Hepatitis E Virus Infection Among Solid Organ Transplant Recipients at a North American Transplant Center.


:Background.  Autochthonous hepatitis E virus (HEV) infection has been reported in over 200 solid organ transplant (SOT) recipients since 2006, yet little is known about the burden of HEV among SOT recipients in North America. We performed a retrospective, cross-sectional study to investigate the prevalence and risk factors associated with HEV infection among SOT recipients at our institution. Methods.  Children and adults (n = 311) who received allografts between 1988 and 2012 at the Johns Hopkins Hospital were assessed for evidence of HEV infection by testing posttransplantation serum samples for HEV antibody by enzyme immunoassay and HEV RNA by reverse transcription quantitative polymerase chain reaction. Individuals with evidence of posttransplant HEV infection (presence of anti-HEV immunoglobulin [Ig]M antibody, anti-HEV IgG seroconversion, or HEV RNA) were compared with individuals without evidence of infection and assessed for risk factors associated with infection. Results.  Twelve individuals (4%) developed posttransplant HEV infection. Posttransplant HEV infection was associated with an increased risk for graft rejection (odds ratio, 14.2; P = .03). No individuals developed chronic infection. Conclusions.  Solid organ transplant recipients in the United States are at risk for posttransplant HEV infection. Further studies are needed to characterize environmental risk factors and the risk of HEV infection after SOT in North America.


Open Forum Infect Dis


Sue PK,Pisanic N,Heaney CD,Forman M,Valsamakis A,Jackson AM,Ticehurst JR,Montgomery RA,Schwarz KB,Nelson KE,Karnsakul W




Has Abstract


2016-01-18 00:00:00












  • Sonography to Rule Out Tuberculosis in Sub-Saharan Africa: A Prospective Observational Study.

    abstract:Background:Patients with suspected tuberculosis are often overtreated with antituberculosis drugs. We evaluated the diagnostic value of the focused assessment with sonography for HIV-associated tuberculosis (FASH) in rural Tanzania. Methods:In a prospective cohort study, the frequency of FASH signs was compared betwee...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Ndege R,Weisser M,Elzi L,Diggelmann F,Bani F,Gingo W,Sikalengo G,Mapesi H,Mchomvu E,Kamwela L,Mnzava D,Battegay M,Reither K,Paris DH,Rohacek M

    更新日期:2019-04-25 00:00:00

  • Sulfamethoxazole-Trimethoprim (Cotrimoxazole) for Skin and Soft Tissue Infections Including Impetigo, Cellulitis, and Abscess.

    abstract::Skin and soft tissue infections (SSTI) affect millions of people globally, which represents a significant burden on ambulatory care and hospital settings. The role of sulfamethoxazole-trimethoprim (SXT) in SSTI treatment, particularly when group A Streptococcus (GAS) is involved, is controversial. We conducted a syste...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章,评审


    authors: Bowen AC,Carapetis JR,Currie BJ,Fowler V Jr,Chambers HF,Tong SYC

    更新日期:2017-11-02 00:00:00

  • Considerations for the Selection and Use of Disinfectants Against SARS-CoV-2 in a Health Care Setting.

    abstract::Proper disinfection using adequate disinfecting agents will be necessary for infection control strategies against coronavirus disease 2019 (COVID-19). However, limited guidance exists on effective surface disinfectants or best practices for their use against severe acute respiratory coronavirus 2. We outlined a proces...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Tyan K,Levin A,Avalos-Pacheco A,Plana D,Rand EA,Yang H,Maliszewski LE,Chylek LA,Atta L,Tye MA,Carmack MM,Oglesby NS,Burgin S,Yu SH,LeBoeuf NR,Kemp JM

    更新日期:2020-08-31 00:00:00

  • Rapid Emergence of a New Clone Impacts the Population at Risk and Increases the Incidence of Type emm89 Group A Streptococcus Invasive Disease.

    abstract:BACKGROUND:Invasive group A Streptococcus (iGAS) disease caused by type emm89 strains has been increasing worldwide, driven by the emergence of an epidemic clonal variant (clade 3 emm89). The clinical characteristics of patients with emm89 iGAS disease, and in particular with clade 3 emm89 iGAS disease, are poorly desc...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Teatero S,Coleman BL,Beres SB,Olsen RJ,Kandel C,Reynolds O,Athey TBT,Musser JM,McGeer A,Fittipaldi N

