Adenosine: Direct and Indirect Actions on Gastric Acid Secretion.

Abstract:

:Composed by a molecule of adenine and a molecule of ribose, adenosine is a paradigm of recyclable nucleoside with a multiplicity of functions that occupies a privileged position in the metabolic and regulatory contexts. Adenosine is formed continuously in intracellular and extracellular locations of all tissues. Extracellular adenosine is a signaling molecule, able to modulate a vast range of physiologic responses in many cells and organs, including digestive organs. The adenosine A1, A2A, A2B, and A3 receptors are P1 purinergic receptors, G protein-coupled proteins implicated in tissue protection. This review is focused on gastric acid secretion, a process centered on the parietal cell of the stomach, which contains large amounts of H+/K+-ATPase, the proton pump responsible for proton extrusion during acid secretion. Gastric acid secretion is regulated by an extensive collection of neural stimuli and endocrine and paracrine agents, which act either directly at membrane receptors of the parietal cell or indirectly through other regulatory cells of the gastric mucosa, as well as mechanic and chemic stimuli. In this review, after briefly introducing these points, we condense the current body of knowledge about the modulating action of adenosine on the pathophysiology of gastric acid secretion and update its significance based on recent findings in gastric mucosa and parietal cells in humans and animal models.

journal_name

Front Physiol

journal_title

Frontiers in physiology

authors

Arin RM,Gorostidi A,Navarro-Imaz H,Rueda Y,Fresnedo O,Ochoa B

doi

10.3389/fphys.2017.00737

subject

Has Abstract

pub_date

2017-09-22 00:00:00

pages

737

issn

1664-042X

journal_volume

8

pub_type

杂志文章,评审
  • The Comparison of Different Stretching Intensities on the Range of Motion and Muscle Stiffness of the Quadriceps Muscles.

    abstract::Muscle strain is one of the most frequent sports injuries, having the rectus femoris (RF) muscle as the reported preferred site of quadriceps muscle strain. The decrease muscle stiffness could be an effective RF muscle strain prevention. In recent studies, a high-intensity static stretching intervention decreased pass...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2020.628870

    authors: Nakamura M,Sato S,Murakami Y,Kiyono R,Yahata K,Sanuki F,Yoshida R,Fukaya T,Takeuchi K

    更新日期:2021-01-13 00:00:00

  • Trawling bats exploit an echo-acoustic ground effect.

    abstract::A water surface acts not only as an optic mirror but also as an acoustic mirror. Echolocation calls emitted by bats at low heights above water are reflected away from the bat, and hence the background clutter is reduced. Moreover, targets on the surface create an enhanced echo. Here, we formally quantified the effect ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2013.00065

    authors: Zsebok S,Kroll F,Heinrich M,Genzel D,Siemers BM,Wiegrebe L

    更新日期:2013-04-05 00:00:00

  • Modifications of myofilament protein phosphorylation and function in response to cardiac arrest induced in a swine model.

    abstract::Cardiac arrest is a prevalent condition with a poor prognosis, attributable in part to persistent myocardial dysfunction following resuscitation. The molecular basis of this dysfunction remains unclear. We induced cardiac arrest in a porcine model of acute sudden death and assessed the impact of ischemia and reperfusi...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2015.00199

    authors: Woodward M,Previs MJ,Mader TJ,Debold EP

    更新日期:2015-07-16 00:00:00

  • Vascular Integrity and Signaling Determining Brain Development, Network Excitability, and Epileptogenesis.

    abstract::Our understanding of the etiological mechanisms leading up to epilepsy has undergone radical changes over time due to more insights into the complexity of the disease. The traditional hypothesis emphasized network hyperexcitability and an imbalance of inhibition and excitation, eventually leading to seizures. In this ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2019.01583

    authors: Baruah J,Vasudevan A,Köhling R

    更新日期:2020-01-22 00:00:00

  • The Spectrum of Scarring in Craniofacial Wound Repair.

