Human Cardiac-Derived Stem/Progenitor Cells Fine-Tune Monocyte-Derived Descendants Activities toward Cardiac Repair.

abstract：:Antiretroviral therapy (ART) for human immunodeficiency virus (HIV) infections has been designed to optimize CD4 T-cell survival and limit HIV replication. Cell types other than CD4 T cells such as monocytes/macrophage, dendritic cells, and granulocytes (collectively known as myeloid cells), are generally not consider...

journal_title：Frontiers in immunology

authors： Murray SM,Zhang Y,Douek DC,Sekaly RP

更新日期：2020-03-04 00:00:00

abstract：:Over the last decade, the acceleration in the clinical use of mesenchymal stromal cells (MSCs) has been nothing short of spectacular. Perhaps most surprising is how little we know about the "MSC product." Although MSCs are being delivered to patients at an alarming rate, the regulatory requirements for MSC therapies (...

journal_title：Frontiers in immunology

authors： Wilson A,Hodgson-Garms M,Frith JE,Genever P

更新日期：2019-05-16 00:00:00

abstract：:Impairment or stimulation of the immune system by ionizing radiation (IR) impacts on immune surveillance of tumor cells and non-malignant cells and can either foster therapy response or side effects/toxicities of radiation therapy. For a better understanding of the mechanisms by which IR modulates T-cell activation an...

journal_title：Frontiers in immunology

authors： Voos P,Fuck S,Weipert F,Babel L,Tandl D,Meckel T,Hehlgans S,Fournier C,Moroni A,Rödel F,Thiel G

更新日期：2018-04-30 00:00:00

abstract：:Vγ9Vδ2-T cells are considered as potent effector cells for tumor immunotherapy through directly killing tumor cells and indirectly regulating other innate and adaptive immune cells to establish antitumoral immunity. The antitumoral activity of Vγ9Vδ2-T cells is governed by a complicated set of activating and inhibitor...

journal_title：Frontiers in immunology

authors： Xiang Z,Tu W

更新日期：2017-08-28 00:00:00

abstract：:Gut microbiota dysbiosis has been implicated in MS and other immune diseases, although it remains unclear how manipulating the gut microbiota may affect the disease course. Using a well-established model of progressive MS triggered by intracranial infection with Theiler's murine encephalomyelitis virus (TMEV), we soug...

journal_title：Frontiers in immunology

authors： Mestre L,Carrillo-Salinas FJ,Mecha M,Feliú A,Espejo C,Álvarez-Cermeño JC,Villar LM,Guaza C

更新日期：2019-06-14 00:00:00

abstract：:Pathogenic autoantibodies can cause inflammation and tissue injury in systemic lupus erythematosus (SLE). Although IgG4 is considered non-inflammatory owing to the unique structure of its hinge region, the role of IgG4 autoantibodies in SLE remains largely unknown. The titers of serum anti-nuclear-IgG antibodies (ANA-...

journal_title：Frontiers in immunology

authors： Pan Q,Xiao H,Shi L,He Y,Cai J,Wu J,Li A,Ye L,Yang C,Liu HF

更新日期：2020-06-17 00:00:00

abstract：:[This corrects the article on p. 299 in vol. 6, PMID: 26150816.]. ...

journal_title：Frontiers in immunology

authors： Frontiers Production Office.

更新日期：2016-04-28 00:00:00

abstract：:HLA antibodies are primary causes of transplant rejection; they recognize epitopes that can be structurally defined by eplets. There are many reviews about HLA epitope-based matching in transplantation. This article describes some personal reflections about epitopes including a historical perspective of HLA typing at ...

journal_title：Frontiers in immunology

authors： Duquesnoy RJ

更新日期：2016-11-28 00:00:00

abstract：:Transfer of recipient regulatory T cells (Tregs) induces mixed chimerism and tolerance in an irradiation-free bone marrow (BM) transplantation (BMT) model involving short-course co-stimulation blockade and mTOR inhibition. Boosting endogenous Tregs pharmacologically in vivo would be an attractive alternative avoiding ...

journal_title：Frontiers in immunology

authors： Granofszky N,Farkas AM,Muckenhuber M,Mahr B,Unger L,Maschke S,Pilat N,Holly R,Wiletel M,Regele H,Wekerle T

更新日期：2017-07-19 00:00:00

abstract：:γ9δ2T cells play a critical role in daily cancer immune surveillance by sensing cancer-mediated metabolic changes. However, a major limitation of the therapeutic application of γ9δ2T cells is their diversity and regulation through innate co-receptors. In order to overcome natural obstacles of γ9δ2T cells, we have deve...

journal_title：Frontiers in immunology

authors： Straetemans T,Kierkels GJJ,Doorn R,Jansen K,Heijhuurs S,Dos Santos JM,van Muyden ADD,Vie H,Clemenceau B,Raymakers R,de Witte M,Sebestyén Z,Kuball J

