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Effect of self-reported walking difficulty on bone mass and bone resorption marker in Japanese people aged 40 years and over.

Abstract：

BACKGROUND:This study aimed to examine the association of walking difficulty with bone mass or bone turnover among community-dwelling Japanese people aged 40 years and older. METHODS:We studied 1097 community-dwelling Japanese people aged 40 years and older (379 men and 718 women) who were invited to participate in periodic health examinations in 2006-2009. Walking difficulty was defined as having difficulty walking 100 m on a level surface (self-administered questionnaire). Calcaneal stiffness index (bone mass) was measured by quantitative ultrasound. Spot urine samples were collected, and urinary N-terminal cross-linking telopeptide of type I collagen (NTx) was measured. Values were corrected for creatinine (Cre) concentration. RESULTS:The prevalence of walking difficulty was significantly higher in women than in men (7.4 vs. 3.4 %, p = 0.011) and significantly increased with age in men (p for trend = 0.02) and women (p for trend <0.001). In univariate analysis, men and women with walking difficulty were older (p < 0.001) and had a lower stiffness index (p < 0.001), compared with those without walking difficulty. Among women, individuals with walking difficulty had significantly higher urinary NTx/Cre than those without walking difficulty (p < 0.001); however, this was not so among men (p = 0.39). Multiple regression analysis adjusted for age, weight, and menopausal status showed a significant association between walking difficulty and lower stiffness index in men (p = 0.004) and women (p = 0.005). In women, walking difficulty was significantly associated with higher NTx/Cre (p = 0.001), but not in men (p = 0.35). CONCLUSIONS:Walking difficulty may contribute to low bone mass in both sexes but might cause high bone turnover in women only.

journal_name

J Physiol Anthropol

journal_title

Journal of physiological anthropology

authors

Abe Y,Nishimura T,Arima K,Kanagae M,Mizukami S,Tomita Y,Okabe T,Goto H,Horiguchi I,Aoyagi K

doi

10.1186/s40101-016-0114-6

subject

Has Abstract

pub_date

2016-10-11 00:00:00

pages

issue

eissn

1880-6791

issn

1880-6805

pii

10.1186/s40101-016-0114-6

journal_volume

pub_type

杂志文章

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Effect of self-reported walking difficulty on bone mass and bone resorption marker in Japanese people aged 40 years and over.