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Chlamydia trachomatis Prevents Apoptosis Via Activation of PDPK1-MYC and Enhanced Mitochondrial Binding of Hexokinase II.

Abstract：

:The intracellular human bacterial pathogen Chlamydia trachomatis pursues effective strategies to protect infected cells against death-inducing stimuli. Here, we show that Chlamydia trachomatis infection evokes 3-phosphoinositide-dependent protein kinase-1 (PDPK1) signaling to ensure the completion of its developmental cycle, further leading to the phosphorylation and stabilization of MYC. Using biochemical approaches and imaging we demonstrate that Chlamydia-induced PDPK1-MYC signaling induces host hexokinase II (HKII), which becomes enriched and translocated to the mitochondria. Strikingly, preventing the HKII interaction with mitochondria using exogenous peptides triggers apoptosis of infected cells as does inhibiting either PDPK1 or MYC, which also disrupts intracellular development of Chlamydia trachomatis. These findings identify a previously unknown pathway activated by Chlamydia infection, which exhibits pro-carcinogenic features. Targeting the PDPK1-MYC-HKII-axis may provide a strategy to overcome therapeutic resistance of infection.

journal_name

EBioMedicine

journal_title

EBioMedicine

authors

Al-Zeer MA,Xavier A,Abu Lubad M,Sigulla J,Kessler M,Hurwitz R,Meyer TF

doi

10.1016/j.ebiom.2017.08.005

subject

Has Abstract

pub_date

2017-09-01 00:00:00

pages

100-110

issn

2352-3964

pii

S2352-3964(17)30322-5

journal_volume

23

pub_type

杂志文章

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