Visceral Fat Dysfunctions in the Rat Social Isolation Model of Psychosis.

Abstract:

:Medication with neuroleptics has been associated with adipose tissue dysfunctions and, in particular, with increased visceral fat amount. However, several studies suggested that antipsychotic treatment might not be the main responsible of fat mass accumulation, as this has been also described in not treated psychotic patients. One of the most used "drug-free" rodent models of psychosis is the social isolation rearing of young adult rats, which provides a non-pharmacologic method of inducing long-term alterations reminiscent of symptoms seen in psychotic patients. Recent data highlighted a crucial role of redox imbalance in adipose tissue dysfunctions, in terms of decreased antioxidant defense and increased reactive oxygen species (ROS). Here, we investigated possible oxidative stress-related biomolecular alterations associated with visceral fat increase in 7 week isolated rats. To this purpose, we quantified total and visceral fat amount by using dual-energy X-ray (DEXA) absorptiometry. On visceral fat, we analyzed the expression of specific ROS-producer genes (Nox1, Nox4, Hmox-1), antioxidant enzymes (Prdx1 and Ucp-1) and oxidative stress-induced damage markers (Cidea, Slc2a4, and Acacb). The impact of oxidative stress on beta3-adrenergic receptors (Adrb3), at both mRNA and protein level, was also assessed. We found that 7 weeks of social isolation induced an increase in total and visceral fat, associated with a decrease in Prdx1 (mRNA and protein) as well as Ucp-1 mRNA levels and an enhanced expression of Nox1 (mRNA and protein) and Hmox-1 mRNA. No differences were detected in Nox4 mRNA levels between grouped and isolated animals. Elevations in Cidea, Slc2a4, and Acacb expression in visceral fat of isolated animals accounted for oxidative stress-related damage in this tissue, further associated with a significant increase in Adrb3 mRNA and protein. Our results provide a novel understanding of the pathological link existing among psychosocial stress-induced psychosis, adipose tissue dysfunctions and redox imbalance, opening new therapeutic perspectives for the treatment of alterations in peripheral tissues associated with this mental disorder.

journal_name

Front Pharmacol

authors

Schiavone S,Camerino GM,Mhillaj E,Zotti M,Colaianna M,De Giorgi A,Trotta A,Cantatore FP,Conte E,Bove M,Tucci P,Morgese MG,Trabace L

doi

10.3389/fphar.2017.00787

subject

Has Abstract

pub_date

2017-11-08 00:00:00

pages

787

issn

1663-9812

journal_volume

8

pub_type

杂志文章
  • Advantages and Limitations of Current Imaging Techniques for Characterizing Liposome Morphology.

    abstract::There are currently a number of imaging techniques available for evaluating the morphology of liposomes and other nanoparticles, with each having its own advantages and disadvantages that should be considered when interpreting data. Controlling and validating the morphology of nanoparticles is of key importance for th...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审

    doi:10.3389/fphar.2018.00080

    authors: Robson AL,Dastoor PC,Flynn J,Palmer W,Martin A,Smith DW,Woldu A,Hua S

    更新日期:2018-02-06 00:00:00

  • DAF-16/FOXO Transcription Factor in Aging and Longevity.

    abstract::Aging is associated with age-related diseases and an increase susceptibility of cancer. Dissecting the molecular mechanisms that underlie aging and longevity would contribute to implications for preventing and treating the age-dependent diseases or cancers. Multiple signaling pathways such as the insulin/IGF-1 signali...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审

    doi:10.3389/fphar.2017.00548

    authors: Sun X,Chen WD,Wang YD

    更新日期:2017-08-23 00:00:00

  • New Insights and Current Approaches in Cardiac Hypertrophy Cell Culture, Tissue Engineering Models, and Novel Pathways Involving Non-Coding RNA.

    abstract::Cardiac hypertrophy is an ongoing clinical challenge, as risk factors such as obesity, smoking and increasing age become more widespread, which lead to an increasing prevalence of developing hypertrophy. Pathological hypertrophy is a maladaptive response to stress conditions, such as pressure overload, and involve a n...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审

    doi:10.3389/fphar.2020.01314

    authors: Kastner N,Zlabinger K,Spannbauer A,Traxler D,Mester-Tonczar J,Hašimbegović E,Gyöngyösi M

