Depression Reduces Accuracy While Parkinsonism Slows Response Time for Processing Positive Feedback in Patients with Parkinson's Disease with Comorbid Major Depressive Disorder Tested on a Probabilistic Category-Learning Task.

Abstract:

:Major depressive disorder (MDD) is the most common non-motor manifestation of Parkinson's disease (PD) affecting 50% of patients. However, little is known about the cognitive correlates of MDD in PD. Using a computer-based cognitive task that dissociates learning from positive and negative feedback, we tested four groups of subjects: (1) patients with PD with comorbid MDD, (2) patients with PD without comorbid MDD, (3) matched patients with MDD alone (without PD), and (4) matched healthy control subjects. Furthermore, we used a mathematical model of decision-making to fit both choice and response time data, allowing us to detect and characterize differences between the groups that are not revealed by cognitive results. The groups did not differ in learning accuracy from negative feedback, but the MDD groups (PD patients with MDD and patients with MDD alone) exhibited a selective impairment in learning accuracy from positive feedback when compared to the non-MDD groups (PD patients without MDD and healthy subjects). However, response time in positive feedback trials in the PD groups (both with and without MDD) was significantly slower than the non-PD groups (MDD and healthy groups). While faster response time usually correlates with poor learning accuracy, it was paradoxical in PD groups, with PD patients with MDD having impaired learning accuracy and PD patients without MDD having intact learning accuracy. Mathematical modeling showed that both MDD groups (PD with MDD and MDD alone) were significantly slower than non-MDD groups in the rate of accumulation of information for stimuli trained by positive feedback, which can lead to lower response accuracy. Conversely, modeling revealed that both PD groups (PD with MDD and PD alone) required more evidence than other groups to make responses, thus leading to slower response times. These results suggest that PD patients with MDD exhibit cognitive profiles with mixed traits characteristic of both MDD and PD, furthering our understanding of both PD and MDD and their often-complex comorbidity. To the best of our knowledge, this is the first study to examine feedback-based learning in PD with MDD while controlling for the effects of PD and MDD.

journal_name

Front Psychiatry

journal_title

Frontiers in psychiatry

authors

Herzallah MM,Khdour HY,Taha AB,Elmashala AM,Mousa HN,Taha MB,Ghanim Z,Sehwail MM,Misk AJ,Balsdon T,Moustafa AA,Myers CE,Gluck MA

doi

10.3389/fpsyt.2017.00084

subject

Has Abstract

pub_date

2017-06-12 00:00:00

pages

84

issn

1664-0640

journal_volume

8

pub_type

杂志文章
  • Prevalence and Correlates of Vitamin D Deficiency in a Sample of 290 Inpatients With Mental Illness.

    abstract::Introduction: Vitamin D inadequacy or deficiency (VDID) has been reported in a high percentage of otherwise healthy individuals. Factors that may contribute to the high prevalence of VDID in people with mental disorders include diet low in vitamin D, poor sunlight exposure, decrease in cutaneous vitamin D synthesis, i...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2019.00167

    authors: Cuomo A,Maina G,Bolognesi S,Rosso G,Beccarini Crescenzi B,Zanobini F,Goracci A,Facchi E,Favaretto E,Baldini I,Santucci A,Fagiolini A

    更新日期:2019-03-29 00:00:00

  • Deficits in agency in schizophrenia, and additional deficits in body image, body schema, and internal timing, in passivity symptoms.

    abstract::Individuals with schizophrenia, particularly those with passivity symptoms, may not feel in control of their actions, believing them to be controlled by external agents. Cognitive operations that contribute to these symptoms may include abnormal processing in agency as well as body representations that deal with body ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2014.00126

    authors: Graham KT,Martin-Iverson MT,Holmes NP,Jablensky A,Waters F

    更新日期:2014-09-10 00:00:00

  • Metacognitive Training Modulates Default-Mode Network Homogeneity During 8-Week Olanzapine Treatment in Patients With Schizophrenia.