    abstract::Fibrosis is intimately linked to wound healing and is one of the largest causes of wound-related morbidity. While scar formation is the normal and inevitable outcome of adult mammalian cutaneous wound healing, scarring varies widely between different anatomical sites. The spectrum of craniofacial wound healing spans a...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2019.00322

    authors: desJardins-Park HE,Mascharak S,Chinta MS,Wan DC,Longaker MT

    更新日期:2019-03-29 00:00:00

  • Effects of Remote Ischemic Preconditioning in Patients Undergoing Off-Pump Coronary Artery Bypass Graft Surgery.

    abstract:Purpose:This study aimed to evaluate effects of remote ischemic preconditioning (RIPC) on myocardial injury in patients undergoing off-pump coronary artery bypass graft surgery (OPCABG). Methods:Sixty-five patients scheduled for the OPCABG were randomly assigned to control (n = 32) or RIPC group (n = 33). All patients...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2019.00495

    authors: Wang H,Lyu Y,Liao Q,Jin L,Xu L,Hu Y,Yu Y,Guo K

    更新日期:2019-04-29 00:00:00

  • Effect of Sublethal Doses of Imidacloprid on the Biological Performance of Aphid Endoparasitoid Aphidius gifuensis (Hymenoptera: Aphidiidae) and Influence on Its Related Gene Expression.

    abstract::The integrated pest management (IPM) strategy was developed and used in combination with pesticides and beneficial biological control agents. To further develop IPM efficiency, it is important to evaluate the side effects of pesticides on biological control agents. Aphidius gifuensis is one of the most important aphid...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2018.01729

    authors: Kang ZW,Liu FH,Pang RP,Tian HG,Liu TX

    更新日期:2018-12-11 00:00:00

  • Physical Activity Level Influences MTHFR Gene Methylation Profile in Diabetic Patients.

    abstract:Introduction:MTHFR methylation status is associated with microvascular complications in diabetes, but the factors influencing this profile remain unknown. Objective:The aim of this study was to evaluate the influence of physical activity level and nutritional status on the methylation profile of the MTHFR gene in pati...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2020.618672

    authors: Diniz TG,Silva AS,Dos Santos Nunes MK,Ribeiro MD,Filho JM,do Nascimento RAF,Gomes CNAP,Evangelista IWQ,de Oliveira NFP,Persuhn DC

    更新日期:2021-01-12 00:00:00

  • Microvascular Dysfunction in Heart Failure With Preserved Ejection Fraction.

    abstract::Heart failure with preserved ejection fraction (HFpEF) is an increasingly studied entity accounting for 50% of all diagnosed heart failure and that has claimed its own dignity being markedly different from heart failure with reduced EF in terms of etiology and natural history (Graziani et al., 2018). Recently, a growi...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2019.01347

    authors: D'Amario D,Migliaro S,Borovac JA,Restivo A,Vergallo R,Galli M,Leone AM,Montone RA,Niccoli G,Aspromonte N,Crea F

    更新日期:2019-11-05 00:00:00

  • Building the Border: Development of the Chordate Neural Plate Border Region and Its Derivatives.

    abstract::The paired cranial sensory organs and peripheral nervous system of vertebrates arise from a thin strip of cells immediately adjacent to the developing neural plate. The neural plate border region comprises progenitors for four key populations of cells: neural plate cells, neural crest cells, the cranial placodes, and ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2020.608880

    authors: Thawani A,Groves AK

    更新日期:2020-12-07 00:00:00

  • Molecular Evidence for the Fitness of Cotton Aphid, Aphis gossypii in Response to Elevated CO2 From the Perspective of Feeding Behavior Analysis.