    更新日期:2017-03-04 00:00:00

  • Continued Sensitivity of Plasmodium falciparum to Artemisinin in Guyana, With Absence of Kelch Propeller Domain Mutant Alleles.

    abstract::Because of concerns about possible emergence of artemisinin resistance strains of Plasmodium falciparum in mining areas of the interior of Guyana, a 7-day artesunate trial was conducted from March to December 2014. The day-3 parasite clearance rate, the efficacy of artesunate at day 28, and polymorphism of Kelch 13 (P...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Rahman R,Martin MJ,Persaud S,Ceron N,Kellman D,Musset L,Carter KH,Ringwald P

    更新日期:2016-08-30 00:00:00

  • Effectiveness of Implementing a Locally Developed Antibiotic Use Guideline for Community-Acquired Cellulitis at a Large Tertiary Care University Hospital in Thailand.

    abstract:Background:To determine the effectiveness of implementing a locally developed clinical practice guideline (CPG) for antibiotic treatment in adults with community-acquired cellulitis at Siriraj Hospital in Bangkok, Thailand. Methods:The CPG for antibiotic treatment of community-acquired cellulitis was developed based o...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Sirijatuphat R,Nookeu P,Thamlikitkul V

    更新日期:2020-09-07 00:00:00

  • Prevalence of Cryptococcal Antigen and Outcomes in People With Human Immunodeficiency Virus in Honduras: A Cohort Study.

    abstract:Background:Cryptococcal meningitis is a major cause of death among people with human immunodeficiency virus (PWH). Cryptococcal antigen (CrAg) testing of asymptomatic patients is an important public health measure to reduce mortality in high-incidence areas. However, limited data exist on CrAg prevalence in Central Ame...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Zuniga-Moya JC,Romero-Reyes LE,Saavedra EB,Montoya S,Varela D,Borjas M,Cerna A,Bejarano S,Martinez P,Lujan K,Erazo K,Lainez I,Pineda L,Yanes D,O'Halloran JA,Spec A

    更新日期:2020-11-13 00:00:00

  • Outcomes of Older Adults With Sepsis at Admission to an Intensive Care Unit.

    abstract::Background.  Sepsis is a major cause of morbidity and mortality among older adults. The main goals of this study were to assess the association of sepsis at intensive care unit (ICU) admission with mortality and to identify predictors associated with increased mortality in older adults. Methods.  We conducted a prospe...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Rowe T,Araujo KL,Van Ness PH,Pisani MA,Juthani-Mehta M

    更新日期:2016-01-21 00:00:00

  • Impact of Procalcitonin-Guided Antibiotic Management on Antibiotic Exposure and Outcomes: Real-world Evidence.

    abstract:Background:Delayed pathogen identification and nonspecific clinical findings make definitive decisions regarding antibiotics challenging. The stimuli of bacterial toxins and inflammation make procalcitonin (PCT) unique in its ability to differentiate bacterial infection from other causes of inflammation, and thus it is...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Broyles MR

    更新日期:2017-10-03 00:00:00

  • Errors in Diagnostic Test Use and Interpretation Contribute to the High Number of Lyme Disease Referrals in a Low-Incidence State.

    abstract::Lyme disease accounted for more than two-thirds (56 of 81, 69.1%) of all tick-borne disease referrals to a large, academic infectious diseases clinic in a low-incidence state. Deviations from diagnostic testing guidelines and errors in test interpretation were common (23 of 35, 65.7%), suggesting that frontline provid...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Boyce RM,Speight C,Lin JT,Farel CE

    更新日期:2020-01-11 00:00:00

  • Immunogenicity and Reactogenicity of a Reduced Schedule of a 4-component Capsular Group B Meningococcal Vaccine: A Randomized Controlled Trial in Infants.

    abstract:Background:The 4-component capsular group B meningococcal vaccine (4CMenB) was licensed as a 4-dose infant schedule but introduced into the United Kingdom as 3 doses at 2, 4, and 12 months of age. We describe the immunogenicity and reactogenicity of the 2 + 1 schedule in infants. Methods:Infants were randomized to rec...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Valente Pinto M,O'Connor D,Galal U,Clutterbuck EA,Robinson H,Plested E,Bibi S,Camara Pellisso S,Hughes H,Kerridge S,Mujadidi YF,Findlow H,Borrow R,Snape MD,Pollard AJ

