Protopanaxadiol and Protopanaxatriol-Type Saponins Ameliorate Glucose and Lipid Metabolism in Type 2 Diabetes Mellitus in High-Fat Diet/Streptozocin-Induced Mice.

abstract：:This study investigated the role of miR-3188 on the proliferation of non-small cell lung cancer cells and its relationship to FOXO1-modulated feedback loop. Two non-small cell lung cancer (NSCLC) cell lines A549 and H1299 were used. RNA silencing was achieved by lentiviral transfection. Cell proliferation was assessed...

journal_title：Frontiers in pharmacology

authors： Wang C,Liu E,Li W,Cui J,Li T

更新日期：2018-12-11 00:00:00

abstract：:This research evaluated the effects of triterpenes on the regulation of STZ-induced hyperglycaemic diabetes through an anti-inflammatory response. Diabetic mice were orally administered various concentrations of triterpenes on a daily basis. Weight gain, volume of drinking water, and liver and spleen weight were recor...

journal_title：Frontiers in pharmacology

authors： Wu YS,Chen SN

更新日期：2016-06-13 00:00:00

abstract：:Depression is a widespread chronic medical illness affecting thoughts, mood, and physical health. However, the limited and delayed therapeutic efficacy of monoaminergic drugs has led to intensive research efforts to develop novel antidepressants. ARN-3236 is the first potent and selective inhibitor of salt-inducible k...

journal_title：Frontiers in pharmacology

authors： Liu Y,Tang W,Ji C,Gu J,Chen Y,Huang J,Zhao X,Sun Y,Wang C,Guan W,Liu J,Jiang B

更新日期：2021-01-14 00:00:00

abstract：:Degradation of cyclic adenosine mono phosphate (cAMP) by phosphodiesterase-4B (PDE-4B) in the inflammatory cells leads to elevated expression of inflammatory cytokines in inflammatory cells. Suppression of cytokines has proved to be beneficial in the treatment of atopic dermatitis (AD). Henceforth, application of PDE4...

journal_title：Frontiers in pharmacology

authors： Purushothaman B,Arumugam P,Song JM

更新日期：2018-05-11 00:00:00

abstract：:The aim of this study was to investigate the regulatory function of the non-coding microRNA-155 (miR-155) and suppressor of cytokine signaling 1 (SOCS1) in alcoholic hepatitis (AH) and its potential mechanism associated with the mitogen-activated protein kinase (MAPK) signaling pathway. Levels of alanine aminotransfer...

journal_title：Frontiers in pharmacology

authors： Liu D,Han P,Gao C,Gao W,Yao X,Liu S

更新日期：2020-04-07 00:00:00

abstract：:Fingolimod is used for the treatment of multiple sclerosis (MS) and targets receptors for the bioactive sphingolipid sphingosine-1-phosphate (S1P). Whether fingolimod or other MS therapies conversely affect plasma concentrations of sphingolipids has, however, not yet been analyzed. Herein, we quantified 15 representat...

journal_title：Frontiers in pharmacology

authors： Ottenlinger FM,Mayer CA,Ferreirós N,Schreiber Y,Schwiebs A,Schmidt KG,Ackermann H,Pfeilschifter JM,Radeke HH

更新日期：2016-11-03 00:00:00

abstract：:Pancreatic cancer (PC) is an aggressive and fatal disease with high incidences of metastasis and recurrence. However, there are no effective treatment options for the majority of PC patients, especially for those with locally advanced tumors and metastatic diseases. Therefore, it is urgently needed to develop safe and...

journal_title：Frontiers in pharmacology

authors： Zhang J,Wang W,Zhou Y,Yang J,Xu J,Xu Z,Xu B,Yan L,Cheng XD,Li M,Qin JJ

更新日期：2020-04-08 00:00:00

abstract：:Acute Respiratory Distress Syndrome (ARDS) is a life-threatening complication that can ensue following Staphylococcus aureus infection. The enterotoxin produced by these bacteria (SEB) acts as a superantigen thereby activating a large proportion of T cells leading to cytokine storm and severe lung injury. Δ9Tetrahydro...

