当前位置： SCI文献检索 > EBioMedicine期刊下所有文献 > Repurposing Cationic Amphiphilic Antihistamines for Cancer Treatment.

Repurposing Cationic Amphiphilic Antihistamines for Cancer Treatment.

Abstract：

:Non-small cell lung cancer (NSCLC) is one of the deadliest cancers worldwide. In search for new NSCLC treatment options, we screened a cationic amphiphilic drug (CAD) library for cytotoxicity against NSCLC cells and identified several CAD antihistamines as inducers of lysosomal cell death. We then performed a cohort study on the effect of CAD antihistamine use on mortality of patients diagnosed with non-localized cancer in Denmark between 1995 and 2011. The use of the most commonly prescribed CAD antihistamine, loratadine, was associated with significantly reduced all-cause mortality among patients with non-localized NSCLC or any non-localized cancer when compared with use of non-CAD antihistamines and adjusted for potential confounders. Of the less frequently described CAD antihistamines, astemizole showed a similar significant association with reduced mortality as loratadine among patients with any non-localized cancer, and ebastine use showed a similar tendency. The association between CAD antihistamine use and reduced mortality was stronger among patients with records of concurrent chemotherapy than among those without such records. In line with this, sub-micromolar concentrations of loratadine, astemizole and ebastine sensitized NSCLC cells to chemotherapy and reverted multidrug resistance in NSCLC, breast and prostate cancer cells. Thus, CAD antihistamines may improve the efficacy of cancer chemotherapy.

journal_name

EBioMedicine

journal_title

EBioMedicine

authors

Ellegaard AM,Dehlendorff C,Vind AC,Anand A,Cederkvist L,Petersen NHT,Nylandsted J,Stenvang J,Mellemgaard A,Østerlind K,Friis S,Jäättelä M

doi

10.1016/j.ebiom.2016.06.013

subject

Has Abstract

pub_date

2016-07-01 00:00:00

pages

130-139

issn

2352-3964

pii

S2352-3964(16)30257-2

journal_volume

9

pub_type

杂志文章

相关文献

EBioMedicine文献大全
  • Molecular subtyping of cancer and nomination of kinase candidates for inhibition with phosphoproteomics: Reanalysis of CPTAC ovarian cancer.

    abstract：BACKGROUND:Molecular subtyping of cancer aimed to predict patient overall survival (OS) and nominate drug targets for patient treatments is central to precision oncology. Owing to the rapid development of phosphoproteomics, we can now measure thousands of phosphoproteins in human cancer tissues. However, limited studie...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2018.12.039

    authors： Tong M,Yu C,Zhan D,Zhang M,Zhen B,Zhu W,Wang Y,Wu C,He F,Qin J,Li T

    更新日期：2019-02-01 00:00:00

  • A panel of five plasma proteins for the early diagnosis of hepatitis B virus-related hepatocellular carcinoma in individuals at risk.

    abstract：BACKGROUND:To improve the early diagnosis of hepatocellular carcinoma (HCC), more effective diagnostic biomarkers are needed. A combination of biomarkers is reported to distinguish individuals with early-stage HCC from at-risk individuals. METHODS:Participants in this study were recruited from six hospitals in China. ...

    journal_title：EBioMedicine

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.ebiom.2020.102638

    authors： Cheng K,Shi J,Liu Z,Jia Y,Qin Q,Zhang H,Wan S,Niu Z,Lu L,Sun J,Xue J,Lu C,Wei X,Guo L,Zhang F,Zhou D,Tang Y,Hu Y,Huang Y,Chen Y,Lau WY,Cheng S,Liu S

    更新日期：2020-02-01 00:00:00

  • Building the Evidence Base of Blood-Based Biomarkers for Early Detection of Cancer: A Rapid Systematic Mapping Review.

    abstract：BACKGROUND:The Early Cancer Detection Consortium is developing a blood-test to screen the general population for early identification of cancer, and has therefore conducted a systematic mapping review to identify blood-based biomarkers that could be used for early identification of cancer. METHODS:A mapping review wit...

    journal_title：EBioMedicine

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.ebiom.2016.07.004

    authors： Uttley L,Whiteman BL,Woods HB,Harnan S,Philips ST,Cree IA,Early Cancer Detection Consortium.

