Skin aging: are adipocytes the next target?

Abstract:

:Dermal white adipose tissue (dWAT) is increasingly appreciated as a special fat depot. The adipocytes in this depot exert a variety of unique effects on their surrounding cells and can undergo massive phenotypic changes. Significant modulation of dWAT content can be observed both in intrinsically and extrinsically aged skin. Specifically, skin that has been chronically photo-damaged displays a reduction of the dWAT volume, caused by the replacement of adipocytes by fibrotic structures. This is likely to be caused by the recently uncovered process described as "adipocyte-myofibroblast transition" (AMT). In addition, contributions of dermal adipocytes to the skin aging processes are also indirectly supported by spatial correlations between the prevalence of hypertrophic scarring and the appearance of signs of skin aging in different ethnic groups. These observations could elevate dermal adipocytes to prime targets in strategies aimed at counteracting skin aging.

journal_name

Aging (Albany NY)

journal_title

Aging

authors

Kruglikov IL,Scherer PE

doi

10.18632/aging.100999

subject

Has Abstract

pub_date

2016-07-01 00:00:00

pages

1457-69

issue

7

issn

1945-4589

pii

100999

journal_volume

8

pub_type

杂志文章,评审

相关文献

Aging-US文献大全
  • Single-cell RNA sequencing of immune cells in gastric cancer patients.

    abstract::Cancer immunotherapy has achieved positive clinical responses in the treatment of various cancers, including gastric cancer (GC). In this study, we characterized the heterogeneity of T cells isolated from GC patients at the single-cell level using single-cell RNA sequencing. We identified different immune cell subtype...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.102774

    authors: Fu K,Hui B,Wang Q,Lu C,Shi W,Zhang Z,Rong D,Zhang B,Tian Z,Tang W,Cao H,Wang X,Chen Z

    更新日期:2020-02-10 00:00:00

  • Association of RAGE gene multiple variants with the risk for COPD and asthma in northern Han Chinese.

    abstract::Clinical and experimental data have shown that the receptor for advanced glycation end products (RAGE) is implicated in the pathogenesis of respiratory disorders. In this study, we genotyped five widely-evaluated variants in RAGE gene, aiming to assess their association with the risk for chronic obstructive pulmonary ...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.101975

    authors: Niu H,Niu W,Yu T,Dong F,Huang K,Duan R,Qumu S,Lu M,Li Y,Yang T,Wang C

    更新日期:2019-05-29 00:00:00

  • Impairment of Pol β-related DNA base-excision repair leads to ovarian aging in mice.

    abstract::The mechanism underlying the association between age and depletion of the human ovarian follicle reserves remains uncertain. Many identified that impaired DNA polymerase β (Pol β)-mediated DNA base-excision repair (BER) drives to mouse oocyte aging. With aging, DNA lesions accumulate in primordial follicles. However, ...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.104123

    authors: Hua K,Wang L,Sun J,Zhou N,Zhang Y,Ji F,Jing L,Yang Y,Xia W,Hu Z,Pan F,Chen X,Yao B,Guo Z

    更新日期:2020-11-20 00:00:00

  • MortalityPredictors.org: a manually-curated database of published biomarkers of human all-cause mortality.

    abstract::Biomarkers of all-cause mortality are of tremendous clinical and research interest. Because of the long potential duration of prospective human lifespan studies, such biomarkers can play a key role in quantifying human aging and quickly evaluating any potential therapies. Decades of research into mortality biomarkers ...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.101280

    authors: Peto MV,De la Guardia C,Winslow K,Ho A,Fortney K,Morgen E

    更新日期:2017-08-31 00:00:00

  • Cortical neurons develop a senescence-like phenotype promoted by dysfunctional autophagy.