    更新日期:2020-08-21 00:00:00

  • Development of a Hyaluronic Acid-Based Nanocarrier Incorporating Doxorubicin and Cisplatin as a pH-Sensitive and CD44-Targeted Anti-Breast Cancer Drug Delivery System.

    abstract::Tumor-targeting nanomaterial-based chemotherapeutic drug delivery systems have been shown to represent an efficacious approach for the treatment of cancer because of their stability in blood circulation and predictable delivery patterns, enhanced tumor-selective drug accumulation, and decreased toxicity to normal tiss...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2020.532457

    authors: Yu T,Li Y,Gu X,Li Q

    更新日期:2020-08-28 00:00:00

  • An Update on in Vivo Imaging of Extracellular Vesicles as Drug Delivery Vehicles.

    abstract::Extracellular vesicles (EVs) are currently being considered as promising drug delivery vehicles. EVs are naturally occurring vesicles that exhibit many characteristics favorable to serve as drug delivery vehicles. In addition, EVs have inherent properties for treatment of cancers and other diseases. For research and c...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审

    doi:10.3389/fphar.2018.00169

    authors: Gangadaran P,Hong CM,Ahn BC

    更新日期:2018-02-28 00:00:00

  • Nuciferine Ameliorates Inflammatory Responses by Inhibiting the TLR4-Mediated Pathway in Lipopolysaccharide-Induced Acute Lung Injury.

    abstract::Acute lung injury (ALI) is a complex syndrome with sepsis occurring in critical patients, who usually lack effective therapy. Nuciferine is a primary bioactive component extracted from the lotus leaf, and it displays extensive pharmacological functions, including anti-cancer, anti-inflammatory, and antioxidant propert...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2017.00939

    authors: Wu H,Yang Y,Guo S,Yang J,Jiang K,Zhao G,Qiu C,Deng G

    更新日期:2017-12-21 00:00:00

  • Circadian Rhythm Protein Bmal1 Modulates Cartilage Gene Expression in Temporomandibular Joint Osteoarthritis via the MAPK/ERK Pathway.

    abstract::The purpose of this study was to elucidate the role of the circadian gene Bmal1 in human cartilage and its crosstalk with the MAPK/ERK signaling pathway in temporomandibular joint osteoarthritis (TMJ-OA). We verified the periodical variation of the circadian gene Bmal1 and then established a modified multiple platform...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2020.527744

    authors: Chen G,Zhao H,Ma S,Chen L,Wu G,Zhu Y,Zhu J,Ma C,Zhao H

    更新日期:2020-09-18 00:00:00

  • Nrf2 as a Potential Mediator of Cardiovascular Risk in Metabolic Diseases.

    abstract::Free radicals act as secondary messengers, modulating a number of important biological processes, including gene expression, ion mobilization in transport systems, protein interactions and enzymatic functions, cell growth, cell cycle, redox homeostasis, among others. In the cardiovascular system, the physiological gen...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审

    doi:10.3389/fphar.2019.00382

    authors: da Costa RM,Rodrigues D,Pereira CA,Silva JF,Alves JV,Lobato NS,Tostes RC

    更新日期:2019-04-12 00:00:00

  • Impaired Spatial Memory and Enhanced Habit Memory in a Rat Model of Post-traumatic Stress Disorder.

    abstract::High levels of emotional arousal can impair spatial memory mediated by the hippocampus, and enhance stimulus-response (S-R) habit memory mediated by the dorsolateral striatum (DLS). The present study was conducted to determine whether these memory systems may be similarly affected in an animal model of post-traumatic ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2017.00663

    authors: Goodman J,McIntyre CK

    更新日期:2017-09-22 00:00:00

  • The Histamine H3 Receptor Antagonist E159 Reverses Memory Deficits Induced by Dizocilpine in Passive Avoidance and Novel Object Recognition Paradigm in Rats.

    abstract::The involvement of histamine H3 receptors (H3Rs) in memory is well known, and the potential of H3R antagonists in therapeutic management of neuropsychiatric diseases, e.g., Alzheimer disease (AD) is well established. Therefore, the effects of histamine H3 receptor (H3R) antagonist E159 (2.5-10 mg/kg, i.p.) in adult ma...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2017.00709

    authors: Alachkar A,Łażewska D,Kieć-Kononowicz K,Sadek B

    更新日期:2017-10-12 00:00:00

  • A Novel Network Pharmacology Strategy to Decode Mechanism of Lang Chuang Wan in Treating Systemic Lupus Erythematosus.

