Managed Entry Agreements for Oncology Drugs: Lessons from the European Experience to Inform the Future.

abstract：:The skin is the first line of defense against pathogen and other environmental pollutant. The body is constantly exposed to reactive oxygen species (ROS) that stimulates inflammatory process in the skin. Many studies have linked ROS to various inflammatory skin diseases. Patients with skin diseases face various challe...

journal_title：Frontiers in pharmacology

authors： Choo WT,Teoh ML,Phang SM,Convey P,Yap WH,Goh BH,Beardall J

更新日期：2020-07-31 00:00:00

abstract：:Neurodegenerative pathologies are among the most serious and socially significant problems of modern medicine, along with cardiovascular and oncological diseases. Several attempts have been made to prevent neuronal death using novel drugs targeted to the cell calcium signaling machinery, but the lack of adequate model...

journal_title：Frontiers in pharmacology

authors： Vigont V,Nekrasov E,Shalygin A,Gusev K,Klushnikov S,Illarioshkin S,Lagarkova M,Kiselev SL,Kaznacheyeva E

更新日期：2018-06-29 00:00:00

abstract：:Short QT syndrome (SQTS) is associated with sudden cardiac arrest. There are limited data on the impact of antiarrhythmic drugs on the outcome of SQTS. Materials and Methods: We studied data that describe the clinical outcome of 62 SQTS patients treated with antiarrhythmic drugs, who were recruited from a pool of pati...

journal_title：Frontiers in pharmacology

authors： El-Battrawy I,Besler J,Li X,Lan H,Zhao Z,Liebe V,Schimpf R,Lang S,Wolpert C,Zhou X,Akin I,Borggrefe M

更新日期：2019-08-02 00:00:00

abstract：:Background and Objectives: Although the relationship between the use of proton pump inhibitors (PPIs) and pulmonary tuberculosis (TB) in Taiwan published in 2014. Due to just only one article and not enough comprehensively, we explore this issue. Methods: We conducted a population-based case-control study to identify ...

journal_title：Frontiers in pharmacology

authors： Cheng KC,Liao KF,Lin CL,Lai SW

更新日期：2017-07-19 00:00:00

abstract：:Objective: Prevalence of osteoporosis in Chinese postmenopausal women has significantly increased over the past decade and oral bisphosphonates are the most potent antiresorptive drugs. The purpose of the present research was to evaluate the cost-effectiveness of oral alendronate for individuals with osteoporosis. We ...

journal_title：Frontiers in pharmacology

authors： You R,Liu Z

更新日期：2020-11-16 00:00:00

abstract：:Bacterial foodborne pathogens are a significant health burden and the recent emergence of pathogenic resistant strains due to the excessive use of antibiotics makes it more difficult to effectively treat infections as a result of contaminated food. Awareness of this impending health crisis has spurred the search for a...

journal_title：Frontiers in pharmacology

authors： Ma DSL,Tan LT,Chan KG,Yap WH,Pusparajah P,Chuah LH,Ming LC,Khan TM,Lee LH,Goh BH

更新日期：2018-02-19 00:00:00

abstract：:Gap junctions are comprised of connexins that form cell-to-cell channels which couple neighboring cells to accommodate the exchange of information. The need for communication does, however, change over time and therefore must be tightly controlled. Although the regulation of connexin protein expression by transcriptio...

journal_title：Frontiers in pharmacology

authors： Axelsen LN,Calloe K,Holstein-Rathlou NH,Nielsen MS

更新日期：2013-10-22 00:00:00

abstract：:Arsenic trioxide is a traditional remedy in Chinese Medicine since ages. Nowadays, it is clinically used to treat acute promyelocytic leukemia (APL) by targeting PML/RARA. However, the drug's activity is broader and the mechanisms of action in other tumor types remain unclear. In this study, we investigated molecular ...

journal_title：Frontiers in pharmacology

authors： Dawood M,Hamdoun S,Efferth T

更新日期：2018-02-27 00:00:00

abstract：:Diabetic nephropathy (DN) is one of the main causes of renal fibrosis and is associated with high morbidity and mortality. Traditional Chinese Medicine (TCM) therapy has a long history of usage in a clinical setting and its usage is increasing. ErHuang Formula (EHF), a Chinese herbal compound, has been clinically used...

journal_title：Frontiers in pharmacology

authors： Shen YL,Jiang YP,Li XQ,Wang SJ,Ma MH,Zhang CY,Zhu JY,Rahman K,Zhang LJ,Luan X,Zhang H

更新日期：2020-01-24 00:00:00

abstract：:Traditional Chinese medicine is one of the complementary and alternative therapies to improve the prognosis of coronary heart disease (CHD). Taohong Siwu Decoction (THSWD), a classical traditional Chinese medication that promotes blood circulation, is clinically beneficial in CHD. However, the underlying mechanism of ...

