NMDA antagonist that induces schizophreniclike effects. It is therefore widely used in experimental models of schizophrenia including prepulse inhibition (PPI) impairments in rodents. Nevertheless, MK-801 has never been tested in monkeys on a PPI paradigm. In order to evaluate...

journal_title：Frontiers in pharmacology

authors： Saletti PG,Maior RS,Hori E,Nishijo H,Tomaz C

更新日期：2015-09-22 00:00:00

abstract：:Dysregulation of the complement system is central to age-related macular degeneration (AMD), the leading cause of blindness in the developed world. Most of the genetic variation associated with AMD resides in complement genes, with the greatest risk associated with polymorphisms in the complement factor H (CFH) gene; ...

journal_title：Frontiers in pharmacology

authors： Stravalaci M,Davi F,Parente R,Gobbi M,Bottazzi B,Mantovani A,Day AJ,Clark SJ,Romano MR,Inforzato A

更新日期：2020-11-26 00:00:00

abstract：:Cell penetrating peptides have been regarded as promising vectors to deliver hydrophilic molecules inside cells. Although they are great tools for research and have high potential as drug delivery systems, their application as drugs is impaired by their low stability in serum. Cyclotides, cyclic disulfide-rich peptide...

journal_title：Frontiers in pharmacology

authors： Huang YH,Chaousis S,Cheneval O,Craik DJ,Henriques ST

更新日期：2015-02-09 00:00:00

abstract：:Background and Objective: Idiopathic central precocious puberty (ICPP) is characterized by early pubertal changes, the acceleration of growth velocity, and rapid bone maturation that often results in reduced adult height. Gonadotrophin-releasing hormone agonist (GnRHa) is currently considered to be an effective therap...

journal_title：Frontiers in pharmacology

authors： Yu HK,Liu X,Chen JK,Wang S,Quan XY

更新日期：2019-02-11 00:00:00

abstract：:Biochanin A (BCA) is an isoflavone mainly found in red clover with poor solubility and oral absorption that is known to have various effects, including anti-inflammatory, estrogen-like, and glucose and lipid metabolism modulatory activity, as well as cancer preventive, neuroprotective, and drug interaction effects. BC...

journal_title：Frontiers in pharmacology

authors： Yu C,Zhang P,Lou L,Wang Y

更新日期：2019-07-12 00:00:00

abstract：:To provide better therapeutic avenues for treating tongue squamous cell carcinoma (TSCC), a series of experiments about the effects of microRNA (miR)-532-3p on TSCC malignant behaviors were carried out. The result showed that miR-532-3p was down-regulated and C-C chemokine receptor 7 (CCR7) was up-regulated in the tum...

journal_title：Frontiers in pharmacology

authors： Feng C,So HI,Yin S,Su X,Xu Q,Wang S,Duan W,Zhang E,Sun C,Xu Z

更新日期：2019-08-29 00:00:00

abstract：:We prepared hybrids consisting of Angelica gigas Nakai (AGN) root or flower extract and layered double hydroxide (LDH) for potential anticancer nanomedicine, as decursin species (DS) in AGN are known to have anticancer activity. Dimethylsulfoxide solvent was determined hybridization reaction media, as it has affinity ...

journal_title：Frontiers in pharmacology

authors： Kim HJ,Lee GJ,Choi AJ,Kim TH,Kim TI,Oh JM

更新日期：2018-07-09 00:00:00

abstract：:Immune cells of the monocyte/macrophage lineage are characterized by their diversity, plasticity, and variety of functions. Among them, macrophages play a central role in antiviral responses, tissue repair, and fibrosis. Macrophages can be reprogrammed by environmental cues, thus changing their phenotype during an ant...

journal_title：Frontiers in pharmacology

authors： Gracia-Hernandez M,Sotomayor EM,Villagra A

更新日期：2020-10-29 00:00:00

abstract：:The orexin system regulates feeding, nutrient metabolism and energy homeostasis. Acute pharmacological blockade of orexin receptor 1 (OXR-1) in rodents induces satiety and reduces normal and palatable food intake. Genetic OXR-1 deletion in mice improves hyperglycemia under high-fat (HF) diet conditions. Here we invest...

journal_title：Frontiers in pharmacology

authors： Steiner MA,Sciarretta C,Pasquali A,Jenck F

更新日期：2013-12-30 00:00:00

abstract：:Background: Little is known about the humanistic burden of small cell lung cancer (SCLC), specifically the impact on health-related quality of life (HRQoL). The aim of this systematic literature review was to explore the impact of SCLC on HRQoL and the patient reported outcomes (PROs) used to capture this impact. Meth...