    更新日期：2016-08-01 00:00:00

  • Contemporary update of overall prognosis and nomogram to predict individualized survival for Chinese patients with eyelid sebaceous carcinoma.

    abstract：BACKGROUND:The prognosis of Chinese patients with eyelid sebaceous carcinoma (SC) has not been updated for >3 decades. The prognostic predictors are multifactorial, and there is no validated prognostic model for eyelid SC. METHODS:This study included 238 consecutive patients with eyelid SC. All eligible patients were ...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2018.09.011

    authors： Zhou C,Shi Y,Chai P,Wu F,Xia W,He X,Shi Y,Huang H,Jia R,Fan X

    更新日期：2018-10-01 00:00:00

  • Circulating tumor cells detection in neuroblastoma patients by EpCAM-independent enrichment and immunostaining-fluorescence in situ hybridization.

    abstract：:Detecting circulating tumor cells (CTCs) has proven valuable for evaluating the prognosis of cancer patients and for studying the mechanisms of treatment resistance. Owing to the lack of universal and specific tumor markers for neuroblastoma (NB), in this prospective study, we adopted an EpCAM-independent method to de...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2018.08.005

    authors： Liu X,Zhang Z,Zhang B,Zheng Y,Zheng C,Liu B,Zheng S,Dong K,Dong R

    更新日期：2018-09-01 00:00:00

  • Flecainide in Amyotrophic Lateral Sclerosis as a Neuroprotective Strategy (FANS): A Randomized Placebo-Controlled Trial.

    abstract：BACKGROUND:Abnormalities in membrane excitability and Na(+) channel function are characteristic of amyotrophic lateral sclerosis (ALS). We aimed to examine the neuroprotective potential, safety and tolerability of the Na(+) channel blocker and membrane stabiliser flecainide in ALS. METHODS:A double-blind, placebo-cont...

    journal_title：EBioMedicine

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.ebiom.2015.11.022

    authors： Park SB,Vucic S,Cheah BC,Lin CS,Kirby A,Mann KP,Zoing MC,Winhammar J,Kiernan MC

    更新日期：2015-12-01 00:00:00

  • Base Excision Repair Gene Polymorphisms and Wilms Tumor Susceptibility.

    abstract：:Base excision repair (BER) is the main mechanism to repair endogenous DNA lesions caused by reactive oxygen species. BER deficiency is linked with cancer susceptibility and premature aging. Single nucleotide polymorphisms (SNPs) within BER genes have been implicated in various human malignancies. Nevertheless, a compr...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2018.06.018

    authors： Zhu J,Jia W,Wu C,Fu W,Xia H,Liu G,He J

    更新日期：2018-07-01 00:00:00

  • Intergenerational Transmission of Enhanced Seizure Susceptibility after Febrile Seizures.

    abstract：:Environmental exposure early in development plays a role in susceptibility to disease in later life. Here, we demonstrate that prolonged febrile seizures induced by exposure of rat pups to a hyperthermic environment enhance seizure susceptibility not only in these hyperthermia-treated rats but also in their future off...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2017.02.006

    authors： Wu D,Feng B,Dai Y,Wu X,Chen B,Xu C,Tang Y,Wang K,Zhang S,Wang S,Luo B,Chen Z

    更新日期：2017-03-01 00:00:00

  • PLAGL2 and POFUT1 are regulated by an evolutionarily conserved bidirectional promoter and are collaboratively involved in colorectal cancer by maintaining stemness.

    abstract：BACKGROUND:Our previous study revealed that PLAGL2 or POFUT1 can promote tumorigenesis and maintain significant positive correlations in colorectal cancer (CRC). However, the mechanism leading to the co-expression and the underlying functional and biological implications remain unclear. METHODS:Clinical tumor tissues ...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.06.051

    authors： Li D,Lin C,Li N,Du Y,Yang C,Bai Y,Feng Z,Su C,Wu R,Song S,Yan P,Chen M,Jain A,Huang L,Zhang Y,Li X

    更新日期：2019-07-01 00:00:00

  • Downregulation of circRNA DMNT3B contributes to diabetic retinal vascular dysfunction through targeting miR-20b-5p and BAMBI.

    abstract：BACKGROUND:Diabetic retinopathy, a vascular complication of diabetes mellitus, is the leading cause of visual impairment and blindness. circRNAs act as competing endogenous RNA, sponging target miRNA and thus influencing mRNA expression in vascular diseases. We investigated whether and how circDNMT3B is involved in ret...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.10.004

    authors： Zhu K,Hu X,Chen H,Li F,Yin N,Liu AL,Shan K,Qin YW,Huang X,Chang Q,Xu GZ,Wang Z

    更新日期：2019-11-01 00:00:00

  • Exosome Derived From Human Umbilical Cord Mesenchymal Stem Cell Mediates MiR-181c Attenuating Burn-induced Excessive Inflammation.