journal_title：Frontiers in pharmacology

authors： Tao T,He T,Mao H,Wu X,Liu X

更新日期：2020-05-08 00:00:00

abstract：:Nowadays, we are experiencing the big data era with the emerging challenge of single data interpretation. Although the advent of high-throughput technologies as well as chemo- and bio-informatics tools presents pan-omics data as the way forward to precision medicine, personalized health care and tailored-made therapeu...

journal_title：Frontiers in pharmacology

authors： Balasopoulou A,Patrinos GP,Katsila T

更新日期：2016-10-27 00:00:00

abstract：:Diverse neuropsychiatric disorders present dysfunctional memory and no effective treatment exits for them; likely as result of the absence of neural markers associated to memory. Neurotransmitter systems and signaling pathways have been implicated in memory and dysfunctional memory; however, their role is poorly under...

journal_title：Frontiers in pharmacology

authors： Meneses A

更新日期：2015-07-21 00:00:00

abstract：:[This corrects the article on p. 3 in vol. 6, PMID: 25741280.]. ...

journal_title：Frontiers in pharmacology

authors： Horbach T,Götz C,Kietzmann T,Dimova EY

更新日期：2016-04-05 00:00:00

abstract：:Oral cancers refer to malignant tumors associated with high morbidity and mortality, and oral squamous cell carcinoma accounts for the majority of cases. It is an important part of head and neck, and oral cancer is one of the six most common cancers in the world. At present, the traditional treatment methods for oral ...

journal_title：Frontiers in pharmacology

authors： Zhao Z,Li D,Wu Z,Wang Q,Ma Z,Zhang C

更新日期：2020-12-17 00:00:00

abstract：:Mint [Mentha longifolia (L.) Hudson] is an aromatic plant that belongs to Lamiaceae family. It is traditionally used as herbal tea in Europe, Australia and North Africa and shows numerous pharmacological effects, such as spasmolytic, antioxidant, antimicrobial and anti-hemolytic. Recently, its antiproliferative role h...

journal_title：Frontiers in pharmacology

authors： Patti F,Palmioli A,Vitalini S,Bertazza L,Redaelli M,Zorzan M,Rubin B,Mian C,Bertolini C,Iacobone M,Armanini D,Barollo S,Airoldi C,Iriti M,Pezzani R

更新日期：2020-02-10 00:00:00

abstract：Background:MicroRNAs are known to regulate carcinogenesis of osteosarcoma. Although, miR-16-5p is known to exert inhibitory effects on several forms of cancers, its effects on the growth and invasion of osteosarcoma have not been studied. Methods:We collected human osteosarcoma specimens and adjacent tissues to detect...

journal_title：Frontiers in pharmacology

authors： Gu Z,Li Z,Xu R,Zhu X,Hu R,Xue Y,Xu W

更新日期：2020-08-26 00:00:00

abstract：:With the highest cancer incidence rate, lung cancer, especially non-small cell lung cancer (NSCLC), is the leading cause of cancer death in the world. Tea (leaves of Camellia sinensis) has been widely used as a traditional beverage beneficial to human health, including anti-NSCLC activity. Theabrownin (TB) is one majo...

journal_title：Frontiers in pharmacology

authors： Wu F,Zhou L,Jin W,Yang W,Wang Y,Yan B,Du W,Zhang Q,Zhang L,Guo Y,Zhang J,Shan L,Efferth T

更新日期：2016-12-02 00:00:00

abstract：:Hachimijiogan (HJG) is a traditional herbal medicine that improves anxiety disorders in patients with dementia. In this study, we tested the hypothesis that HJG exerts neurotrophic factor-like effects to ameliorate memory impairment in Alzheimer disease (AD) model rats. First, we describe that HJG acts to induce neuri...

journal_title：Frontiers in pharmacology

authors： Kubota K,Fukue H,Sato H,Hashimoto K,Fujikane A,Moriyama H,Watanabe T,Katsurabayashi S,Kainuma M,Iwasaki K

更新日期：2017-11-21 00:00:00

abstract：:Hypertension-induced cardiac apoptosis is a major contributor to early-stage heart-failure. Our previous studies have found that p53-mediated mitochondrial fission is involved in aldosterone-induced podocyte apoptosis. However, it is not clear that whether p53-induced mitochondrial fission is critical for hypertensive...

journal_title：Frontiers in pharmacology

authors： Qi J,Wang F,Yang P,Wang X,Xu R,Chen J,Yuan Y,Lu Z,Duan J

更新日期：2018-03-09 00:00:00

abstract：:Background and Aims:Kickxia ramosissima (Wall.) Janch (or Nanorrhinum ramosissimum (Wall.) Betsche is a well-known medicinal plant in Pakistan that is traditionally used in diabetic and inflammatory conditions. Because little information is available on its phytochemical composition, a range of constituents were isola...

journal_title：Frontiers in pharmacology

authors： Amin A,Tuenter E,Foubert K,Iqbal J,Cos P,Maes L,Exarchou V,Apers S,Pieters L