    更新日期:2020-04-29 00:00:00

  • Comparison of Adverse Drug Reactions Between Patients Treated With Ceftaroline or Ceftriaxone: A Single-Center, Matched Cohort Study.

    abstract:Background:Little information is available on the relative tolerability of ceftaroline versus other cephalosporins in clinical practice. We sought to compare adverse drug reactions (ADRs) associated with ceftaroline with those associated with ceftriaxone in hospitalized patients. Materials and Methods:This was a retro...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Jansen JW,Linneman TW,Tan X,Moenster RP

    更新日期:2019-06-13 00:00:00

  • Human Immunodeficiency Virus-1 Sequence Changes and Drug Resistance Mutation Among Virologic Failures of Lopinavir/Ritonavir Monotherapy: AIDS Clinical Trials Group Protocol A5230.

    abstract:: Background.  The mechanism of virologic failure (VF) of lopinavir/ritonavir (LPV/r) monotherapy is not well understood. We assessed sequence changes in human immunodeficiency virus-1 reverse-transcriptase (RT) and protease (PR) regions. Methods. ...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Vardhanabhuti S,Katzenstein D,Bartlett J,Kumarasamy N,Wallis CL

    更新日期:2016-08-24 00:00:00

  • Hyaluronidase-Facilitated High-Dose Subcutaneous IgG Effectively Controls Parvovirus B19 Infection in a Pediatric Cardiac Transplant Patient With Severe T-Cell Lymphopenia.

    abstract::We treated three pediatric cardiac transplant patients with chronic parvovirus viremia with high-dose intravenous immunoglobulin (HD-IVIG). One patient with severe T-cell lymphopenia suffered recurrent viremia and aseptic meningitis, which resolved remarkably when he was switched to high-dose hyaluronidase-facilitated...

    journal_title:Open forum infectious diseases



    authors: Cruz RJ,Dasso JF,Duff C,Krasnopero D,Long Z,Ellison M,Nieves D,Sriaroon P,Asante-Korang A,Walter JE

    更新日期:2020-03-12 00:00:00

  • Evaluation of Real-time PCR for Diagnosis of Post-Kala-azar Dermal Leishmaniasis in Endemic Foci of Bangladesh.

    abstract:Background:Post-kala-azar dermal leishmaniasis (PKDL) is a sequel to visceral leishmaniasis (VL), which is found in VL-endemic countries including Bangladesh. Because of these enigmatic cases, the success of the National Kala-azar Elimination Program is under threat. To date, diagnostic methods for PKDL cases in endemi...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Ghosh P,Hasnain MG,Hossain F,Khan MAA,Chowdhury R,Faisal K,Mural MA,Baker J,Nath R,Ghosh D,Maruf S,Shomik MS,Haque R,Matlashewski G,Hamano S,Duthie MS,Mondal D

    更新日期:2018-09-15 00:00:00

  • Role of HCV Viremia in Corroborated HCV Transmission Events Within Young Adult Injecting Partnerships.

    abstract:Background:Hepatitis C virus (HCV), a major cause of morbidity and mortality, is common and rising among young persons who inject drugs (PWID). Reducing the level of viremia may be an intervention, yet the impact of viremia on HCV transmission is unknown. Methods:We conducted a prospective study of injecting partnersh...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Hahn JA,Tully DC,Evans JL,Morris MD,Briceno A,Bean DJ,Allen TM,Page K

    更新日期:2019-04-25 00:00:00

  • The Yield and Consistency of the Detection of SARS-CoV-2 in Multiple Respiratory Specimens.

    abstract:Background:Few studies have compared the yield of reverse transcription polymerase chain reaction (RT-PCR) assays in nasopharyngeal swabs, oropharyngeal swabs, and sputum for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection. Methods:We conducted an observational study in Beijing Ditan Hospital, C...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Zhang H,Chen M,Zhang Y,Wen J,Wang Y,Wang L,Guo J,Liu C,Li D,Wang Y,Bai J,Gao G,Wang S,Yang D,Yu F,Yan L,Wan G,Zhang F

    更新日期:2020-08-26 00:00:00

  • Safety and Efficacy of Ombitasvir, Paritaprevir With Ritonavir ± Dasabuvir With or Without Ribavirin in Patients With Human Immunodeficiency Virus-1 and Hepatitis C Virus Genotype 1 or Genotype 4 Coinfection: TURQUOISE-I Part 2.