journal_title：Frontiers in pharmacology

authors： Mohammed A,Alghetaa H,Sultan M,Singh NP,Nagarkatti P,Nagarkatti M

更新日期：2020-06-16 00:00:00

abstract：:Nrf2 (Nuclear Factor Erythroid 2 Related Factor 2) transcription factor not only regulates oxidative stress response, but also represses inflammation by regulating cytokines production and cross-talking with NF-κB signaling pathways. Nrf2 plays an essential role in liver injury induced by oxidative stress and inflamma...

journal_title：Frontiers in pharmacology

authors： Yang YQ,Yan XT,Wang K,Tian RM,Lu ZY,Wu LL,Xu HT,Wu YS,Liu XS,Mao W,Xu P,Liu B

更新日期：2018-08-29 00:00:00

abstract：:Three new dimeric naphthoquinones, 5,4'-dihydroxy-1'-methoxy-6,6'-dimethyl-7,3'-binaphthyl-1,4,5',8'-tetraone (1), 5',8'-dihydroxy-5-methoxy-6,6'-dimethyl-7,3'-binaphthyl-1,4,1',4'-tetraone (2) and 8,5',8'-trihydroxy-6,6'-dimethyl-7,3'-binaphthyl-1,4,1',4'-tetraone (3), were isolated from the roots of Diospyros lotus....

journal_title：Frontiers in pharmacology

authors： Rauf A,Uddin G,Siddiqui BS,Molnár J,Csonka Á,Ahmad B,Szabó D,Farooq U,Khan A

更新日期：2015-12-16 00:00:00

abstract：:With multiple omics strategies being applied to several cancer genomics projects, researchers have the opportunity to develop a rational planning of targeted cancer therapy. The investigation of such numerous and diverse pharmacogenomic datasets is a complex task. It requires biological knowledge and skills on a set o...

journal_title：Frontiers in pharmacology

authors： Belizário JE,Sangiuliano BA,Perez-Sosa M,Neyra JM,Moreira DF

更新日期：2016-09-29 00:00:00

abstract：:Panax ginseng has been used as an herbal medicine for thousands of years. Most of its pharmacological effects are attributed to its constituent ginsenosides, including 20(S)-25-methoxyl-dammarane-3β, 12β, 20-triol (20(S)-25-OCH3-PPD), which is one of the protopanaxadiol type ginsenosides. It has been found to exhibit ...

journal_title：Frontiers in pharmacology

authors： Kim D,Park M,Haleem I,Lee Y,Koo J,Na YC,Song G,Lee J

更新日期：2020-04-22 00:00:00

abstract：:Objectives: The aim of this study is to conduct an analysis on the regulation and application of managed entry agreements (MEA) for oncology drugs across different European countries. Methods: Literature search and document analysis were performed between September 2015 and June 2016 to collect information on the regu...

journal_title：Frontiers in pharmacology

authors： Pauwels K,Huys I,Vogler S,Casteels M,Simoens S

更新日期：2017-04-04 00:00:00

abstract：:Skeletal dysplasias represent a large and diverse group of rare conditions affecting collagen and bone. They can be clinically classified based on radiographic and physical features, and many can be further defined at a molecular level (Bonafe et al., 2015). Early diagnosis is critical to proper medical management inc...

journal_title：Frontiers in pharmacology

authors： Jelin AC,O'Hare E,Blakemore K,Jelin EB,Valle D,Hoover-Fong J

更新日期：2017-03-06 00:00:00

abstract：INTRODUCTION:Nicotinic acetylcholine receptors are present in the cerebral white matter (WM). We hypothesized that WM response to nicotine can be detected by diffusion tensor imaging (DTI); and that such responses may be associated with nicotine-led cognitive enhancement in sustained attention. METHODS:A randomized, n...

