Paracetamol Medication During Pregnancy: Insights on Intake Frequencies, Dosages and Effects on Hematopoietic Stem Cell Populations in Cord Blood From a Longitudinal Prospective Pregnancy Cohort.

abstract：:Inter-individual variability has been a major hurdle to optimize disease management. Precision medicine holds promise for improving health and healthcare via tailor-made therapeutic strategies. Herein, we outline the paradigm of "pharmacometabolomics-aided pharmacogenomics" in autoimmune diseases. We envisage merging ...

journal_title：EBioMedicine

authors： Katsila T,Konstantinou E,Lavda I,Malakis H,Papantoni I,Skondra L,Patrinos GP

更新日期：2016-02-02 00:00:00

abstract：BACKGROUND:In a placebo-controlled trial of the peptide-based therapeutic HIV-1 p24Gag vaccine candidate Vacc-4x, participants on combination antiretroviral therapy (cART) received six immunizations over 18weeks, followed by analytical treatment interruption (ATI) between weeks 28 and 52. Cell-mediated immune responses...

journal_title：EBioMedicine

authors： Huang Y,Pantaleo G,Tapia G,Sanchez B,Zhang L,Trondsen M,Hovden AO,Pollard R,Rockstroh J,Ökvist M,Sommerfelt MA

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:In Western cohorts, the prevalence of incidental findings (IFs) or incidentalome, referring to variants in genes that are unrelated to the patient's primary condition, is between 0.86% and 8.8%. However, data on prevalence and type of IFs in Asian population is lacking. METHODS:In 2 cohorts of individuals w...

journal_title：EBioMedicine

authors： Jamuar SS,Kuan JL,Brett M,Tiang Z,Tan WL,Lim JY,Liew WK,Javed A,Liew WK,Law HY,Tan ES,Lai A,Ng I,Teo YY,Venkatesh B,Reversade B,Tan EC,Foo R

更新日期：2016-02-04 00:00:00

abstract：BACKGROUND:Abnormalities in membrane excitability and Na(+) channel function are characteristic of amyotrophic lateral sclerosis (ALS). We aimed to examine the neuroprotective potential, safety and tolerability of the Na(+) channel blocker and membrane stabiliser flecainide in ALS. METHODS:A double-blind, placebo-cont...

journal_title：EBioMedicine

authors： Park SB,Vucic S,Cheah BC,Lin CS,Kirby A,Mann KP,Zoing MC,Winhammar J,Kiernan MC

更新日期：2015-12-01 00:00:00

abstract：:This study aimed to develop and validate a prognostic nomogram for recurrence-free survival (RFS) after surgery in the absence of adjuvant therapy to guide the selection for adjuvant imatinib therapy based on Residual Neural Network (ResNet). The ResNet model was developed based on contrast-enhanced computed tomograph...

journal_title：EBioMedicine

authors： Chen T,Liu S,Li Y,Feng X,Xiong W,Zhao X,Yang Y,Zhang C,Hu Y,Chen H,Lin T,Zhao M,Liu H,Yu J,Xu Y,Zhang Y,Li G

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:SARS-CoV-2 infection (COVID-19 disease) can induce systemic vascular involvement contributing to morbidity and mortality. SARS-CoV-2 targets epithelial and endothelial cells through the ACE2 receptor. The anatomical involvement of the coronary tree is not explored yet. METHODS:Cardiac autopsy tissue of the ...

journal_title：EBioMedicine

authors： Maccio U,Zinkernagel AS,Shambat SM,Zeng X,Cathomas G,Ruschitzka F,Schuepbach RA,Moch H,Varga Z

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Population-level monitoring of hepatitis C virus (HCV) infected people across the cascade of care identifies gaps in access and engagement in care and treatment. We characterized a population-level cascade of care for HCV in British Columbia (BC), Canada and identified factors associated with leakage at each...

journal_title：EBioMedicine

authors： Janjua NZ,Kuo M,Yu A,Alvarez M,Wong S,Cook D,Wong J,Grebely J,Butt ZA,Samji H,Ramji A,Tyndall M,Krajden M