    abstract::Senescent cells accumulate in various tissues and organs with aging altering surrounding tissue due to an active secretome, and at least in mice their elimination extends healthy lifespan and ameliorates several chronic diseases. Whether all cell types senesce, including post-mitotic cells, has been poorly described m...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.102181

    authors: Moreno-Blas D,Gorostieta-Salas E,Pommer-Alba A,Muciño-Hernández G,Gerónimo-Olvera C,Maciel-Barón LA,Konigsberg M,Massieu L,Castro-Obregón S

    更新日期:2019-08-30 00:00:00

  • APOE ε4 allele accelerates age-related multi-cognitive decline and white matter damage in non-demented elderly.

    abstract::Advanced age and apolipoprotein E (APOE) ε4 allele are both associated with increased risk of the Alzheimer's disease (AD). However, the extent of the joint contribution of APOE ε4 allele and age on the brain white matter integrity, cognition and their relationship are unclear. We assessed the age-related variation di...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103367

    authors: Sun J,Zhu Z,Chen K,Wei D,Li X,Li H,Zhang J,Chen X,Chen Y,Zhang Z

    更新日期:2020-06-22 00:00:00

  • N-acetyl-cysteine prevents age-related hearing loss and the progressive loss of inner hair cells in γ-glutamyl transferase 1 deficient mice.

    abstract::Genetic factors combined with oxidative stress are major determinants of age-related hearing loss (ARHL), one of the most prevalent disorders of the elderly. Dwarf grey mice, Ggt1dwg/dwg, are homozygous for a loss of function mutation of the g-glutamyl transferase 1 gene, which encodes an important antioxidant enzyme ...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.100927

    authors: Ding D,Jiang H,Chen GD,Longo-Guess C,Muthaiah VP,Tian C,Sheppard A,Salvi R,Johnson KR

    更新日期:2016-04-01 00:00:00

  • GSG2 (Haspin) promotes development and progression of bladder cancer through targeting KIF15 (Kinase-12).

    abstract::Bladder cancer is the most commonly diagnosed malignant tumor in urological system worldwide. The relationship between GSG2 and bladder cancer has not been demonstrated and remains unclear. In this study, it was demonstrated that GSG2 was up-regulated in bladder cancer tissues compared with the normal tissues and its ...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103005

    authors: Chen Y,Fu D,Zhao H,Cheng W,Xu F

    更新日期:2020-05-21 00:00:00

  • LINC01419 facilitates hepatocellular carcinoma growth and metastasis through targeting EZH2-regulated RECK.

    abstract::Long non-coding RNAs (lncRNAs) have been reported to play significant roles in human tumorigenesis, for example, in hepatocellular carcinoma (HCC). This study explored the role of LINC01419, a new lncRNA, in HCC. In vitro study revealed that LINC01419 promotes growth and migration of HCC cells. Genes that affected cel...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103321

    authors: Zhang G,Chen X,Ma L,Ding R,Zhao L,Ma F,Deng X

    更新日期:2020-06-10 00:00:00

  • The neurocognitive and BDNF changes of multicomponent exercise for community-dwelling older adults with mild cognitive impairment or dementia: a systematic review and meta-analysis.

    abstract::Our goal was to examine whether multicomponent exercise performed by older adults with mild cognitive impairment or dementia as group-based exercise in community have beneficial effects on cognition and brain-derived neurotrophic factor. Eight studies were identified through Emabase, Medline, PubMed. Searches combined...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.102918

    authors: Wang X,Wang H,Ye Z,Ding G,Li F,Ma J,Hua W

    更新日期:2020-03-19 00:00:00

  • Do senescence markers correlate in vitro and in situ within individual human donors?

    abstract::Little is known on how well senescence markers in vitro and in situ correlate within individual donors. We studied correlations between the same and different in vitro markers. Furthermore, we tested correlations between in vitro markers with in situ p16INK4a positivity.From 100 donors (20-91 years), cultured dermal f...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.101389

    authors: Waaijer MEC,Gunn DA,van Heemst D,Slagboom PE,Sedivy JM,Dirks RW,Tanke HJ,Westendorp RGJ,Maier AB

