A Subset of Extreme Human Immunodeficiency Virus (HIV) Controllers Is Characterized by a Small HIV Blood Reservoir and a Weak T-Cell Activation Level.

abstract：Background:We characterized the extent of antiretroviral therapy (ART) experience and postdischarge mortality among hospitalized HIV-infected adults in Zambia. Methods:At a central hospital with an opt-out HIV testing program, we enrolled HIV-infected adults (18+ years) admitted to internal medicine using a population...

journal_title：Open forum infectious diseases

authors： Haachambwa L,Kandiwo N,Zulu PM,Rutagwera D,Geng E,Holmes CB,Sinkala E,Claassen CW,Mugavero MJ,Wa Mwanza M,Turan JM,Vinikoor MJ

更新日期：2019-07-16 00:00:00

abstract：BACKGROUND:Endothelial activation and dysfunction play a central role in the pathogenesis of sepsis and viral hemorrhagic fevers. Hantaviral disease is a viral hemorrhagic fever and is characterized by capillary dysfunction, although the underlying mechanisms for hantaviral disease are not fully elucidated. METHODS:Th...

journal_title：Open forum infectious diseases

authors： Connolly-Andersen AM,Thunberg T,Ahlm C

更新日期：2014-05-29 00:00:00

abstract：Background:Clinical features of Lyme disease (LD) range from localized skin lesions to serious disseminated disease. Information on risk factors for Lyme arthritis, facial palsy, carditis, and meningitis is limited but could facilitate disease recognition and elucidate pathophysiology. Methods:Patients from high-incid...

journal_title：Open forum infectious diseases

authors： Kwit NA,Nelson CA,Max R,Mead PS

更新日期：2017-11-18 00:00:00

abstract：:Invasive aspergillosis (IA) is the most serious mold infection encountered in patients with iatrogenic immunosuppression. IA is also a major cause of mortality and morbidity in individuals with primary immunodeficiency (PID). Although Aspergillus fumigatus is the most common etiologic agent of IA reported in PID patie...

journal_title：Open forum infectious diseases

authors： Seyedmousavi S,Lionakis MS,Parta M,Peterson SW,Kwon-Chung KJ

更新日期：2018-09-26 00:00:00

abstract：BACKGROUND:Because hospitals in a region are connected via patient sharing, a norovirus outbreak in one hospital may spread to others. METHODS:We utilized our Regional Healthcare Ecosystem Analyst software to generate an agent-based model of all the acute care facilities in Orange County (OC), California and simulated...

journal_title：Open forum infectious diseases

authors： Bartsch SM,Huang SS,Wong KF,Avery TR,Lee BY

更新日期：2014-07-02 00:00:00

abstract：:Immune suppression is a recognized risk factor for necrotizing fasciitis. In patients with hematological malignancies, a profoundly immunocompromised group, the predominant causative organisms are Gram negative. Clinical presentation and outcomes in these patients are similar to the immunocompetent. The Laboratory Ris...

journal_title：Open forum infectious diseases

authors： Foo RM,Tung ML,Poon LM,Chan D,Smitasin N,Koh LP,Chng WJ,Chai LY

更新日期：2015-06-12 00:00:00

abstract：:Among a cohort of men who have sex with men in a pre-exposure prophylaxis (PrEP) adherence trial, syphilis requiring treatment was associated with white coat dosing (increased PrEP adherence immediately preceding study visits) when compared with participants with optimal drug concentrations. The findings highlight the...

journal_title：Open forum infectious diseases

authors： Blair CS,Beymer MR,Kofron RM,Bolan RK,Jordan WC,Haubrich RH,Wohl AR,Landovitz RJ

更新日期：2020-08-07 00:00:00

abstract：Background:Little information is available on the relative tolerability of ceftaroline versus other cephalosporins in clinical practice. We sought to compare adverse drug reactions (ADRs) associated with ceftaroline with those associated with ceftriaxone in hospitalized patients. Materials and Methods:This was a retro...

journal_title：Open forum infectious diseases

authors： Jansen JW,Linneman TW,Tan X,Moenster RP

更新日期：2019-06-13 00:00:00

abstract：:Elimination of a rifamycin from the treatment regimen for tuberculosis negatively impacts outcomes. Cross-reactivity between the rifamycins after drug eruptions is unclear. We report 6 consecutive human immunodeficiency virus-infected patients with rifampicin-associated drug rash with eosinophilia and systemic symptom...

journal_title：Open forum infectious diseases

authors： Lehloenya RJ,Dlamini S,Muloiwa R,Kakande B,Ngwanya MR,Todd G,Dheda K

更新日期：2016-06-20 00:00:00

abstract：:Background.  Cryptococcal meningitis is a leading cause of death in people living with human immunodeficiency virus (HIV)/acquired immune deficiency syndrome. The World Health Organizations recommends pre-antiretroviral treatment (ART) cryptococcal antigen (CRAG) screening in persons with CD4 below 100 cells/µL. We as...