    abstract:BACKGROUND:Ombitasvir, paritaprevir with ritonavir, and dasabuvir (OBV/PTV/r ± DSV) ±ribavirin (RBV) are approved to treat hepatitis C virus (HCV) genotype 1 and 4 infection. Here, we investigate the safety and efficacy of OBV/PTV/r + DSV ±RBV for HCV genotype 1, and OBV/PTV/r + RBV for HCV genotype 4, in human immunod...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Rockstroh JK,Orkin C,Viani RM,Wyles D,Luetkemeyer AF,Lazzarin A,Soto-Malave R,Nelson MR,Bhagani SR,Klinker HHF,Rizzardini G,Girard PM,Tural C,Shulman NS,Mobashery N,Hu YB,Fredrick LM,Pilot-Matias T,Trinh R,Gane E

    更新日期:2017-07-22 00:00:00

  • Lessons Learned From a Randomized Controlled Trial of Short-Course Intravenous Antibiotic Therapy for Erysipelas and Cellulitis of the Lower Limb (Switch Trial).

    abstract:Background:The diagnosis of cellulitis is made clinically without a gold standard diagnostic test, and cellulitis has many disease mimics. There is currently no consensus for optimal antimicrobial treatment duration or method of antimicrobial delivery. Methods:This was a randomized controlled open-label multicenter tr...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Clarke MC,Cheng AC,Pollard JG,Birch M,Cowan RU,Linke JA,Walton AL,Friedman ND

    更新日期:2019-07-20 00:00:00

  • Hepatitis C Elimination in People With HIV Is Contingent on Closing Gaps in the HIV Continuum.

    abstract:Background:Bolstered by the high efficacy of hepatitis C virus (HCV) treatment, the World Health Organization has called for HCV elimination by 2030. People with HIV (PWH) have been identified as a population in which elimination should be prioritized. Methods:We examined progress in HCV elimination through the HCV ca...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Falade-Nwulia O,Sutcliffe CG,Mehta SH,Moon J,Chander G,Keruly J,Katzianer J,Thomas DL,Moore RD,Sulkowski MS

    更新日期:2019-09-30 00:00:00

  • Safety and Immunogenicity of Modified Vaccinia Ankara-Bavarian Nordic Smallpox Vaccine in Vaccinia-Naive and Experienced Human Immunodeficiency Virus-Infected Individuals: An Open-Label, Controlled Clinical Phase II Trial.

    abstract::Background.  First- and second-generation smallpox vaccines are contraindicated in individuals infected with human immunodeficiency virus (HIV). A new smallpox vaccine is needed to protect this population in the context of biodefense preparedness. The focus of this study was to compare the safety and immunogenicity of...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Overton ET,Stapleton J,Frank I,Hassler S,Goepfert PA,Barker D,Wagner E,von Krempelhuber A,Virgin G,Meyer TP,Müller J,Bädeker N,Grünert R,Young P,Rösch S,Maclennan J,Arndtz-Wiedemann N,Chaplin P

    更新日期:2015-05-05 00:00:00

  • Acute Weight Gain After Switch to Emtricitabine/Tenofovir Alafenamide for Human Immunodeficiency Virus Pre-Exposure Prophylaxis.

    abstract::We report a case of acute weight gain after switching from emtricitabine/tenofovir disoproxil to emtricitabine/tenofovir alafenamide for human immunodeficiency virus pre-exposure prophylaxis. ...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Selvaraj SV,Bares SH,Havens JP

    更新日期:2020-09-24 00:00:00

  • Multiple-Dose Oral Fosfomycin for Treatment of Complicated Urinary Tract Infections in the Outpatient Setting.

    abstract:Background:Few published studies exist to describe the off-label use of multiple-dose fosfomycin for outpatient treatment of complicated urinary tract infections (UTI). The purpose of this study was to characterize the patients, infections, drug susceptibilities, and outcomes of multiple-dose fosfomycin episodes for ou...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Derington CG,Benavides N,Delate T,Fish DN

    更新日期:2020-01-29 00:00:00

  • Symptomatic Acute Toxoplasmosis in Returning Travelers.

    abstract::We report a family who acquired acute toxoplasmosis after a trip to Central America. One member developed severe clinical manifestations including bilateral chorioretinitis, hepatitis, and myocarditis requiring therapy. Symptomatic acute toxoplasmosis is unusual and possesses a diagnostic challenge. We discuss the cli...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Henao-Martínez AF,Franco-Paredes C,Palestine AG,Montoya JG