    abstract::Complex disease is a cascade process which is associated with functional abnormalities in multiple proteins and protein-protein interaction (PPI) networks. One drug one target has not been able to perfectly intervene complex diseases. Increasing evidences show that Chinese herb formula usually treats complex diseases ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2020.512877

    authors: Gao Y,Wang KX,Wang P,Li X,Chen JJ,Zhou BY,Tian JS,Guan DG,Qin XM,Lu AP

    更新日期:2020-10-02 00:00:00

  • DeCoST: A New Approach in Drug Repurposing From Control System Theory.

    abstract::In this paper, we propose DeCoST (Drug Repurposing from Control System Theory) framework to apply control system paradigm for drug repurposing purpose. Drug repurposing has become one of the most active areas in pharmacology since the last decade. Compared to traditional drug development, drug repurposing may provide ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2018.00583

    authors: Nguyen TM,Muhammad SA,Ibrahim S,Ma L,Guo J,Bai B,Zeng B

    更新日期:2018-06-05 00:00:00

  • Short-Term Efficacy and Tolerability of Paroxetine Versus Placebo for Panic Disorder: A Meta-Analysis of Randomized Controlled Trials.

    abstract:Objective:To explore the short-term efficacy and tolerability of paroxetine in the treatment of panic disorder in adults. Methods:Multiple electronic databases were searched to find randomized controlled trials (RCTs) on paroxetine and panic disorder. The primary efficacy outcomes were: the mean change compared to the...

    journal_title:Frontiers in pharmacology

    pub_type:

    doi:10.3389/fphar.2020.00275

    authors: Zhang B,Wang C,Cui L,Gao J,Wang C,Tan X,Fang S

    更新日期:2020-03-31 00:00:00

  • Advances and Challenges of Liposome Assisted Drug Delivery.

    abstract::The application of liposomes to assist drug delivery has already had a major impact on many biomedical areas. They have been shown to be beneficial for stabilizing therapeutic compounds, overcoming obstacles to cellular and tissue uptake, and improving biodistribution of compounds to target sites in vivo. This enables...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审

    doi:10.3389/fphar.2015.00286

    authors: Sercombe L,Veerati T,Moheimani F,Wu SY,Sood AK,Hua S

    更新日期:2015-12-01 00:00:00

  • Antioxidant and Anti-tyrosinase Activities of Phenolic Extracts from Rape Bee Pollen and Inhibitory Melanogenesis by cAMP/MITF/TYR Pathway in B16 Mouse Melanoma Cells.

    abstract::Rape bee pollen possesses many nutritional and therapeutic properties because of its abundant nutrimental and bioactive components. In this study, free (FPE) and bound (BPE) phenolic extracts of rape bee pollen were obtained, phenolic and flavonoid contents were determined, and composition of phenolic acids was analyz...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2017.00104

    authors: Sun L,Guo Y,Zhang Y,Zhuang Y

    更新日期:2017-03-09 00:00:00

  • Layered Double Hydroxide Nanomaterials Encapsulating Angelica gigas Nakai Extract for Potential Anticancer Nanomedicine.

    abstract::We prepared hybrids consisting of Angelica gigas Nakai (AGN) root or flower extract and layered double hydroxide (LDH) for potential anticancer nanomedicine, as decursin species (DS) in AGN are known to have anticancer activity. Dimethylsulfoxide solvent was determined hybridization reaction media, as it has affinity ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2018.00723

    authors: Kim HJ,Lee GJ,Choi AJ,Kim TH,Kim TI,Oh JM

    更新日期:2018-07-09 00:00:00

  • miR-133: A Suppressor of Cardiac Remodeling?

    abstract::Cardiac remodeling, which is characterized by mechanical and electrical remodeling, is a significant pathophysiological process involved in almost all forms of heart diseases. MicroRNAs (miRNAs) are a group of non-coding RNAs of 20-25 nucleotides in length that primarily regulate gene expression by promoting mRNA degr...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审

    doi:10.3389/fphar.2018.00903

    authors: Li N,Zhou H,Tang Q

    更新日期:2018-08-17 00:00:00

  • Corrigendum: Chronic MK-801 Application in Adolescence and Early Adulthood: A Spatial Working Memory Deficit in Adult Long-Evans Rats But No Changes in the Hippocampal NMDA Receptor Subunits.

