Abstract:
:In this review, reports were retrieved in which vitamin D status, as assessed by serum 25-hydroxyvitamin D [25(OH)D] levels, was measured in South African population groups with varied skin colours and ethnicities. Healthy children and adults were generally vitamin D-sufficient [25(OH)D level >50 nmol/L] but the majority of those aged above 65 years were deficient. A major role for exposure to solar ultraviolet radiation (UVR) in determining 25(OH)D levels was apparent, with the dietary contribution being minor. Limited data exist regarding the impact of recent changes in lifestyles on vitamin D status, such as urbanisation. With regard to disease susceptibility, 11 of 22 relevant publications indicated association between low 25(OH)D levels and disease, with deficiency most notably found in individuals with tuberculosis and HIV-1. Information on the relationship between vitamin D receptor variants and ethnicity, disease or treatment response in the South African population groups demonstrated complex interactions between genetics, epigenetics and the environment. Whether vitamin D plays an important role in protection against the range of diseases that currently constitute a large burden on the health services in South Africa requires further investigation. Only then can accurate advice be given about personal sun exposure or dietary vitamin D supplementation.
journal_name
Int J Environ Res Public Healthauthors
Norval M,Coussens AK,Wilkinson RJ,Bornman L,Lucas RM,Wright CYdoi
10.3390/ijerph13101019subject
Has Abstractpub_date
2016-10-18 00:00:00issue
10eissn
1661-7827issn
1660-4601pii
ijerph13101019journal_volume
13pub_type
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journal_title:International journal of environmental research and public health
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更新日期:2013-11-08 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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