journal_title：Open forum infectious diseases

authors： Letang E,Müller MC,Ntamatungiro AJ,Kimera N,Faini D,Furrer H,Battegay M,Tanner M,Hatz C,Boulware DR,Glass TR

更新日期：2015-04-02 00:00:00

abstract：Background:The Short Physical Performance Battery (SPPB) is a well regarded physical functioning assessment including balance, gait speed, and chair-stand tests. Its use has not been widely assessed in human immunodeficiency virus (HIV) care. We evaluated the feasibility of integrating the SPPB into care of aging peopl...

journal_title：Open forum infectious diseases

authors： Crane HM,Miller ME,Pierce J,Willig AL,Case ML,Wilkin AM,Brown S,Asirot MG,Fredericksen RJ,Saag MS,Landay AL,High KP

更新日期：2019-03-11 00:00:00

abstract：Background:Kindergarten-entry vaccination requirements have played an important role in controlling vaccine-preventable diseases in the United States. Forty-eight states and the District of Colombia offer nonmedical exemptions to vaccines, ranging in stringency. Methods:We analyzed state-level exemption data from 2011...

journal_title：Open forum infectious diseases

authors： Omer SB,Porter RM,Allen K,Salmon DA,Bednarczyk RA

更新日期：2017-11-15 00:00:00

abstract：Background:To determine the effectiveness of implementing a locally developed clinical practice guideline (CPG) for antibiotic treatment in adults with community-acquired cellulitis at Siriraj Hospital in Bangkok, Thailand. Methods:The CPG for antibiotic treatment of community-acquired cellulitis was developed based o...

journal_title：Open forum infectious diseases

authors： Sirijatuphat R,Nookeu P,Thamlikitkul V

更新日期：2020-09-07 00:00:00

abstract：:Lyme disease accounted for more than two-thirds (56 of 81, 69.1%) of all tick-borne disease referrals to a large, academic infectious diseases clinic in a low-incidence state. Deviations from diagnostic testing guidelines and errors in test interpretation were common (23 of 35, 65.7%), suggesting that frontline provid...

journal_title：Open forum infectious diseases

authors： Boyce RM,Speight C,Lin JT,Farel CE

更新日期：2020-01-11 00:00:00

abstract：:We developed an open-access, Excel-based model simulating currently recommended and alternative algorithms for adult HIV testing as a preliminary investigation of trade-offs between accuracy and costs. Despite higher costs, simpler HIV testing algorithms incorporating point of care nucleic acid testing may improve out...

journal_title：Open forum infectious diseases

authors： Neilan AM,Cohn JE,Lemaire JF,Sacks E,Alban R,Freedberg KA,Walensky RP,Ciaranello AL

更新日期：2018-08-29 00:00:00

abstract：Background:Hydatid disease is a severe health problem in endemic areas. In recent years, the incidence of this disease in China has been increasing. As the imaging characteristics of pancreatic echinococcosis (PE) are similar to those of cystic diseases, such as cysts, tuberculosis, and tumors, PE is often misdiagnosed...

journal_title：Open forum infectious diseases

authors： Gou L,Gao F,Tiheiran M,Guo H

更新日期：2020-04-03 00:00:00

abstract：:Surveillance represents an important informational tool for planning actions to monitor emerging antimicrobial resistance. Antimicrobial resistance surveillance (ARS) programs may have many different designs and can be grouped in 2 major categories based on their main objectives: (1) public health ARS programs and (2)...

journal_title：Open forum infectious diseases

authors： Sader HS,Rhomberg PR,Fuhrmeister AS,Mendes RE,Flamm RK,Jones RN

更新日期：2019-03-15 00:00:00

abstract：Background:The Affordable Care Act's (ACA's) major reforms started in 2014. In addition to assessing HIV clinicians' ACA knowledge and attitudes, this study aims to evaluate HIV clinicians' perspectives on whether the ACA has impacted the quality of HIV care and whether it addresses the main barriers to HIV care. Meth...

journal_title：Open forum infectious diseases

authors： McManus KA,Ferey J,Farrell E,Dillingham R

更新日期：2020-06-10 00:00:00

abstract：Background:New approaches are needed to provide care to persons with HIV who do not engage in conventionally organized HIV clinics. The Max Clinic in Seattle, Washington, is a walk-in, incentivized HIV care model located in a public health STD clinic that provides care in collaboration with a comprehensive HIV primary ...

journal_title：Open forum infectious diseases

authors： Dombrowski JC,Galagan SR,Ramchandani M,Dhanireddy S,Harrington RD,Moore A,Hara K,Eastment M,Golden MR

更新日期：2019-06-26 00:00:00

abstract：:The FilmArray meningitis/encephalitis (ME) panel is a novel syndromic, nucleic acid amplification test for diagnosis of acute meningitis and encephalitis. Emerging data on its performance are concerning for false-positive results. We present a case of tuberculous meningitis misdiagnosed as herpes simplex virus-1 encep...