    abstract::[This corrects the article on p. 42 in vol. 9, PMID: 29487522.]. ...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,已发布勘误

    doi:10.3389/fphar.2018.00693

    authors: Uttl L,Petrasek T,Sengul H,Svojanovska M,Lobellova V,Vales K,Radostova D,Tsenov G,Kubova H,Mikulecka A,Svoboda J,Stuchlik A

    更新日期:2018-06-20 00:00:00

  • Apatinib Combined With SOX Regimen in Conversion Treatment of Advanced Gastric Cancer: A Case Series and Literature Review.

    abstract::Gastric cancer is a common digestive tract tumor and the second most prevalent cancer. The prognosis of advanced gastric cancer is poor. Conversion therapy can reduce tumor burden, downgrade tumor, and increase the possibility of complete resection, thus prolonging the survival time of patients with gastric cancer. In...

    journal_title:Frontiers in pharmacology

    pub_type:

    doi:10.3389/fphar.2020.01027

    authors: Jiang D,Xu Y,Chen Y,Jiang J,Wang M,Yang M,Chen Z,Yang L

    更新日期:2020-07-14 00:00:00

  • Immunosuppressive Activity of Artemisia argyi Extract and Isolated Compounds.

    abstract::The need for novel drugs for the treatment of autoimmune diseases is high, since available pharmaceuticals often have substantial side effects and limited efficacy. Natural products are a good starting point in the development of immunosuppressive leads. Since enhanced T cell proliferation is a common feature of autoi...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2020.00402

    authors: Zimmermann-Klemd AM,Reinhardt JK,Morath A,Schamel WW,Steinberger P,Leitner J,Huber R,Hamburger M,Gründemann C

    更新日期:2020-04-08 00:00:00

  • UPLC-QTOF/MSE and Bioassay Are Available Approaches for Identifying Quality Fluctuation of Xueshuantong Lyophilized Powder in Clinic.

    abstract::Xueshuantong Lyophilized Powder (XST), consisting of a series of saponins extracted from Panax notoginseng, is widely applied to treat acute cerebral infarction, stroke, and coronary heart disease in China. However, most adverse drug reactions (ADR) in clinic are caused by quality problems of XST. In this study, six b...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2018.00633

    authors: Yang ZR,Wang ZH,Tang JF,Yan Y,Yue SJ,Feng WW,Shi ZY,Meng XT,Peng C,Wang CY,Meng DL,Yan D

    更新日期:2018-06-15 00:00:00

  • Antidepressant and Anti-Neuroinflammatory Effects of Bangpungtongsung-San.

    abstract::Bangpungtongsung-san (BTS) is a traditional Korean medicine consisting of 18 herbs, some which have antidepressant effects. Here, we used an animal model of reserpine-induced depression and lipopolysaccharide (LPS)-stimulated BV2 microglia to assess the antidepressant and anti-neuroinflammatory effects of BTS. Aside f...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2020.00958

    authors: Park BK,Kim NS,Kim YR,Yang C,Jung IC,Jang IS,Seo CS,Choi JJ,Lee MY

    更新日期:2020-07-10 00:00:00

  • Integrated UPLC-Q/TOF-MS Technique and MALDI-MS to Study of the Efficacy of YiXinshu Capsules Against Heart Failure in a Rat Model.

    abstract::Background: Yixinshu Capsules (YXSC) are widely used in Chinese medicine for the treatment of cardiovascular diseases. However, the therapeutic mechanisms of action are not well understood. Method: In this study, a metabonomic approach based on integrated UPLC-Q/TOF-MS technique and MALDI-MS was utilized to explore po...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2019.01474

    authors: Xu J,Li X,Zhang F,Tang L,Wei J,Lei X,Wang H,Zhang Y,Li D,Tang X,Li G,Tang S,Wu H,Yang H

    更新日期:2019-12-06 00:00:00

  • Calenduloside E Analogues Protecting H9c2 Cardiomyocytes Against H2O2-Induced Apoptosis: Design, Synthesis and Biological Evaluation.

