Abstract：
:This study investigates differences and associations between urinary mineral concentrations and calcaneal bone measures assessed by quantitative ultrasonography (QUS) in 4322 children (3.1-11.9 years, 50.6% boys) from seven European countries. Urinary mineral concentrations and calcaneal QUS parameters differed significantly across countries. Clustering revealed a lower stiffness index (SI) in children with low and medium urinary mineral concentrations, and a higher SI in children with high urinary mineral concentrations. Urinary sodium (uNa) was positively correlated with urinary calcium (uCa), and was positively associated with broadband ultrasound attenuation and SI after adjustment for age, sex and fat-free mass. Urinary potassium (uK) was negatively correlated with uCa but positively associated with speed of sound after adjustment. No association was found between uCa and QUS parameters after adjustment, but when additionally adjusting for uNa, uCa was negatively associated with SI. Our findings suggest that urinary mineral concentrations are associated with calcaneal QUS parameters and may therefore implicate bone properties. These findings should be confirmed in longitudinal studies that include the food intake and repeated measurement of urinary mineral concentrations to better estimate usual intake and minimize bias.
journal_name
Int J Environ Res Public Healthauthors
Van den Bussche K,Herrmann D,De Henauw S,Kourides YA,Lauria F,Marild S,Molnár D,Moreno LA,Veidebaum T,Ahrens W,Sioen I,On Behalf Of The Dedipac Consortiumdoi
10.3390/ijerph13050471subject
Has Abstractpub_date
2016-05-05 00:00:00issue
5eissn
1661-7827issn
1660-4601pii
ijerph13050471journal_volume
13pub_type
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