Microbial Neuraminidase Induces a Moderate and Transient Myelin Vacuolation Independent of Complement System Activation.

abstract：:Several studies have demonstrated the advantages of the bilateral vs. unilateral cochlear implantation in listeners with bilateral severe to profound hearing loss. However, it remains unclear to what extent bilaterally implanted listeners have access to binaural cues, e.g., accurate processing of interaural timing dif...

journal_title：Frontiers in neurology

authors： Ausili SA,Agterberg MJH,Engel A,Voelter C,Thomas JP,Brill S,Snik AFM,Dazert S,Van Opstal AJ,Mylanus EAM

更新日期：2020-09-30 00:00:00

abstract：:Background and objective: The trajectories of long-term and domain-specific cognitive alterations over a decade after stroke are largely unknown. This study aims to investigate the dynamic alterations of domain-specific cognitive performance among young stroke survivors over 10 years after their first stroke. Methods:...

journal_title：Frontiers in neurology

authors： Elgh E,Hu X

更新日期：2019-02-12 00:00:00

abstract：:Humans evolved a symbiotic relationship with their gut microbiome, a complex microbial community composed of bacteria, archaea, protists, and viruses, including bacteriophages. The enteric nervous system (ENS) is a gateway for the bidirectional communication between the brain and the gut, mostly through the vagus nerv...

journal_title：Frontiers in neurology

authors： Santos SF,de Oliveira HL,Yamada ES,Neves BC,Pereira A Jr

更新日期：2019-06-04 00:00:00

abstract：:Parkinson's disease (PD) is a common neurodegenerative disorder characterized by loss of dopamine neurons. Since a seminal report was published in the early twentieth century, a growing body of literature has suggested that patients with PD display characteristic personality traits, such as cautiousness and inflexibil...

journal_title：Frontiers in neurology

authors： Abe N,Kawasaki I,Hosokawa H,Baba T,Takeda A

更新日期：2018-05-24 00:00:00

abstract：:Numerous studies suggest that the increased activity of p38MAPK plays an important role in the abnormal immune and inflammatory response observed in the course of neurodegenerative diseases such as Alzheimer's disease. On the other hand, high levels of p38MAPK are present in the brain during normal aging, suggesting t...

journal_title：Frontiers in neurology

authors： Martín-Segura A,Casadomé-Perales Á,Fazzari P,Mas JM,Artigas L,Valls R,Nebreda AR,Dotti CG

更新日期：2019-06-25 00:00:00

abstract：:Major advances in neonatal care have led to significant improvements in survival rates for preterm infants, but this occurs at a cost, with a strong causal link between preterm birth and neurological deficits, including cerebral palsy (CP). Indeed, in high-income countries, up to 50% of children with CP were born pret...

journal_title：Frontiers in neurology

authors： Li J,McDonald CA,Fahey MC,Jenkin G,Miller SL

更新日期：2014-10-09 00:00:00

abstract：:Myasthenia gravis (MG) is the most common autoimmune disorder affecting the neuromuscular junction, characterized by skeletal muscle weakness and fatigability. It is caused by autoantibodies targeting proteins of the neuromuscular junction; ~85% of MG patients have autoantibodies against the muscle acetylcholine recep...

journal_title：Frontiers in neurology

authors： Lazaridis K,Tzartos SJ

更新日期：2020-11-30 00:00:00

abstract：:Background: Non-invasive brain-computer interfaces (BCI) represent an emerging technology for enabling persons with impaired or lost grasping and reaching functions due to high spinal cord injury (SCI) to control assistive devices. A major drawback of BCIs is a high rate of false classifications. The robustness and pe...

journal_title：Frontiers in neurology

authors： Keyl P,Schneiders M,Schuld C,Franz S,Hommelsen M,Weidner N,Rupp R

更新日期：2019-01-31 00:00:00

abstract：:Animal models of concussion, traumatic brain injury (TBI), and chronic traumatic encephalopathy (CTE) are widely available and routinely deployed in laboratories around the world. Effective animal modeling requires careful consideration of four basic principles. First, animal model use must be guided by clarity of def...

journal_title：Frontiers in neurology

authors： Wojnarowicz MW,Fisher AM,Minaeva O,Goldstein LE

更新日期：2017-06-01 00:00:00

abstract：:In order to better understand how to identify and treat student-athletes who experience concussions, better insight into reporting behavior of athletes is needed. This study aims to identify information influencing athletes' attitudes toward reporting their concussions and the perceived trajectory of their recovery bo...