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Tissue stem cells (SCs) and cancer cells proliferation is regulated by many common signalling mechanisms. These mechanisms temporally balance proliferation and differentiation events during normal tissue homeostasis and repair. However, the effect of these aberrant signalling mechanisms on the ultimate fate ...

journal_title：EBioMedicine

authors： Chovatiya GL,Sunkara RR,Roy S,Godbole SR,Waghmare SK

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Intake of ω-3 PUFAs have been demonstrated to have positive effects on pregnancy outcome, whose receptor, GPR120, regulates several cellular functions including differentiation, metabolism and immune reaction. However, whether GPR120 is involved in decidualization and pregnancy remains unknown. METHODS:Deci...

journal_title：EBioMedicine

authors： Huang J,Xue M,Zhang J,Yu H,Gu Y,Du M,Ye W,Wan B,Jin M,Zhang Y

更新日期：2019-01-01 00:00:00

abstract：:Macrophage aging is pathogenic in numerous diseases, including age-related macular degeneration (AMD), a leading cause of blindness in older adults. Although prior studies have explored the functional consequences of macrophage aging, less is known about its cellular basis or what defines the transition from physiolog...

journal_title：EBioMedicine

authors： Lin JB,Sene A,Santeford A,Fujiwara H,Sidhu R,Ligon MM,Shankar VA,Ban N,Mysorekar IU,Ory DS,Apte RS

更新日期：2018-06-01 00:00:00

abstract：:Traumatic brain injury (TBI) is a major cause of death and disability worldwide, especially in children and young adults. TBI is an example of a medical condition where there are still major lacks in diagnostics and outcome prediction. Here we apply comprehensive metabolic profiling of serum samples from TBI patients ...

journal_title：EBioMedicine

authors： Orešič M,Posti JP,Kamstrup-Nielsen MH,Takala RSK,Lingsma HF,Mattila I,Jäntti S,Katila AJ,Carpenter KLH,Ala-Seppälä H,Kyllönen A,Maanpää HR,Tallus J,Coles JP,Heino I,Frantzén J,Hutchinson PJ,Menon DK,Tenovuo O,Hyötyl

更新日期：2016-10-01 00:00:00

abstract：:As our population grows older, age-related pathologies are becoming more prevalent. Deterioration of skeletal muscle and the immune system manifests as sarcopenia and immune senescence respectively. The disease burden of these pathologies emphasizes the need for a better understanding of the underlying mechanisms. Ske...

journal_title：EBioMedicine

authors： Nelke C,Dziewas R,Minnerup J,Meuth SG,Ruck T

更新日期：2019-11-01 00:00:00

abstract：:Chronic kidney disease (CKD) is a global health problem, and novel therapies to treat CKD are urgently needed. Here, we show that inhibition of G0/G1 switch 2 (G0s2) ameliorates renal inflammation in a mouse model of CKD. Renal expression of chemokine (C-C motif) ligand 2 (Ccl2) was increased in response to p65 activa...

journal_title：EBioMedicine

authors： Matsunaga N,Ikeda E,Kakimoto K,Watanabe M,Shindo N,Tsuruta A,Ikeyama H,Hamamura K,Higashi K,Yamashita T,Kondo H,Yoshida Y,Matsuda M,Ogino T,Tokushige K,Itcho K,Furuichi Y,Nakao T,Yasuda K,Doi A,Amamoto T,Aramaki

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Metastasis is a major obstacle in the treatment of bladder cancer (BC). Circular RNAs exert various functions in the aggressive biological behaviour of cancers. In this study, we aimed to elucidate how circPICALM influences BC metastasis. METHODS:The expression of circPICALM was analysed by real-time PCR. T...

journal_title：EBioMedicine

authors： Yan D,Dong W,He Q,Yang M,Huang L,Kong J,Qin H,Lin T,Huang J

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:High-molecular-weight kininogen is a cofactor of the human contact system, an inflammatory response mechanism that is activated during sepsis. It has been shown that high-molecular-weight kininogen contributes to endotoxemia, but is not critical for local host defense during pneumonia by Gram-negative bacter...