    abstract：:Mesenchymal stem cell (MSC)-derived exosomes have diverse functions in regulating wound healing and inflammation; however, the molecular mechanism of human umbilical cord MSC (hUCMSC)-derived exosomes in regulating burn-induced inflammation is not well understood. We found that burn injury significantly increased the ...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2016.04.030

    authors： Li X,Liu L,Yang J,Yu Y,Chai J,Wang L,Ma L,Yin H

    更新日期：2016-06-01 00:00:00

  • Development of a preoperative prediction nomogram for lymph node metastasis in colorectal cancer based on a novel serum miRNA signature and CT scans.

    abstract：BACKGROUND:Preoperative prediction of lymph node (LN) status is of crucial importance for appropriate treatment planning in patients with colorectal cancer (CRC). In this study, we sought to develop and validate a non-invasive nomogram model to preoperatively predict LN metastasis in CRC. METHODS:Development of the no...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2018.09.052

    authors： Qu A,Yang Y,Zhang X,Wang W,Liu Y,Zheng G,Du L,Wang C

    更新日期：2018-11-01 00:00:00

  • Neurobiological Correlates and Predictors of Two Distinct Personality Trait Pathways to Escalated Alcohol Use.

    abstract：BACKGROUND:The delineation of the behavioral neurobiological mechanisms underlying the heterogeneous pathways for alcohol use disorders (AUDs) is ostensibly imperative for the development of more cost-effective treatments predicated on better understanding of this complex psychopathology. METHODS:1) Forty-eight high a...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2017.11.025

    authors： Shakra MA,Leyton M,Moghnieh H,Pruessner J,Dagher A,Pihl R

    更新日期：2018-01-01 00:00:00

  • Galactosylation and Sialylation Levels of IgG Predict Relapse in Patients With PR3-ANCA Associated Vasculitis.

    abstract：OBJECTIVE:The objective of our study is to investigate the Fc glycosylation profiles of both antigen-specific IgG targeted against proteinase 3 (PR3-ANCA) and total IgG as prognostic markers of relapse in patients with Granulomatosis with Polyangiitis (GPA). METHODS:Seventy-five patients with GPA and a PR3-ANCA rise d...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2017.01.033

    authors： Kemna MJ,Plomp R,van Paassen P,Koeleman CAM,Jansen BC,Damoiseaux JGMC,Cohen Tervaert JW,Wuhrer M

    更新日期：2017-03-01 00:00:00

  • Discovery, validation and sequencing of urinary peptides for diagnosis of liver fibrosis-A multicentre study.

    abstract：BACKGROUND:Liver fibrosis is a consequence of chronic inflammation and is associated with protein changes within the hepatocytes structure. In this study, we aimed to investigate if this is reflected by the urinary proteome and can be explored to diagnose liver fibrosis in patients with chronic liver disease. METHODS:...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.103083

    authors： Bannaga AS,Metzger J,Kyrou I,Voigtländer T,Book T,Melgarejo J,Latosinska A,Pejchinovski M,Staessen JA,Mischak H,Manns MP,Arasaradnam RP

    更新日期：2020-12-01 00:00:00

  • Implementation and use of whole exome sequencing for metastatic solid cancer.

    abstract：BACKGROUND:Genomically-guided clinical trials are performed across different tumor types sharing genetic mutations, but trial organization remains complex. Here we address the feasibility and utility of routine somatic and constitutional exome analysis in metastatic cancer patients. METHODS:Exoma trial (NCT02840604) i...

    journal_title：EBioMedicine

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/j.ebiom.2019.102624

    authors： Réda M,Richard C,Bertaut A,Niogret J,Collot T,Fumet JD,Blanc J,Truntzer C,Desmoulins I,Ladoire S,Hennequin A,Favier L,Bengrine L,Vincent J,Hervieu A,Dusserre JG,Lepage C,Foucher P,Borg C,Albuisson J,Arnould L,Na

    更新日期：2020-01-01 00:00:00

  • Analysis of gene expression signatures identifies prognostic and functionally distinct ovarian clear cell carcinoma subtypes.

    abstract：BACKGROUND:Ovarian clear cell carcinoma (OCCC) is a histological subtype of epithelial ovarian cancer (EOC) with distinct pathological, biological, and molecular features. OCCCs are more resistant to conventional treatment regimen of EOC and have the worst stage-adjusted prognosis amongst EOC subtypes. As the OCCC inci...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.11.017

    authors： Tan TZ,Ye J,Yee CV,Lim D,Ngoi NYL,Tan DSP,Huang RY

    更新日期：2019-12-01 00:00:00

  • miR-4739 mediates pleural fibrosis by targeting bone morphogenetic protein 7.