journal_title：Frontiers in pharmacology

authors： Bennett BM,Wells JR,Panter C,Yuan Y,Penrod JR

更新日期：2017-06-15 00:00:00

abstract：:Product mislabeling and/or species fraud in Traditional Chinese Medicine (TCM) not only decrease TCM quality, but also pose a potential health issue to the end user. Up to now, methods to control TCM quality have been developed to detect specific metabolites or identify the original species. However, species quantific...

journal_title：Frontiers in pharmacology

authors： Zhao B,Xiong C,Li J,Zhang D,Shi Y,Sun W,Duan X

更新日期：2020-11-26 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fphar.2020.00739.]. ...

journal_title：Frontiers in pharmacology

authors： Huang J,Hei GR,Yang Y,Liu CC,Xiao JM,Long YJ,Peng XJ,Yang Y,Zhao JP,Wu RR

更新日期：2020-06-10 00:00:00

abstract：:Why antidepressants vary in terms of efficacy is currently unclear. Despite the leadership of selective serotonin reuptake inhibitors (SSRIs) in the treatment of depression, the precise neurobiological mechanisms involved in their therapeutic action are poorly understood. A better knowledge of molecular interactions b...

journal_title：Frontiers in pharmacology

authors： Gardier AM

更新日期：2013-08-08 00:00:00

abstract：:Understanding the mechanistic basis for temozolomide (TMZ)-induced glioma resistance is an important obstacle in developing an effective form of chemotherapy for this type of tumor. Glycogenolysis is known to play an essential role in cellular proliferation and potassium homeostasis and involves the glycogen phosphory...

journal_title：Frontiers in pharmacology

authors： Xu J,Zhang Y,Guo X,Sun T

更新日期：2018-08-07 00:00:00

abstract：:We report on a patient who developed acute liver failure while being treated with metamizole. After liver transplantation, the patient recovered rapidly. Liver biopsy showed massive necrosis and lobular infiltration of lymphocytes. A lymphocyte transformation test performed 20 months after transplantation was positive...

journal_title：Frontiers in pharmacology

authors： Krisai P,Rudin D,Grünig D,Scherer K,Pichler W,Terracciano L,Krähenbühl S

更新日期：2019-09-11 00:00:00

abstract：:The melanocortin-4 receptor (MC4R) is a potential drug target for treatment of obesity, anxiety, depression, and sexual dysfunction. Crystal structures for MC4R are not yet available, which has hindered successful structure-based drug design. Using microsecond-scale molecular-dynamics simulations, we have investigated...

journal_title：Frontiers in pharmacology

authors： Saleh N,Kleinau G,Heyder N,Clark T,Hildebrand PW,Scheerer P

更新日期：2018-06-01 00:00:00

abstract：:Arsenic trioxide is a traditional remedy in Chinese Medicine since ages. Nowadays, it is clinically used to treat acute promyelocytic leukemia (APL) by targeting PML/RARA. However, the drug's activity is broader and the mechanisms of action in other tumor types remain unclear. In this study, we investigated molecular ...

journal_title：Frontiers in pharmacology

authors： Dawood M,Hamdoun S,Efferth T

更新日期：2018-02-27 00:00:00

abstract：:Pre-eclampsia is a hypertensive disorder of pregnancy initiated by placental insufficiency and chronic ischemia. In response, several pathways activated in the placenta are responsible for the maternal syndrome, including increased production of the anti-angiogenic protein, sFlt-1, and inflammatory cytokines, especial...

journal_title：Frontiers in pharmacology

authors： George EM,Stout JM,Stec DE,Granger JP

更新日期：2015-08-17 00:00:00

abstract：:Purpose: Gender differences exist in the prevalence of asthma and allergic diseases, partially due to the effects of sex hormones on the development of allergic manifestations. Women, compared with men, are more prone to suffer allergic asthma, experience difficulties in controlling asthma symptoms, and show adverse r...

journal_title：Frontiers in pharmacology

authors： Esposito R,Spaziano G,Giannattasio D,Ferrigno F,Liparulo A,Rossi A,Roviezzo F,Sessa M,Falciani M,Berrino L,Polverino M,Polverino F,D'Agostino B

更新日期：2019-09-24 00:00:00

abstract：:Background: Up to date, the efficacy and safety of warfarin treatment in atrial fibrillation patients receiving hemodialysis remain controversial. So we performed this meta-analysis to try to offer recommendations regarding warfarin management in this population. Methods: We searched Pubmed, Embase, and Cochrane libra...

journal_title：Frontiers in pharmacology

authors： Lei H,Yu LT,Wang WN,Zhang SG

更新日期：2018-11-06 00:00:00

abstract：:The endogenous cannabinoid (endocannabinoid) system regulates a diverse array of physiological processes and unsurprisingly possesses considerable potential targets for the potential treatment of numerous disease states, including two receptors (i.e., CB1 and CB2 receptors) and enzymes regulating their endogenous liga...