    abstract::Rising atmospheric carbon dioxide (CO2) concentration is likely to influence insect-plant interactions. Aphid, as a typical phloem-feeding herbivorous insect, has shown consistently more positive responses in fitness to elevated CO2 concentrations than those seen in leaf-chewing insects. But, little is known about the...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2018.01444

    authors: Jiang S,Dai Y,Lu Y,Fan S,Liu Y,Bodlah MA,Parajulee MN,Chen F

    更新日期:2018-11-12 00:00:00

  • Brain dysfunction as one cause of CFS symptoms including difficulty with attention and concentration.

    abstract::We have been able to reduce substantially patient pool heterogeneity by identifying phenotypic markers that allow the researcher to stratify chronic fatigue syndrome (CFS) patients into subgroups. To date, we have shown that stratifying based on the presence or absence of comorbid psychiatric diagnosis leads to a grou...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2013.00109

    authors: Natelson BH

    更新日期:2013-05-20 00:00:00

  • KCNE Regulation of K(+) Channel Trafficking - a Sisyphean Task?

    abstract::Voltage-gated potassium (Kv) channels shape the action potentials of excitable cells and regulate membrane potential and ion homeostasis in excitable and non-excitable cells. With 40 known members in the human genome and a variety of homomeric and heteromeric pore-forming α subunit interactions, post-translational mod...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2012.00231

    authors: Kanda VA,Abbott GW

    更新日期:2012-06-28 00:00:00

  • Tailoring Mathematical Models to Stem-Cell Derived Cardiomyocyte Lines Can Improve Predictions of Drug-Induced Changes to Their Electrophysiology.

    abstract::Human induced pluripotent stem cell derived cardiomyocytes (iPSC-CMs) have applications in disease modeling, cell therapy, drug screening and personalized medicine. Computational models can be used to interpret experimental findings in iPSC-CMs, provide mechanistic insights, and translate these findings to adult cardi...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2017.00986

    authors: Lei CL,Wang K,Clerx M,Johnstone RH,Hortigon-Vinagre MP,Zamora V,Allan A,Smith GL,Gavaghan DJ,Mirams GR,Polonchuk L

    更新日期:2017-12-12 00:00:00

  • Xinnao Shutong Modulates the Neuronal Plasticity Through Regulation of Microglia/Macrophage Polarization Following Chronic Cerebral Hypoperfusion in Rats.

    abstract::Xinnao shutong (XNST) capsules have been clinically used in China to treat cerebrovascular diseases. Previous studies have demonstrated that XNST has significant neuroprotective effects against acute cerebral ischemic stroke. The present study investigated the effects and mechanisms of XNST treatment following chronic...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2018.00529

    authors: Wang L,Wang R,Chen Z,Zhao H,Luo Y

    更新日期:2018-05-15 00:00:00

  • The Probable, Possible, and Novel Functions of ERp29.

    abstract::The luminal endoplasmic reticulum (ER) protein of 29 kDa (ERp29) is a ubiquitously expressed cellular agent with multiple critical roles. ERp29 regulates the biosynthesis and trafficking of several transmembrane and secretory proteins, including the cystic fibrosis transmembrane conductance regulator (CFTR), the epith...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2020.574339

    authors: Brecker M,Khakhina S,Schubert TJ,Thompson Z,Rubenstein RC

    更新日期:2020-09-08 00:00:00

  • Generation of Human CRY1 and CRY2 Knockout Cells Using Duplex CRISPR/Cas9 Technology.

    abstract::Circadian clocks are endogenous oscillators essential for orchestrating daily rhythms in physiology, metabolism and behavior. While mouse models have been instrumental to elucidate the molecular mechanism of circadian rhythm generation, our knowledge about the molecular makeup of circadian oscillators in humans is sti...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2019.00577

    authors: Börding T,Abdo AN,Maier B,Gabriel C,Kramer A

    更新日期:2019-05-09 00:00:00

  • Model-Supported Radiotherapy Personalization: In silico Test of Hyper- and Hypo-Fractionation Effects.