journal_title：Frontiers in neurology

authors： Oddo A,O'Conor E,Shore S,Piraino M,Gibney K,Tsao J,Stanfill AG

更新日期：2019-07-05 00:00:00

abstract：BACKGROUND:The neural constraints underlying hemiparetic gait dysfunction are associated with abnormal kinetic outflow and altered muscle synergy structure. Recent evidence from our lab implicates the lesioned hemisphere in mediating the expression of abnormally coupled hip adduction and knee extension synergy, suggest...

journal_title：Frontiers in neurology

authors： Tan AQ,Dhaher YY

更新日期：2017-08-07 00:00:00

abstract：INTRODUCTION:Fatigue is the most frequently reported persistent symptom following a mild traumatic brain injury (mTBI), but the explanations for the persisting fatigue symptoms in mTBI remain controversial. In this study, we investigated the change of cerebral blood flow during the performance of a psychomotor vigilanc...

journal_title：Frontiers in neurology

authors： Möller MC,Nordin LE,Bartfai A,Julin P,Li TQ

更新日期：2017-09-21 00:00:00

abstract：:Purpose: Stroke-associated pneumonia (SAP), a common complication in acute ischemic stroke (AIS) patients, is associated with poor prognosis after AIS. Inflammation plays an important role in the development of SAP. In this study, we aimed to explore the association between the monocyte-to-lymphocyte ratio (MLR) and S...

journal_title：Frontiers in neurology

authors： Cheng HR,Song JY,Zhang YN,Chen YB,Lin GQ,Huang GQ,He JC,Wang Z

更新日期：2020-10-06 00:00:00

abstract：:Spontaneous intracerebral hemorrhage (SICH) is the most lethal type of stroke. Half of these deaths occur within the acute phase. Frequently observed deterioration during the acute phase is often due to rebleeding or peri-hematomal expansion. The exact pathogenesis that leads to rebleeding or peri-hemorrhagic edema re...

journal_title：Frontiers in neurology

authors： Babi MA,James ML

更新日期：2017-01-19 00:00:00

abstract：:This chapter overviews research neuroimaging findings of patients with medication-overuse headache (MOH). Results indicate; (i) correlations between neuropathology and medication-overuse; (ii) changes in brain morphology and cortical function; and (iii) brain recovery subsequent to withdrawal of medication that was ov...

journal_title：Frontiers in neurology

authors： Chong CD

更新日期：2020-01-28 00:00:00

abstract：:Background: Listeria rhombencephalitis, infection of the brainstem with Listeria monocytogenes, occurs mainly in humans and farmed ruminants and is associated with high fatality rates. Small ruminants (goats and sheep) are a large animal model due to neuropathological similarities. The purpose of this study was to def...

journal_title：Frontiers in neurology

authors： Precht C,Vermathen P,Henke D,Staudacher A,Lauper J,Seuberlich T,Oevermann A,Schweizer-Gorgas D

更新日期：2020-12-14 00:00:00

abstract：:The interaction of Mesial Temporal Lobe Epilepsy (mTLE) with the circadian system control is apparent from an oscillatory pattern of limbic seizures, daytime's effect on seizure onset and the efficacy of antiepileptic drugs. Moreover, seizures per se can interfere with the biological rhythm output, including circadian...

journal_title：Frontiers in neurology

authors： Matos HC,Koike BDV,Pereira WDS,de Andrade TG,Castro OW,Duzzioni M,Kodali M,Leite JP,Shetty AK,Gitaí DLG

更新日期：2018-08-02 00:00:00

abstract：:Attention impairment may provide a cohesive neurobiological explanation for clusters of clinical symptoms that occur after a concussion; therefore, objective quantification of attention is needed. Visually tracking a moving target is an attention-dependent sensorimotor function, and eye movement can be recorded easily...

journal_title：Frontiers in neurology

authors： Maruta J,Spielman LA,Rajashekar U,Ghajar J

更新日期：2018-07-26 00:00:00

abstract：:SARS-CoV-2 is a highly pathogenic coronavirus that has caused an ongoing worldwide pandemic. Emerging in Wuhan, China in December 2019, the virus has spread rapidly around the world. Corona virus disease 2019 (COVID-19), which is caused by SARS-CoV-2, has resulted in significant morbidity and mortality. The most promi...

journal_title：Frontiers in neurology

authors： Khateb M,Bosak N,Muqary M

更新日期：2020-06-23 00:00:00

abstract：:Background: Differentiating idiopathic Parkinson's disease (IPD) from atypical Parkinsonian disorders (APD) is challenging, especially in early disease stages. Postural instability and gait difficulty (PIGD) are substantial motor impairments of IPD and APD. Clinical evidence implies that patients with APD have larger ...

journal_title：Frontiers in neurology

authors： Gaßner H,Raccagni C,Eskofier BM,Klucken J,Wenning GK

更新日期：2019-01-22 00:00:00

abstract：BACKGROUND AND PURPOSE:The aim of this study was to systematically review the efficacy and tolerability of gabapentin in the treatment of sleep disturbance in patients with medical illness. METHODS:PubMed was searched for randomized, double-blinded, placebo-controlled trials that reported sleep changes during gabapent...

