当前位置： SCI文献检索 > Open Forum Infectious Diseases期刊下所有文献 > Hepatitis C Virus Treatment Access Among Human Immunodeficiency Virus and Hepatitis C Virus (HCV)-Coinfected People Who Inject Drugs in Guangzhou, China: Implications for HCV Treatment Expansion.

Hepatitis C Virus Treatment Access Among Human Immunodeficiency Virus and Hepatitis C Virus (HCV)-Coinfected People Who Inject Drugs in Guangzhou, China: Implications for HCV Treatment Expansion.

Abstract：

:Background.  Hepatitis C virus (HCV) treatment access among human immunodeficiency virus (HIV)/HCV-coinfected people who inject drugs is poor, despite a high burden of disease in this population. Understanding barriers and facilitators to HCV treatment uptake is critical to the implementation of new direct-acting antivirals. Methods.  We conducted in-depth interviews with patients, physicians, and social workers at an HIV treatment facility and methadone maintenance treatment centers in Guangzhou, China to identify barriers and facilitators to HCV treatment. We included patients who were in various stages of HCV treatment and those who were not treated. We used standard qualitative methods and organized data into themes. Results.  Interview data from 29 patients, 8 physicians, and 3 social workers were analyzed. Facilitators and barriers were organized according to a modified Consolidated Framework for Implementation Research schematic. Facilitators included patient trust in physicians, hope for a cure, peer networks, and social support. Barriers included ongoing drug use, low HCV disease knowledge, fragmented reimbursement systems, HIV exceptionalism, and stigma. Conclusions.  Expanding existing harm reduction programs, HIV treatment programs, and social services may facilitate scale-up of direct-acting antivirals globally. Improving integration of ancillary social and mental health services within existing HIV care systems may facilitate HCV treatment access.

journal_name

Open Forum Infect Dis

journal_title

Open forum infectious diseases

authors

Chu CE,Wu F,He X,Zhou K,Cheng Y,Cai W,Geng E,Volberding P,Tucker JD

doi

10.1093/ofid/ofw065

subject

Has Abstract

pub_date

2016-06-24 00:00:00

pages

ofw065

issue

2

issn

2328-8957

pii

ofw065

journal_volume

3

pub_type

杂志文章

相关文献

Open Forum Infectious Diseases文献大全
  • Appropriateness of gram-negative agent use at a tertiary care hospital in the setting of significant antimicrobial resistance.

    abstract：:Background.  Practicing antimicrobial stewardship in the setting of widespread antimicrobial resistance among gram-negative bacilli, particularly in urban areas, is challenging. Methods.  We conducted a retrospective cross-sectional study at a tertiary care hospital with an established antimicrobial stewardship progra...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofv009

    authors： Vora NM,Kubin CJ,Furuya EY

    更新日期：2015-02-19 00:00:00

  • Serum Amyloid P Component and Systemic Fungal Infection: Does It Protect the Host or Is It a Trojan Horse?

    abstract：:It is a striking observation that tissue of patients invaded by the deep mycoses often lacks evidence of an inflammatory response. This lack of host response is often attributed to neutropenia secondary to chemotherapy. However, systematic studies do not support this simplistic explanation. However, invasive fungal le...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofw166

    authors： Klotz SA,Sobonya RE,Lipke PN,Garcia-Sherman MC

    更新日期：2016-08-03 00:00:00

  • Public Awareness of Sepsis Is Low in Sweden.

    abstract：:Background.  Sepsis is a serious and common condition with high mortality and morbidity. The public awareness, knowledge, and perception of sepsis in Sweden are unknown. Methods.  A survey was performed using an online interview distributed to adults, aged 18-74, between March 6 and 9, 2015. Results.  A total of 1001 ...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofv161

    authors： Mellhammar L,Christensson B,Linder A

    更新日期：2015-10-26 00:00:00

  • Addressing the Disease Burden of Vertically Acquired Hepatitis C Virus Infection Among Opioid-Exposed Infants.

    abstract：Background:This study aims to estimate the disease burden of vertically acquired hepatitis C virus (HCV) in a large Midwestern hospital and to identify factors associated with HCV diagnostic testing among high-risk infants. Methods:This is a retrospective analysis of an infant cohort (n = 58 427) born from 2014 to 201...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofz448

    authors： Protopapas S,Murrison LB,Wexelblatt SL,Blackard JT,Hall ES

    更新日期：2019-10-21 00:00:00

  • Successful Fecal Microbiota Transplantation in a Patient Suffering From Irritable Bowel Syndrome and Recurrent Urinary Tract Infections.

