Morin Inhibits Proliferation of SW480 Colorectal Cancer Cells by Inducing Apoptosis Mediated by Reactive Oxygen Species Formation and Uncoupling of Warburg Effect.

abstract：:In the last years, many clinical studies have revealed that some cisplatin-treated cancer survivors have a significantly increased risk of cardiovascular events, being cisplatin-induced cardiovascular toxicity an increasing concern. The aim of the present work was to evaluate the cardiovascular alterations induced by ...

journal_title：Frontiers in pharmacology

authors： Herradón E,González C,Uranga JA,Abalo R,Martín MI,López-Miranda V

更新日期：2017-05-08 00:00:00

abstract：:Despite major advances, cancer remains one of the largest burdens of disease worldwide. One reason behind this is that killing tumor cells without affecting healthy surrounding tissue remains a largely elusive prospect, despite the widespread availability of cytotoxic chemotherapeutic agents. To meet these modern heal...

journal_title：Frontiers in pharmacology

authors： Marshall ML,Wagstaff KM

更新日期：2020-07-24 00:00:00

abstract：:In glaucoma, studies revealed an involvement of the complement system. In an experimental autoimmune glaucoma model, immunization with an optic nerve homogenate antigen (ONA) led to retinal ganglion cell (RGC) loss, while intraocular pressure (IOP) remained unchanged. Here, we investigated the therapeutic effect of a ...

journal_title：Frontiers in pharmacology

authors： Reinehr S,Gomes SC,Gassel CJ,Asaad MA,Stute G,Schargus M,Dick HB,Joachim SC

更新日期：2019-12-02 00:00:00

abstract：:15-F2t-Isoprostane, a reliable biomarker of oxidative stress, has been found elevated in exhaled breath condensate (EBC), a non-invasive technique for sampling of airway secretions, in patients with cystic fibrosis (CF). Azithromycin has antioxidant properties in experimental models of CF, but its effects on oxidative...

journal_title：Frontiers in pharmacology

authors： Montuschi P,Lucidi V,Paris D,Montemitro E,Shohreh R,Mores N,Melck D,Santini G,Majo F,Motta A

更新日期：2018-06-18 00:00:00

abstract：:In Mexico, the Adenophyllum aurantium (L.) Strother plant is consumed as an infusion to treat intestinal diseases such as amoebiasis, which is an endemic health problem in Mexico and other countries. However, the effect of A. aurantium on Entamoeba histolytica, the causative agent of amoebiasis, is unknown. An aerial ...

journal_title：Frontiers in pharmacology

authors： Herrera-Martínez M,Hernández-Ramírez VI,Hernández-Carlos B,Chávez-Munguía B,Calderón-Oropeza MA,Talamás-Rohana P

更新日期：2016-06-27 00:00:00

abstract：:We report on a patient who developed acute liver failure while being treated with metamizole. After liver transplantation, the patient recovered rapidly. Liver biopsy showed massive necrosis and lobular infiltration of lymphocytes. A lymphocyte transformation test performed 20 months after transplantation was positive...

journal_title：Frontiers in pharmacology

authors： Krisai P,Rudin D,Grünig D,Scherer K,Pichler W,Terracciano L,Krähenbühl S

更新日期：2019-09-11 00:00:00

abstract：:Uterine leiomyomas are the most common benign neoplasms in women of reproductive age. However, non-surgical treatments for uterine myomas have not been fully evaluated. In Korea and China, Gyejibongnyeong-hwan (GBH) is widely used to treat gynecological diseases. Thus, we investigated the effects of GBH in human uteri...

journal_title：Frontiers in pharmacology

authors： Lee SM,Choi ES,Ha E,Ji KY,Shin SJ,Jung J

更新日期：2019-09-25 00:00:00

abstract：:Objective: To investigate the effects of Suo Quan Wan (SQW), a traditional Chinese herbal formula, on the overactive bladder (OAB) of type 2 diabetes mellitus (T2DM) mouse models, particularly on its function of mediating the gene and protein expression levels of myosin Va and SLC17A9. Materials and Methods: After 4 w...

journal_title：Frontiers in pharmacology

authors： Wang J,Lian DW,Yang XF,Xu YF,Chen FJ,Lin WJ,Wang R,Tang LY,Ren WK,Fu LJ,Huang P,Cao HY

更新日期：2019-05-24 00:00:00

abstract：:Calcium ions (Ca2+) play a major role in the cardiac excitation-contraction coupling. Intracellular Ca2+ concentration increases during systole and falls in diastole thereby determining cardiac contraction and relaxation. Normal cardiac function also requires perfect organization of the ion currents at the cellular le...

journal_title：Frontiers in pharmacology

authors： Kistamás K,Veress R,Horváth B,Bányász T,Nánási PP,Eisner DA

更新日期：2020-02-25 00:00:00

abstract：:Dolutegravir (DTG) is a second-generation integrase strand transfer inhibitor (INSTI) and INSTIs are the latest class of potent anti-HIV drugs. Compared to the first generation INSTIs, raltegravir, and elvitegravir, DTG shows a limited cross-resistance profile. More interestingly, clinical resistance mutations to DTG ...