journal_title：Frontiers in neurology

authors： Liu GJ,Karim MR,Xu LL,Wang SL,Yang C,Ding L,Wang YF

更新日期：2017-07-14 00:00:00

abstract：:During neurorehabilitation, clinical measurements are widely adopted to evaluate behavioral improvements after treatment. However, it is not able to identify or monitor the change of central nervous system (CNS) of each individual patient. Resting-state functional magnetic resonance imaging (rs-fMRI) has been widely u...

journal_title：Frontiers in neurology

authors： Ge Y,Pan Y,Wu Q,Dou W

更新日期：2019-11-01 00:00:00

abstract：Background:There is increasing interest in stem cell therapy as another treatment modality in stroke, particularly for patients who are unable to receive endovascular clot retrieval or thrombolysis therapies, or for whom standard treatment has failed. We have recently shown that human amniotic epithelial cells (hAECs) ...

journal_title：Frontiers in neurology

authors： Phan TG,Ma H,Lim R,Sobey CG,Wallace EM

更新日期：2018-06-07 00:00:00

abstract：:Objective: The objective of this study was to investigate the roles and mechanisms of inflammatory mediators NLRP3 and IL-1β in refractory temporal epilepsy brain injury. Method: First, the brain tissue and the peripheral blood of children undergoing intractable temporal lobe epilepsy surgery were analyzed as research...

journal_title：Frontiers in neurology

authors： Wu C,Zhang G,Chen L,Kim S,Yu J,Hu G,Chen J,Huang Y,Zheng G,Huang S

更新日期：2020-02-07 00:00:00

abstract：:Background: Elderly patients account for 30% of acute ischemic stroke (AIS) but are under-represented in randomized controlled trials of endovascular thrombectomy (EVT). Meta-analysis of "real world" studies evaluating 90-day outcomes in elderly patients ≥80 years have been limited to small numbers undergoing EVT with...

journal_title：Frontiers in neurology

authors： Sharobeam A,Cordato DJ,Manning N,Cheung A,Wenderoth J,Cappelen-Smith C

更新日期：2019-03-20 00:00:00

abstract：:Antiphospholipid syndrome (APS) is an autoimmune antibody-mediated condition characterized by thrombotic events and/or pregnancy morbidity in association with persistent positivity to antiphospholipid antibodies (aPL). The nervous system is frequently affected, as intracranial vessels are the most frequent site of art...

journal_title：Frontiers in neurology

authors： Fleetwood T,Cantello R,Comi C

更新日期：2018-11-26 00:00:00

abstract：:Accurate prediction of the early stage of Alzheimer's disease (AD) is important but very challenging. The goal of this study was to utilize predictors for diagnosis conversion to AD based on integrating resting-state functional MRI (rs-fMRI) connectivity analysis and structural MRI (sMRI). We included 177 subjects in ...

journal_title：Frontiers in neurology

authors： Hojjati SH,Ebrahimzadeh A,Babajani-Feremi A

更新日期：2019-08-30 00:00:00

abstract：:New-onset refractory status epilepticus (NORSE) is a rare but challenging condition occurring in a previously healthy patient, often with no identifiable cause. We describe the electro-clinical features and outcomes in a group of patients with NORSE who all demonstrated a typical magnetic resonance imaging (MRI) sign ...

journal_title：Frontiers in neurology

authors： Meletti S,Giovannini G,d'Orsi G,Toran L,Monti G,Guha R,Kiryttopoulos A,Pascarella MG,Martino T,Alexopoulos H,Spilioti M,Slonkova J

更新日期：2017-03-27 00:00:00

abstract：:Purpose: Rapid muscle fatigue limits clinical applications of functional electrical stimulation (FES) for individuals with motor impairments. This study aimed to characterize the sustainability of muscle force elicited with a novel transcutaneous nerve stimulation technique. Method: A hemiplegic chronic stroke survivo...

journal_title：Frontiers in neurology

authors： Zheng Y,Shin H,Hu X

更新日期：2018-12-04 00:00:00

abstract：:Cyclooxygenase (COX)-2 and matrix metalloproteinase (MMP)-9 are two crucial mediators contributing to blood-brain barrier (BBB) damage during cerebral ischemia. However, it is not known whether MMP-9 activation is involved in COX-2-mediated BBB disruption in ischemic stroke. In this study, we hypothesized that genetic...

journal_title：Frontiers in neurology

authors： Yang C,Yang Y,DeMars KM,Rosenberg GA,Candelario-Jalil E

更新日期：2020-08-20 00:00:00