Red Eye: A Guide for Non-specialists.

abstract：BACKGROUND:The effectiveness of intraoral appliances (IOA), maxillary expansion (ME), and maxillomandibular advancement (MMA) in the treatment of children and adults with obstructive sleep apnea (OSA) has not yet been adequately assessed. METHODS:An umbrella review was performed based on established guidelines for evi...

journal_title：Deutsches Arzteblatt international

authors： Koretsi V,Eliades T,Papageorgiou SN

更新日期：2018-03-23 00:00:00

abstract：BACKGROUND:Direct (non-vitamin-K-dependent) oral anticoagulants (DOAC) are given as an alternative to vitamin K antagonists (VKA) to prevent stroke and embolic disease in patients with atrial fibrillation that is not due to pathology of the heart valves. Fatal hemorrhage is rarer when DOACs are given (nonvalvular atria...

journal_title：Deutsches Arzteblatt international

authors： Maegele M,Grottke O,Schöchl H,Sakowitz OA,Spannagl M,Koscielny J

更新日期：2016-09-05 00:00:00

abstract：BACKGROUND:Lung cancer is the leading cause of death from cancer in Germany. 90% of cases are due to the inhalation of tobacco smoke. About 40% of patients with newly diagnosed lung cancer are still smokers. A structured smoking cessation program is medically reasonable in this situation but is only rarely offered. ME...

journal_title：Deutsches Arzteblatt international

authors： Andreas S,Rittmeyer A,Hinterthaner M,Huber RM

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:As of 1 April 2007, pharmacists in Germany filling prescriptions covered by the statutory health insurance system (Gesetzliche Krankenversicherung, GKV) are required, whenever possible, to dispense a preparation that contains the same active substance and for which a rebate contract is in effect. The physici...

journal_title：Deutsches Arzteblatt international

authors： Hoffmann F,Glaeske G,Pfannkuche MS

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:Dermatologists, paediatricians, and general practitioners are often consulted by worried parents for the evaluation of a cutaneous tumor. METHODS:Selective literature review. RESULTS:Only 1-2% of skin tumors excised in children turn out to be malignant when examined histologically. Warning signs of maligna...

journal_title：Deutsches Arzteblatt international

authors： Hamm H,Höger PH

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:Treatment with checkpoint inhibitors such as anti-programmed death-1 (anti-PD-1), anti-PD-ligand 1 (anti-PD-L1), and anti-cytotoxic T-lymphocyte antigen-4 (anti-CTLA-4) antibodies can prolong the survival of cancer patients, but it also induces autoimmune side effects in 86-96% of patients by activating the ...

journal_title：Deutsches Arzteblatt international

authors： Heinzerling L,de Toni EN,Schett G,Hundorfean G,Zimmer L

更新日期：2019-02-22 00:00:00

abstract：BACKGROUND:The neuropsychiatric symptoms of dementia, including aggressiveness, agitation, depression, and apathy are often treated with psychotropic drugs and are a frequent reason for hospitalization, placing an economic burden on the health care system. International guidelines recommend syndrome-specific pharmacoth...

journal_title：Deutsches Arzteblatt international

authors： Majic T,Pluta JP,Mell T,Aichberger MC,Treusch Y,Gutzmann H,Heinz A,Rapp MA

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:The long-term use of opioid analgesic drugs to treat chronic non-cancer pain (CNCP) is a major component of pain pharmacotherapy. The interpretation of the evidence concerning its efficacy and risks is currently debated. METHODS:An interdisciplinary evidence- and consensus-based S3 guideline was updated on ...

journal_title：Deutsches Arzteblatt international

authors： Häuser W,Bock F,Engeser P,Tölle T,Willweber-Strumpfe A,Petzke F

更新日期：2014-10-24 00:00:00

abstract：BACKGROUND:Patients with ovarian cancer usually present to a family physician with nonspecific symptoms, most often abdominal pain. The outcome depends above all on the stage of the disease when it is diagnosed and on the quality of treatment. METHODS:This article is based on a review of selected publications from 200...

journal_title：Deutsches Arzteblatt international

authors： Burges A,Schmalfeldt B

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:The treatment options for bcr-abl positive chronic myelogenous leukemia (CML) include chemotherapy, immune therapy, allogeneic stem cell transplantation, and molecular therapy. The tyrosine kinase inhibitor imatinib was approved for the treatment of CML in 2002. Data from clinical trials allow a comparison o...