    abstract：Background:Irritable bowel syndrome (IBS) is a chronic and debilitating functional gastrointestinal disorder affecting 9%-23% of the population across the world. The relative efficacy of fecal microbiota transplantation (FMT) on IBS symptoms was demonstrated in a double-blind, randomized study. Methods:We describe the...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofz398

    authors： Hocquart M,Pham T,Kuete E,Tomei E,Lagier JC,Raoult D

    更新日期：2019-10-14 00:00:00

  • Evaluation of Real-time PCR for Diagnosis of Post-Kala-azar Dermal Leishmaniasis in Endemic Foci of Bangladesh.

    abstract：Background:Post-kala-azar dermal leishmaniasis (PKDL) is a sequel to visceral leishmaniasis (VL), which is found in VL-endemic countries including Bangladesh. Because of these enigmatic cases, the success of the National Kala-azar Elimination Program is under threat. To date, diagnostic methods for PKDL cases in endemi...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofy234

    authors： Ghosh P,Hasnain MG,Hossain F,Khan MAA,Chowdhury R,Faisal K,Mural MA,Baker J,Nath R,Ghosh D,Maruf S,Shomik MS,Haque R,Matlashewski G,Hamano S,Duthie MS,Mondal D

    更新日期：2018-09-15 00:00:00

  • Group B Streptococci Colonization in Pregnant Guatemalan Women: Prevalence, Risk Factors, and Vaginal Microbiome.

    abstract：BACKGROUND:Infection causes 1 of every 5 neonatal deaths globally. Group B Streptococcus (GBS) is the most significant pathogen, although little is known about its epidemiology and risk in low-income countries. METHODS:A cross-sectional study in 2015 at a public hospital in Guatemala City enrolled women ≥35 weeks' ges...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofx020

    authors： Rick AM,Aguilar A,Cortes R,Gordillo R,Melgar M,Samayoa-Reyes G,Frank DN,Asturias EJ

    更新日期：2017-02-08 00:00:00

  • Interferon Lambda 4 Genotype Is Associated With Jaundice and Elevated Aminotransferase Levels During Acute Hepatitis C Virus Infection: Findings From the InC3 Collaborative.

    abstract：:Symptomatic acute HCV infection and interferon lambda 4 (IFNL4) genotypes are important predictors of spontaneous viral clearance. Using data from a multicohort database (Injecting Cohorts [InC3] Collaborative), we establish an independent association between host IFNL4 genotype and symptoms of acute hepatitis C virus...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofw024

    authors： Page K,Mirzazadeh A,Rice TM,Grebely J,Kim AY,Cox AL,Morris MD,Hellard M,Bruneau J,Shoukry NH,Dore GJ,Maher L,Lloyd AR,Lauer G,Prins M,McGovern BH

    更新日期：2016-02-08 00:00:00

  • Human Immunodeficiency Virus-1 Sequence Changes and Drug Resistance Mutation Among Virologic Failures of Lopinavir/Ritonavir Monotherapy: AIDS Clinical Trials Group Protocol A5230.

    abstract：: Background.  The mechanism of virologic failure (VF) of lopinavir/ritonavir (LPV/r) monotherapy is not well understood. We assessed sequence changes in human immunodeficiency virus-1 reverse-transcriptase (RT) and protease (PR) regions. Methods. ...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofw154

    authors： Vardhanabhuti S,Katzenstein D,Bartlett J,Kumarasamy N,Wallis CL

    更新日期：2016-08-24 00:00:00

  • "Is a Bird in the Hand Worth 5 in the Bush?": A Comparison of 3 Data-to-Care Referral Strategies on HIV Care Continuum Outcomes in San Francisco.

    abstract：Background:Health departments utilize HIV surveillance data to identify people with HIV (PWH) who need re-linkage to HIV care as part of an approach known as Data to Care (D2C.) The most accurate, effective, and efficient method of identifying PWH for re-linkage is unknown. Methods:We evaluated referral and care conti...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofaa369

    authors： Sachdev DD,Mara E,Hughes AJ,Antunez E,Kohn R,Cohen S,Scheer S

    更新日期：2020-08-21 00:00:00

  • Standardized electrolyte supplementation and fluid management improves survival during amphotericin therapy for cryptococcal meningitis in resource-limited settings.