    更新日期:2018-02-28 00:00:00

  • FX5 as a non-steroidal GR antagonist improved glucose homeostasis in type 2 diabetic mice via GR/HNF4α/miR-122-5p pathway.

    abstract::Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease characterized by glucose metabolic disorders, and gluconeogenesis inhibiting is a promisingly therapeutic strategy for T2DM. Glucocorticoid receptor (GR) is tightly implicated in the regulation of gluconeogenesis, although the underlying mechanism remains ...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.202275

    authors: Xu X,Chen Y,Zhu D,Zhao T,Xu R,Wang J,Hu L,Shen X

    更新日期:2020-12-09 00:00:00

  • Aberrantly glycosylated integrin α3β1 is a unique urinary biomarker for the diagnosis of bladder cancer.

    abstract::Bladder cancer (BC) is the most common malignancy of the urinary tract. We developed a new and ELISA kit for detecting aberrantly glycosylated integrin α3β1 (AG31) in human urine. We analysed urine samples (n=408) of patients with BC, renal cell carcinoma (RCC), prostate cancer (PC), cystitis, nephritis, and prostatit...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103297

    authors: Jin D,Zhang R,Chen H,Li C

    更新日期:2020-06-13 00:00:00

  • Silencing KIF14 reverses acquired resistance to sorafenib in hepatocellular carcinoma.

    abstract::For nearly a decade, sorafenib has served as a first-line chemotherapeutic drug for the treatment of hepatocellular carcinoma (HCC), but it displays only limited efficacy against advanced drug-resistant HCC. Regorafenib, the first second-line drug approved for treatment after sorafenib failure, can reverse resistance ...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.104028

    authors: Zhu Q,Ren H,Li X,Qian B,Fan S,Hu F,Xu L,Zhai B

    更新日期:2020-11-16 00:00:00

  • A model integrating donor gene polymorphisms predicts fibrosis after liver transplantation.

    abstract::Post-transplant liver fibrosis (PTLF) is a common and severe complication in liver recipients. In this study, we assessed the impact of donor liver genetics on the development of PTLF. A total of 232 patients undergoing liver transplantation were included. Twenty-two single nucleotide polymorphisms (SNPs) associated w...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.202302

    authors: Wang C,Zhang X,Ling Q,Zheng S,Xu X

    更新日期:2020-12-03 00:00:00

  • A nomogram combining long non-coding RNA expression profiles and clinical factors predicts survival in patients with bladder cancer.

    abstract::Bladder cancer (BCa) is a heterogeneous disease with various tumorigenic mechanisms and clinical behaviors. The current tumor-node-metastasis (TNM) staging system is inadequate to predict overall survival (OS) in BCa patients. We developed a BCa-specific, long-non-coding-RNA (lncRNA)-based nomogram to improve survival...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.102782

    authors: Wang Y,Du L,Yang X,Li J,Li P,Zhao Y,Duan W,Chen Y,Wang Y,Mao H,Wang C

    更新日期:2020-02-12 00:00:00

  • Role of apoptosis in disease.

    abstract::Since the initial description of apoptosis, a number of different forms of cell death have been described. In this review we will focus on classic caspase-dependent apoptosis and its variations that contribute to diseases. Over fifty years of research have clarified molecular mechanisms involved in apoptotic signaling...

    journal_title:Aging

    pub_type: 杂志文章,评审

    doi:10.18632/aging.100459

    authors: Favaloro B,Allocati N,Graziano V,Di Ilio C,De Laurenzi V

    更新日期:2012-05-01 00:00:00

  • Slower rates of accumulation of DNA damage in leukocytes correlate with longer lifespans across several species of birds and mammals.

