Association Study of Transforming Growth Factor Alpha TaqI Polymorphism and the Risk of Cleft Lip and/or Palate in an Iranian Population.

abstract：:As a result of human socio-economic activity, industrial wastes have increased alarmingly. Plastic pollution is globally distributed across the world due to its properties of buoyancy and durability. Two broad classes of plastic-related chemicals are of critical concern for human health-bisphenol-A or BPA, and additiv...

journal_title：Birth defects research

authors： Solleiro-Villavicencio H,Gomez-De León CT,Del Río-Araiza VH,Morales-Montor J

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:The teratogenic effects of prenatal alcohol exposure (PAE) have been extensively documented over the course of 45 years of research and psychiatric problems are pervasive in this population. In adults with PAE, suicidal risk is high but less is known about the suicidal risk in adolescents with fetal alcohol ...

journal_title：Birth defects research

authors： O'Connor MJ,Portnoff LC,Lebsack-Coleman M,Dipple KM

更新日期：2019-07-15 00:00:00

abstract：:The blood-brain barrier (BBB) serves as a gateway for passage of drugs, chemicals, nutrients, metabolites, and hormones between vascular and neural compartments in the brain. Here, we review BBB development with regard to the microphysiology of the neurovascular unit (NVU) and the impact of BBB disruption on brain dev...

journal_title：Birth defects research

authors： Saili KS,Zurlinden TJ,Schwab AJ,Silvin A,Baker NC,Hunter ES 3rd,Ginhoux F,Knudsen TB

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVES:Strategies for conducting juvenile dose ranging studies before definitive toxicity juvenile animal studies (JAS) have evolved, but the aim of demonstrating study design robustness and efficient animal use remains the same. The objective of dose selection is to identify a strategy to achieve consistent system...

journal_title：Birth defects research

authors： Posobiec LM,Laffan SB

更新日期：2020-12-14 00:00:00

abstract：:Evidences indicate that the decline of female fertility is becoming a common problem over the past few decades. Environmental exposure of Bisphenol A (BPA) has been considered as an endocrine-disrupting chemical deleteriously affecting human reproductions. To better understand the effect of BPA exposure on human ovari...

journal_title：Birth defects research

authors： Qi J,Liu L,Yang J,Gao X,Zhang W

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVE:Assess temporal trends in congenital microcephaly. METHODS:We used Texas inpatient discharge diagnoses between 2000 and 2015, restricting to newborns. Between 2000 and 2003, the maximum number of fields for recording diagnostic codes was eight, and between 2004 and 2015 it was 24. Microcephaly was classified...

journal_title：Birth defects research

authors： Waller DK,Tark JY,Agopian AJ,Shewale J,Ganduglia-Cazaban C,Hoyt AT,Scheuerle AE,Langlois PH

更新日期：2019-06-01 00:00:00

abstract：:Cannabis use during adolescence has been linked to deleterious effects on brain integrity. This article summarizes findings from two prospective investigations (3 and 6 years, on average) on adolescent cannabis use from our laboratory that utilize structural neuroimaging and neurocognitive assessment approaches. Acros...

journal_title：Birth defects research

authors： Jacobus J,Courtney KE,Hodgdon EA,Baca R

更新日期：2019-10-15 00:00:00

abstract：:Small animal models, particularly mouse models, of human diseases are becoming an indispensable tool for biomedical research. Studies in animal models have provided important insights into the etiology of diseases and accelerated the development of therapeutic strategies. Detailed phenotypic characterization is essent...

journal_title：Birth defects research

authors： Wu YL,Lo CW

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Most states have now passed legislation mandating pulse oximetry for all newborns, or have promulgated regulations or guidelines to encourage use of routine pulse oximetry. State-based birth defects registries may be well positioned to track and evaluate critical congenital heart disease (CCHD) screening cov...

journal_title：Birth defects research

authors： Case AP,Miller SD,McClain MR

更新日期：2017-11-01 00:00:00

abstract：:In 2016, Centers for Disease Control and Prevention (CDC) established surveillance of pregnant women with Zika virus infection and their infants in the U.S. states, territories, and freely associated states. To identify cases of Zika-associated birth defects, subject matter experts review data reported from medical re...

journal_title：Birth defects research

authors： Lusk R,Zimmerman J,VanMaldeghem K,Kim S,Roth NM,Lavinder J,Fulton A,Raycraft M,Ellington SR,Galang RR

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Hypospadias is a common birth defect that might be caused by inadequate fusion of the urethral folds in the process of male external genital development. We intended to discover the crucial long noncoding RNAs (lncRNAs) regulating autophagy from the gene expression profile of the genital tubercle (GT) of dib...