更新日期：2018-05-30 00:00:00

abstract：:Cytotoxic chemotherapeutics (CCTs) are widely used in the treatment of cancer. Although their mechanisms of action have been best understood in terms of targeting the apparatus of mitosis, an ability to stimulate anti-tumor immune responses is increasing the recognition of these agents as immunotherapies. Immune check...

journal_title：Frontiers in immunology

authors： Opzoomer JW,Sosnowska D,Anstee JE,Spicer JF,Arnold JN

更新日期：2019-07-17 00:00:00

abstract：:Intercellular communication is crucial to the immune system response. In the recent years, the discovery of exosomes has changed the way immune response orchestration was understood. Exosomes are able to operate as independent units that act as mediators in both physiological and pathological conditions. These structu...

journal_title：Frontiers in immunology

authors： Sastre B,Cañas JA,Rodrigo-Muñoz JM,Del Pozo V

更新日期：2017-07-21 00:00:00

abstract：:B cells are capable of receptor-mediated responses to foreign antigens. Recognition of microbial-derived nucleic acid (NA) by toll-like receptors (TLRs) 7 and 9 in B cells has been substantiated. Endogenous NA released from damaged or dying cells can also be immunogenic in certain contexts and can incite aberrant acti...

journal_title：Frontiers in immunology

authors： Suthers AN,Sarantopoulos S

更新日期：2017-07-13 00:00:00

abstract：:Antibody-derived chimeric antigen receptor (CAR) T cell therapy has achieved gratifying breakthrough in hematologic malignancies but has shown limited success in solid tumor immunotherapy. Monoclonal antibody, TAB004, specifically recognizes the aberrantly glycosylated tumor form of MUC1 (tMUC1) in all subtypes of bre...

journal_title：Frontiers in immunology

authors： Zhou R,Yazdanifar M,Roy LD,Whilding LM,Gavrill A,Maher J,Mukherjee P

更新日期：2019-05-24 00:00:00

abstract：:The so-called shock and kill therapies aim to combine HIV-1 reactivation by latency-reversing agents (LRA) with immune clearance to purge the HIV-1 reservoir. The clinical use of LRA has demonstrated detectable perturbations in the HIV-1 reservoir without measurable reductions to date. Consequently, fundamental questi...

journal_title：Frontiers in immunology

authors： Ruiz A,Blanch-Lombarte O,Jimenez-Moyano E,Ouchi D,Mothe B,Peña R,Galvez C,Genescà M,Martinez-Picado J,Goulder P,Barnard R,Howell B,Clotet B,Prado JG

更新日期：2019-01-22 00:00:00

abstract：:Background: Obesity is a condition with a complex pathophysiology characterized by both chronic low-grade inflammation and changes in the gut microbial ecosystem. These alterations can affect the metabolism of tryptophan (TRP), an essential amino acid and precursor of serotonin (5-HT), kynurenine (KYN), and indoles. T...

journal_title：Frontiers in immunology

authors： Cussotto S,Delgado I,Anesi A,Dexpert S,Aubert A,Beau C,Forestier D,Ledaguenel P,Magne E,Mattivi F,Capuron L

更新日期：2020-04-15 00:00:00

abstract：:The sensory nervous and immune systems, historically considered autonomous, actually work in concert to promote host defense and tissue homeostasis. These systems interact with each other through a common language of cell surface G protein-coupled receptors and receptor tyrosine kinases as well as cytokines, growth fa...

journal_title：Frontiers in immunology

authors： Foster SL,Seehus CR,Woolf CJ,Talbot S

更新日期：2017-11-03 00:00:00

abstract：:Sex-related differences in asthma prevalence are well established and change through the reproductive phases of life. As children, boys have increased prevalence of asthma compared to girls. However, as adults, women have increased prevalence of asthma compared to men. Many factors, including genetics, environment, im...

journal_title：Frontiers in immunology

authors： Shah R,Newcomb DC

更新日期：2018-12-18 00:00:00

abstract：:Human pathogen Campylobacter jejuni is a significant risk factor for the development of long-term intestinal dysfunction although the cellular and molecular mechanisms remain scantily defined. IL-23 is an emerging therapeutic target for the treatment of inflammatory intestinal diseases, however its role in C. jejuni-d...

journal_title：Frontiers in immunology

authors： Jing X,Korchagina AA,Shein SA,Muraoka WT,Koroleva E,Tumanov AV

更新日期：2021-01-06 00:00:00

abstract：:Transplant tolerance induced in adult animals is mediated by alloantigen-specific CD4+CD25+ T cells, yet in many models, proliferation of CD4+ T cells from hosts tolerant to specific-alloantigen in vitro is not impaired. To identify changes that may diagnose tolerance, changes in the patterns of proliferation of CD4+,...

journal_title：Frontiers in immunology

authors： Hall BM,Robinson CM,Plain KM,Verma ND,Tran GT,Nomura M,Carter N,Boyd R,Hodgkinson SJ