    更新日期:2018-03-09 00:00:00

  • Vaccine Effectiveness Against Influenza-Associated Lower Respiratory Tract Infections in Hospitalized Adults, Louisville, Kentucky, 2010-2013.

    abstract:Background:Preventing severe complications of influenza such as hospitalization is a public health priority; however, estimates of influenza vaccine effectiveness (VE) against influenza-associated acute lower respiratory tract infection (LRTI) hospitalizations are limited. We examined influenza VE against influenza-ass...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Chow EJ,Rolfes MA,Carrico RL,Furmanek S,Ramirez JA,Ferdinands JM,Fry AM,Patel MM

    更新日期:2020-06-30 00:00:00

  • Antibiotic Treatment Versus No Treatment for Asymptomatic Bacteriuria in Kidney Transplant Recipients: A Multicenter Randomized Trial.

    abstract:Background:Whether antibiotic treatment of asymptomatic bacteriuria (AB) can prevent acute graft pyelonephritis (AGP) in kidney transplant (KT) recipients has not been elucidated. Methods:In this multicenter, open-label, nonblinded, prospective, noninferiority, randomized controlled trial, we compared antibiotic treat...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Sabé N,Oriol I,Melilli E,Manonelles A,Bestard O,Polo C,Los Arcos I,Perelló M,Garcia D,Riera L,Tebé C,Len Ò,Moreso F,Cruzado JM,Carratalà J

    更新日期:2019-05-21 00:00:00

  • Physician Decisions to Defer Antiretroviral Therapy in Key Populations: Implications for Reducing Human Immunodeficiency Virus Incidence and Mortality in Malaysia.

    abstract:BACKGROUND:Antiretroviral therapy (ART) is recommended for all people living with human immunodeficiency virus (HIV), yet physician attitudes and prescribing behaviors toward members of key risk populations may limit ART access and undermine treatment as prevention strategies. METHODS:Physicians in Malaysia (N = 214) ...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Ferro EG,Culbert GJ,Wickersham JA,Marcus R,Steffen AD,Pauls HA,Westergaard RP,Lee CK,Kamarulzaman A,Altice FL

    更新日期:2017-01-25 00:00:00

  • Corticosteroids for Posttransplant Immune Reconstitution Syndrome in Cryptococcus gattii Meningoencephalitis: Case Report and Literature Review.

    abstract::Cryptococcus gattii represents an emerging fungal pathogen of immunocompromised and immunocompetent hosts in the United States. To our knowledge, this is the first case of posttransplant immune reconstitution syndrome due to C. gattii meningoencephalitis successfully treated with corticosteroids. We also report succes...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Canfield GS,Henao-Martínez AF,Franco-Paredes C,Zhelnin K,Wilson ML,Shihadeh KC,Wyles D,Gardner EM

    更新日期:2019-10-23 00:00:00

  • Difficulties of Identifying the Early HIV Antibody Seroconversion Period Depending on the Confirmatory Assay.

    abstract:Background:Identification of HIV infection at the early stage is valuable for patient management, for prevention, and for research purposes. In practice, identification of a recent HIV infection at diagnosis proves challenging after HIV antibody seroconversion but can be suspected using Western blots (WBs) or immunoblo...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Stefic K,Mahjoub N,Desouche C,Néré ML,Thierry D,Delaugerre C,Barin F,Chaix ML

    更新日期:2020-04-21 00:00:00

  • Sustained Circulating Bacterial Deoxyribonucleic Acid Is Associated With Complicated Staphylococcus aureus Bacteremia.

    abstract:Background:Staphylococcus aureus (SA) bacteremia often requires a long treatment duration with antibiotics to prevent relapse due to the ability of SA to establish reservoirs of infection in sites such as heart and bone. These metastatic sites of infection cannot be serially sampled to monitor the clearance of SA infec...

    journal_title:Open forum infectious diseases

    pub_type: 杂志文章


    authors: Gutierrez J,Guimaraes AO,Lewin-Koh N,Berhanu A,Xu M,Cao Y,Kim J,Yan D,Chang JK,Dinoso JB,Koss CA,Clemenzi-Allen A,Chambers HF,Peck MC,Baruch A,Rosenberger CM

    更新日期:2019-02-26 00:00:00