journal_title：Birth defects research

authors： Feng X,Huang E,Gao Y,Zhang Y,Zhou Y

更新日期：2021-01-15 00:00:00

abstract：BACKGROUND:Despite the numerous reports on the limb body wall complex (LBWC), this association has never been adequately defined. Amniotic bands (AB) are frequently present but their role remains unclear. Since most reports were based on clinical and often subjective diagnoses, the aim of this work was to define LBWC a...

journal_title：Birth defects research

authors： Rittler M,Campaña H,Poletta FA,Santos MR,Gili JA,Pawluk MS,Cosentino VR,Gimenez L,Lopez-Camelo JS

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:The different mechanisms leading to a solitary kidney should be differentiated because the long-term outcome might be different. The fetal period is the best moment to make a true diagnosis of congenital unilateral renal agenesis (URA). The objective was to determine the prevalence of URA at birth. The secon...

journal_title：Birth defects research

authors： Laurichesse Delmas H,Kohler M,Doray B,Lémery D,Francannet C,Quistrebert J,Marie C,Perthus I

更新日期：2017-09-01 00:00:00

abstract：:Over 50% of patients with 22q11.2 deletion syndrome (DS) have a conotruncal or related cardiac defect (CTRD). We hypothesized that similar genetic variants, developmental pathways and biological functions, contribute to disease risk for CTRD in patients without a 22q11.2 deletion (ND-CTRD) and with a 22q11.2 deletion ...

journal_title：Birth defects research

authors： Xie HM,Taylor DM,Zhang Z,McDonald-McGinn DM,Zackai EH,Stambolian D,Hakonarson H,Morrow BE,Emanuel BS,Goldmuntz E

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:With the increasing birth prevalence of hypospadias, there is growing concern for pollutant exposure interfering with normal penile development. We assess the association between hypospadias and hormonally active hazardous air pollutants (HAHAPs) through a nationwide database of hazardous air pollutants and ...

journal_title：Birth defects research

authors： Sheth KR,Kovar E,White JT,Chambers TM,Peckham-Gregory EC,O'Neill M,Langlois PH,Seth A,Scheurer ME,Lupo PJ,Jorgez CJ

更新日期：2019-04-15 00:00:00

abstract：BACKGROUND:Many therapies to treat cancer are gonadotoxic and can lead to infertility. New strategies to diminish the side effects and protective plans during and after chemotherapy are needed. Therefore, bone marrow mesenchymal stem cells (BM-MSCs) as a novel solution were investigated against doxorubicin (Dox)-induce...

journal_title：Birth defects research

authors： Abdelaziz MH,Salah El-Din EY,El-Dakdoky MH,Ahmed TA

更新日期：2019-08-01 00:00:00

abstract：:Cytomegalovirus (CMV) is a DNA herpesvirus that is common worldwide. The two known main sources of primary CMV infection during pregnancy are through sexual activity and contact with young children. Primary infection occurs in approximately 1 to 4% of pregnancies, and is mostly asymptomatic in immunocompetent adults. ...

journal_title：Birth defects research

authors： Davis NL,King CC,Kourtis AP

更新日期：2017-03-15 00:00:00

abstract：BACKGROUND:Cardiac fibrosis is a cardinal feature of multiple types of cardiovascular disease, which lead to heart failure. Multiple studies connect adverse maternal environment (AME) with cardiac fibrosis. AME does not always result in fibrosis, though. An additional "insult", such as an adult Western diet (WD), is fr...

journal_title：Birth defects research

authors： Spearman AD,Ke X,Fu Q,Lane RH,Majnik A

更新日期：2018-12-01 00:00:00

abstract：:OEIS is the acronym of a malformations complex association including omphalocele, exstrophy of bladder or cloaca, imperforate anus, and spinal defects. It has a very low prevalence, ranging from 1/82,000 to 1/200,000 live births (LB). The etiology of OEIS is unknown. Virtually all cases are sporadic, and specific asso...

journal_title：Birth defects research

authors： Arteaga-Vázquez J,Luna-Muñoz L,Morales-Suárez JJ,Mutchinick OM

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:The acronym VATER/VACTERL refers to the rare nonrandom association of the following component features (CF): vertebral defects (V), anorectal malformations (A), cardiac defects (C), tracheoesophageal fistula with or without esophageal atresia, renal malformations (R), and limb defects (L). Patients presentin...

