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Classics in Chemical Neuroscience: Haloperidol.

Abstract：

:The discovery of haloperidol catalyzed a breakthrough in our understanding of the biochemical basis of schizophrenia, improved the treatment of psychosis, and facilitated deinstitutionalization. In doing so, it solidified the role for chemical neuroscience as a means to elucidate the molecular underpinnings of complex neuropsychiatric disorders. In this Review, we will cover aspects of haloperidol's synthesis, manufacturing, metabolism, pharmacology, approved and off-label indications, and adverse effects. We will also convey the fascinating history of this classic molecule and the influence that it has had on the evolution of neuropsychopharmacology and neuroscience.

journal_name

ACS Chem Neurosci

journal_title

ACS chemical neuroscience

authors

Tyler MW,Zaldivar-Diez J,Haggarty SJ

doi

10.1021/acschemneuro.7b00018

subject

Has Abstract

pub_date

2017-03-15 00:00:00

pages

444-453

issue

3

issn

1948-7193

journal_volume

8

pub_type

杂志文章

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