    abstract:Background:Previous studies have revealed the efficacy of metacognitive training for schizophrenia. However, the underlying mechanisms of metacognitive training on brain function alterations, including the default-mode network (DMN), remain unknown. The present study explored treatment effects of metacognitive training...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00234

    authors: Shan X,Liao R,Ou Y,Ding Y,Liu F,Chen J,Zhao J,Guo W,He Y

    更新日期:2020-03-27 00:00:00

  • Primary and Secondary Diagnoses of Gambling Disorder and Psychiatric Comorbidity in the Swedish Health Care System-A Nationwide Register Study.

    abstract::Background: Psychiatric comorbidity is common in gambling disorder, a condition with low rates of treatment seeking. There is a paucity of documented nationwide data on gambling disorder and its co-occurring psychiatric comorbidities in the health care system. Methods: This is a nationwide register-based study of all ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2018.00426

    authors: Håkansson A,Karlsson A,Widinghoff C

    更新日期:2018-09-07 00:00:00

  • High Psychiatric Morbidity and Comorbidity Among Female Prisoners in Hunan, China.

    abstract:Background:High prevalence of mental disorders has been found among female prisoners in Western countries, however, little is known about the epidemiology of mental disorders in such populations in China. This study aims to investigate psychiatric morbidity and comorbidity among sentenced prisoners in a female prison i...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00271

    authors: Zhong S,Zhu X,Chen Y,Guo H,Luo C,Liang X,Wang F,Chen H,Zhou J,Wang X

    更新日期:2020-04-14 00:00:00

  • Long-Term Test-Retest Reliability of Auditory Gamma Oscillations Between Different Clinical EEG Systems.

    abstract:Objective:There is increasing interest in the utility of gamma-band activity for assessing various brain functions, including perception, language, memory, and cognition. The auditory steady-state response (ASSR) involves neural activity in the brain elicited by trains of a click sound, and its maximum response is obta...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00876

    authors: Hirano Y,Nakamura I,Tamura S,Onitsuka T

    更新日期:2020-09-02 00:00:00

  • Using structural neuroimaging to make quantitative predictions of symptom progression in individuals at ultra-high risk for psychosis.

    abstract::Neuroimaging holds the promise that it may one day aid the clinical assessment of individual psychiatric patients. However, the vast majority of studies published so far have been based on average differences between groups, which do not permit accurate inferences at the level of the individual. We examined the potent...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2013.00187

    authors: Tognin S,Pettersson-Yeo W,Valli I,Hutton C,Woolley J,Allen P,McGuire P,Mechelli A

    更新日期:2014-01-29 00:00:00

  • Age-Related Changes in Item Responses to the Patient Health Questionnaire-9: Evidence From the National Health and Nutrition Examination Survey.

    abstract:Background:Epidemiological studies have shown that total scores in depression screening scales change with age, but the mechanism underlying these age-related changes remains unclear. Previous research has indicated that item responses in depression screening scales exhibit characteristic distributions in the general p...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00723

    authors: Tomitaka S,Kawasaki Y,Ide K,Akutagawa M,Ono Y,Furukawa TA

    更新日期:2020-07-22 00:00:00

  • Pathways from cannabis to psychosis: a review of the evidence.

    abstract::The nature of the relationship between cannabis use (CU) and psychosis is complex and remains unclear. Researchers and clinicians remain divided regarding key issues such as whether or not cannabis is an independent cause of psychosis and schizophrenia. This paper reviews the field in detail, examining questions of ca...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2013.00128

    authors: Burns JK

    更新日期:2013-10-14 00:00:00

  • Sex Differences in the Peripheral Immune System in Patients with Depression.