journal_title：Frontiers in pharmacology

authors： Kochunov P,Du X,Moran LV,Sampath H,Wijtenburg SA,Yang Y,Rowland LM,Stein EA,Hong LE

更新日期：2013-09-18 00:00:00

abstract：:In a screening of Sudanese medicinal plants for antiprotozoal activity, the chloroform fractions obtained by liquid-liquid partitioning from ethanolic extracts of fruits of Croton gratissimus var. gratissimus and stems of Cuscuta hyalina Roth ex Schult. exhibited in vitro activity against axenically grown Leishmania d...

journal_title：Frontiers in pharmacology

authors： Mahmoud AB,Danton O,Kaiser M,Khalid S,Hamburger M,Mäser P

更新日期：2020-08-14 00:00:00

abstract：:Endothelial cells play a critical role in the process of angiogenesis during skin wound healing. The migration and proliferation of endothelial cells are processes that are initiated by the hypoxic microenvironment in a wound, but the underlying mechanisms remain largely unknown. Here, we identified a novel role for m...

journal_title：Frontiers in pharmacology

authors： Zhang J,Li L,Zhang Q,Yang X,Zhang C,Zhang X,Zhang D,Lv Y,Song H,Chen B,Liu Y,Hu J,Huang Y

更新日期：2019-04-16 00:00:00

abstract：:Alzheimer's disease (AD) is the most widespread form of dementia, affecting about 45 million people worldwide. Although the β-amyloid peptide (Aβ) remains the most acknowledged culprit of AD, the multiple failures of Aβ-centric therapies call for alternative therapeutic approaches. Conceivably, the complexity of the A...

journal_title：Frontiers in pharmacology

authors： Balducci C,Forloni G

更新日期：2019-07-03 00:00:00

abstract：:Hippocampal theta activity is related to spatial information processing, and high-frequency theta activity, in particular, has been linked to efficient spatial memory performance. Theta activity is regulated by the synchronizing ascending system (SAS), which includes mesencephalic and diencephalic relays. The supramam...

journal_title：Frontiers in pharmacology

authors： Hernández-Pérez JJ,Gutiérrez-Guzmán BE,López-Vázquez MÁ,Olvera-Cortés ME

更新日期：2015-10-29 00:00:00

abstract：Background:Dose requirements of vitamin K antagonists are associated with CYP2C9 and VKORC1, but, compared to warfarin, less data is available about phenprocoumon. Furthermore, the effects on dose stability and anticoagulation quality are still unclear. Methods:Aim was to scrutinize phenprocoumon dose requirements, do...

journal_title：Frontiers in pharmacology

authors： Schneider KL,Kunst M,Leuchs AK,Böhme M,Weckbecker K,Kastenmüller K,Bleckwenn M,Holdenrieder S,Coch C,Hartmann G,Stingl JC

更新日期：2020-01-28 00:00:00

abstract：:Due to our interest in the chemical space of organic dyes to identify potential small-molecule inhibitors (SMIs) for protein-protein interactions (PPIs), we initiated a screen of such compounds to assess their inhibitory activity against the interaction between SARS-CoV-2 spike protein and its cognate receptor ACE2, w...

journal_title：Frontiers in pharmacology

authors： Bojadzic D,Alcazar O,Buchwald P

更新日期：2021-01-13 00:00:00

abstract：:B lymphocytes play a critical role in humoral immunity. Abnormal B cell development and function cause a variety of hematological malignancies such as myeloma, B cell lymphoma, and leukemia. Histone deacetylase 6 (HDAC6) inhibitors alone or in combination with other drugs have shown efficacy in several hematological m...

journal_title：Frontiers in pharmacology

authors： Yang J,Li D,Zhou J

更新日期：2020-06-26 00:00:00

abstract：:Recent investigations of the treatment for hematologic neoplasms have focused on targeting epigenetic regulators. The DNA methyltransferase inhibitor 5-azacytidine (AZA) has produced good results in the treatment of patients with myelodysplastic syndromes. The mechanism underlying its pharmacological activity involves...

