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The promising impact of molecular profiling on treatment strategies in oral cancers.

Abstract：

:Oral squamous cell carcinoma (OSCC) is a major cause of cancer-associated morbidity and mortality. Although OSCC may develop from easily accessible oral preneoplastic lesions (OPLs), no intervention has been reported so far that reduces the rate of malignant transformation. A comprehensive molecular characterization of oral carcinogenesis may help refining treatment strategies both in patients with OPLs and OSCC. Herein, we review main molecular alterations occurring at different steps during oral carcinogenesis and show how molecularly-based medicine and surgery may impact the outcome of OSCC in the future.

journal_name

J Stomatol Oral Maxillofac Surg

journal_title

Journal of stomatology, oral and maxillofacial surgery

authors

Foy JP,Saintigny P,Goudot P,Schouman T,Bertolus C

doi

10.1016/j.jormas.2017.05.004

subject

Has Abstract

pub_date

2017-09-01 00:00:00

pages

242-247

issue

4

eissn

2468-8509

issn

2468-7855

pii

S2468-7855(17)30094-0

journal_volume

118

pub_type

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