journal_title：Frontiers in pharmacology

authors： Wainberg MA,Han YS

更新日期：2015-04-29 00:00:00

abstract：Objective:Huangqin decoction (HQD), a classical traditional Chinese medicinal formula, has been commonly used to treat gastrointestinal diseases for thousands of years. We investigated the anti-inflammatory effects and underlying mechanisms of HQD on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC). Method...

journal_title：Frontiers in pharmacology

authors： Li MY,Luo HJ,Wu X,Liu YH,Gan YX,Xu N,Zhang YM,Zhang SH,Zhou CL,Su ZR,Huang XQ,Zheng XB

更新日期：2020-01-20 00:00:00

abstract：:Dizocilpine (MK-801) is a non-competitive NMDA antagonist that induces schizophreniclike effects. It is therefore widely used in experimental models of schizophrenia including prepulse inhibition (PPI) impairments in rodents. Nevertheless, MK-801 has never been tested in monkeys on a PPI paradigm. In order to evaluate...

journal_title：Frontiers in pharmacology

authors： Saletti PG,Maior RS,Hori E,Nishijo H,Tomaz C

更新日期：2015-09-22 00:00:00

abstract：:This research evaluated the effects of triterpenes on the regulation of STZ-induced hyperglycaemic diabetes through an anti-inflammatory response. Diabetic mice were orally administered various concentrations of triterpenes on a daily basis. Weight gain, volume of drinking water, and liver and spleen weight were recor...

journal_title：Frontiers in pharmacology

authors： Wu YS,Chen SN

更新日期：2016-06-13 00:00:00

abstract：:Flavonoids are the largest class of plant polyphenols, with common structure of diphenylpropanes, consisting of two aromatic rings linked through three carbons and are abundant in both daily diets and medicinal plants. Fueled by the recognition of consuming flavonoids to get better health, researchers became intereste...

journal_title：Frontiers in pharmacology

authors： Qiu T,Wu D,Yang L,Ye H,Wang Q,Cao Z,Tang K

更新日期：2018-08-15 00:00:00

abstract：:Cardiovascular diseases (CVDs) are the major public health problem and a leading cause of morbidity and mortality on a global basis. Wenxin Keli (WXKL), a formally classical Chinese patent medicine with obvious efficacy and favorable safety, plays a great role in the management of patients with CVDs. Accumulating evid...

journal_title：Frontiers in pharmacology

authors： Tian G,Sun Y,Liu S,Li C,Chen S,Qiu R,Zhang X,Li Y,Li M,Shang H

更新日期：2018-09-05 00:00:00

abstract：:Although endothelin (ET)-1 is a highly potent vasoconstrictor with considerable efficacy in numerous vascular beds, the role of endogenous ET-1 in the regulation of vascular tone remains unclear. The perspective that ET-1 plays little role in the on-going regulation of vascular tone at least under physiologic conditio...

journal_title：Frontiers in pharmacology

authors： Rapoport RM,Merkus D

更新日期：2017-10-24 00:00:00

abstract：:Most breast and prostate tumors are hormone-dependent, making it possible to use hormone therapy in patients with these tumors. The design of effective endocrine drugs that block the growth of tumors and have no severe side effects is a challenge. Thereupon, synthetic steroids are promising therapeutic drugs for the t...

journal_title：Frontiers in pharmacology

authors： Scherbakov AM,Komkov AV,Komendantova AS,Yastrebova MA,Andreeva OE,Shirinian VZ,Hajra A,Zavarzin IV,Volkova YA

更新日期：2018-01-10 00:00:00

abstract：:Particulate matter poses health risk to developing organisms. To investigate particulate matters with a diameter smaller than 2.5 um (PM2.5)-induced developmental cardiotoxicity, fertile chicken eggs were exposed to PM2.5 via air cell injection at doses of 0.05, 0.2, 0.5, 2, and 5 mg/egg kg. Morphological changes in t...

journal_title：Frontiers in pharmacology

authors： Jiang Q,Zhang C,Chen S,Shi L,Li DC,Lv N,Cui L,Chen Y,Zheng Y

更新日期：2020-06-05 00:00:00

abstract：:Styryllactones, a class of compounds obtained from the genus Goniothalamus (Annonaceae), have demonstrated in vitro antitumor activity. However, the aqueous solubility of these compounds is poor. In this study, we identified the absolute configurations of the previously isolated compounds, which were first isolated in...

journal_title：Frontiers in pharmacology

authors： Ma R,Chen JT,Ji XY,Xu XL,Mu Q

更新日期：2020-04-22 00:00:00

abstract：:Wenxin Keli (WXKL) is a widely used Chinese botanical drug for the treatment of arrhythmia, which is consisted of four herbs and amber. In the present study, we analyzed the chemical composition of WXKL using liquid chromatography coupled with high-resolution mass spectrometry (LC-HRMS) to tentatively identify 71 comp...

