Stress-induced elevation of the ST segment in the rat electrocardiogram is normalized by an adrenoceptor blocker.

abstract：:1. Epidemiological evidence indicates that low birthweight increases the risk of a number of adult-onset diseases. It is now apparent that many babies with a low birthweight may have been subjected to a combination of reduced growth rates in utero as well as preterm birth. However, the long-term effects of preterm bir...

journal_title：Clinical and experimental pharmacology & physiology

authors： Cock ML,Camm EJ,Louey S,Joyce BJ,Harding R

更新日期：2001-11-01 00:00:00

abstract：:1. In an isolated right atrial preparation, an increase in right atrial pressure (RAP) produces an increase in atrial rate. This rate response is larger and occurs faster when there is background vagal or muscarinic stimulation. 2. We hypothesized that in the latter situation, an increase in RAP antagonizes the effect...

journal_title：Clinical and experimental pharmacology & physiology

authors： Han S,Wilson SJ,Bolter CP

更新日期：2010-09-01 00:00:00

abstract：:1. Inflammation, particularly the pro-inflammatory cytokine tumour necrosis factor (TNF), increases necrosis of skeletal muscle. Depletion of inflammatory cells, such as neutrophils, cromolyn blockade of mast cell degranulation or pharmacological blockade of TNF reduces necrosis of dystrophic myofibres in the mdx mous...

journal_title：Clinical and experimental pharmacology & physiology

authors： Grounds MD,Radley HG,Gebski BL,Bogoyevitch MA,Shavlakadze T

更新日期：2008-07-01 00:00:00

abstract：:1. In order to find an anaesthesia with minimum perturbation to the metabolism of chylomicrons, the effects of seven different anaesthetic agents on clearance from plasma of chylomicron-like emulsions were compared. 2. Avertin, urethane, fentanyl, and a ketamine/xylazine mixture all slowed the removal from plasma of e...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mortimer BC,Umeda Y,Elsegood CL,Redgrave TG

更新日期：1993-01-01 00:00:00

abstract：:1. The aim of the present study was to perform an in vivo estimation of the Michaelis-Menten constants of the major metabolic pathways of paracetamol (APAP). 2. A two-occasion, single-dose cross-over trial was performed using 60 and 90 mg/kg doses of APAP in healthy patients undergoing third molar dental extraction. P...

journal_title：Clinical and experimental pharmacology & physiology

authors： Reith D,Medlicott NJ,Kumara De Silva R,Yang L,Hickling J,Zacharias M

更新日期：2009-01-01 00:00:00

abstract：:1. The hepatic reticulo-endothelial cell population is generally assumed to increase in size, along with the liver, during ageing in rats. However, this has not been rigorously established. 2. Using electron microscopy and stereological techniques, the present study has shown that the volume densities of hepatocytes a...

journal_title：Clinical and experimental pharmacology & physiology

authors： Martin G,Sewell RB,Yeomans ND,Smallwood RA

更新日期：1992-07-01 00:00:00

abstract：:1. The present study was designed to determine the effects of ginkgolide A, ginkgolide B and quercetin on CYP3A protein expression and enzyme activity in primary cultures of human hepatocytes. 2. Hepatocytes were pretreated with ginkgolide A, ginkgolide B and quercetin (at 1, 3, 10 and 30 micromol/L) for 48 h and then...

journal_title：Clinical and experimental pharmacology & physiology

authors： He N,Cai HB,Xie HG,Collins X,Edeki TI,Strom SC

更新日期：2007-07-01 00:00:00

abstract：:Glycerophospholipids (GPs) and sphingolipids (SPs) are important lipid components in the body and play biological functions. Omega-3 polyunsaturated fatty acids (n-3 PUFAs) are important nutrients, and their supplements are commonly used for preventing some diseases. However, the effect of n-3 PUFAs on the human glyce...

journal_title：Clinical and experimental pharmacology & physiology

authors： Yan M,Cai WB,Hua T,Cheng Q,Ai D,Jiang HF,Zhang X

更新日期：2020-07-01 00:00:00

abstract：:1. This study investigated the effect of atrial natriuretic peptide on renin release from the kidney. The in vitro direct effect was examined in the animal experiment using renal cortical slices of rat, and the in vivo effect was observed in the human infusion study. 2. In the in vitro experiments, alpha-human atrial ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ishimitsu T,Hirata Y,Matsuoka H,Ishii M,Sugimoto T,Kangawa K,Matsuo H

更新日期：1992-10-01 00:00:00

abstract：:Hypertension developed within 5 weeks in uninephrectomized rats administered deoxycorticosterone acetate (DOCA, 30 mg/kg, s.c., weekly) and given isotonic saline to drink. Chronic dietary administration of tryptophan (50 g/kg food) reduced intake of saline solution and prevented the elevation of systolic blood pressur...

