Natural Killer Cell Interactions with Classical and Non-Classical Human Leukocyte Antigen Class I in HIV-1 Infection.

abstract：:Rheumatoid arthritis (RA) associated anti-citrullinated protein autoantibodies (ACPA) target a wide range of modified proteins. Citrullination occurs during physiological processes such as apoptosis, yet little is known about the interaction of ACPA with nuclear antigens or apoptotic cells. Since uncleared apoptotic c...

journal_title：Frontiers in immunology

authors： Lloyd KA,Wigerblad G,Sahlström P,Garimella MG,Chemin K,Steen J,Titcombe PJ,Marklein B,Zhou D,Stålesen R,Ossipova E,Lundqvist C,Ekwall O,Rönnelid J,Mueller DL,Karlsson MCI,Kaplan MJ,Skriner K,Klareskog L,Wermeling F

更新日期：2019-01-04 00:00:00

abstract：BACKGROUND:Graft-vs-host disease (GVHD) is a major complication of allogenic bone marrow transplantation (BMT). Targeting costimulatory molecules with antagonist antibodies could dampen the excessive immune response that occurs, while preserving the beneficial graft vs leukemia (GVL) of the allogeneic response. Previou...

journal_title：Frontiers in immunology

authors： Burlion A,Brunel S,Petit NY,Olive D,Marodon G

更新日期：2017-06-30 00:00:00

abstract：:The transfer of maternal immune factors to the newborn is critical for protection from infectious disease in early life. Maternally acquired passive immunity provides protection until the infant is beyond early life's increased susceptibility to severe infections or until active immunity is achieved following infant's...

journal_title：Frontiers in immunology

authors： Abu-Raya B,Smolen KK,Willems F,Kollmann TR,Marchant A

更新日期：2016-08-31 00:00:00

abstract：:Sepsis is one of the well-established diseases with specific patterns of neutrophil dysfunctions. Previous studies demonstrated sepsis-related neutrophil dysfunctions in comparison with subjects without infection. Since sepsis and infection are recently recognized as distinctive processes, whether these neutrophil dys...

journal_title：Frontiers in immunology

authors： Seree-Aphinan C,Vichitkunakorn P,Navakanitworakul R,Khwannimit B

更新日期：2020-12-23 00:00:00

abstract：:Non-steroidal anti-inflammatory drugs (NSAIDs) induce ulcers in the gastrointestinal tract, including the stomach and small intestine. NSAID-induced gastric ulcers can be prevented by taking acid-neutralizing/inhibitory drugs and cytoprotective agents. In contrast, there are no medicines to control NSAID-induced small...

journal_title：Frontiers in immunology

authors： Park AM,Khadka S,Sato F,Omura S,Fujita M,Hsu DK,Liu FT,Tsunoda I

更新日期：2020-09-23 00:00:00

abstract：:There have been few in vivo studies on the effect of aluminum hydroxide adjuvant and its influence on the immune response to vaccination. In this study, lambs received a parallel subcutaneous treatment with either commercial vaccines containing aluminum hydroxide or an equivalent dose of this compound only with the ai...

journal_title：Frontiers in immunology

authors： Varela-Martínez E,Abendaño N,Asín J,Sistiaga-Poveda M,Pérez MM,Reina R,de Andrés D,Luján L,Jugo BM

更新日期：2018-10-23 00:00:00

abstract：:We conducted a prospective study of 312 patients (194 with multiple myeloma, 118 with lymphomas) receiving high-dose conditioning chemotherapy and autologous hematopoietic stem cell transplantation (auto-HSCT). Polymorphisms of MBL2 and MASP2 genes were investigated and serial measurements of serum concentrations of m...

journal_title：Frontiers in immunology

authors： Świerzko AS,Michalski M,Sokołowska A,Nowicki M,Eppa Ł,Szala-Poździej A,Mitrus I,Szmigielska-Kapłon A,Sobczyk-Kruszelnicka M,Michalak K,Gołos A,Wierzbowska A,Giebel S,Jamroziak K,Kowalski ML,Brzezińska O,Thiel S,Jenseniu

