Abstract:
:Thalamotomy at the ventralis intermedius nucleus has been an effective treatment method for essential tremor, but how the brain network changes immediately responding to this deliberate lesion and then reorganizes afterwards are not clear. Taking advantage of a non-cranium-opening MRI-guided focused ultrasound ablation technique, we investigated functional network changes due to a focal lesion. To classify the diverse time courses of those network changes with respect to symptom-related long-lasting treatment effects and symptom-unrelated transient effects, we applied graph-theoretic analyses to longitudinal resting-state functional magnetic resonance imaging data before and 1 day, 7 days, and 3 months after thalamotomy with essential tremor. We found reduced average connections among the motor-related areas, reduced connectivity between substantia nigra and external globus pallidum and reduced total connection in the thalamus after thalamotomy, which are all associated with clinical rating scales. The average connectivity among whole brain regions and inter-hemispheric network asymmetry show symptom-unrelated transient increases, indicating temporary reconfiguration of the whole brain network. In summary, thalamotomy regulates interactions over the motor network via symptom-related connectivity changes but accompanies transient, symptom-unrelated diaschisis in the global brain network. This study suggests the significance of longitudinal network analysis, combined with minimal-invasive treatment techniques, in understanding time-dependent diaschisis in the brain network due to a focal lesion.
journal_name
Front Neuroljournal_title
Frontiers in neurologyauthors
Jang C,Park HJ,Chang WS,Pae C,Chang JWdoi
10.3389/fneur.2016.00184subject
Has Abstractpub_date
2016-10-24 00:00:00pages
184issn
1664-2295journal_volume
7pub_type
杂志文章abstract::Traumatic brain injury (TBI) is understood as an interplay between the initial injury, subsequent secondary injuries, and a complex host response all of which are highly heterogeneous. An understanding of the underlying biology suggests a number of windows where mechanistically inspired interventions could be targeted...
journal_title:Frontiers in neurology
pub_type: 杂志文章,评审
doi:10.3389/fneur.2017.00450
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pub_type: 杂志文章,评审
doi:10.3389/fneur.2017.00240
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doi:10.3389/fneur.2019.00829
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.3389/fneur.2012.00166
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pub_type: 杂志文章
doi:10.3389/fneur.2019.01397
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journal_title:Frontiers in neurology
pub_type: 杂志文章,评审
doi:10.3389/fneur.2017.00159
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journal_title:Frontiers in neurology
pub_type: 杂志文章
doi:10.3389/fneur.2018.00055
更新日期:2018-02-08 00:00:00
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pub_type: 杂志文章,评审
doi:10.3389/fneur.2020.00715
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pub_type: 杂志文章,评审
doi:10.3389/fneur.2017.00141
更新日期:2017-04-20 00:00:00
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journal_title:Frontiers in neurology
pub_type: 杂志文章
doi:10.3389/fneur.2014.00166
更新日期:2014-09-16 00:00:00
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pub_type: 杂志文章
doi:10.3389/fneur.2020.00838
更新日期:2020-08-12 00:00:00
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journal_title:Frontiers in neurology
pub_type: 杂志文章
doi:10.3389/fneur.2018.00399
更新日期:2018-06-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.3389/fneur.2017.00684
更新日期:2017-12-13 00:00:00
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pub_type: 杂志文章
doi:10.3389/fneur.2018.00593
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pub_type: 杂志文章
doi:10.3389/fneur.2018.01037
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journal_title:Frontiers in neurology
pub_type: 杂志文章
doi:10.3389/fneur.2013.00061
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pub_type: 杂志文章
doi:10.3389/fneur.2017.00620
更新日期:2017-11-21 00:00:00
abstract::[This corrects the article DOI: 10.3389/fneur.2020.563609.]. ...
journal_title:Frontiers in neurology
pub_type: 已发布勘误
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更新日期:2020-11-12 00:00:00
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pub_type: 杂志文章
doi:10.3389/fneur.2019.00752
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pub_type: 杂志文章
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