journal_title：Clinical and experimental pharmacology & physiology

authors： Fregly MJ,Fater DC

更新日期：1986-11-01 00:00:00

abstract：:Following the potent efficacy of β-D-Mannuronic acid in a breast cancer murine model, we evaluated the efficacy of this novel non-steroidal anti-inflammatory drug in breast cancer patients in the present clinical trial. The study was an 8-week randomized, controlled, phase II clinical trial (IRCT: 2017012213739N7 (in ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kashefi S,Omranipour R,Mahmoodzadeh H,Ahmadi H,Alikhassi A,Hosseini M,Cuzzocrea S,Rehm BHA,Matsuo H,Mirshafiey A

更新日期：2019-06-01 00:00:00

abstract：:1. A comparison has been made of the effects of three acetylcholine antagonists--hexamethonium, tubocurarine and pancuronium--on maximal tetani of limb muscles of cats under chloralose anaesthesia. In most experiments, the indirectly stimulated soleus muscle was studied, but observations were also made on the tibialis...

journal_title：Clinical and experimental pharmacology & physiology

authors： Bowman WC,Webb SN

更新日期：1976-11-01 00:00:00

abstract：:1. The effects of endogenous and exogenous acetylcholine (ACh) on nitrergic relaxations elicited by electrical field stimulation (EFS) were studied in guinea-pig endothelium-denuded basilar artery preparations precontracted with 1 micromol/L prostaglandin F(2 alpha) and a possible role of K+ channels in mediating the ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Jiang F,Li CG,Rand MJ

更新日期：1999-10-01 00:00:00

abstract：:1. Direct cortical stimulation of motor and sensory areas of the cortex in experimental animals and some neurosurgical patients has provided much useful physiological information. Some of the benefits of this approach can be provided in awake volunteer subjects using new techniques which activate the motor cortex thor...

journal_title：Clinical and experimental pharmacology & physiology

authors： Gandevia SC

更新日期：1996-10-01 00:00:00

abstract：:1. Stroke is the second most common cause of death and a major cause of disability worldwide. Despite increasing knowledge of the cellular and molecular mechanisms that occur in stroke, there are still large gaps in our understanding that are impeding therapeutic progress. In addition, there are no drugs yet that can ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sun XL,Hu G

更新日期：2010-02-01 00:00:00

abstract：:The pharmacological actions of 2,6-di-tert-butyl-4-(3-hydroxy-2-spiropentylpropyl)-phenol (BSPP), a putative presynaptic GABA(B) receptor modulator, were examined in electrically stimulated rat neocortical brain slices preloaded with [3H]-GABA or [3H]-glutamic acid. At 10 mmol/L, BSPP inhibited the release of [3H]-GAB...

journal_title：Clinical and experimental pharmacology & physiology

authors： Parker DA,Marino V,Ong J,Puspawati NM,Prager RH

更新日期：2008-09-01 00:00:00

abstract：:Sarcopenia, defined by reduced appendicular skeletal muscle mass (ASM)/height2 (ASMI), is associated with increased arterial stiffness (brachial-ankle pulse wave velocity, baPWV) and wave reflection (augmentation index, AIx). Blood pressure (BP) responses to metaboreflex activation (post-exercise muscle ischemia, PEMI...

journal_title：Clinical and experimental pharmacology & physiology

authors： Figueroa A,Alvarez-Alvarado S,Jaime SJ,Johnson SA,Campbell JC,Feresin RG,Elam ML,Navaei N,Pourafshar S,Arjmandi BH

更新日期：2016-12-01 00:00:00

abstract：:The epithelial sodium channel (ENaC) has long been recognized as playing a vital role in blood pressure (BP) regulation due to its involvement in fluid balance. The genes encoding the three ENaC subunits are likewise important contributors to hypertension, both in rare monogenic diseases and in the general population....

journal_title：Clinical and experimental pharmacology & physiology

authors： Büsst CJ

更新日期：2013-08-01 00:00:00

abstract：:1. The effects of ATP and some of its more stable analogues have been examined upon preparations of epididymal and prostatic halves of vasa deferentia and of cauda epididymides from rats that had undergone vasectomy by medial transection of the vas deferens. 2. After unilateral vasectomy, the potencies of ATP, beta, g...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ventura S,DeGaris RM,Stead CK,Pennefather JN

更新日期：1990-08-01 00:00:00

abstract：:1. Stimulation of the mesolimbic dopamine system, by micro-injection of the substance P analogue [pGlu5,MePhe8,Sar9] substance P (DiMe-C7) into the ventral tegmental area induced a prolonged increase in blood pressure and circulating levels of vasopressin. 2. In the present study, this treatment produced a significant...