journal_title：Frontiers in pharmacology

authors： Liu H,Chen X,Zhao X,Zhao B,Qian K,Shi Y,Baruscotti M,Wang Y

更新日期：2018-11-13 00:00:00

abstract：:Although initially described as an anti-tumor mediator, tumor necrosis factor-alpha (TNF) is generally considered as the master pro-inflammatory cytokine. It plays a crucial role in the pathogenesis of inflammatory diseases, such as rheumatoid arthritis (RA), inflammatory bowel disease, ankylosing spondylitis (AS), an...

journal_title：Frontiers in pharmacology

authors： Li P,Zheng Y,Chen X

更新日期：2017-07-12 00:00:00

abstract：:The aim of the study was to characterize phytochemicals in an infusion of the aerial parts of tarragon (Artemisia dracunculus L.) using ultra-high-performance liquid chromatography diode array detector electrospray ionisation tandem mass spectrometry UHPLC-DAD-ESI-MS/MS method, as well as an evaluation of its effects ...

journal_title：Frontiers in pharmacology

authors： Majdan M,Kiss AK,Hałasa R,Granica S,Osińska E,Czerwińska ME

更新日期：2020-08-13 00:00:00

abstract：:Effect of peripheral cannabinoid receptor 1 (CB1R) blockade by AM6545 in the monosodium glutamate (MSG)-induced hypometabolic and hypothalamic obesity was observed, and the impact on intraperitoneal adipose tissue and adipokines was investigated. The MSG mice is characterized by excessive abdominal obesity, and combin...

journal_title：Frontiers in pharmacology

authors： Ma H,Zhang G,Mou C,Fu X,Chen Y

更新日期：2018-03-20 00:00:00

abstract：:Retinitis pigmentosa (RP) is an inherited ocular disorder with no effective treatment. RP onset and progression trigger a cascade of retinal disorders that lead to the death of photoreceptors. After photoreceptors death, neuronal, glial and vascular remodeling can be observed in the retina. The purpose of this study w...

journal_title：Frontiers in pharmacology

authors： Gimeno-Hernández R,Cantó A,Fernández-Carbonell A,Olivar T,Hernández-Rabaza V,Almansa I,Miranda M

更新日期：2020-12-23 00:00:00

abstract：:Classically, the endocannabinoid system (ECS) consists of endogenous lipids, of which the best known are anandamide (AEA) and 2 arachidonoylglycerol (2-AG), their enzyme machinery for synthesis and degradation and their specific receptors, cannabinoid receptor one (CB1) and cannabinoid receptor two (CB2). However, end...

journal_title：Frontiers in pharmacology

authors： Riquelme-Sandoval A,de Sá-Ferreira CO,Miyakoshi LM,Hedin-Pereira C

更新日期：2020-12-09 00:00:00

abstract：:The dialysis of human and mouse neutrophils in patch clamp experiments in the conventional whole-cell mode induces the emergence of a chloride (Cl-) current that appeared to be primarily regulated by cytoplasmic ionic strength. The characteristics of this current resembled that of the classical, and ubiquitous volume-...

journal_title：Frontiers in pharmacology

authors： Behe P,Foote JR,Levine AP,Platt CD,Chou J,Benavides F,Geha RS,Segal AW

更新日期：2017-05-12 00:00:00

abstract：:In spite of recent therapeutic advances, multiple myeloma (MM) remains a malignancy with very low curability. This has been partly attributed to the existence of a drug-resistant subpopulation known as cancer stem cells (CSCs). MM-CSCs are equipped with the necessary tools that render them highly resistant to virtuall...

journal_title：Frontiers in pharmacology

authors： Issa ME,Wijeratne EMK,Gunatilaka AAL,Cuendet M

更新日期：2017-09-08 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fphar.2020.00512.]. ...

journal_title：Frontiers in pharmacology

authors： Jiang YH,Jiang LY,Wang YC,Ma DF,Li X

更新日期：2020-05-29 00:00:00

abstract：:Endothelium dysfunction induced by reactive oxygen species (ROS) is an important initial event at the onset of myocardial ischemia/reperfusion in which the Egr-1 transcription factor often serves as a master switch for various damage pathways following reperfusion injury. We hypothesized that an intracellular ROS/MAPK...

journal_title：Frontiers in pharmacology

authors： Lu S,Zhang Y,Zhong S,Gao F,Chen Y,Li W,Zheng F,Shi G

更新日期：2017-01-05 00:00:00

abstract：:Background: New treatment platforms that can prevent acute respiratory distress syndrome (ARDS) or reduce its mortality rate in high-risk coronavirus disease 2019 (COVID-19) patients, such as those with an underlying cancer, are urgently needed. Rejuveinix (RJX) is an intravenous formulation of anti-oxidants and anti-...

journal_title：Frontiers in pharmacology

authors： Uckun FM,Carlson J,Orhan C,Powell J,Pizzimenti NM,van Wyk H,Ozercan IH,Volk M,Sahin K

更新日期：2020-11-10 00:00:00