更新日期：2018-09-20 00:00:00

abstract：:The Signaling Lymphocyte Activation Molecule Family (SLAMF) genes, which encode cell-surface receptors that modulate innate and adaptive immune responses, lay within a genomic region of human and mouse chromosome 1 that confers a predisposition for the development of systemic lupus erythematosus (SLE). Herein, we demo...

journal_title：Frontiers in immunology

authors： de Salort J,Cuenca M,Terhorst C,Engel P,Romero X

更新日期：2013-07-31 00:00:00

abstract：:The generation of antibodies against protein antigens (such as donor-specific HLA molecules) requires that T follicular helper cells (Tfh) provide help to B cells. Immunosuppressive (IS) armamentarium prevents T cell activation, yet a significant proportion of renal transplant patients develop donor-specific antibodie...

journal_title：Frontiers in immunology

authors： Dahdal S,Saison C,Valette M,Bachy E,Pallet N,Lina B,Koenig A,Monneret G,Defrance T,Morelon E,Thaunat O

更新日期：2019-02-05 00:00:00

abstract：Background:The immune regulatory properties of semaphorin3A (sema3A) (both innate and adaptive) are well established in many in vitro studies. The injection of sema3A into a mice model of rheumatoid arthritis was proven to be highly beneficial, both in attenuating clinical symptoms and in decreasing inflammatory mechan...

journal_title：Frontiers in immunology

authors： Bejar J,Kessler O,Sabag AD,Sabo E,Itzhak OB,Neufeld G,Vadasz Z

更新日期：2018-04-04 00:00:00

abstract：:T-dependent humoral immune responses to infection involve a collaboration between B and CD4 T cell activation, migration, and co-stimulation, thereby culminating in the formation of germinal centers (GCs) and eventual differentiation into memory cells and long-lived plasma cells (PCs). CD4 T cell-derived signals drive...

journal_title：Frontiers in immunology

authors： Good-Jacobson KL,Groom JR

更新日期：2018-03-08 00:00:00

abstract：:Plasmodium vivax is the most common species that cause malaria outside of the African continent. The development of an efficacious vaccine would contribute greatly to control malaria. Recently, using bacterial and adenoviral recombinant proteins based on the P. vivax circumsporozoite protein (CSP), we demonstrated the...

journal_title：Frontiers in immunology

authors： Gimenez AM,Lima LC,Françoso KS,Denapoli PMA,Panatieri R,Bargieri DY,Thiberge JM,Andolina C,Nosten F,Renia L,Nussenzweig RS,Nussenzweig V,Amino R,Rodrigues MM,Soares IS

更新日期：2017-10-11 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fimmu.2018.00707.]. ...

journal_title：Frontiers in immunology

authors： Greaves SA,Peterson JN,Torres RM,Pelanda R

更新日期：2018-09-27 00:00:00

abstract：:Background: Elevated interleukin-6 (IL-6) and complement activation are associated with detrimental effects of inflammation in coronary artery disease (CAD). The complement anaphylatoxins C5a and C3a interact with their receptors; the highly inflammatory C5aR1, and the C5aR2 and C3aR. We evaluated the effect of the IL...

journal_title：Frontiers in immunology

authors： Orrem HL,Nilsson PH,Pischke SE,Kleveland O,Yndestad A,Ekholt K,Damås JK,Espevik T,Bendz B,Halvorsen B,Gregersen I,Wiseth R,Andersen GØ,Ueland T,Gullestad L,Aukrust P,Barratt-Due A,Mollnes TE

更新日期：2018-09-12 00:00:00

abstract：:Flow cytometry has emerged as a useful technology that has facilitated our understanding of the human immune system. Primary immune deficiency disorders (PIDDs) are a heterogeneous group of inherited disorders affecting the immune system. More than 350 genes causing various PIDDs have been identified. While the initia...

journal_title：Frontiers in immunology

authors： Rawat A,Arora K,Shandilya J,Vignesh P,Suri D,Kaur G,Rikhi R,Joshi V,Das J,Mathew B,Singh S