journal_title：Deutsches Arzteblatt international

authors： von Bubnoff N,Duyster J

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:As life expectancies rise and the number of persons over age 75 in the population increases, the proper treatment of elderly cardiac patients is becoming a matter of ever greater medical and political importance. METHODS:In collaboration with the German Federal Quality Assurance Office (Bundesgeschäftsstell...

journal_title：Deutsches Arzteblatt international

authors： Friedrich I,Simm A,Kötting J,Thölen F,Fischer B,Silber RE

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:A number of studies have revealed higher postoperative mortality after operations that were performed toward the end of the week. It is not yet known whether a day-of-the-week effect exists after visceral surgical procedures for cancer in Germany. METHODS:Data on resections of carcinomas of the colon, rectu...

journal_title：Deutsches Arzteblatt international

authors： Anger F,Wellner U,Klinger C,Lichthardt S,Haubitz I,Löb S,Keck T,Germer CT,Buhr HJ,Wiegering A

更新日期：2020-08-03 00:00:00

abstract：BACKGROUND:Isolated non-compaction cardiomyopathy (NCCM) was first described in 1984. This disorder, a primary genetic cardiomyopathy, is now attracting increased attention. METHOD:The current state of the epidemiology, pathogenesis, pathophysiology, clinical features, diagnosis, treatment, and prognosis of NCCM are d...

journal_title：Deutsches Arzteblatt international

authors： Engberding R,Stöllberger C,Ong P,Yelbuz TM,Gerecke BJ,Breithardt G

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:25% of all women report involuntary loss of urine, and 7% may require treatment. METHODS:This review is based on a selection of pertinent literature, including guidelines and Cochrane reviews. RESULTS:The assessment of pelvic floor dysfunction in women begins with a basic evaluation that is followed by spe...

journal_title：Deutsches Arzteblatt international

authors： Jundt K,Peschers U,Kentenich H

更新日期：2015-08-17 00:00:00

abstract：BACKGROUND:An estimated 200 to 500 patients develop life-threatening acute liver failure (ALF) in Germany each year. Only sparse data are currently available on the epidemiology and causes of this condition and on potential treatments for it. This article summarizes our current knowledge of the causes, clinical course,...

journal_title：Deutsches Arzteblatt international

authors： Canbay A,Tacke F,Hadem J,Trautwein C,Gerken G,Manns MP

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:Pre-hospital hypotension in trauma patients is associated with high mortality. Especially for patients with severe traumatic brain injury (TBI), arterial normotension or even hypertension (AHT) is considered an important mechanism for sustaining adequate cerebral perfusion pressure. The effect of pre-hospita...

journal_title：Deutsches Arzteblatt international

authors： Sellmann T,Miersch D,Kienbaum P,Flohé S,Schneppendahl J,Lefering R,DGU Trauma Registry.

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Patients with acquired brain injury who have been discharged from inpatient neurological rehabilitation often continue to suffer from limited independence, participation, and quality of life. Participation-focused outpatient treatment (in German: teilhabeorientierte ambulan. METHODS:In a randomized, control...

journal_title：Deutsches Arzteblatt international

authors： Bender A,Adrion C,Fischer L,Huber M,Jawny K,Straube A,Mansmann U

更新日期：2016-09-23 00:00:00

abstract：BACKGROUND:Medication reviews and medication management are being used more and more around the world to improve medication safety. Both of these tools were originally conceived as pharmaceutical care activities and have recently been developed into interdisciplinary approaches. We studied the efficacy of interprofessi...

journal_title：Deutsches Arzteblatt international

authors： Köberlein-Neu J,Mennemann H,Hamacher S,Waltering I,Jaehde U,Schaffert C,Rose O

更新日期：2016-11-04 00:00:00

abstract：BACKGROUND:An estimated 1.4 to 2.6 million people in German suffer from drug dependence. Most of them are long-term users of benzodiazepines (BZD), Z drugs (ZD), or opioid analgesics (OA). METHODS:This analysis is based on prescription data from patients of the national statutory health insurance system in the German ...

journal_title：Deutsches Arzteblatt international

authors： Buth S,Holzbach R,Martens MS,Neumann-Runde E,Meiners O,Verthein U

更新日期：2019-09-13 00:00:00

abstract：BACKGROUND:Because the course of Legg-Calvé-Perthes disease (LCPD) is highly variable, its appropriate diagnostic evaluation and treatment are still debated. METHODS:The authors selectively review the literature, present their own study findings, and discuss the guidelines of the German Society for Orthopedics and Ort...