    abstract::Modulation of apoptosis is therapeutically effective in cardiomyocytes damage. Calenduloside E (CE), a naturally occurring triterpenoid saponin, is a potent anti-apoptotic agent. However, little is known about its synthetic analogues on the protective effects in apoptosis of cardiomyocytes. The present research was pe...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2017.00862

    authors: Tian Y,Du YY,Shang H,Wang M,Sun ZH,Wang BQ,Deng D,Wang S,Xu XD,Sun GB,Sun XB

    更新日期:2017-11-23 00:00:00

  • To Inhibit or Enhance? Is There a Benefit to Positive Allosteric Modulation of P2X Receptors?

    abstract::The family of ligand-gated ion channels known as P2X receptors were discovered several decades ago. Since the cloning of the seven P2X receptors (P2X1-P2X7), a huge research effort has elucidated their roles in regulating a range of physiological and pathophysiological processes. Transgenic animals have been influenti...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审

    doi:10.3389/fphar.2020.00627

    authors: Stokes L,Bidula S,Bibič L,Allum E

    更新日期:2020-05-12 00:00:00

  • Postoperative Ileus and Postoperative Gastrointestinal Tract Dysfunction: Pathogenic Mechanisms and Novel Treatment Strategies Beyond Colorectal Enhanced Recovery After Surgery Protocols.

    abstract::Postoperative ileus (POI) and postoperative gastrointestinal tract dysfunction (POGD) are well-known complications affecting patients undergoing intestinal surgery. GI symptoms include nausea, vomiting, pain, abdominal distention, bloating, and constipation. These iatrogenic disorders are associated with extended hosp...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章,评审

    doi:10.3389/fphar.2020.583422

    authors: Mazzotta E,Villalobos-Hernandez EC,Fiorda-Diaz J,Harzman A,Christofi FL

    更新日期:2020-11-24 00:00:00

  • Simvastatin Enhances Activity and Trafficking of α7 Nicotinic Acetylcholine Receptor in Hippocampal Neurons Through PKC and CaMKII Signaling Pathways.

    abstract::Simvastatin (SV) enhances glutamate release and synaptic plasticity in hippocampal CA1 region upon activation of α7 nicotinic acetylcholine receptor (α7nAChR). In this study, we examined the effects of SV on the functional activity of α7nAChR on CA1 pyramidal cells using patch-clamp recording and explored the underlyi...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2018.00362

    authors: Chen T,Wang Y,Zhang T,Zhang B,Chen L,Zhao L,Chen L

    更新日期:2018-04-12 00:00:00

  • Chromatin Regulation by HP1γ Contributes to Survival of 5-Azacytidine-Resistant Cells.

    abstract::Recent investigations of the treatment for hematologic neoplasms have focused on targeting epigenetic regulators. The DNA methyltransferase inhibitor 5-azacytidine (AZA) has produced good results in the treatment of patients with myelodysplastic syndromes. The mechanism underlying its pharmacological activity involves...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2018.01166

    authors: Imanishi S,Umezu T,Kobayashi C,Ohta T,Ohyashiki K,Ohyashiki JH

    更新日期:2018-10-16 00:00:00

  • Total Extracts of Abelmoschus manihot L. Attenuates Adriamycin-Induced Renal Tubule Injury via Suppression of ROS-ERK1/2-Mediated NLRP3 Inflammasome Activation.

    abstract::Abelmoschus manihot (L.) Medik. (Malvaceae) is a herb used in traditional Chinese medicine to treat some kidney diseases. To date, the detailed mechanisms by which A. manihot improves some kinds of renal disease are not fully understood. In this study, we established Adriamycin-induced NRK-52E cells, the normal rat ki...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2019.00567

    authors: Li W,He W,Xia P,Sun W,Shi M,Zhou Y,Zhu W,Zhang L,Liu B,Zhu J,Zhu Y,Zhou E,Sun M,Gao K

    更新日期:2019-05-28 00:00:00

  • Unblocking High-Value Botanical Value Chains: Is There a Role for Blockchain Systems?

    abstract::Blockchain systems are a fast emerging and a currently widely discussed novel strategy for a decentralized cryptographically enhanced digital ledger recording transactions among stakeholders. This perspective paper looks at its potential uses in the context of high value and mostly low volume botanical material traded...

    journal_title:Frontiers in pharmacology

    pub_type: 杂志文章

    doi:10.3389/fphar.2019.00396

    authors: Heinrich M,Scotti F,Booker A,Fitzgerald M,Kum KY,Löbel K

    更新日期:2019-04-24 00:00:00