更新日期：2017-05-01 00:00:00

abstract：:Using pharmacogenetics in guiding drug therapy experiences a steady increase in uptake, although still leads to discussions as to its clinical use. Psychiatry constitutes a field where pharmacogenomic testing might help in guiding drug therapy. To address current challenges, this minireview provides an update regardin...

journal_title：Frontiers in pharmacology

authors： van Schaik RHN,Müller DJ,Serretti A,Ingelman-Sundberg M

更新日期：2020-09-11 00:00:00

abstract：:Hairy cell leukemia (HCL) is a chronic lymphoproliferative B-cell disorder where the B-RAF V600E mutation has been recently detected, as reported for solid neoplasias but not for other B-cell lymphomas. The digital droplet PCR (dd-PCR) is a molecular technique that, without standard references, is able to accurately q...

journal_title：Frontiers in pharmacology

authors： Guerrini F,Paolicchi M,Ghio F,Ciabatti E,Grassi S,Salehzadeh S,Ercolano G,Metelli MR,Del Re M,Iovino L,Petrini I,Carulli G,Cecconi N,Rousseau M,Cervetti G,Galimberti S

更新日期：2016-10-13 00:00:00

abstract：:Photodamages caused by UVA radiation induced oxidative injuries are closely related to photoaging and skin cancer. Paeoniflorin (PF), extracted from the root of Paeonia lactiflora, has been reported to be an effective antioxidant. PLIN2, known as adipose differentiation-related protein, has been previously involved in...

journal_title：Frontiers in pharmacology

authors： Lu YS,Jiang Y,Yuan JP,Jiang SB,Yang Y,Zhu PY,Sun YZ,Qi RQ,Liu T,Wang HX,Wu Y,Gao XH,Chen HD

更新日期：2020-05-15 00:00:00

abstract：:Intestinal barrier dysfunction is an important clinical problem in various acute and chronic pathological conditions. Ferulic acid (FA) can attenuate the intestinal epithelial barrier dysfunction, however, the underlying mechanism remains unclear. The present study aimed to uncover the protective effect of FA on intes...

journal_title：Frontiers in pharmacology

authors： He S,Guo Y,Zhao J,Xu X,Wang N,Liu Q

更新日期：2020-04-03 00:00:00

abstract：:Background: Inhibiting proliferation and inducing apoptosis of myofibroblasts is becoming one of the promising and effective ways to treat hypertrophic scar. ABT-263, as an orally bioavailable BCL-2 family inhibitor, has showed great antitumor characteristics by targeting tumor cell apoptosis. The objective of this st...

journal_title：Frontiers in pharmacology

authors： Yang X,Xiao Y,Zhong C,Shu F,Xiao S,Zheng Y,Xia Z

更新日期：2021-01-14 00:00:00

abstract：:The skin is the main barrier that protects us against environmental stressors (physical, chemical, and biological). These stressors, combined with internal factors, are responsible for cutaneous aging. Furthermore, they negatively affect the skin and increase the risk of cutaneous diseases, particularly skin cancer. T...

journal_title：Frontiers in pharmacology

authors： Parrado C,Mercado-Saenz S,Perez-Davo A,Gilaberte Y,Gonzalez S,Juarranz A

更新日期：2019-07-09 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fphar.2020.00739.]. ...

journal_title：Frontiers in pharmacology

authors： Huang J,Hei GR,Yang Y,Liu CC,Xiao JM,Long YJ,Peng XJ,Yang Y,Zhao JP,Wu RR

更新日期：2020-06-10 00:00:00

abstract：:Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene and remains the most common life-shortening diseases affecting the exocrine organs. The absence of this channel results in an imbalance of ion concentrations across the cell membrane and results in more a...

journal_title：Frontiers in pharmacology

authors： Bardin P,Sonneville F,Corvol H,Tabary O

更新日期：2018-10-08 00:00:00

abstract：:Melanoma immunotherapy, specifically the autotransplant of dendritic cells charged with tumors antigens, has shown promising results in clinical trials. The positive clinical effects of this therapy have been associated to increased Th17 response and delayed-type hypersensitivity (DTH) against to tumor antigens. Some ...

journal_title：Frontiers in pharmacology

authors： Robles-Planells C,Michelson SA,Mena J,Escrig D,Rojas JL,Sanchez-Guerrero G,Hernández R,Barrera-Avalos C,Rojo LE,Sauma D,Kalergis AM,Imarai M,Fernández R,Robles CA,Leiva-Salcedo E,Santander R,Escobar A,Acuña-Castillo C

更新日期：2019-10-22 00:00:00

abstract：:Hupresin is a new affinity resin that binds butyrylcholinesterase (BChE) in human plasma and acetylcholinesterase (AChE) solubilized from red blood cells (RBC). Hupresin is available from the CHEMFORASE company. BChE in human plasma binds to Hupresin and is released with 0.1 M trimethylammonium bromide (TMA) with full...

journal_title：Frontiers in pharmacology

authors： Onder S,David E,Tacal O,Schopfer LM,Lockridge O

更新日期：2017-10-10 00:00:00