Abstract:
:Gram-negative bacteria are intrinsically resistant to many antibiotics. Species that have acquired multidrug resistance and cause infections that are effectively untreatable present a serious threat to public health. The problem is broadly recognized and tackled at both the fundamental and applied levels. This paper summarizes current advances in understanding the molecular bases of the low permeability barrier of Gram-negative pathogens, which is the major obstacle in discovery and development of antibiotics effective against such pathogens. Gaps in knowledge and specific strategies to break this barrier and to achieve potent activities against difficult Gram-negative bacteria are also discussed.
journal_name
ACS Infect Disjournal_title
ACS infectious diseasesauthors
Zgurskaya HI,Löpez CA,Gnanakaran Sdoi
10.1021/acsinfecdis.5b00097subject
Has Abstractpub_date
2015-01-01 00:00:00pages
512-522issue
11issn
2373-8227journal_volume
1pub_type
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