Degradable Hollow Mesoporous Silicon/Carbon Nanoparticles for Photoacoustic Imaging-Guided Highly Effective Chemo-Thermal Tumor Therapy in Vitro and in Vivo.

abstract：:Identification of novel targets for triple-negative breast cancer (TNBC) is an urgent task as targeted therapies have increased the lifespans of Oestrogen Receptor +/ Progesterone Receptor + and HER2+ cancer patients. Methods: genes involved in protein processing in the endoplasmic reticulum, which have been reported ...

journal_title：Theranostics

authors： Fu W,Sun H,Zhao Y,Chen M,Yang X,Liu Y,Jin W

更新日期：2019-08-21 00:00:00

abstract：:Luminal androgen receptor (LAR) breast cancer accounts for 10% of all triple-negative breast cancers (TNBC). Anti-androgen therapy for this subtype is in development, but yields only partial clinical benefits. In this study, we aimed to characterize the genomic alterations of LAR TNBC, to analyze activation of the PI3...

journal_title：Theranostics

authors： Coussy F,Lavigne M,de Koning L,Botty RE,Nemati F,Naguez A,Bataillon G,Ouine B,Dahmani A,Montaudon E,Painsec P,Chateau-Joubert S,Laetitia F,Larcher T,Vacher S,Chemlali W,Briaux A,Melaabi S,Salomon AV,Guinebretiere JM

更新日期：2020-01-01 00:00:00

abstract：:Background: The dense fibrotic stroma enveloping pancreatic tumors is a major cause of drug resistance. Pancreatic stellate cells (PSCs) in the stroma can be activated to induce intra-tumor fibrosis and worsen patient survival; however, the molecular basics for the regulation of PSC activation remains unclear. Methods...

journal_title：Theranostics

authors： Wang HC,Lin YL,Hsu CC,Chao YJ,Hou YC,Chiu TJ,Huang PH,Tang MJ,Chen LT,Shan YS

更新日期：2019-09-23 00:00:00

abstract：:Natural polysaccharides have received a lot of attention in the biomedical field. Indeed, sources of polysaccharides, extracted or produced from plants, bacteria, fungi or algae, are diverse and renewable. Moreover, recent progresses in polysaccharide chemistry and nanotechnologies allow elaborating new dedicated nano...

journal_title：Theranostics

authors： Silva AK,Letourneur D,Chauvierre C

更新日期：2014-03-11 00:00:00

abstract：:Non-invasive PET imaging of CXCR4 expression in cancer and inflammation as well as CXCR4-targeted radioligand therapy (RLT) have recently found their way into clinical research by the development of the theranostic agents [68Ga]PentixaFor (cyclo(D-Tyr1-D-[NMe]Orn2(AMBS-[68Ga]DOTA)-Arg3-Nal4-Gly5) = [68Ga]DOTA-AMBS-CPC...

journal_title：Theranostics

authors： Osl T,Schmidt A,Schwaiger M,Schottelius M,Wester HJ

更新日期：2020-07-09 00:00:00

abstract：:Background: Lung cancer has a high mortality rate and is resistant to multiple chemotherapeutics. Natural Borneol (NB) is a monoterpenoid compound that facilitates the bioavailability of drugs. In this study, we investigated the effects of NB on chemosensitivity in the A549 human lung adenocarcinoma cell line and to e...

journal_title：Theranostics

authors： Lai H,Liu C,Hou L,Lin W,Chen T,Hong A

更新日期：2020-08-13 00:00:00

abstract：:Successful anticancer chemotherapy requires targeting tumors efficiently and further potential to eliminate cancer stem cell (CSC) subpopulations. Since CD44 is present on many types of CSCs, and it binds specially to hyaluronic acid (HA), we tested whether coating solid lipid nanoparticles with hyaluronan (HA-SLNs)wo...

journal_title：Theranostics

authors： Shen H,Shi S,Zhang Z,Gong T,Sun X

更新日期：2015-04-05 00:00:00

abstract：PURPOSE:The ability to longitudinally monitor cell grafts and assess their condition is critical for the clinical translation of stem cell therapy in regenerative medicine. Developing an inducible genetic magnetic resonance imaging (MRI) reporter will enable non-invasive and longitudinal monitoring of stem cell grafts ...