journal_title：Clinical and experimental pharmacology & physiology

authors： van den Buuse M,Wilks DP,Cornish JL

更新日期：1998-07-01 00:00:00

abstract：:1. Insulin-like growth factor (IGF)-I has acute effects on cardiovascular function, including a well-characterized vasodilator response in isolated arteries. In addition to increasing the release of nitric oxide, IGF-I also has effects on a variety of other signalling pathways that affect vascular tone, in particular ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Cao N,Lau S,Nguyen TT,White PJ

更新日期：2006-12-01 00:00:00

abstract：:The aim of this study was to investigate whether enoxaparin (ENX) administration would increase seroma risk and worsen mesh tissue recovery in an experimental rat hernia repair model. Fifty-six adult male Wistar-Albino rats were included in the study. Rats were equally and randomly separated into seven groups: Group 1...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ozkececi ZT,Gonul Y,Karavelioglu A,Bozkurt MF,Kacar E,Bal A,Ozsoy M,Turamanlar O,Celep B

更新日期：2016-07-01 00:00:00

abstract：:1. Deposition of β-amyloid (Aβ) peptide is a defining pathological hallmark of Alzheimer's disease (AD) and is involved in memory impairment. Evidence suggests that activation of an extracellular signal-regulated kinase (ERK) pathway is related to Aβ accumulation. Thus, the aim of the present study was to investigate ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Jin P,Choi DY,Hong JT

更新日期：2012-10-01 00:00:00

abstract：:The pressor responses to angiotensin II injections of 29, 117 and 468 pmol/kg and infusion at 54 pmol/kg per min were compared in near-term pregnant and matched non-pregnant rabbits. The responses to noradrenaline injections of 652, 2608 and 10 432 pmol/kg and infusion at 1185 pmol/kg per min were similarly compared. ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Joels N,Humphreys PW

更新日期：1985-11-01 00:00:00

abstract：:Melanoma is an aggressive skin malignancy with a high mortality. Astrocyte elevated gene-1 (AEG-1), a downstream target of Ras and c-Myc, has been implicated in the development of multiple tumours, but its role in melanoma remains unclear. In the present study, the role of AEG-1 in melanoma was explored through AEG-1 ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhang Y,Peng G,Wang Y,Cui L,Wu W,Wang L,Liu C,Han X

更新日期：2017-07-01 00:00:00

abstract：:Apelin receptors (APJ) cross-talk with other G-protein-coupled receptors. However, the role of APJ interaction with opioid receptors (OPR) on the cardiovascular effects of apelin in hypertension is not clear. Renovascular hypertension was induced by placing a Plexiglas clip on the left kidney of rats. After 16 weeks, ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Rostamzadeh F,Najafipour H,Yeganeh-Hajahmadi M,Joukar S

更新日期：2018-02-01 00:00:00

abstract：:Although 7,8-dihydroxyflavone (7,8-DHF), a synthetic agonist specific for tyrosine kinase receptor B (TrkB), has been reported to promote intestinal dynamics, its effect on gastric dynamics has not been studied as yet. In this study, we explored how 7,8-DHF affected the carbachol (CCh)-induced contraction of rat gastr...

journal_title：Clinical and experimental pharmacology & physiology

authors： He B,Qu Z,Tian Z,Zhao K,Wei L,Ma L

更新日期：2018-11-01 00:00:00

abstract：:1. We have reported previously that instant coffee contains ligands for opiate receptors with characteristics similar to those of opiate antagonists. 2. A concentrate of receptor-active ligands from instant coffee was prepared by serial treatments involving Amberlite XAD-2, flash chromatography and gel permeation chro...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wynne KN,Familari M,Boublik JH,Drummer OH,Rae ID,Funder JW

更新日期：1987-10-01 00:00:00

abstract：:1. To investigate the effect of an exercise training programme on antihypertensive drug requirements, 19 sedentary subjects (14 men and five women) with mild essential hypertension (systolic blood pressure greater than 140 mmHg but less than 180 mmHg), aged 29-55 years, were randomly assigned to 16 weeks of moderate i...

journal_title：Clinical and experimental pharmacology & physiology

authors： Allen DH,Puddey IB,Morton AR,Beilin LJ

更新日期：1991-05-01 00:00:00

abstract：:1. (-)[125I]-Cyanopindolol (CYP) binding to non-beta-adrenoceptor sites in dog kidney was characterized in homogenate preparations and their distribution in sections determined using autoradiography. 2. In homogenate studies, (-)[125I]-CYP bound to a single population of non-interacting sites (Bmax = 5.45, s.e.m. = 1....

journal_title：Clinical and experimental pharmacology & physiology

authors： Lew R,Summers RJ

更新日期：1987-09-01 00:00:00