    abstract：BACKGROUND:Amphotericin B is the preferred treatment for cryptococcal meningitis, but it has cumulative severe side effects, including nephrotoxicity, hypokalemia, and hypomagnesemia. Amphotericin-induced severe hypokalemia may predispose the patient to cardiac arrhythmias and death, and there is very little data avail...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofu070

    authors： Bahr NC,Rolfes MA,Musubire A,Nabeta H,Williams DA,Rhein J,Kambugu A,Meya DB,Boulware DR

    更新日期：2014-08-25 00:00:00

  • Sofosbuvir-Based Direct-Acting Antiviral Therapies for HCV in People Receiving Opioid Substitution Therapy: An Analysis of Phase 3 Studies.

    abstract：Background:Hepatitis C virus (HCV) direct-acting antiviral therapy is effective among people receiving opioid substitution therapy (OST), but studies are limited by small numbers of nongenotype 1 (GT1) patients. The aim of this study was to evaluate the treatment completion, adherence, SVR12, and safety of sofosbuvir-b...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofy001

    authors： Grebely J,Feld JJ,Wyles D,Sulkowski M,Ni L,Llewellyn J,Mir HM,Sajed N,Stamm LM,Hyland RH,McNally J,Brainard DM,Jacobson I,Zeuzem S,Bourlière M,Foster G,Afdhal N,Dore GJ

    更新日期：2018-02-09 00:00:00

  • Whole Genome Sequencing of Peruvian Klebsiella pneumoniae Identifies Novel Plasmid Vectors Bearing Carbapenem Resistance Gene NDM-1.

    abstract：Background:Klebsiella pneumoniae is a bacterial pathogen with increasing rates of resistance to carbapenem antibiotics, but the population structure and genetic drivers of carbapenem-resistant K pneumoniae (CRKP) remain underexplored in developing countries. Carbapenem-resistant K pneumoniae were recently introduced in...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofaa266

    authors： Roach D,Waalkes A,Abanto J,Zunt J,Cucho C,Soria J,Salipante SJ

    更新日期：2020-07-02 00:00:00

  • Disseminated Mycobacterium abscessus Infection Secondary to an Infected Vascular Stent: Case Report and Review of the Literature.

    abstract：:Mycobacterium abscessus is a rapidly growing, multidrug-resistant mycobacteria, commonly associated with pulmonary, skin, and soft tissue infections. We describe a rare case of M abscessus endovascular stent infection; only 3 cases of graft infections have previously been reported. ...

    journal_title：Open forum infectious diseases

    pub_type：

    doi：10.1093/ofid/ofy207

    authors： Tejura N,Bontempo G,Chew D

    更新日期：2018-08-23 00:00:00

  • HIV Testing After a First Positive Rapid Diagnostic Test: A Role for Nucleic Acid Testing?

    abstract：:We developed an open-access, Excel-based model simulating currently recommended and alternative algorithms for adult HIV testing as a preliminary investigation of trade-offs between accuracy and costs. Despite higher costs, simpler HIV testing algorithms incorporating point of care nucleic acid testing may improve out...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofy170

    authors： Neilan AM,Cohn JE,Lemaire JF,Sacks E,Alban R,Freedberg KA,Walensky RP,Ciaranello AL

    更新日期：2018-08-29 00:00:00

  • Switch to Raltegravir From Protease Inhibitor or Nonnucleoside Reverse-Transcriptase Inhibitor Does not Reduce Visceral Fat In Human Immunodeficiency Virus-Infected Women With Central Adiposity.

    abstract：:Human immunodeficiency virus-infected women with central adiposity switched to raltegravir-based antiretroviral therapy immediately or after 24 weeks. No statistically significant changes in computed tomography-quantified visceral adipose tissue (VAT) or subcutaneous fat were observed, although 48 weeks of raltegravir...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofv059

    authors： Lake JE,McComsey GA,Hulgan T,Wanke CA,Mangili A,Walmsley SL,Currier JS

    更新日期：2015-04-26 00:00:00

  • Risk Factors for Indeterminate Outcome on Interferon Gamma Release Assay in Non-US-Born Persons Screened for Latent Tuberculosis Infection.