journal_title：Theranostics

authors： Cho IK,Moran SP,Paudyal R,Piotrowska-Nitsche K,Cheng PH,Zhang X,Mao H,Chan AW

更新日期：2014-07-27 00:00:00

abstract：:Rationale: Tumor microenvironment interacts with tumor cells to regulate their stemness properties through various cytokines and cytokine receptors. Previous studies revealed the possible role of interleukin 20 receptor subunit alpha (IL20RA) signaling in the progression of several types of tumors. However, its regula...

journal_title：Theranostics

authors： Gao W,Wen H,Liang L,Dong X,Du R,Zhou W,Zhang X,Zhang C,Xiang R,Li N

更新日期：2021-01-01 00:00:00

abstract：:Liquid biopsy of tumor through isolation of circulating tumor cells (CTCs) allows non-invasive, repetitive, and systemic sampling of disease. Although detecting and enumerating CTCs is of prognostic significance in metastatic cancer, it is conceivable that performing molecular and functional characterization on CTCs w...

journal_title：Theranostics

authors： Chen JF,Zhu Y,Lu YT,Hodara E,Hou S,Agopian VG,Tomlinson JS,Posadas EM,Tseng HR

更新日期：2016-06-15 00:00:00

abstract：:Sodium/iodide symporter (NIS)-mediated iodide uptake in thyroid follicular cells is the basis of clinical utilization of radioiodines. The cloning of the NIS gene enabled applications of NIS as a reporter gene in both preclinical and translational research. Non-invasive NIS imaging with radioactive iodides and iodide ...

journal_title：Theranostics

authors： Jiang H,DeGrado TR

更新日期：2018-06-24 00:00:00

abstract：:Recently, researchers identified a distinct vessel subtype called type H vessels that couple angiogenesis and osteogenesis. We previously found that type H vessels are reduced in ovariectomy (OVX)-induced osteoporotic mice, and preosteoclasts are able to secrete platelet-derived growth factor-BB (PDGF-BB) to stimulate...

journal_title：Theranostics

authors： Huang J,Yin H,Rao SS,Xie PL,Cao X,Rao T,Liu SY,Wang ZX,Cao J,Hu Y,Zhang Y,Luo J,Tan YJ,Liu ZZ,Wu B,Hu XK,Chen TH,Chen CY,Xie H

更新日期：2018-03-28 00:00:00

abstract：:MicroRNAs (miRs) are small non-coding RNAs that negatively regulate gene expression by binding to the 3` untranslated regions (3`UTR) of their target mRNAs. MiRs were shown to play pivotal roles in tissue development and function and are also involved in the pathogenesis of various diseases including cancer. MicroRNA-...

journal_title：Theranostics

authors： Novák J,Kružliak P,Bienertová-Vašků J,Slabý O,Novák M

更新日期：2014-01-02 00:00:00

abstract：:This is the initial report of an α-based pre-targeted radioimmunotherapy (PRIT) using 225Ac and its theranostic pair, 111In. We call our novel tumor-targeting DOTA-hapten PRIT system "proteus-DOTA" or "Pr." Herein we report the first results of radiochemistry development, radiopharmacology, and stoichiometry of tumor ...

journal_title：Theranostics

authors： Cheal SM,McDevitt MR,Santich BH,Patel M,Yang G,Fung EK,Veach DR,Bell M,Ahad A,Vargas DB,Punzalan B,Pillarsetty NVK,Xu H,Guo HF,Monette S,Michel AO,Piersigilli A,Scheinberg DA,Ouerfelli O,Cheung NV,Larson SM

更新日期：2020-09-14 00:00:00

abstract：:To generate a more efficient in vivo reporter and therapeutic gene, we optimized the coding sequence of the human sodium/iodide symporter (NIS) gene by replacing NIS DNA codons from wild type to new codons having the highest usage in human gene translation. The Codon Adaptation Index (CAI), representing the number of ...