journal_title：EBioMedicine

authors： Köhler J,Maletzki C,Koczan D,Frank M,Springer A,Steffen C,Revenko AS,MacLeod AR,Mikkat S,Kreikemeyer B,Oehmcke-Hecht S

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Tumor cells benefit from tumor-associated macrophages (TAMs) promoting tumor growth and modulating functions of other cells in tumor microenvironment (TME). However, how tumor cells regulate the property of TAMs during tumor invasion remains to be defined. METHODS:Mouse tumor models and cancer patients' sam...

journal_title：EBioMedicine

authors： Wang R,Liu Y,Liu L,Chen M,Wang X,Yang J,Gong Y,Ding BS,Wei Y,Wei X

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Although significant progress has been made in understanding the mechanisms of steatosis and insulin resistance, the physiological functions of the epigenetic regulators in these processes remain largely elusive. METHODS:Hepatocyte-specific Arid1a knockout mice were administrated with high-fat diet (HFD) fo...

journal_title：EBioMedicine

authors： Qu YL,Deng CH,Luo Q,Shang XY,Wu JX,Shi Y,Wang L,Han ZG

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Accelerated telomere shortening may cause cancer via chromosomal instability, making it a potentially useful biomarker. However, publications on blood telomere length (BTL) and cancer are inconsistent. We prospectively examined BTL measures over time and cancer incidence. METHODS:We included 792 Normative A...

journal_title：EBioMedicine

authors： Hou L,Joyce BT,Gao T,Liu L,Zheng Y,Penedo FJ,Liu S,Zhang W,Bergan R,Dai Q,Vokonas P,Hoxha M,Schwartz J,Baccarelli A

更新日期：2015-04-13 00:00:00

abstract：:Anti-retroviral therapy successfully suppresses HIV-1 infection, but fails to provide a cure. During infection Type 1 IFNs normally play an essential role in viral clearance, but in vivo IFN-α only has a modest impact on HIV-1 infection, suggesting its possible targeting by HIV. Here, we report that the HIV protein, V...

journal_title：EBioMedicine

authors： Gargan S,Ahmed S,Mahony R,Bannan C,Napoletano S,O'Farrelly C,Borrow P,Bergin C,Stevenson NJ

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Due to the lack of protective immunity of humans towards the newly emerged SARS-CoV-2, this virus has caused a massive pandemic across the world resulting in hundreds of thousands of deaths. Thus, a vaccine is urgently needed to contain the spread of the virus. METHODS:Here, we describe Newcastle disease vi...

journal_title：EBioMedicine

authors： Sun W,Leist SR,McCroskery S,Liu Y,Slamanig S,Oliva J,Amanat F,Schäfer A,Dinnon KH 3rd,García-Sastre A,Krammer F,Baric RS,Palese P

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:KRAS mutations are the most frequent oncogenic aberration in lung adenocarcinoma. KRAS mutant isoforms differentially shape tumour biology and influence drug responses. This heterogeneity challenges the development of effective therapies for patients with KRAS-driven non-small cell lung cancer (NSCLC). METH...

journal_title：EBioMedicine

authors： Wang H,Lv Q,Xu Y,Cai Z,Zheng J,Cheng X,Dai Y,Jänne PA,Ambrogio C,Köhler J

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Recurrent implantation failure (RIF) remains a critical and challenging problem in assisted reproductive technology mainly due to impaired decidualization. The endocytic and transcytotic activity in the endometrium are crucial for decidualization. The most representative endocytic gene is the C-terminal Eps1...

journal_title：EBioMedicine

authors： Zhou Q,Yan G,Ding L,Liu J,Yu X,Kong S,Zhang M,Wang Z,Liu Y,Jiang Y,Kong N,Sun J,Sun H

更新日期：2019-12-01 00:00:00

abstract：INTRODUCTION:Therapeutic options for diffuse malignant peritoneal mesothelioma (DMPM) are limited to surgery and locoregional chemotherapy. Despite improvements in survival rates, patients eventually succumb to disease progression. We investigated splicing deregulation both as molecular prognostic factor and potential ...