    abstract:BACKGROUND:Females are twice as likely as males to experience depression. Recent findings indicate a relationship linking inflammation with depression. Whether the higher prevalence of depression in women is sex-specific or if inflammation contributes to a higher prevalence of depression in females is unclear. Thus, th...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2017.00108

    authors: Birur B,Amrock EM,Shelton RC,Li L

    更新日期:2017-06-16 00:00:00

  • IPS in Supported Housing: Fidelity and Employment Outcomes Over a 4 Year Period.

    abstract::Background: People with severe mental illness have difficulties finding and maintaining competitive employment. This is particularly so for those living in supported housing who, by definition, have significant day-to-day support needs: in the Netherlands only 3 to 5% of people with serious mental health problems who ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.622061

    authors: Roeg D,de Winter L,Bergmans C,Couwenbergh C,McPherson P,Killaspy H,van Weeghel J

    更新日期:2021-01-14 00:00:00

  • Increased Absolute Glutamate Concentrations and Glutamate-to-Creatine Ratios in Patients With Methamphetamine Use Disorders.

    abstract::Introduction: Previous studies have indicated that changes in the concentration of glutamate and related metabolites may mediate the progression of addiction in patients with methamphetamine (MA) use disorders. In the present study, we utilized magnetic resonance spectroscopy (MRS) to investigate absolute glutamate co...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2018.00368

    authors: Yang W,Yang R,Luo J,He L,Liu J,Zhang J

    更新日期:2018-08-31 00:00:00

  • Modeling Trait Anxiety: From Computational Processes to Personality.

    abstract::Computational methods are increasingly being applied to the study of psychiatric disorders. Often, this involves fitting models to the behavior of individuals with subclinical character traits that are known vulnerability factors for the development of psychiatric conditions. Anxiety disorders can be examined with ref...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2017.00001

    authors: Raymond JG,Steele JD,Seriès P

    更新日期:2017-01-23 00:00:00

  • Posttraumatic Stress Disorder and Related Disorders among Female Yazidi Refugees following Islamic State of Iraq and Syria Attacks-A Case Series and Mini-Review.

    abstract::Following the severe attacks by the so-called "Islamic State of Iraq and Syria" on the Yazidi population, which started in summer 2014, the state government of Baden-Württemberg, Germany, funded a Special-Quota Project to bring 1,000 very ill or left-behind women and children who were being held hostage to 22 cities a...

    journal_title:Frontiers in psychiatry

    pub_type:

    doi:10.3389/fpsyt.2017.00282

    authors: Gerdau I,Kizilhan JI,Noll-Hussong M

    更新日期:2017-12-13 00:00:00

  • Bias Toward Drug-Related Stimuli Is Affected by Loading Working Memory in Abstinent Ex-Methamphetamine Users.

    abstract::Background: There is a trade-off between drug-related impulsive process and cognitive reflective process among ex-drug abusers. The present study aimed to investigate the impulsive effects of methamphetamine-related stimuli on working memory (WM) performance by manipulating WM load in abstinent ex-methamphetamine user...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2019.00776

    authors: Deldar Z,Ekhtiari H,Pouretemad HR,Khatibi A

    更新日期:2019-10-22 00:00:00

  • Effects of Trazodone on Sleep Quality and Cognitive Function in Arteriosclerotic Cerebral Small Vessel Disease Comorbid With Chronic Insomnia.

    abstract:Background:Chronic insomnia is common in patients with arteriosclerotic cerebral small vessel disease (CSVD) and aggravates the cognitive impairment caused by CSVD. Low-dose trazodone is effective in treating insomnia, but it is unclear whether it can also improve cognitive function in CSVD patients. This study was per...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00620

    authors: Wang J,Liu S,Zhao C,Han H,Chen X,Tao J,Lu Z

    更新日期:2020-06-30 00:00:00

  • Regional Cerebral Blood Flow in Mania: Assessment Using 320-Slice Computed Tomography.

