Viral Escape in the Central Nervous System with Multidrug-Resistant Human Immunodeficiency Virus-1.

Abstract:

:In this study, we report the case of a patient infected with human immunodeficiency virus (HIV)-1 who developed ataxia and neurocognitive impairment due to viral escape within the central nervous system (CNS) with a multidrug-resistant HIV-1 despite long-term viral suppression in plasma. Antiretroviral therapy optimization with drugs with high CNS penetration led to viral suppression in the CSF, regression of ataxia, and improvement of neurocognitive symptoms.

journal_name

Open Forum Infect Dis

authors

Béguelin C,Vázquez M,Bertschi M,Yerly S,de Jong D,Gutbrod K,Rauch A,Cusini A

doi

10.1093/ofid/ofv210

subject

Has Abstract

pub_date

2015-12-28 00:00:00

pages

ofv210

issue

1

issn

2328-8957

pii

ofv210

journal_volume

3

pub_type

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