    abstract::Although there is previous evidence showing an increase in various types of DNA damage with aging in mice and humans, a comparative study determining accumulation rates of DNA double strand breaks, as determined by presence of phosphorylated histone H2AX (γH2AX), in leukocytes of individuals of different ages from phy...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.102430

    authors: Whittemore K,Martínez-Nevado E,Blasco MA

    更新日期:2019-11-15 00:00:00

  • Assessment of real-time three-dimensional echocardiography as a tool for evaluating left atrial volume and function in patients with type 2 diabetes mellitus.

    abstract:OBJECTIVE:To assess the value of real-time three-dimensional echocardiography (RT-3DE) in evaluating changes in left atrial volume and function in type 2 diabetes mellitus (DM) and type 2 diabetic nephropathy (DN) patients. METHOD:104 control subjects, 109 DN patients, and 111 DM patients were recruited and underwent ...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.202218

    authors: Li X,Dong Y,Zheng C,Wang P,Xu M,Zou C,Wang L

    更新日期:2020-12-03 00:00:00

  • Characterization of variations in IL23A and IL23R genes: possible roles in multiple sclerosis and other neuroinflammatory demyelinating diseases.

    abstract::Multiple sclerosis is among the most serious inflammatory demyelinating diseases (IDD). Interleukin-23A (IL23A) regulates and coordinates the activities of immune cells by interacting with its receptor IL23R and plays key roles in the pathogenesis of immune inflammatory diseases. IDD, deemed to be a kind of autoimmune...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.101058

    authors: Li FF,Zhu XD,Yan P,Jin MH,Yue H,Zhang Q,Fu J,Liu SL

    更新日期:2016-11-26 00:00:00

  • Co-expression network analysis identified hub genes critical to triglyceride and free fatty acid metabolism as key regulators of age-related vascular dysfunction in mice.

    abstract::Background: Aging has often been linked to age-related vascular disorders. The elucidation of the putative genes and pathways underlying vascular aging likely provides useful insights into vascular diseases at advanced ages. Transcriptional regulatory network analysis is the key to describing genetic interactions betw...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.102275

    authors: Li H,Wang X,Lu X,Zhu H,Li S,Duan S,Zhao X,Zhang F,Alterovitz G,Wang F,Li Q,Tian XL,Xu M

    更新日期:2019-09-12 00:00:00

  • Identification of an 88-microRNA signature in whole blood for diagnosis of hepatocellular carcinoma and other chronic liver diseases.

    abstract::Hepatocellular carcinoma (HCC) is a common cancer with very poor survival due to lack of reliable biomarker for early diagnosis. In this study, we investigated microRNA (miRNA) profile of whole blood with a custom microarray containing probes for 1849 miRNA species in a total 213 successive subjects who were divided i...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.101253

    authors: Long XR,Zhang YJ,Zhang MY,Chen K,Zheng XFS,Wang HY

    更新日期:2017-06-27 00:00:00

  • Human amnion-derived mesenchymal stem cells promote osteogenic differentiation of human bone marrow mesenchymal stem cells via H19/miR-675/APC axis.

    abstract::Bone volume inadequacy is an emerging clinical problem impairing the feasibility and longevity of dental implants. Human bone marrow mesenchymal stem cells (HBMSCs) have been widely used in bone remodeling and regeneration. This study examined the effect of long noncoding RNAs (lncRNAs)-H19 on the human amnion-derived...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103277

    authors: Ma X,Bian Y,Yuan H,Chen N,Pan Y,Zhou W,Gao S,Du X,Hao S,Yan Z,Li X,Liu K,Xu F,Wang Y,Du Y

    更新日期:2020-05-20 00:00:00

  • CO2 lattice laser reverses skin aging caused by UVB.

    abstract::The carbon dioxide (CO2) lattice laser has been successfully used to treat facial skin photoaging induced by UV light. In this study, we analyzed the effect of CO2 lattice laser irradiation on skin photoaging, and investigated the underlying mechanisms. Our results demonstrate that the laser promoted collagen synthesi...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103063

    authors: Wang H,Guo B,Hui Q,Lin F,Tao K

    更新日期:2020-04-20 00:00:00

  • Efficacy and safety of tocilizumab in COVID-19 patients.