    abstract::Objectives: While evidence that episodes of mania in bipolar I are associated with changes in bioenergetic and regional cerebral blood flow (rCBF) and cerebral blood flow velocity (rCBFV), both the regions and the extent of these changes have not yet been defined. Therefore, we determined the pattern of regional cereb...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2018.00296

    authors: Wang Y,Liu X,Li P,Zhou H,Yang L,Zheng L,Xie P,Li L,Liao DJ,Liu Q,Fang D

    更新日期:2018-07-04 00:00:00

  • Measuring Psychological Change and Predicting Recidivism Following the Swedish One-to-One Program.

    abstract::The One-to-One program aims to reduce criminal recidivism among prisoners shortly awaiting release, and among probationers. Of 1,484 program participants in Sweden, 776 contained adequate data for analysis. Pre- and post-program scores were available for the Alternative Thinking Test, Levenson's Locus of Control Scale...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2019.00811

    authors: Berman AH,Gajecki M,Morien P,Priestley P

    更新日期:2019-11-29 00:00:00

  • Mothers With Postpartum Psychiatric Disorders: Proposal for an Adapted Method to Assess Maternal Sensitivity in Interaction With the Child.

    abstract::About 15% of mothers suffer from postpartum psychiatric disorders, such as depression, anxiety, or psychosis. Numerous studies have shown maternal caregiving behavior to be negatively affected under these circumstances. The current study sets out to shed light on specific caregiving behaviors of affected mothers in th...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2019.00471

    authors: Heinisch C,Galeris MG,Gabler S,Simen S,Junge-Hoffmeister J,Fößel J,Spangler G

    更新日期:2019-07-22 00:00:00

  • Frequency-Specific Regional Homogeneity Alterations in Tourette Syndrome.

    abstract::Tourette syndrome (TS) is a developmental neuropsychiatric disorder with onset during childhood. Because of its complex spectrum of phenotypes, the underlying pathophysiology of TS is still unclear. Resting-state functional magnetic resonance imaging demonstrated aberrant spontaneous neural synchronization in conventi...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.543049

    authors: Lou YT,Li XL,Wang Y,Ji GJ,Zang YF,Wang J,Feng JH

    更新日期:2020-12-17 00:00:00

  • Conditioned fear associated phenotypes as robust, translational indices of trauma-, stressor-, and anxiety-related behaviors.

    abstract::Post-traumatic stress disorder (PTSD) is a heterogeneous disorder that affects individuals exposed to trauma (e.g., combat, interpersonal violence, and natural disasters). It is characterized by hyperarousal, intrusive reminders of the trauma, avoidance of trauma-related cues, and negative cognition and mood. This het...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2014.00088

    authors: Briscione MA,Jovanovic T,Norrholm SD

    更新日期:2014-07-21 00:00:00

  • Altered Functional Connectivity of Striatum Based on the Integrated Connectivity Model in First-Episode Schizophrenia.

    abstract::Background: The human striatum is a heterogeneous structure involved in diverse functional domains that related to distinct striatum subregions. Striatal dysfunction was thought to be a fundamental element in schizophrenia. However, the connectivity pattern of striatum solely based on functional or structural characte...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2019.00756

    authors: Zhang B,Lin P,Wang X,Öngür D,Ji X,Situ W,Yao S,Wang X

    更新日期:2019-10-18 00:00:00

  • Cognitive Impairment and Affective Disorders in Patients With Obstructive Sleep Apnea Syndrome.

    abstract::Sleep-related breathing disorders could be accompanied by or caused by a variety of medical conditions. They are considered to be a significant medical and social problem. Together with excessive daytime sleepiness, patients with obstructive sleep apnea experience neuropsychological symptoms such as anxiety, attention...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2018.00357

    authors: Bilyukov RG,Nikolov MS,Pencheva VP,Petrova DS,Georgiev OB,Mondeshki TL,Milanova VK

    更新日期:2018-08-07 00:00:00

  • Does Chronic Cannabis Use Impact Risky Decision-Making: An Examination of fMRI Activation and Effective Connectivity?

