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Serum Amyloid P Component and Systemic Fungal Infection: Does It Protect the Host or Is It a Trojan Horse?

Abstract：

:It is a striking observation that tissue of patients invaded by the deep mycoses often lacks evidence of an inflammatory response. This lack of host response is often attributed to neutropenia secondary to chemotherapy. However, systematic studies do not support this simplistic explanation. However, invasive fungal lesions are characterized by abundant fungal functional amyloid, which in turn is bound by serum amyloid P component (SAP). We postulate that SAP is important in the local immune response in invasive fungal infections. The interaction between fungal functional amyloid, SAP, and the immune response in deep mycoses is discussed.

journal_name

Open Forum Infect Dis

journal_title

Open forum infectious diseases

authors

Klotz SA,Sobonya RE,Lipke PN,Garcia-Sherman MC

doi

10.1093/ofid/ofw166

subject

Has Abstract

pub_date

2016-08-03 00:00:00

pages

ofw166

issue

3

issn

2328-8957

pii

ofw166

journal_volume

3

pub_type

杂志文章

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