更新日期：2019-09-11 00:00:00

abstract：:The vast initial diversity of the antibody repertoire is generated centrally by means of a complex series of V(D)J gene rearrangement events, variation in the site of gene segment joining, and TdT catalyzed N-region addition. Although the diversity is great, close inspection has revealed distinct and unique characteri...

journal_title：Frontiers in immunology

authors： Mroczek ES,Ippolito GC,Rogosch T,Hoi KH,Hwangpo TA,Brand MG,Zhuang Y,Liu CR,Schneider DA,Zemlin M,Brown EE,Georgiou G,Schroeder HW Jr

更新日期：2014-03-19 00:00:00

abstract：:The mechanism by which antigen binding to the T cell antigen receptor (TCR) generates intracellular signaling, a process termed TCR triggering, is incompletely understood. A large body of experimental evidence has implicated multiple biophysical/biochemical effects and multiple molecules in the process of TCR triggeri...

journal_title：Frontiers in immunology

authors： Dushek O

更新日期：2012-01-10 00:00:00

abstract：:Intravenous immunoglobulin (IVIG) is used as replacement therapy in patients with antibody deficiencies and at higher dosages in immune-mediated disorders. Although different mechanisms have been described in vitro, the in vivo immunomodulatory effects of IVIG are poorly understood. Different studies have suggested th...

journal_title：Frontiers in immunology

authors： Mitrevski M,Marrapodi R,Camponeschi A,Cavaliere FM,Lazzeri C,Todi L,Visentini M

更新日期：2015-01-22 00:00:00

abstract：:γδ T cells represent an evolutionarily primitive T cell subset characterized by distinct T cell receptors (TCRs) and innate and adaptive immune functions. However, the presence of this T cell subset in ancient vertebrates remains unclear. In this study, γδ T cells from a zebrafish (Danio rerio) model were subjected to...

journal_title：Frontiers in immunology

authors： Wan F,Hu CB,Ma JX,Gao K,Xiang LX,Shao JZ

更新日期：2017-01-09 00:00:00

abstract：:Rationale: Caspase-1 is a zymogen whose activation predominantly depends upon the assembly of ASC monomers into insoluble prion-like polymers (specks). ASC polymers support caspase-1 dimer formation inducing a proximity mediated auto-activation of caspase-1. Therefore, the amount and nature of ASC monomers and polymer...

journal_title：Frontiers in immunology

authors： Gavrilin MA,McAndrew CC,Prather ER,Tsai M,Spitzer CR,Song MA,Mitra S,Sarkar A,Shields PG,Diaz PT,Wewers MD

更新日期：2020-03-19 00:00:00

abstract：:Tolerogenic dendritic cells (DCs) work through silencing of differentiated antigen-specific T cells, activation and expansion of naturally occurring T regulatory cells (Tregs), transfer of regulatory properties to T cells, and the differentiation of naïve T cells into Tregs. Due to an operational definition based on T...

journal_title：Frontiers in immunology

authors： Nikolic T,Roep BO

更新日期：2013-05-14 00:00:00

abstract：:Background: Iron deficiency may impair adaptive immunity and is common among African infants at time of vaccination. Whether iron deficiency impairs vaccine response and whether iron supplementation improves humoral vaccine response is uncertain. Methods: We performed two studies in southern coastal Kenya. In a birth ...

journal_title：Frontiers in immunology

authors： Stoffel NU,Uyoga MA,Mutuku FM,Frost JN,Mwasi E,Paganini D,van der Klis FRM,Malhotra IJ,LaBeaud AD,Ricci C,Karanja S,Drakesmith H,King CH,Zimmermann MB

更新日期：2020-07-13 00:00:00

abstract：:Signaling through Toll-like receptor 7 (TLR7) drives the production of type I IFN and promotes the activation of autoreactive B cells and is implicated in the pathogenesis of systemic lupus erythematosus (SLE). While TLR7 has been extensively studied in murine lupus, much less is known about its role in the pathogenes...