    abstract：Background:Non-US-born individuals account for the majority of active tuberculosis (TB) in the United States. Interferon gamma release assay (IGRA) is the preferred diagnostic test for latent TB but can produce an indeterminate result. We investigated the prevalence and predictors of an indeterminate IGRA (IND-IGRA) in...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofy184

    authors： Sharninghausen JC,Shapiro AE,Koelle DM,Kim HN

    更新日期：2018-07-27 00:00:00

  • Development and Validation of a Model to Predict Growth of Potentially Antibiotic-Resistant Gram-Negative Bacilli in Critically Ill Children With Suspected Infection.

    abstract：Background:Risk-based guidelines aid empiric antibiotic selection for critically ill adults with suspected infection with Gram-negative bacilli with high potential for antibiotic resistance (termed high-risk GNRs). Neither evidence-based guidelines for empiric antibiotic selection nor validated risk factors predicting ...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofy278

    authors： Karsies T,Moore-Clingenpeel M,Hall M

    更新日期：2018-10-24 00:00:00

  • Clofazimine in Nontuberculous Mycobacterial Infections: A Growing Niche.

    abstract：:Infection secondary to rapidly growing mycobacteria (RGM) is associated with significant morbidity and mortality, especially in individuals with underlying structural lung disease or immune compromise. Such infections, particularly those caused by the Mycobacterium abscessus group, are challenging to treat due to high...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章,评审

    doi：10.1093/ofid/ofx147

    authors： McGuffin SA,Pottinger PS,Harnisch JP

    更新日期：2017-07-20 00:00:00

  • A 7-Year-Old Child With Headaches and Prolonged Fever Associated With Oral and Nail Lesions.

    abstract：:A 7-year-old child of Turkish origin presented with headache and vomiting in the context of prolonged fever of unknown source. At examination, oral candidiasis and chronic onychomycosis were noted. A Candida meningoencephalitis was diagnosed and intravenous Amphotericin B liposomal was given during 6 months relayed by...

    journal_title：Open forum infectious diseases

    pub_type：

    doi：10.1093/ofid/ofz229

    authors： Martin S,Balligand E,Peeters J,Nassogne MC,Mondovits B,Loop M,de Selys A,Vanclaire J,Vermylen C,De Bruyckere JJ,Chatzis O,Puel A,Gilliaux O,Van Der Linden D

    更新日期：2019-11-03 00:00:00

  • West Nile Virus Central Nervous System Infection in Patients Treated With Rituximab: Implications for Diagnosis and Prognosis, With a Review of Literature.

    abstract：:The spectrum of West Nile virus (WNV) infection continues to be elucidated. Many cases of WNV are asymptomatic; however, in immunocompromised patients, symptoms are more likely to be severe. We describe fatal WNV central nervous system disease in lymphoma patients who received rituximab, blunting the inflammatory resp...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofv136

    authors： Morjaria S,Arguello E,Taur Y,Sepkowitz K,Hatzoglou V,Nemade A,Rosenblum M,Cavalcanti MS,Palomba ML,Kaltsas A

    更新日期：2015-09-19 00:00:00

  • The Yield and Consistency of the Detection of SARS-CoV-2 in Multiple Respiratory Specimens.

    abstract：Background:Few studies have compared the yield of reverse transcription polymerase chain reaction (RT-PCR) assays in nasopharyngeal swabs, oropharyngeal swabs, and sputum for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection. Methods:We conducted an observational study in Beijing Ditan Hospital, C...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofaa379

    authors： Zhang H,Chen M,Zhang Y,Wen J,Wang Y,Wang L,Guo J,Liu C,Li D,Wang Y,Bai J,Gao G,Wang S,Yang D,Yu F,Yan L,Wan G,Zhang F

    更新日期：2020-08-26 00:00:00

  • Impact of Procalcitonin-Guided Antibiotic Management on Antibiotic Exposure and Outcomes: Real-world Evidence.

    abstract：Background:Delayed pathogen identification and nonspecific clinical findings make definitive decisions regarding antibiotics challenging. The stimuli of bacterial toxins and inflammation make procalcitonin (PCT) unique in its ability to differentiate bacterial infection from other causes of inflammation, and thus it is...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofx213

    authors： Broyles MR

    更新日期：2017-10-03 00:00:00

  • Correlates of Immunity to Influenza as Determined by Challenge of Children with Live, Attenuated Influenza Vaccine.

    abstract：:Background.  The efficacy of live, attenuated live attenuated influenza vaccine(LAIV) and inactivated influenza vaccine(IIV) is poorly explained by either single or composite immune responses to vaccination. Protective biomarkers were therefore studied in response to LAIV or IIV followed by LAIV challenge in children....

