Primary Sjogren's Syndrome Associated With Treatment-Resistant Obsessive-Compulsive Disorder.

Abstract:

:There is an increasing awareness that autoimmune diseases can present with neuropsychiatric manifestations. We present the case of a 17-year-old female requiring psychiatric hospitalization for obsessive-compulsive disorder and major depressive disorder with mixed affective features, who was subsequently diagnosed with primary Sjogren's syndrome. Treatment with potent immunosuppression resulted in remission of psychiatric illness. Due to a lack of awareness and/or the lack of specific biomarkers, clinicians may not associate psychiatric symptoms with autoimmune disease, including primary Sjogren's syndrome. This case demonstrates that Sjogren's syndrome may be a causative or aggravating factor in mental disorders and that autoimmune diseases should be carefully considered in the differential diagnosis of psychiatric illness especially in cases of concurrent physical symptomatology and severity or treatment resistance of psychiatric disease.

journal_name

Front Psychiatry

journal_title

Frontiers in psychiatry

authors

Ong LTC,Galambos G,Brown DA

doi

10.3389/fpsyt.2017.00124

subject

Has Abstract

pub_date

2017-07-11 00:00:00

pages

124

issn

1664-0640

journal_volume

8

pub_type

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