Enhanced Burst-Suppression and Disruption of Local Field Potential Synchrony in a Mouse Model of Focal Cortical Dysplasia Exhibiting Spike-Wave Seizures.

abstract：:Cortical sensory systems are active with rich patterns of activity during sleep and under light anesthesia. Remarkably, this activity shares many characteristics with those present when the awake brain responds to sensory stimuli. We review two specific forms of such activity: slow-wave activity (SWA) in the adult bra...

journal_title：Frontiers in neural circuits

authors： McVea DA,Murphy TH,Mohajerani MH

更新日期：2016-12-21 00:00:00

abstract：:Complex motor behaviors are thought to be coordinated by networks of brain nuclei that may control different elementary motor programs. Transparent zebrafish larvae offer the opportunity to analyze the functional organization of motor control networks by optical manipulations of neuronal activity during behavior. We e...

journal_title：Frontiers in neural circuits

authors： Fajardo O,Zhu P,Friedrich RW

更新日期：2013-04-17 00:00:00

abstract：:Serotonin (5-HT) selectively excites subpopulations of pyramidal neurons in the neocortex via activation of 5-HT2A (2A) receptors coupled to Gq subtype G-protein alpha subunits. Gq-mediated excitatory responses have been attributed primarily to suppression of potassium conductances, including those mediated by KV7 pot...

journal_title：Frontiers in neural circuits

authors： Stephens EK,Baker AL,Gulledge AT

更新日期：2018-01-18 00:00:00

abstract：:Multiple components of "γ-oscillations" between 30-170 Hz in the CA1 region of the hippocampus have been described, based on their coherence with oscillations in other brain regions and on their cross-frequency coupling with local θ-oscillations. However, it remains unclear whether the different sub-bands are generate...

journal_title：Frontiers in neural circuits

authors： Balakrishnan S,Pearce RA

更新日期：2015-01-12 00:00:00

abstract：:Complex spatial representations in the hippocampal formation and related cortical areas require input from the head direction system. However, a recurrent finding is that behavior apparently supported by these spatial representations does not appear to require input from generative head direction regions, i.e., latera...

journal_title：Frontiers in neural circuits

authors： Dillingham CM,Vann SD

更新日期：2019-09-13 00:00:00

abstract：:One of the large remaining challenges in the field of zebrafish neuroscience is the establishment of techniques and preparations that permit the recording and perturbation of neural activity in animals that can interact meaningfully with the environment. Since it is very difficult to do this in freely behaving zebrafi...

journal_title：Frontiers in neural circuits

authors： Engert F

更新日期：2013-01-25 00:00:00

abstract：:Optogenetic stimulation of the mouse cortex can be used to generate motor maps that are similar to maps derived from electrode-based stimulation. Here we present a refined set of procedures for repeated light-based motor mapping in ChR2-expressing mice implanted with a bilateral thinned-skull chronic window and a chro...

journal_title：Frontiers in neural circuits

authors： Silasi G,Boyd JD,Ledue J,Murphy TH

更新日期：2013-07-25 00:00:00

abstract：:Both abnormalities of resting-state cerebral blood flow (CBF) and functional connectivity in Wilson's disease (WD) have been identified by several studies. Whether the coupling of CBF and functional connectivity is imbalanced in WD remains largely unknown. To assess this possibility, 27 patients with WD and 27 sex- an...

journal_title：Frontiers in neural circuits

authors： Hu S,Wu H,Xu C,Wang A,Wang Y,Shen T,Huang F,Kan H,Li C

更新日期：2019-04-18 00:00:00

abstract：:How do local circuits in the inferior colliculus (IC) process and transform spectral and temporal sound information? Using a four-tetrode array we examined the functional properties of the IC and metrics of its micro circuitry by recording neural activity from neighboring single neurons in the cat. Spectral and tempor...

journal_title：Frontiers in neural circuits

authors： Chen C,Rodriguez FC,Read HL,Escabí MA

更新日期：2012-09-27 00:00:00

abstract：:Water-homeostasis is a fundamental physiological process for terrestrial life. In vertebrates, thirst drives water intake, but the neuronal circuits that connect the physiology of water regulation with emotional context are poorly understood. Vasopressin (VP) is a prominent messenger in this circuit, as well as L-glut...

journal_title：Frontiers in neural circuits

authors： Zhang L,Hernández VS,Vázquez-Juárez E,Chay FK,Barrio RA

更新日期：2016-03-31 00:00:00

abstract：:The primary (S1) and secondary (S2) somatosensory cortices project to several trigeminal sensory nuclei. One putative function of these corticofugal projections is the gating of sensory transmission through the trigeminal principal nucleus (Pr5), and some have proposed that S1 and S2 project differentially to the spin...