journal_title：EBioMedicine

authors： Sciarrillo R,Wojtuszkiewicz A,El Hassouni B,Funel N,Gandellini P,Lagerweij T,Buonamici S,Blijlevens M,Zeeuw van der Laan EA,Zaffaroni N,Deraco M,Kusamura S,Würdinger T,Peters GJ,Molthoff CFM,Jansen G,Kaspers GJL,Cloos J

更新日期：2019-01-01 00:00:00

abstract：:Detecting circulating tumor cells (CTCs) has proven valuable for evaluating the prognosis of cancer patients and for studying the mechanisms of treatment resistance. Owing to the lack of universal and specific tumor markers for neuroblastoma (NB), in this prospective study, we adopted an EpCAM-independent method to de...

journal_title：EBioMedicine

authors： Liu X,Zhang Z,Zhang B,Zheng Y,Zheng C,Liu B,Zheng S,Dong K,Dong R

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:Impaired fracture healing represents an ongoing clinical challenge, as treatment options remain limited. Calcitonin gene-related peptide (CGRP), a neuropeptide targeted by emerging anti-migraine drugs, is also expressed in sensory nerve fibres innervating bone tissue. METHOD:Bone healing following a femoral...

journal_title：EBioMedicine

authors： Appelt J,Baranowsky A,Jahn D,Yorgan T,Köhli P,Otto E,Farahani SK,Graef F,Fuchs M,Herrera A,Amling M,Schinke T,Frosch KH,Duda GN,Tsitsilonis S,Keller J

更新日期：2020-09-01 00:00:00

abstract：:Therapies against hepatitis B virus (HBV) have improved in recent decades; however, the development of individualized treatments has been limited by the lack of individualized infection models. In this study, we used human induced pluripotent stem cell (hiPSC) to generate a functional liver organoid (LO) that inherite...

journal_title：EBioMedicine

authors： Nie YZ,Zheng YW,Miyakawa K,Murata S,Zhang RR,Sekine K,Ueno Y,Takebe T,Wakita T,Ryo A,Taniguchi H

更新日期：2018-09-01 00:00:00

abstract：:Metabolic alteration constitutes a hallmark of cancer. Glycolysis and antioxidant pathways in kidney cancer are elevated, with frequent mutation of the VHL gene. Intratumor genetic heterogeneity has been recently demonstrated in kidney cancer. However, intratumor metabolic heterogeneity has not been investigated. Here...

journal_title：EBioMedicine

authors： Okegawa T,Morimoto M,Nishizawa S,Kitazawa S,Honda K,Araki H,Tamura T,Ando A,Satomi Y,Nutahara K,Hara T

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:The delineation of the behavioral neurobiological mechanisms underlying the heterogeneous pathways for alcohol use disorders (AUDs) is ostensibly imperative for the development of more cost-effective treatments predicated on better understanding of this complex psychopathology. METHODS:1) Forty-eight high a...

journal_title：EBioMedicine

authors： Shakra MA,Leyton M,Moghnieh H,Pruessner J,Dagher A,Pihl R

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Urea, the end product of protein metabolism, has been considered to have negligible toxicity for a long time. Our previous study showed a depression phenotype in urea transporter (UT) B knockout mice, which suggests that abnormal urea metabolism may cause depression. The purpose of this study was to determin...

journal_title：EBioMedicine

authors： Wang H,Huang B,Wang W,Li J,Chen Y,Flynn T,Zhao M,Zhou Z,Lin X,Zhang Y,Xu M,Li K,Tian K,Yuan D,Zhou P,Hu L,Zhong D,Zhu S,Li J,Chen D,Wang K,Liang J,He Q,Sun J,Shi J,Yan L,Sands JM,Xie Z,Lian X,Xu

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Clinical trials on multiple sclerosis with repeated injections of monoclonal antibodies depleting CD4+ T cells have not resulted in much success as a disease therapy. Here, we developed an immunotherapy for EAE in mice by combining a transient depletion of T cells together with the administration of neuron d...

journal_title：EBioMedicine

authors： Kasagi S,Wang D,Zhang P,Zanvit P,Chen H,Zhang D,Li J,Che L,Maruyama T,Nakatsukasa H,Wu R,Jin W,Sun L,Chen W

更新日期：2019-06-01 00:00:00