journal_title：Frontiers in immunology

authors： Wang T,Marken J,Chen J,Tran VB,Li QZ,Li M,Cerosaletti K,Elkon KB,Zeng X,Giltiay NV

更新日期：2019-06-04 00:00:00

abstract：:The aberrant expression of human endogenous retrovirus (HERV) elements of the HERV-W family has been associated with different diseases, including multiple sclerosis (MS). In particular, the expression of the envelope protein (Env) from the multiple sclerosis-associated retrovirus (MSRV), a member of HERV-W family and...

journal_title：Frontiers in immunology

authors： Charvet B,Reynaud JM,Gourru-Lesimple G,Perron H,Marche PN,Horvat B

更新日期：2018-12-06 00:00:00

abstract：:There is a strong correlation between dysregulation of the gastrointestinal microbiota and development of allergic diseases. The most prevalent therapies for relieving asthma symptoms are associated with serious side effects, and therefore novel approaches are needed. Our objective was to elucidate whether oral admini...

journal_title：Frontiers in immunology

authors： Ghiamati Yazdi F,Zakeri A,van Ark I,Leusink-Muis T,Braber S,Soleimanian-Zad S,Folkerts G

更新日期：2020-06-04 00:00:00

abstract：:The induction and modulation of the immune response to vaccination can be rationally designed by combining different vaccine formulations for priming and boosting. Here, we investigated the impact of heterologous prime-boost approaches on the vaccine-specific cellular and humoral responses specific for a mycobacterial...

journal_title：Frontiers in immunology

authors： Ciabattini A,Pettini E,Fiorino F,Lucchesi S,Pastore G,Brunetti J,Santoro F,Andersen P,Bracci L,Pozzi G,Medaglini D

更新日期：2018-03-12 00:00:00

abstract：:Immunoglobulin superfamily member (IgSF) proteins play a significant role in regulating immune responses with surface expression on all immune cell subsets, making the IgSF an attractive family of proteins for therapeutic targeting in human diseases. We have developed a directed evolution platform capable of engineeri...

journal_title：Frontiers in immunology

authors： Levin SD,Evans LS,Bort S,Rickel E,Lewis KE,Wu RP,Hoover J,MacNeil S,La D,Wolfson MF,Rixon MW,Dillon SR,Kornacker MG,Swanson R,Peng SL

更新日期：2020-01-21 00:00:00

abstract：:The management of chronic inflammatory diseases, such as inflammatory bowel disease, psoriasis, and rheumatoid arthritis has significantly improved over the last decade with the clinical availability of anti-TNF-α biologics. Despite this undoubted treatment success, a combination of acquired resistance together with a...

journal_title：Frontiers in immunology

authors： Ubah OC,Steven J,Kovaleva M,Ferguson L,Barelle C,Porter AJR,Barelle CJ

更新日期：2017-12-22 00:00:00

abstract：:CD8+ T cells represent one of the most versatile immune cells critical for clearing away viral infections. Due to their important role, CD8+ T cell activation and memory formation during viral infection have been the focus of several studies recently. Although CD8+ T cell activation and memory formation have been asso...

journal_title：Frontiers in immunology

authors： Gupta SS,Wang J,Chen M

更新日期：2020-05-22 00:00:00

abstract：:Elevated serum amyloid A (SAA) levels may promote endothelial dysfunction, which is linked to cardiovascular and renal pathologies. We investigated the effect of SAA on vascular and renal function in apolipoprotein E-deficient (ApoE-/-) mice. Male ApoE-/- mice received vehicle (control), low-level lipopolysaccharide (...

journal_title：Frontiers in immunology

authors： Chami B,Hossain F,Hambly TW,Cai X,Aran R,Fong G,Vellajo A,Martin NJJ,Wang X,Dennis JM,Sharma A,Shihata WA,Chin-Dusting JPF,de Haan JB,Sharland A,Geczy CL,Freedman B,Witting PK

更新日期：2019-03-07 00:00:00