journal_title：Frontiers in pharmacology

authors： Schurman LD,Lichtman AH

更新日期：2017-02-17 00:00:00

abstract：:SARS-CoV-2 is the most recent coronavirus which crossed the species barrier in 2019 and provoked a still ongoing and dangerous pandemic known as coronavirus disease 2019 (COVID-19). The SARS-CoV-2 infection has triggered an impressive amount of clinical and experimental studies to identify an effective and safe therap...

journal_title：Frontiers in pharmacology

authors： Iacob S,Iacob DG

更新日期：2020-08-26 00:00:00

abstract：:Particulate matter poses health risk to developing organisms. To investigate particulate matters with a diameter smaller than 2.5 um (PM2.5)-induced developmental cardiotoxicity, fertile chicken eggs were exposed to PM2.5 via air cell injection at doses of 0.05, 0.2, 0.5, 2, and 5 mg/egg kg. Morphological changes in t...

journal_title：Frontiers in pharmacology

authors： Jiang Q,Zhang C,Chen S,Shi L,Li DC,Lv N,Cui L,Chen Y,Zheng Y

更新日期：2020-06-05 00:00:00

abstract：:The aim of the study was to characterize phytochemicals in an infusion of the aerial parts of tarragon (Artemisia dracunculus L.) using ultra-high-performance liquid chromatography diode array detector electrospray ionisation tandem mass spectrometry UHPLC-DAD-ESI-MS/MS method, as well as an evaluation of its effects ...

journal_title：Frontiers in pharmacology

authors： Majdan M,Kiss AK,Hałasa R,Granica S,Osińska E,Czerwińska ME

更新日期：2020-08-13 00:00:00

abstract：:Medication with neuroleptics has been associated with adipose tissue dysfunctions and, in particular, with increased visceral fat amount. However, several studies suggested that antipsychotic treatment might not be the main responsible of fat mass accumulation, as this has been also described in not treated psychotic ...

journal_title：Frontiers in pharmacology

authors： Schiavone S,Camerino GM,Mhillaj E,Zotti M,Colaianna M,De Giorgi A,Trotta A,Cantatore FP,Conte E,Bove M,Tucci P,Morgese MG,Trabace L

更新日期：2017-11-08 00:00:00

abstract：:Background: Modeling and simulation is increasingly used to study pediatric pharmacokinetics, but clinical implementation of age-appropriate doses lags behind. Therefore, we aimed to develop model-informed doses using published pharmacokinetic data and a decision framework to adjust dosing guidelines based on these do...

journal_title：Frontiers in pharmacology

authors： Hartman SJF,Swaving JGE,van Beek SW,van Groen BD,de Hoop M,van der Zanden TM,Ter Heine R,de Wildt SN

更新日期：2020-12-16 00:00:00

abstract：:Background: The effects of drug treatment on veterans, who have a high risk of post-traumatic stress disorder (PTSD), are not clear, and the guidelines are different from the recommendations of the recent meta-analysis. Our goal was to find the efficacy and frequencies of complications of drugs that can treat PTSD in ...

journal_title：Frontiers in pharmacology

authors： Zhao YF,Huang ZD,Gu HY,Guo GL,Yuan RX,Zhang C

更新日期：2020-12-17 00:00:00

abstract：:Cardiac hypertrophy is an ongoing clinical challenge, as risk factors such as obesity, smoking and increasing age become more widespread, which lead to an increasing prevalence of developing hypertrophy. Pathological hypertrophy is a maladaptive response to stress conditions, such as pressure overload, and involve a n...

journal_title：Frontiers in pharmacology

authors： Kastner N,Zlabinger K,Spannbauer A,Traxler D,Mester-Tonczar J,Hašimbegović E,Gyöngyösi M

更新日期：2020-08-21 00:00:00

abstract：:Zinc doped copper oxide nanocomposites (Zn-CuO NPs) is a novel doped metal nanomaterial synthesized by our group using the sonochemical method. Our previous studies have shown that Zn-CuO NPs could inhibit cancer cell proliferation by inducing apoptosis via ROS-mediated pathway. In the present study, we studied the an...

journal_title：Frontiers in pharmacology

authors： Li X,Xu H,Li C,Qiao G,Farooqi AA,Gedanken A,Liu X,Lin X

更新日期：2019-04-02 00:00:00

abstract：:Natural brain repair after stroke is extremely limited, and current therapeutic options are even more scarce with no clinical break-through in sight. Despite restricted regeneration in the central nervous system, we have previously proved that human umbilical cord blood mono-nuclear cells (UCB-MC) transduced with aden...

journal_title：Frontiers in pharmacology

authors： Sokolov ME,Bashirov FV,Markosyan VA,Povysheva TV,Fadeev FO,Izmailov AA,Kuztetsov MS,Safiullov ZZ,Shmarov MM,Naroditskyi BS,Palotás A,Islamov RR

更新日期：2018-02-15 00:00:00