    abstract::The need for radiotherapy personalization is now widely recognized, however, it would require considerations not only on the probability of control and survival of the tumor, but also on the possible toxic effects, on the quality of the expected life and the economic efficiency of the treatment. In this paper, we prop...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2018.01445

    authors: Belfatto A,Jereczek-Fossa BA,Baroni G,Cerveri P

    更新日期:2018-10-15 00:00:00

  • Role of NADPH Oxidase-4 in Human Endothelial Progenitor Cells.

    abstract::Introduction: Endothelial progenitor cells (EPCs) display a unique ability to promote angiogenesis and restore endothelial function in injured blood vessels. NADPH oxidase 4 (NOX4)-derived hydrogen peroxide (H2O2) serves as a signaling molecule and promotes endothelial cell proliferation and migration as well as prote...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2017.00150

    authors: Hakami NY,Ranjan AK,Hardikar AA,Dusting GJ,Peshavariya HM

    更新日期:2017-03-23 00:00:00

  • First description of phosphofructokinase deficiency in spain: identification of a novel homozygous missense mutation in the PFKM gene.

    abstract::Phosphofructokinase deficiency is a very rare autosomal recessive disorder, which belongs to group of rare inborn errors of metabolism called glycogen storage disease. Here we report on a new mutation in the phosphofructokinase (PFK) gene PFKM identified in a 65-years-old woman who suffered from lifelong intermittent ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2013.00393

    authors: Vives-Corrons JL,Koralkova P,Grau JM,Mañú Pereira Mdel M,Van Wijk R

    更新日期:2013-12-30 00:00:00

  • Effect of Low Versus High Tidal-Volume Total Liquid Ventilation on Pulmonary Inflammation.

    abstract::Animal experiments suggest that total liquid ventilation (TLV) induces less ventilator-induced lung injury (VILI) than conventional mechanical gas ventilation. However, TLV parameters that optimally minimize VILI in newborns remain unknown. Our objective was to compare lung inflammation between low (L-VT) and high (H-...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2020.00603

    authors: Sage M,See W,Nault S,Morin C,Michalski C,Chabot B,Marouan S,Lavoie PM,Micheau P,Praud JP,Fortin-Pellerin É

    更新日期:2020-06-18 00:00:00

  • Skeletal Muscles Do Not Undergo Apoptosis During Either Atrophy or Programmed Cell Death-Revisiting the Myonuclear Domain Hypothesis.

    abstract::Skeletal muscles are the largest cells in the body and are one of the few syncytial ones. There is a longstanding belief that a given nucleus controls a defined volume of cytoplasm, so when a muscle grows (hypertrophy) or shrinks (atrophy), the number of myonuclei change accordingly. This phenomenon is known as the "m...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2018.01887

    authors: Schwartz LM

    更新日期:2019-01-25 00:00:00

  • Role of Toll-Like Receptor 4 on Osteoblast Metabolism and Function.

    abstract::Inflammation is a process whose main function is to fight against invading pathogens or foreign agents. Nonetheless, it is widely accepted that inflammation takes part in multiple processes in a physiological or pathophysiological context. Among these processes the inflammation has been closely related to bone metabol...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2018.00504

    authors: Alonso-Pérez A,Franco-Trepat E,Guillán-Fresco M,Jorge-Mora A,López V,Pino J,Gualillo O,Gómez R

    更新日期:2018-05-08 00:00:00

  • Nanotherapeutics for Treatment of Pulmonary Arterial Hypertension.

    abstract::Pulmonary arterial hypertension (PAH) is a devastating and fatal chronic lung disease. While current pharmacotherapies have improved patient quality of life, PAH drugs suffer from limitations in the form of short-term pharmacokinetics, instability, and poor organ specificity. Traditionally, nanotechnology-based delive...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2018.00890

    authors: Segura-Ibarra V,Wu S,Hassan N,Moran-Guerrero JA,Ferrari M,Guha A,Karmouty-Quintana H,Blanco E