更新日期：2017-08-22 00:00:00

abstract：:Delivery of high doses of radiation to thoracic region, particularly with non-small cell lung cancer patients, becomes difficult due to subsequent complications arising in the lungs of the patient. Radiation-induced pneumonitis is an early event evident in most radiation exposed patients observed within 2-4 months of ...

journal_title：Frontiers in immunology

authors： Kainthola A,Haritwal T,Tiwari M,Gupta N,Parvez S,Tiwari M,Prakash H,Agrawala PK

更新日期：2017-05-02 00:00:00

abstract：:Vaccination against Salmonella Typhi using the Vi capsular polysaccharide, a T-cell independent antigen, can protect from the development of typhoid fever. This implies that antibodies to Vi alone can protect in the absence of a T cell-mediated immune response; however, protective Vi antibodies have not been well-char...

journal_title：Frontiers in immunology

authors： Dahora LC,Jin C,Spreng RL,Feely F,Mathura R,Seaton KE,Zhang L,Hill J,Jones E,Alam SM,Dennison SM,Pollard AJ,Tomaras GD

更新日期：2019-11-01 00:00:00

abstract：:Primary immunodeficiencies (PIDs) are genetic disorders impairing host immunity, leading to life-threatening infections, autoimmunity, and/or malignancies. Genomic technologies have been critical for expediting the discovery of novel genetic defects underlying PIDs, expanding our knowledge of the complex clinical phen...

journal_title：Frontiers in immunology

authors： Seleman M,Hoyos-Bachiloglu R,Geha RS,Chou J

更新日期：2017-07-24 00:00:00

abstract：:Despite the role of pigs as a source of new Influenza A Virus viruses (IAV) potentially capable of initiating human pandemics, immune responses to swine influenza virus (SwIV) in pigs are not fully understood. Several SwIV epitopes presented by swine MHC (SLA) class I have been identified using different approaches ei...

journal_title：Frontiers in immunology

authors： Baratelli M,Morgan S,Hemmink JD,Reid E,Carr BV,Lefevre E,Montaner-Tarbes S,Charleston B,Fraile L,Tchilian E,Montoya M

更新日期：2020-09-16 00:00:00

abstract：:The T cell population in an individual needs to avoid harmful activation by self peptides while maintaining the ability to respond to an unknown set of foreign peptides. This property is acquired by a combination of thymic and extra-thymic mechanisms. We extend current models for the development of self/non-self discr...

journal_title：Frontiers in immunology

authors： Best K,Chain B,Watkins C

更新日期：2015-08-07 00:00:00

abstract：:Immune evasion is an important cancer hallmark and the understanding of its mechanisms has generated successful therapeutic approaches. Induction of immunogenic cell death (ICD) is expected to attract immune cell populations that promote innate and adaptive immune responses. Here, we present a critical advance for our...

journal_title：Frontiers in immunology

authors： Cerqueira OLD,Clavijo-Salomon MA,Cardoso EC,Citrangulo Tortelli Junior T,Mendonça SA,Barbuto JAM,Strauss BE

更新日期：2020-10-22 00:00:00

abstract：:Neddylation is a type of post-translational protein modifications, in which neural precursor cell expressed developmentally downregulated protein 8 (NEDD8) is covalently conjugated to the lysine residues of target substrates. The best characterized principal substrates of neddylation are the cullin-RING ligases (CRLs)...

journal_title：Frontiers in immunology

authors： Yu G,Liu X,Tang J,Xu C,Ouyang G,Xiao W

更新日期：2019-06-25 00:00:00

abstract：:Antibodies are commonly used in organ transplant induction therapy and to treat autoimmune disorders. The effects of some biologics on the human immune system remain incompletely characterized and a deeper understanding of their mechanisms of action may provide useful insights for their clinical application. The goal ...

journal_title：Frontiers in immunology

authors： Binder C,Sellberg F,Cvetkovski F,Berglund E,Berglund D

更新日期：2020-11-11 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have been recommended as the first-line therapy for non-small cell lung cancer (NSCLC) patients harboring EGFR mutations. However, acquired resistance to EGFR-TKIs is inevitable. Although immune checkpoint blockades (ICBs) targeting the programm...

journal_title：Frontiers in immunology

authors： Wu D,Liu Y,Li X,Liu Y,Yang Q,Liu Y,Wu J,Tian C,Zeng Y,Zhao Z,Xiao Y,Gu F,Zhang K,Hu Y,Liu L

更新日期：2020-07-23 00:00:00

abstract：:Bullous pemphigoid (BP) is a common autoimmune blistering disease in which autoantibodies mainly target the hemidesmosomal component BP180 (also known as type XVII collagen) in basal keratinocytes. Various triggering factors are known to induce BP onset, including radiotherapy, burns, ultraviolet exposure, surgery, an...

journal_title：Frontiers in immunology

authors： Mai Y,Nishie W,Sato K,Hotta M,Izumi K,Ito K,Hosokawa K,Shimizu H

更新日期：2018-04-12 00:00:00