journal_title：Theranostics

authors： Kim YH,Youn H,Na J,Hong KJ,Kang KW,Lee DS,Chung JK

更新日期：2015-01-01 00:00:00

abstract：:Purpose: Breast cancer imaging methods lack diagnostic accuracy, in particular for patients with dense breast tissue, and improved techniques are critically needed. The purpose of this study was to evaluate antibody-indocyanine green (ICG) conjugates, which undergo dynamic absorption spectrum shifts after cellular end...

journal_title：Theranostics

authors： Wilson KE,Bachawal SV,Abou-Elkacem L,Jensen K,Machtaler S,Tian L,Willmann JK

更新日期：2017-04-03 00:00:00

abstract：:Background: Patients with advanced soft tissue sarcomas (STS) have a dismal prognosis with few effective therapeutic options. A defect in the homologous recombination repair (HRR) pathway can accumulate DNA repair errors and gene mutations, which can lead to tumorigenesis. BRCAness describes tumors with an HRR deficie...

journal_title：Theranostics

authors： Li H,Tu J,Zhao Z,Chen L,Qu Y,Li H,Yao H,Wang X,Lee DF,Shen J,Wen L,Huang G,Xie X

更新日期：2020-07-25 00:00:00

abstract：:Up to one-third of diffuse large B cell lymphoma (DLBCL) patients eventually develop resistance to R-CHOP regimen, while the remaining therapeutic options are limited. Thus, understanding the underlying mechanisms and developing therapeutic approaches are urgently needed. Methods: We generated two germinal center B ce...

journal_title：Theranostics

authors： Chen J,Ge X,Zhang W,Ding P,Du Y,Wang Q,Li L,Fang L,Sun Y,Zhang P,Zhou Y,Zhang L,Lv X,Li L,Zhang X,Zhang Q,Xue K,Gu H,Lei Q,Wong J,Hu W

更新日期：2020-02-10 00:00:00

abstract：:The most frequent malignancy of the pancreas is the pancreatic ductal adenocarcinoma (PDAC). Despite many efforts PDAC has still a dismal prognosis. Biomarkers for early disease stage diagnosis as a prerequisite for a potentially curative treatment are still missing. Novel blood-based markers may help to overcome this...

journal_title：Theranostics

authors： Berger AW,Schwerdel D,Reinacher-Schick A,Uhl W,Algül H,Friess H,Janssen KP,König A,Ghadimi M,Gallmeier E,Bartsch DK,Geissler M,Staib L,Tannapfel A,Kleger A,Beutel A,Schulte LA,Kornmann M,Ettrich TJ,Seufferlein T

更新日期：2019-02-12 00:00:00

abstract：:Stem cell therapy holds promise for treatment of intractable diseases and injured organs. For clinical translation, it is pivotal to understand the homing, engraftment, and differentiation processes of stem cells in a living body. Here we report near-infrared (NIR) fluorescent semiconductor polymer dots (Pdots) for br...

journal_title：Theranostics

authors： Chen D,Li Q,Meng Z,Guo L,Tang Y,Liu Z,Yin S,Qin W,Yuan Z,Zhang X,Wu C

更新日期：2017-04-10 00:00:00

abstract：:Lateral flow assay (LFA) has become one of the most widely used point-of-care diagnostic methods due to its simplicity and low cost. While easy to use, LFA suffers from its low sensitivity and poor quantification, which largely limits its applications for early disease diagnosis and requires further testing to elimina...

journal_title：Theranostics

authors： Ye H,Liu Y,Zhan L,Liu Y,Qin Z

更新日期：2020-03-15 00:00:00

abstract：:Great progress has been made in the field of tumor immunotherapy in the past decade. However, the therapeutic effects of immune checkpoint blockade (ICB) against ovarian cancer are still limited. Recently, an inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6i) has been reported to enhance antitumor immunity in pre...

