Abstract:
:In this short review, we want to summarize the current findings on the role of vitamin-D in multiple sclerosis (MS), schizophrenia, and autism. Many studies have highlighted hypovitaminosis-D as a potential environmental risk factor for a variety of conditions such as MS, asthma, cardiovascular disease, and, more recently, psychiatric diseases. However, whether hypovitaminosis-D is a potential causative factor for the development or activity in these conditions or whether hypovitaminosis-D may be due to increased vitamin-D consumption by an activated immune system (reverse causation) is the focus of intense research. Here, we will discuss current evidence exploring the role of vitamin-D in MS, schizophrenia, and autism and its impact on adaptive and innate immunity, antimicrobial defense, the microbiome, neuroinflammation, behavior, and neurogenesis. More work is needed to gain insight into its role in the underlying pathophysiology of these conditions as it may offer attractive means of intervention and prevention.
journal_name
Front Psychiatryjournal_title
Frontiers in psychiatryauthors
Kočovská E,Gaughran F,Krivoy A,Meier UCdoi
10.3389/fpsyt.2017.00047subject
Has Abstractpub_date
2017-03-27 00:00:00pages
47issn
1664-0640journal_volume
8pub_type
杂志文章,评审abstract:Background:Depression has become one of the most common problems faced by athletes. In many mental health problems, its production and development mechanisms and influencing factors have received full attention from researchers, whereas boxers' depression has received limited attention. This study explored the relation...
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