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofw108

    authors： Wright PF,Hoen AG,Ilyushina NA,Brown EP,Ackerman ME,Wieland-Alter W,Connor RI,Jegaskanda S,Rosenberg-Hasson Y,Haynes BC,Luke CJ,Subbarao K,Treanor JJ

    更新日期：2016-05-23 00:00:00

  • Outcomes of Older Adults With Sepsis at Admission to an Intensive Care Unit.

    abstract：:Background.  Sepsis is a major cause of morbidity and mortality among older adults. The main goals of this study were to assess the association of sepsis at intensive care unit (ICU) admission with mortality and to identify predictors associated with increased mortality in older adults. Methods.  We conducted a prospe...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofw010

    authors： Rowe T,Araujo KL,Van Ness PH,Pisani MA,Juthani-Mehta M

    更新日期：2016-01-21 00:00:00

  • Trends in Hospitalizations Related to Invasive Aspergillosis and Mucormycosis in the United States, 2000-2013.

    abstract：BACKGROUND:Invasive aspergillosis (IA) and mucormycosis contribute to substantial mortality, especially among immunocompromised persons, including those with hematopoietic stem cell transplant (HSCT), hematologic malignancy (HM), and solid organ transplant (SOT). METHODS:Using International Classification of Diseases,...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofw268

    authors： Vallabhaneni S,Benedict K,Derado G,Mody RK

    更新日期：2017-01-13 00:00:00

  • Is It Actionable? An Evaluation of the Rapid PCR-Based Blood Culture Identification Panel on the Management of Gram-Positive and Gram-Negative Blood Stream Infections.

    abstract：Background:There is growing interest in the use of rapid blood culture identification (BCID) in antimicrobial stewardship programs (ASPs). Although many studies have looked at its clinical and economic utility, its comparative utility in gram-positive and gram-negative blood stream infections (BSIs) has not been as wel...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofy308

    authors： Tseng AS,Kasule SN,Rice F,Mi L,Chan L,Seville MT,Grys TE

    更新日期：2018-12-11 00:00:00

  • Far East Scarlet-Like Fever: A Review of the Epidemiology, Symptomatology, and Role of Superantigenic Toxin: Yersinia pseudotuberculosis-Derived Mitogen A.

    abstract：:Far East scarlet-like fever (FESLF) is a severe inflammatory disease that occurs sporadically and in outbreaks in Russia and Japan. Far East scarlet-like fever is caused by Yersinia pseudotubuclosis infection, an organism that typically causes self-limiting gastroenteritis in Europe. Studies suggest the ability of Far...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章,评审

    doi：10.1093/ofid/ofv202

    authors： Amphlett A

    更新日期：2015-12-17 00:00:00

  • Counterfeit Rabies Vaccines: The Philippine Experience.

    abstract：Background:In December 2018, a large, tertiary, university-affiliated hospital in the Philippines discovered that their legitimate supply chain was infiltrated with counterfeit rabies vaccines. Methods:All vials suspected to be counterfeit were quarantined and surrendered to the Philippine Food and Drug Administration...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofaa313

    authors： Henson KER,Santiago AAC,Namqui SS

    更新日期：2020-07-22 00:00:00

  • Rapid Emergence of a New Clone Impacts the Population at Risk and Increases the Incidence of Type emm89 Group A Streptococcus Invasive Disease.

    abstract：BACKGROUND:Invasive group A Streptococcus (iGAS) disease caused by type emm89 strains has been increasing worldwide, driven by the emergence of an epidemic clonal variant (clade 3 emm89). The clinical characteristics of patients with emm89 iGAS disease, and in particular with clade 3 emm89 iGAS disease, are poorly desc...

    journal_title：Open forum infectious diseases

    pub_type： 杂志文章

    doi：10.1093/ofid/ofx042

    authors： Teatero S,Coleman BL,Beres SB,Olsen RJ,Kandel C,Reynolds O,Athey TBT,Musser JM,McGeer A,Fittipaldi N

    更新日期：2017-03-04 00:00:00