journal_title：Deutsches Arzteblatt international

authors： Nelitz M,Lippacher S,Krauspe R,Reichel H

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:The many varieties of cystic pancreatic tumor, and especially intraductal papillary mucinous neoplasia (IPMN), have attracted increased attention recently. Their incidence may be rising, and their histopathological evaluation and classification have become more precise than before. METHODS:We discuss the cu...

journal_title：Deutsches Arzteblatt international

authors： Grützmann R,Post S,Saeger HD,Niedergethmann M

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Basically two types of sweating exist: thermoregulatory and emotional sweating. They are controlled by different centers: thermo regulatory sweating is regulated predominantly by the hypothalamus, emotional sweating predominantly by the limbic system. Enhanced sweating, called hyperhidrosis, can be generaliz...

journal_title：Deutsches Arzteblatt international

authors： Schlereth T,Dieterich M,Birklein F

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Optimizing the emergency medical care chain might shorten the time to treatment of patients with ST-elevation myocardial infarction (STEMI). The initial care by a physician, and, in particular, correct ECG interpretation, are critically important factors. METHODS:From 1999 onward, data on the care of patien...

journal_title：Deutsches Arzteblatt international

authors： Stockburger M,Maier B,Fröhlich G,Rutsch W,Behrens S,Schoeller R,Theres H,Poloczek S,Plock G,Schühlen H

更新日期：2016-07-25 00:00:00

abstract：BACKGROUND:Habitually shortened nighttime sleep is a common phenomenon in childhood and adolescence, sometimes associated with chronic sleep reduction (CSR). CSR is associated with impairments of performance ability and emotional well-being. The extent to which children and adolescents in Germany suffer from CSR is unc...

journal_title：Deutsches Arzteblatt international

authors： Paschke K,Laurenz L,Thomasius R

更新日期：2020-10-02 00:00:00

abstract：BACKGROUND:Monoclonal antibodies (mAb) and fusion proteins (FP) are increasingly being used in children and adolescents. In this review, we analyze the evidence for their safety and efficacy in the treatment of the most common chronic inflammatory diseases. METHODS:We systematically searched PubMed, AWMF.org, and othe...

journal_title：Deutsches Arzteblatt international

authors： Niehues T,Özgür TT

更新日期：2019-10-18 00:00:00

abstract：BACKGROUND:High-altitude travel, for mountain climbing, trekking, or sightseeing, has become very popular. Therefore, the awareness of its dangers has increased, and many prospective travelers seek medical advice before setting forth on their trip. METHODS:We selectively searched the literature for relevant original a...

journal_title：Deutsches Arzteblatt international

authors： Schommer K,Bärtsch P

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Multiple sclerosis (MS) is the most common autoimmune disease of the central nervous system. There are at least 150 000 persons with MS in Germany. Recent years have seen the approval of new drugs against. METHODS:This article is based on pertinent literature retrieved by a selective search in PubMed as wel...

journal_title：Deutsches Arzteblatt international

authors： Havla J,Warnke C,Derfuss T,Kappos L,Hartung HP,Hohlfeld R

更新日期：2016-12-26 00:00:00

abstract：BACKGROUND:Delirium is a common complication in elderly hospitalized patients. It prolongs the length of hospital stay, raises costs, increases the workload of the nursing staff, and may necessitate transfer of the patient to a nursing home. The risk of postoperative delirium is particularly high in elderly patients wi...

journal_title：Deutsches Arzteblatt international

authors： Kratz T,Heinrich M,Schlauß E,Diefenbacher A

更新日期：2015-04-24 00:00:00

abstract：BACKGROUND:The treatment of pregnant women who have illnesses unrelated to pregnancy can cause uncertainty among physicians. METHODS:We searched the PubMed database and specialty guidelines from Germany and abroad (the guidelines of the German Society for Gynecology and Obstetrics, the American Congress of Obstetri ci...

journal_title：Deutsches Arzteblatt international

authors： Bolz M,Körber S,Reimer T,Buchmann J,Schober HC,Briese V

更新日期：2017-09-15 00:00:00

abstract：BACKGROUND:Pilonidal disease is an acute or chronic infection in the subcutaneous fatty tissue, mainly in the natal cleft. Its incidence in Germany in 2012 was 48 cases per 100 000 persons per year. METHODS:This review is based on pertinent publications retrieved by a selective literature search. RESULTS:The numerous...

journal_title：Deutsches Arzteblatt international

authors： Iesalnieks I,Ommer A

更新日期：2019-01-07 00:00:00