    abstract::In this retrospective study we assessed the efficacy and safety of tocilizumab in patients with critical or severe coronavirus disease 2019 (COVID-19). We enrolled 181 patients admitted to Huoshenshan Hospital (Wuhan, China) with confirmed COVID-19 between January 2020 and February 2020. Ninety-two patients were treat...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103988

    authors: Zheng KL,Xu Y,Guo YF,Diao L,Kong XY,Wan XJ,Zhao F,Ning FZ,Wang LB,Qiao F,Zhao JM,Zhou JH,Zhong YQ,Wu SX,Chen Y,Jin G,Dong YC

    更新日期:2020-10-08 00:00:00

  • Ovulation and ovarian wound healing are impaired with advanced reproductive age.

    abstract::Aging is associated with reduced tissue remodeling efficiency and increased fibrosis, characterized by excess collagen accumulation and altered matrix degradation. Ovulation, the process by which an egg is released from the ovary, is one of the most dynamic cycles of tissue wounding and repair. Because the ovary is on...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103237

    authors: Mara JN,Zhou LT,Larmore M,Johnson B,Ayiku R,Amargant F,Pritchard MT,Duncan FE

    更新日期:2020-05-14 00:00:00

  • Cross-platform genomic identification and clinical validation of breast cancer diagnostic biomarkers.

    abstract:INTRODUCTION:Circulating non-coding RNA is an ideal source to discover novel biomarkers for non-invasive screening. However, studies for the discovery of universal miRNAs in serum and exosomes for breast cancer early diagnosis are limited. METHODS:Based on bioinformatic analysis, in vitro and in vivo studies were perf...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.202388

    authors: Liu D,Li B,Shi X,Zhang J,Chen AM,Xu J,Wang W,Huang K,Gao J,Zheng Z,Liu D,Wang H,Shi W,Chen L,Xu J

    更新日期:2021-01-20 00:00:00

  • Osteoprotegerin as a biomarker of geriatric frailty syndrome.

    abstract::The lack of a univocal definition of frailty, a condition frequently found in the elderly population which is correlated with an increased risk of mortality, has prompted the search for clinical and laboratory parameters associated with this condition. Whereas OPG is a protein involved in different pathophysiological ...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.102083

    authors: Valentini A,Cianfarani MA,Tarantino U,Di Daniele N,Bertoli A

    更新日期:2019-07-17 00:00:00

  • Risk factors for severe cases of COVID-19: a retrospective cohort study.

    abstract:BACKGROUND:SARS-CoV-2 has raged around the world since March, 2020. We aim to describe the clinical characteristics and risk factors of severe patients with COVID-19 in Guangzhou. RESULTS:The severity and mortality of COVID-19 was 10.4% and 0.3% respectively. And each 1-year increase in age (OR, 1.057; 95% CI, 1.018-1...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103803

    authors: He F,Luo Q,Lei M,Fan L,Shao X,Huang G,Zeng J,Zhao Z,Qin S,Yang Z,Yu N,Yang L,Cao J

    更新日期:2020-08-15 00:00:00

  • Hexosamine pathway but not interstitial changes mediates glucotoxicity in pancreatic β-cells as assessed by cytosolic Ca2+ response to glucose.

    abstract::Hyperglycemia impairs insulin secretion as well as insulin action, being recognized as the glucotoxicity that accelerates diabetes. However, the mechanism underlying the glucotoxicity in pancreatic β-cells is not thoroughly understood. Hyperglycemia alters glucose metabolism within β-cells and interstitial conditions ...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.100647

    authors: Yanagida K,Maejima Y,Santoso P,Otgon-Uul Z,Yang Y,Sakuma K,Shimomura K,Yada T

    更新日期:2014-03-01 00:00:00