journal_title：Frontiers in neural circuits

authors： Smith JB,Watson GD,Alloway KD,Schwarz C,Chakrabarti S

更新日期：2015-09-30 00:00:00

abstract：:A moving visual figure may contain first-order signals defined by variation in mean luminance, as well as second-order signals defined by constant mean luminance and variation in luminance envelope, or higher-order signals that cannot be estimated by taking higher moments of the luminance distribution. Separating thes...

journal_title：Frontiers in neural circuits

authors： Aptekar JW,Keles MF,Mongeau JM,Lu PM,Frye MA,Shoemaker PA

更新日期：2014-10-31 00:00:00

abstract：:Recent evidence suggests that parallel synapses from the same axonal branch onto the same dendritic branch have almost identical strength. It has been proposed that this alignment is only possible through learning rules that integrate activity over long time spans. However, learning mechanisms such as spike-timing-dep...

journal_title：Frontiers in neural circuits

authors： Hartmann C,Miner DC,Triesch J

更新日期：2016-01-13 00:00:00

abstract：:Limbic brain regions drive goal-directed behaviors. These behaviors often require dynamic motor responses, but the functional connectome of limbic structures in the diencephalon that control locomotion is not well known. The A11 region, within the posterior diencephalon has been postulated to contribute to motor funct...

journal_title：Frontiers in neural circuits

authors： Koblinger K,Jean-Xavier C,Sharma S,Füzesi T,Young L,Eaton SEA,Kwok CHT,Bains JS,Whelan PJ

更新日期：2018-10-11 00:00:00

abstract：:In drug users, drug-related cues alone can induce dopamine release in the dorsal striatum. Instructive cues activate inputs to the striatum from both dopaminergic and cholinergic neurons, which are thought to work together to support motor learning and motivated behaviors. Imbalances in these neuromodulatory influence...

journal_title：Frontiers in neural circuits

authors： Crittenden JR,Lacey CJ,Lee T,Bowden HA,Graybiel AM

更新日期：2014-05-28 00:00:00

abstract：:Homeostatic regulation of REM sleep drive, as measured by an increase in the number of REM sleep transitions, plays a key role in neuronal and behavioral plasticity (i.e., learning and memory). Deficits in REM sleep homeostatic drive (RSHD) are implicated in the development of many neuropsychiatric disorders. Yet, the...

journal_title：Frontiers in neural circuits

authors： Datta S,Oliver MD

更新日期：2017-09-14 00:00:00

abstract：:Recent advances in imaging tools are inspiring zebrafish researchers to tackle ever more ambitious questions in the neurosciences. Behaviorally fundamental conserved neural networks can now be potentially studied using zebrafish from a brain-wide scale to molecular resolution. In this perspective, we offer a roadmap b...

journal_title：Frontiers in neural circuits

authors： Leung LC,Wang GX,Mourrain P

更新日期：2013-04-24 00:00:00

abstract：:mRNP granules at adult central synapses are postulated to regulate local mRNA translation and synapse plasticity. However, they are very poorly characterized in vivo. Here, in Drosophila olfactory synapses, we present early observations and characterization of candidate synaptic mRNP particles, one of which contains a...

journal_title：Frontiers in neural circuits

authors： Hillebrand J,Pan K,Kokaram A,Barbee S,Parker R,Ramaswami M

更新日期：2010-11-03 00:00:00

abstract：:Genetic labeling of neurons with a specific response feature is an emerging technology for precise dissection of brain circuits that are functionally heterogeneous at the single-cell level. While immediate early gene mapping has been widely used for decades to identify brain regions which are activated by external sti...

journal_title：Frontiers in neural circuits

authors： Kawashima T,Okuno H,Bito H

更新日期：2014-04-23 00:00:00

abstract：:"Dye-coupling", whole-mount immunohistochemistry for gap junction channel protein connexin 35 (Cx35), and freeze-fracture replica immunogold labeling (FRIL) reveal an abundance of electrical synapses/gap junctions at glutamatergic mixed synapses in the 14th spinal segment that innervates the adult male gonopodium of W...

journal_title：Frontiers in neural circuits

authors： Serrano-Velez JL,Rodriguez-Alvarado M,Torres-Vazquez II,Fraser SE,Yasumura T,Vanderpool KG,Rash JE,Rosa-Molinar E