    abstract：BACKGROUND:Pleural fibrosis is defined as excessive depositions of matrix components that result in pleural tissue architecture destruction and dysfunction. In severe cases, the progression of pleural fibrosis leads to lung entrapment, resulting in dyspnea and respiratory failure. However, the mechanism of pleural fibr...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.02.057

    authors： Wang M,Xiong L,Jiang LJ,Lu YZ,Liu F,Song LJ,Xiang F,He XL,Yu F,Shuai SY,Ma WL,Ye H

    更新日期：2019-03-01 00:00:00

  • OVA66 promotes tumour angiogenesis and progression through enhancing autocrine VEGF-VEGFR2 signalling.

    abstract：BACKGROUND:Activation of autocrine VEGF-VEGFR2 signalling in tumour cells activates cell proliferation, survival, and angiogenesis, all of which are crucial for tumour progression. Ovarian cancer-associated antigen 66 (OVA66) is now known to be overexpressed in multiple tumours and plays a role in tumour development, b...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.02.051

    authors： Song F,Chen Q,Rao W,Zhang R,Wang Y,Ge H,Wei Q

    更新日期：2019-03-01 00:00:00

  • Functional Characterization of Native, High-Affinity GABAA Receptors in Human Pancreatic β Cells.

    abstract：:In human pancreatic islets, the neurotransmitter γ-aminobutyric acid (GABA) is an extracellular signaling molecule synthesized by and released from the insulin-secreting β cells. The effective, physiological GABA concentration range within human islets is unknown. Here we use native GABAA receptors in human islet β ce...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2018.03.014

    authors： Korol SV,Jin Z,Jin Y,Bhandage AK,Tengholm A,Gandasi NR,Barg S,Espes D,Carlsson PO,Laver D,Birnir B

    更新日期：2018-04-01 00:00:00

  • MYC status as a determinant of synergistic response to Olaparib and Palbociclib in ovarian cancer.

    abstract：BACKGROUND:While PARP inhibitors and CDK4/6 inhibitors, the two classes of FDA-approved agents, have shown promising clinical benefits, there is an urgent need to develop new therapeutic strategies to improve clinical response. Meanwhile, extending the utility of these inhibitors beyond their respective molecularly def...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.03.027

    authors： Yi J,Liu C,Tao Z,Wang M,Jia Y,Sang X,Shen L,Xue Y,Jiang K,Luo F,Liu P,Cheng H

    更新日期：2019-05-01 00:00:00

  • A New Metastatic Lymph Node Classification-based Survival Predicting Model in Patients With Small Bowel Adenocarcinoma: A Derivation and Validation Study.

    abstract：BACKGROUND:Current methods of lymph node (LN) staging are controversial in predicting the survival of SBA. We aimed to develop an alternative LN-classification-based nomogram to individualize SBA prognosis. METHODS:Based on the data from the Surveillance, Epidemiology, and End Results (SEER) database of patients diagn...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2018.05.022

    authors： Wu S,Chen JN,Zhang QW,Tang CT,Zhang XT,Tang MY,Li XB,Ge ZZ

    更新日期：2018-06-01 00:00:00

  • AMPK Re-Activation Suppresses Hepatic Steatosis but its Downregulation Does Not Promote Fatty Liver Development.

    abstract：:Nonalcoholic fatty liver disease is a highly prevalent component of disorders associated with disrupted energy homeostasis. Although dysregulation of the energy sensor AMP-activated protein kinase (AMPK) is viewed as a pathogenic factor in the development of fatty liver its role has not been directly demonstrated. Une...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2018.01.008

    authors： Boudaba N,Marion A,Huet C,Pierre R,Viollet B,Foretz M

    更新日期：2018-02-01 00:00:00

  • An integrative pharmacogenomics analysis identifies therapeutic targets in KRAS-mutant lung cancer.

    abstract：BACKGROUND:KRAS mutations are the most frequent oncogenic aberration in lung adenocarcinoma. KRAS mutant isoforms differentially shape tumour biology and influence drug responses. This heterogeneity challenges the development of effective therapies for patients with KRAS-driven non-small cell lung cancer (NSCLC). METH...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.10.012

    authors： Wang H,Lv Q,Xu Y,Cai Z,Zheng J,Cheng X,Dai Y,Jänne PA,Ambrogio C,Köhler J

    更新日期：2019-11-01 00:00:00

  • Improving B-mode ultrasound diagnostic performance for focal liver lesions using deep learning: A multicentre study.

