Abstract:
:Because of concerns about possible emergence of artemisinin resistance strains of Plasmodium falciparum in mining areas of the interior of Guyana, a 7-day artesunate trial was conducted from March to December 2014. The day-3 parasite clearance rate, the efficacy of artesunate at day 28, and polymorphism of Kelch 13 (PfK13)-the marker of artemisinin resistance-were assessed. The study confirmed the continued sensitivity of P falciparum to artemisinin. A 7-day course of artesunate was 100% efficacious with only 2% (95% confidence interval, .1%-10.9%) of enrolled subjects positive at day 3. All day-0 parasite samples were wild type. Continued resistance monitoring is nevertheless recommended, given the widespread availability and uncontrolled use of artemisinin drugs in mining areas of Guyana.
journal_name
Open Forum Infect Disjournal_title
Open forum infectious diseasesauthors
Rahman R,Martin MJ,Persaud S,Ceron N,Kellman D,Musset L,Carter KH,Ringwald Pdoi
10.1093/ofid/ofw185subject
Has Abstractpub_date
2016-08-30 00:00:00pages
ofw185issue
3issn
2328-8957pii
ofw185journal_volume
3pub_type
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