    abstract::With the increase in use of cannabis and its shifting legal status in the United States, cannabis use has become an important research focus. While studies of other drug populations have shown marked increases in risky decision-making, the literature on cannabis users is not as clear. The current study examined the pe...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.599256

    authors: Raymond DR,Paneto A,Yoder KK,O'Donnell BF,Brown JW,Hetrick WP,Newman SD

    更新日期:2020-11-27 00:00:00

  • Characteristics of Adolescents Affected by Mass Psychogenic Illness Outbreaks in Schools in Nepal: A Case-Control Study.

    abstract::This paper presents the first systematic case-control study of correlates of mass psychogenic illness (MPI) in an adolescent school population. MPI is generally construed as a dissociative phenomenon spread by social contagion to individuals who are prone to dissociation. We sought to test if the correlates of dissoci...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.493094

    authors: Sapkota RP,Brunet A,Kirmayer LJ

    更新日期:2020-11-17 00:00:00

  • Using EEG-Guided Basket and Umbrella Trials in Psychiatry: A Precision Medicine Approach for Cognitive Impairment in Schizophrenia.

    abstract::Due to advances over the last several decades, many fields of medicine are moving toward a precision medicine approach where treatments are tailored to nuanced patient factors. While in some disciplines these innovations are commonplace leading to unique biomarker-guided experimental medicine trials, there are no such...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章,评审

    doi:10.3389/fpsyt.2018.00554

    authors: Joshi YB,Light GA

    更新日期:2018-11-19 00:00:00

  • Prenatal IV Cocaine: Alterations in Auditory Information Processing.

    abstract::One clue regarding the basis of cocaine-induced deficits in attentional processing is provided by the clinical findings of changes in the infants' startle response; observations buttressed by neurophysiological evidence of alterations in brainstem transmission time. Using the IV route of administration and doses that ...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2011.00038

    authors: Mactutus CF,Harrod SB,Hord LL,Moran LM,Booze RM

    更新日期:2011-06-28 00:00:00

  • Repeated Exposure to the "Spice" Cannabinoid JWH-018 Induces Tolerance and Enhances Responsiveness to 5-HT1A Receptor Stimulation in Male Rats.

    abstract::Naphthalen-1-yl-(1-pentylindol-3-yl)methanone (JWH-018) is a synthetic compound found in psychoactive "spice" products that activates cannabinoid receptors. Preclinical evidence suggests that exposure to synthetic cannabinoids increases 5-HT2A/2C receptor function in the brain, an effect which might contribute to psyc...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2018.00055

    authors: Elmore JS,Baumann MH

    更新日期:2018-02-27 00:00:00

  • Neural Correlates of Own- and Other-Face Perception in Body Dysmorphic Disorder.

    abstract:Background:Body dysmorphic disorder (BDD) is characterized by an excessive preoccupation with one or more perceived flaws in one's own appearance. Previous studies provided evidence for deficits in configural and holistic processing in BDD. Preliminary evidence suggests abnormalities at an early stage of visual process...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.00302

    authors: Ritter V,Kaufmann JM,Krahmer F,Wiese H,Stangier U,Schweinberger SR

    更新日期:2020-04-24 00:00:00

  • Criminal Responsibility Scale: Development and Validation of a Psychometric Tool Structured in Clinical Vignettes for Criminal Responsibility Assessments in Brazil.

    abstract::Criminal responsibility assessment is undertaken by psychologists or psychiatrists to assess offenders' legal capacities, which vary among countries or regional legislations. There are two psychometric tools (i.e., checklists) validated for criminal responsibility assessment: the Roger Criminal Responsibility Scale, a...

    journal_title:Frontiers in psychiatry

    pub_type: 杂志文章

    doi:10.3389/fpsyt.2020.579243

    authors: Meyer LF,Leal CCS,Omena AAS,Mecler K,Valença AM

    更新日期:2020-11-27 00:00:00