    更新日期:2018-07-13 00:00:00

  • Immediate/Early vs. Delayed Invasive Strategy for Patients with Non-ST-Segment Elevation Acute Coronary Syndromes: A Systematic Review and Meta-Analysis.

    abstract::Invasive coronary revascularization has been shown to improve prognoses in patients with non-ST-segment elevation acute coronary syndromes (NSTE-ACS), but the optimal timing of intervention remains unclear. This meta-analysis is to evaluate the outcomes in immediate (<2 h), early (<24 h), and delayed invasive group an...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章,评审

    doi:10.3389/fphys.2017.00952

    authors: Li Y,Zhang Z,Xiong X,Cho WC,Hu D,Gao Y,Shang H,Xing Y

    更新日期:2017-11-27 00:00:00

  • Relationship Between Distance Run Per Week, Omega-3 Index, and Arachidonic Acid (AA)/Eicosapentaenoic Acid (EPA) Ratio: An Observational Retrospective Study in Non-elite Runners.

    abstract::Background: Tissue availability of polyunsaturated fatty acids (PUFA) depends on several factors, including dietary intake, physical exercise, genetic variation, and metabolic turnover. However, there is limited evidence whether running training activity per se may influence indices associated with PUFA metabolism suc...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2019.00487

    authors: Davinelli S,Corbi G,Righetti S,Casiraghi E,Chiappero F,Martegani S,Pina R,De Vivo I,Simopoulos AP,Scapagnini G

    更新日期:2019-04-26 00:00:00

  • Nedd4-2 and the regulation of epithelial sodium transport.

    abstract::Nedd4-2 is a ubiquitin ligase previously demonstrated to regulate endocytosis and lysosomal degradation of the epithelial Na(+) channel (ENaC) and other ion channels and transporters. Recent studies using Nedd4-2 knockout mice specifically in kidney or lung epithelia has revealed a critical role for this E3 ubiquitin ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2012.00212

    authors: Rotin D,Staub O

    更新日期:2012-06-21 00:00:00

  • The MEK-Inhibitor Selumetinib Attenuates Tumor Growth and Reduces IL-6 Expression but Does Not Protect against Muscle Wasting in Lewis Lung Cancer Cachexia.

    abstract::Cachexia, or wasting of skeletal muscle and fat, afflicts many patients with chronic diseases including cancer, organ failure, and AIDS. Muscle wasting reduces quality of life and decreases response to therapy. Cachexia is caused partly by elevated inflammatory cytokines, including interleukin-6 (IL-6). Others and we ...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2016.00682

    authors: Au ED,Desai AP,Koniaris LG,Zimmers TA

    更新日期:2017-01-18 00:00:00

  • Entropy Production and the Pressure-Volume Curve of the Lung.

    abstract::We investigate analytically the production of entropy during a breathing cycle in healthy and diseased lungs. First, we calculate entropy production in healthy lungs by applying the laws of thermodynamics to the well-known transpulmonary pressure-volume (P-V) curves of the lung under the assumption that lung tissue be...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2016.00073

    authors: Oliveira CL,Araújo AD,Bates JH,Andrade JS Jr,Suki B

    更新日期:2016-03-01 00:00:00

  • Effects of High-Intensity Resistance Training on Fitness and Fatness in Older Men With Osteosarcopenia.

    abstract::To date, there has been no study on the long-term effects of resistance exercise on sarcopenia and obesity indices for people with sarcopenia. The present study thus aimed to determine the effect of 18 months of periodized, high-velocity/intensity/effort progressive resistance training (HIT-RT) on body composition and...

    journal_title:Frontiers in physiology

    pub_type: 杂志文章

    doi:10.3389/fphys.2020.01014

    authors: Kemmler W,Kohl M,Fröhlich M,Engelke K,von Stengel S,Schoene D

    更新日期:2020-08-27 00:00:00