journal_title：Theranostics

authors： Zhang QF,Li J,Jiang K,Wang R,Ge JL,Yang H,Liu SJ,Jia LT,Wang L,Chen BL

更新日期：2020-08-25 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) have emerged as integral components of E2F1-regulated gene regulatory networks (GRNs), but their implication in advanced or treatment-refractory malignancy is unknown. Methods: We combined high-throughput transcriptomic approaches with bioinformatics and structure modeling to search for ...

journal_title：Theranostics

authors： Logotheti S,Marquardt S,Gupta SK,Richter C,Edelhäuser BAH,Engelmann D,Brenmoehl J,Söhnchen C,Murr N,Alpers M,Singh KP,Wolkenhauer O,Heckl D,Spitschak A,Pützer BM

更新日期：2020-07-29 00:00:00

abstract：:Aims: Pathological cardiac fibrosis and hypertrophy are common features of left ventricular remodeling that often progress to heart failure (HF). Endothelial cells (ECs) are the most abundant non-myocyte cells in adult mouse heart. Simvastatin, a strong inducer of Krüppel-like Factor 2 (Klf2) in ECs, ameliorates press...

journal_title：Theranostics

authors： Li H,Wang Y,Liu J,Chen X,Duan Y,Wang X,Shen Y,Kuang Y,Zhuang T,Tomlinson B,Chan P,Yu Z,Cheng Y,Zhang L,Liu Z,Zhang Y,Zhao Z,Zhang Q,Liu J

更新日期：2021-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.7150/thno.21477.]. ...

journal_title：Theranostics

authors： Cao J,Wang X,Dai T,Wu Y,Zhang M,Cao R,Zhang R,Wang G,Jiang R,Zhou BP,Shi J,Kang T

更新日期：2021-01-01 00:00:00

abstract：:Targeting cancer stem cells (CSCs) has been proposed as a new strategy to eradicate malignancies, including hepatocellular carcinoma (HCC). However, the mechanisms by which CSCs sustain their self-renewal and chemoresistance remain elusive. Nanog is a master transcriptional regulator of stemness, especially in CSCs. I...

journal_title：Theranostics

authors： Cao J,Zhao M,Liu J,Zhang X,Pei Y,Wang J,Yang X,Shen B,Zhang J

更新日期：2019-01-24 00:00:00

abstract：:Meniscus deficiency, the most common and refractory disease in human knee joints, often progresses to osteoarthritis (OA) due to abnormal biomechanical distribution and articular cartilage abrasion. However, due to its anisotropic spatial architecture, complex biomechanical microenvironment, and limited vascularity, m...

journal_title：Theranostics

authors： Li Z,Wu N,Cheng J,Sun M,Yang P,Zhao F,Zhang J,Duan X,Fu X,Zhang J,Hu X,Chen H,Ao Y

更新日期：2020-04-06 00:00:00

abstract：:[This corrects the article DOI: 10.7150/thno.27882.]. ...

journal_title：Theranostics

authors： Qin C,Liu Q,Hu ZW,Zhou LQ,Shang K,Bosco DB,Wu LJ,Tian DS,Wang W

更新日期：2020-07-10 00:00:00

abstract：:Cell-based immunotherapy for the treatment of hematologic malignancies, such as leukemia and lymphoma, has seen much success and played an increasingly important role in clinical studies. Nevertheless, the efficacy of immunotherapy in solid tumors still needs improvements due to the immunosuppressive properties of tum...

journal_title：Theranostics

authors： Qian X,Shi Z,Qi H,Zhao M,Huang K,Han D,Zhou J,Liu C,Liu Y,Lu Y,Yuan X,Zhao J,Kang C

更新日期：2019-10-14 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC), an epithelial malignancy affecting a variety of subsites in the oral cavity, is prevalent in Asia. The survival rate of OSCC patients has not improved over the past decades due to its heterogeneous etiology, genetic aberrations, and treatment outcomes. Improvement in therapeutic st...

journal_title：Theranostics

authors： Su SC,Lin CW,Liu YF,Fan WL,Chen MK,Yu CP,Yang WE,Su CW,Chuang CY,Li WH,Chung WH,Yang SF

更新日期：2017-02-26 00:00:00