journal_title：Frontiers in pharmacology

authors： Imanishi S,Umezu T,Kobayashi C,Ohta T,Ohyashiki K,Ohyashiki JH

更新日期：2018-10-16 00:00:00

abstract：:Osteoporosis is a bone disease characterized by increasing osseous fragility and fracture due to the reduced bone mass and microstructural degradation. Primary pharmacological strategies for the treatment of osteoporosis, hormone replacement treatment (HRT), and alendronate therapies may produce adverse side-effects a...

journal_title：Frontiers in pharmacology

authors： He J,Li X,Wang Z,Bennett S,Chen K,Xiao Z,Zhan J,Chen S,Hou Y,Chen J,Wang S,Xu J,Lin D

更新日期：2019-11-25 00:00:00

abstract：:Vector-borne diseases like malaria, filariasis, and dengue are transmitted by mosquitoes and they cause global mortality and morbidity due to an increased resistance against commercial insecticides. The present study was aimed to evaluate the neurobehavioral toxicity, knock-down effect, histopathology, ovicidal, adult...

journal_title：Frontiers in pharmacology

authors： Ragavendran C,Srinivasan R,Kim M,Natarajan D

更新日期：2018-11-26 00:00:00

abstract：:This study investigates the protein expression of C-MYC, BCL-2, and BCL-6 in diffuse large B-cell lymphoma (DLBCL) and their relationship with genetic abnormalities. A retrospective study of 42 cases on paraffin-embedded tissue specimens diagnosed with DLBCL was performed using immunohistochemistry (IHC) and fluoresce...

journal_title：Frontiers in pharmacology

authors： Zhang Y,Wang H,Ren C,Yu H,Fang W,Zhang N,Gao S,Hou Q

更新日期：2019-01-07 00:00:00

abstract：:Scoring functions play an important role in structure-based virtual screening. It has been widely accepted that target-specific scoring functions (TSSFs) may achieve better performance compared with universal scoring functions in actual drug research and development processes. A method that can effectively construct T...

journal_title：Frontiers in pharmacology

authors： Wang D,Cui C,Ding X,Xiong Z,Zheng M,Luo X,Jiang H,Chen K

更新日期：2019-08-22 00:00:00

abstract：:There is currently a strong interest in using high-throughput in-vitro ion-channel screening data to make predictions regarding the cardiac toxicity potential of a new compound in both animal and human studies. A recent FDA think tank encourages the use of biophysical mathematical models of cardiac myocytes for this p...

journal_title：Frontiers in pharmacology

authors： Mistry HB,Davies MR,Di Veroli GY

更新日期：2015-03-24 00:00:00

abstract：:"Lipotoxicity" induced by free fatty acids (FAs) plays a central role in the pathogenesis of many metabolic diseases, with few treatment options available today. Hydrogen sulfide (H2S), a novel gaseous signaling molecule, has been reported to have a variety of pharmacological properties, but its effect on FAs metaboli...

journal_title：Frontiers in pharmacology

authors： Zhao C,Yu N,Li W,Cai H,Liu M,Hu Y,Liu Y,Tang M

更新日期：2020-09-23 00:00:00

abstract：:Cannabinoids exhibit anti-inflammatory and antitumorigenic properties. Contrary to most cannabinoids present in the Cannabis plant, some, such as O-1602 and abnormal cannabidiol, have no or only little affinity to the CB1 or CB2 cannabinoid receptors and instead exert their effects through other receptors. Here, we in...

journal_title：Frontiers in pharmacology

authors： Tomko A,O'Leary L,Trask H,Achenbach JC,Hall SR,Goralski KB,Ellis LD,Dupré DJ

更新日期：2019-09-27 00:00:00