更新日期：2014-06-26 00:00:00

abstract：:CORTICAL GABAERGIC INTERNEURONS IN RODENTS ORIGINATE IN THREE SUBCORTICAL REGIONS: the medial ganglionic eminence (MGE), the lateral/caudal ganglionic eminence (LGE/CGE), and the preoptic area (POA). Each of these neuroepithelial precursor domains contributes different interneuron subtypes to the cortex. Neuronal NOS ...

journal_title：Frontiers in neural circuits

authors： Magno L,Oliveira MG,Mucha M,Rubin AN,Kessaris N

更新日期：2012-09-24 00:00:00

abstract：:Recording of identified neuronal network activity using genetically encoded calcium indicators (GECIs) requires labeling that is cell type-specific and bright enough for the detection of functional signals. However, specificity and strong expression are often not achievable using the same promoter. Here we present a c...

journal_title：Frontiers in neural circuits

authors： Kuhn B,Ozden I,Lampi Y,Hasan MT,Wang SS

更新日期：2012-07-31 00:00:00

abstract：:Parental migration has caused millions of children left behind, especially in China and India. Left-behind children (LBC) have a high risk of mental disorders and may present negative life outcomes in the future. However, little is known whether there are cerebral structural alterations in LBC in relative to those wit...

journal_title：Frontiers in neural circuits

authors： Fu Y,Xiao Y,Du M,Mao C,Fu G,Yang L,Liu X,Sweeney JA,Lui S,Yan Z

更新日期：2019-05-08 00:00:00

abstract：:Fluorescent calcium (Ca(2+)) indicator proteins (FCIPs) are promising tools for functional imaging of cellular activity in living animals. However, they have still not reached their full potential for in vivo imaging of neuronal activity due to limitations in expression levels, dynamic range, and sensitivity for repor...

journal_title：Frontiers in neural circuits

authors： Lütcke H,Murayama M,Hahn T,Margolis DJ,Astori S,Zum Alten Borgloh SM,Göbel W,Yang Y,Tang W,Kügler S,Sprengel R,Nagai T,Miyawaki A,Larkum ME,Helmchen F,Hasan MT

更新日期：2010-04-29 00:00:00

abstract：:The intracerebral local field potential (LFP) is a measure of brain activity that reflects the highly dynamic flow of information across neural networks. This is a composite signal that receives contributions from multiple neural sources, yet interpreting its nature and significance may be hindered by several confound...

journal_title：Frontiers in neural circuits

authors： Herreras O

更新日期：2016-12-15 00:00:00

abstract：:Since the discovery of grid cells in rat entorhinal cortex, many models of their hexagonally arrayed spatial firing fields have been suggested. We review the models and organize them according to the mechanisms they use to encode position, update the positional code, read it out in the spatial grid pattern, and learn ...

journal_title：Frontiers in neural circuits

authors： Zilli EA

更新日期：2012-04-18 00:00:00

abstract：:Mitral and tufted cells (MTCs) of the mammalian olfactory bulb are connected via dendrodendritic synapses with inhibitory interneurons in the external plexiform layer. The range, spatial layout, and temporal properties of inhibitory interactions between MTCs mediated by inhibitory interneurons remain unclear. Therefor...

journal_title：Frontiers in neural circuits

authors： Lehmann A,D'Errico A,Vogel M,Spors H

更新日期：2016-03-22 00:00:00

abstract：:We have made use of the δ subunit-selective allosteric modulator DS2 (4-chloro-N-[2-(2-thienyl)imidazo[1,2-a]pyridine-3-yl benzamide) to assay the contribution of δ-GABAARs to tonic and phasic conductance changes in the cerebellum, thalamus and neocortex. In cerebellar granule cells, an enhancement of the tonic conduc...

journal_title：Frontiers in neural circuits

authors： Ye Z,McGee TP,Houston CM,Brickley SG

更新日期：2013-12-23 00:00:00

abstract：:The assembly of neural circuits involves multiple sequential steps such as the specification of cell-types, their migration to proper brain locations, morphological and physiological differentiation, and the formation and maturation of synaptic connections. This intricate and often prolonged process is guided by elabo...

journal_title：Frontiers in neural circuits

authors： Paul A,Cai Y,Atwal GS,Huang ZJ

更新日期：2012-06-26 00:00:00

abstract：:A fluorescent voltage sensor protein "Flare" was created from a Kv1.4 potassium channel with YFP situated to report voltage-induced conformational changes in vivo. The RNA virus Sindbis introduced Flare into neurons in the binocular region of visual cortex in rat. Injection sites were selected based on intrinsic optic...

journal_title：Frontiers in neural circuits

authors： Ahrens KF,Heider B,Lee H,Isacoff EY,Siegel RM

更新日期：2012-03-22 00:00:00