journal_title：Open forum infectious diseases

authors： Gomez CA,Pinsky BA,Liu A,Banaei N

更新日期：2016-12-07 00:00:00

abstract：BACKGROUND:Clostridium difficile infection (CDI) is no longer restricted to hospital settings, and population-based incidence measures are needed. Understanding the determinants of CDI incidence will allow for more meaningful comparisons of rates and accurate national estimates. METHODS:Data from active population- an...

journal_title：Open forum infectious diseases

authors： Lessa FC,Mu Y,Winston LG,Dumyati GK,Farley MM,Beldavs ZG,Kast K,Holzbauer SM,Meek JI,Cohen J,McDonald LC,Fridkin SK

更新日期：2014-07-28 00:00:00

abstract：Background:The diagnosis of cellulitis is made clinically without a gold standard diagnostic test, and cellulitis has many disease mimics. There is currently no consensus for optimal antimicrobial treatment duration or method of antimicrobial delivery. Methods:This was a randomized controlled open-label multicenter tr...

journal_title：Open forum infectious diseases

authors： Clarke MC,Cheng AC,Pollard JG,Birch M,Cowan RU,Linke JA,Walton AL,Friedman ND

更新日期：2019-07-20 00:00:00

abstract：Background:We recently reported that the levels of activation, exhaustion, and terminal differentiation within the peripheral T-cell compartment were increased in men who have sex with men (MSM) compared with blood bank donors. During activation and differentiation, T cells undergo metabolic changes to maintain their e...

journal_title：Open forum infectious diseases

authors： Kruize Z,Maurer I,van Dort KA,van den Elshout MAM,Hoornenborg E,Booiman T,Prins M,Kootstra NA

更新日期：2020-07-05 00:00:00

abstract：:We report a case of acute weight gain after switching from emtricitabine/tenofovir disoproxil to emtricitabine/tenofovir alafenamide for human immunodeficiency virus pre-exposure prophylaxis. ...

journal_title：Open forum infectious diseases

authors： Selvaraj SV,Bares SH,Havens JP

更新日期：2020-09-24 00:00:00

abstract：:Infection secondary to rapidly growing mycobacteria (RGM) is associated with significant morbidity and mortality, especially in individuals with underlying structural lung disease or immune compromise. Such infections, particularly those caused by the Mycobacterium abscessus group, are challenging to treat due to high...

journal_title：Open forum infectious diseases

authors： McGuffin SA,Pottinger PS,Harnisch JP

更新日期：2017-07-20 00:00:00

abstract：:Methods.  In a cross-sectional substudy of the Multicenter AIDS Cohort Study, noncontrast cardiac computed tomography (CT) scanning for coronary artery calcium (CAC) scoring was performed on all men, and, for men with normal renal function, coronary CT angiography (CTA) was performed. Associations between fat depots (...

journal_title：Open forum infectious diseases

authors： Palella FJ Jr,McKibben R,Post WS,Li X,Budoff M,Kingsley L,Witt MD,Jacobson LP,Brown TT

更新日期：2016-06-16 00:00:00

abstract：Background:Patients heterozygous for mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene may be more susceptible to respiratory infections than the general population. Methods :We conducted a retrospective case-control study using health insurance claims. We identified patients as either h...

journal_title：Open forum infectious diseases

authors： Polgreen PM,Brown GD,Hornick DB,Ahmad F,London B,Stoltz DA,Comellas AP

更新日期：2018-11-01 00:00:00

abstract：:Despite the widespread outbreak, few cases of Zika virus associated with cardiac manifestations have been described. We present a case of pericarditis in the setting of an acute, symptomatic Zika virus infection in a traveler returning from St. Thomas. Clinicians should be alert for this potential complication of Zika...

journal_title：Open forum infectious diseases

authors： Waggoner JJ,Rouphael N,Xu Y,Natrajan M,Lai L,Patel SM,Levit RD,Edupuganti S,Mulligan MJ

更新日期：2017-05-18 00:00:00

abstract：:This manuscript explores the ethics of human inoculation experiments in young healthy adults with wild-type severe acute respiratory sydrome coronavirus 2 (SARS-CoV-2) as a tool to evaluate vaccine efficacy in the context of the Nuremberg Code, the Declaration of Helsinki, and the Belmont Report, and in the context of...

journal_title：Open forum infectious diseases

authors： Spinola SM,Broderick C,Zimet GD,Ott MA

更新日期：2020-12-28 00:00:00

abstract：BACKGROUND:Intra-abdominal infections (IAI) constitute a common reason for hospitalization. However, there is lack of standardization in empiric management of (1) anaerobes, (2) enterococci, (3) fungi, and (4) multidrug-resistant organisms (MDRO). The recommendation is to institute empiric coverage for some of these or...

journal_title：Open forum infectious diseases

authors： Marcus G,Levy S,Salhab G,Mengesha B,Tzuman O,Shur S,Burke E,Mayeda RC,Cochavi L,Perluk I,Zaidenstein R,Lazarovitch T,Dadon M,Marchaim D

更新日期：2016-12-20 00:00:00