    abstract：BACKGROUND:The diagnosis performance of B-mode ultrasound (US) for focal liver lesions (FLLs) is relatively limited. We aimed to develop a deep convolutional neural network of US (DCNN-US) for aiding radiologists in classification of malignant from benign FLLs. MATERIALS AND METHODS:This study was conducted in 13 hosp...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.102777

    authors： Yang Q,Wei J,Hao X,Kong D,Yu X,Jiang T,Xi J,Cai W,Luo Y,Jing X,Yang Y,Cheng Z,Wu J,Zhang H,Liao J,Zhou P,Song Y,Zhang Y,Han Z,Cheng W,Tang L,Liu F,Dou J,Zheng R,Yu J,Tian J,Liang P

    更新日期：2020-06-01 00:00:00

  • Accumulation of mitochondrial 7S DNA in idiopathic and LRRK2 associated Parkinson's disease.

    abstract：BACKGROUND:Both idiopathic and familial Parkinson's disease are associated with mitochondrial dysfunction. Mitochondria have their own mitochondrial DNA (mtDNA) and previous studies have reported that the release of mtDNA is a biomarker of Parkinson's disease. METHODS:We have now investigated the relationship between ...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2019.09.015

    authors： Podlesniy P,Puigròs M,Serra N,Fernández-Santiago R,Ezquerra M,Tolosa E,Trullas R

    更新日期：2019-10-01 00:00:00

  • Value of folate receptor-positive circulating tumour cells in the clinical management of indeterminate lung nodules: A non-invasive biomarker for predicting malignancy and tumour invasiveness.

    abstract：BACKGROUND:Non-invasive lung adenocarcinoma could benefit from limited resection, nonetheless, there is a lack of method to determine preoperative tumour invasiveness. We aimed to investigate whether folate receptor-positive circulating tumour cells (FR+-CTCs) in combination with maximum tumour diameter (MTD) determine...

    journal_title：EBioMedicine

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/j.ebiom.2019.02.028

    authors： Zhou Q,Geng Q,Wang L,Huang J,Liao M,Li Y,Ding Z,Yang S,Zhao H,Shen Q,Pan C,Lou J,Lu S,Chen C,Luo Q

    更新日期：2019-03-01 00:00:00

  • Extracellular Vesicles Secreted by Human Adipose-derived Stem Cells (hASCs) Improve Survival Rate of Rats with Acute Liver Failure by Releasing lncRNA H19.

    abstract：:It has previously been reported that human adipose-derived stem cells (hASCs) can promote the regeneration of damaged tissues in rats with liver failure through a 'paracrine effect'. Here we demonstrate a therapeutic effect of hASCs derived Extracellular Vesicles (EVs) on rat models with acute liver failure, as shown ...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2018.07.015

    authors： Jin Y,Wang J,Li H,Gao S,Shi R,Yang D,Wang X,Wang X,Zhu L,Wang X,Chen C,Ning K,Gao Z,Xu J,Fu Q

    更新日期：2018-08-01 00:00:00

  • Ex-vivo delivery of monoclonal antibody (Rituximab) to treat human donor lungs prior to transplantation.

    abstract：BACKGROUND:Ex-vivo lung perfusion (EVLP) is an innovative platform for assessing donor lungs in the pre-transplant window. In this study, we demonstrate an extension of its utility by administering the anti-CD20 monoclonal antibody, Rituximab, during EVLP. We hypothesized that this would lead to targeted depletion of a...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.102994

    authors： Ku TJY,Ribeiro RVP,Ferreira VH,Galasso M,Keshavjee S,Kumar D,Cypel M,Humar A

    更新日期：2020-10-01 00:00:00

  • Modeling polymorphic ventricular tachycardia at rest using patient-specific induced pluripotent stem cell-derived cardiomyocytes.

    abstract：BACKGROUND:While mutations in the cardiac type 2 ryanodine receptor (RyR2) have been linked to exercise-induced or catecholaminergic polymorphic ventricular tachycardia (CPVT), its association with polymorphic ventricular tachycardia (PMVT) occurring at rest is unclear. We aimed at constructing a patient-specific human...

    journal_title：EBioMedicine

    pub_type： 杂志文章

    doi：10.1016/j.ebiom.2020.103024

    authors： Sleiman Y,Souidi M,Kumar R,Yang E,Jaffré F,Zhou T,Bernardin A,Reiken S,Cazorla O,Kajava AV,Moreau A,Pasquié JL,Marks AR,Lerman BB,Chen S,Cheung JW,Evans T,Lacampagne A,Meli AC

    更新日期：2020-10-01 00:00:00