journal_title：Birth defects research

authors： Zhang R,Marsch F,Kause F,Degenhardt F,Schmiedeke E,Märzheuser S,Hoppe B,Bachour H,Boemers TM,Schäfer M,Spychalski N,Neser J,Leonhardt J,Kosch F,Ure B,Gómez B,Lacher M,Deffaa OJ,Palta M,Wittekindt B,Kleine K,Schm

更新日期：2017-07-17 00:00:00

abstract：:The World Health Organization currently recommends quinine+clindamycin for use against malaria in the first trimester. This may soon change to recommending artemisinin-based combination therapies (standard duration of dosing = 3 days). The non-artemisinin partner drugs include amodiaquine, lumefantrine, mefloquine, pi...

journal_title：Birth defects research

authors： Clark RL

更新日期：2017-08-15 00:00:00

abstract：BACKGROUND:The diagnosis of fetal alcohol syndrome (FAS) rests on identification of characteristic facial, growth, and central nervous system (CNS) features. Public health surveillance of FAS depends on documentation of these characteristics. We evaluated if reporting of FAS characteristics is associated with the type ...

journal_title：Birth defects research

authors： Andrews JG,Galindo MK,Meaney FJ,Benavides A,Mayate L,Fox D,Pettygrove S,O'Leary L,Cunniff C

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:During the Zika virus (ZIKV) outbreak, an urgent need existed for strong partnerships to disseminate Zika-related information to pregnant women and women of child-bearing age. METHODS:The Centers for Disease Control and Prevention (CDC) partnered with MotherToBaby, a national organization experienced in pro...

journal_title：Birth defects research

authors： Harris-Sagaribay L,Chambers CD,Perrotta K,Polen KD,Honein MA,Wasternack E

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:A cardinal feature of prenatal ethanol exposure is CNS damage, resulting in a continuum of neurological and behavioral impairments that are described by the term fetal alcohol spectrum disorders (FASD). FASDs are variable and depend on several factors, including the amount, timing, and duration of prenatal e...

journal_title：Birth defects research

authors： Buckley DM,Sidik A,Kar RD,Eberhart JK

更新日期：2019-07-15 00:00:00

abstract：:Birth defects are the leading cause of infant death in the United States and among the top causes of pediatric death and hospitalization. Despite the devastating impact of birth defects, we understand little of their etiology impeding progress towards treatment and prevention. Moreover, while surgical interventions ha...

journal_title：Birth defects research

authors： Khokha MK,Mitchell LE,Wallingford JB

更新日期：2017-01-30 00:00:00

abstract：BACKGROUND:To objectively describe craniofacial, visual, and neurological features associated with amniotic band syndrome (ABS) and discuss likely associated multifactorial etiology. METHODS:A retrospective review of patients identified with ABS and concomitant limb involvement and craniofacial features was conducted....

journal_title：Birth defects research

authors： Lies S,Beckwith T,Mills J,Butler L,Ezaki M,Oishi S

更新日期：2019-11-15 00:00:00

abstract：:The aerodigestive and communicative behaviors of anencephalic and hydranencephalic patients are assessed from literature sources and are compared with documented neural structures present in the brainstem, subcortical, and cortical regions of the brain. Much of the data analyzed corroborate previous neurological studi...

journal_title：Birth defects research

authors： Radford K,Taylor RC,Hall JG,Gick B

更新日期：2019-01-15 00:00:00

abstract：:The AV7909 vaccine, consists of the Anthrax Vaccine Adsorbed (AVA) bulk drug substance and the immunostimulatory Toll-like receptor 9 agonist oligodeoxynucleotide adjuvant CPG 7909. The purpose of this research was to evaluate the potential maternal, reproductive, and developmental toxicity of AV7909 in rats to suppor...

journal_title：Birth defects research

authors： Mylchreest E,Smiley MA,Ballin JD,Blauth B,Shearer J,Reece J,Ionin B,Savransky V

更新日期：2021-01-01 00:00:00

abstract：:Maternal-neonate separation for human newborns has been the standard of care since the last century; low birth weight and preterm infants are still routinely separated from their mothers. With advanced technology, survival is good, but long-term developmental outcomes are very poor for these especially vulnerable newb...

journal_title：Birth defects research

authors： Bergman NJ

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Neural tube defects (NTDs) are severe congenital malformations. Folate supplementation can reduce the risk, but cannot prevent all NTDs, suggesting other reasons for folate-resistant NTDs. The present study assesses placental fatty acid composition, eicosanoids, and cytokines as risk factors for NTDs in a Ch...

journal_title：Birth defects research

authors： Li K,Zhang X,Pei L,Chen G,Liu J,Wahlqvist ML,Zheng X,Li D

更新日期：2017-05-01 00:00:00