Abstract:
BACKGROUND:The aim of this study was to investigate the plasma levels of complement C3a, C4a, and C5a in different types of neovascular age-related macular degeneration (nAMD) and whether the levels were related to patients' responsiveness to anti-VEGF therapy. RESULTS:Ninety-six nAMD patients (including 61 with choroidal neovascularisation (CNV), 17 with retinal angiomatous proliferation (RAP), 14 with polypoidal choroidal vasculopathy (PCV) and 4 unclassified patients) and 43 controls were recruited to this case-control study. Subretinal fibrosis was observed in 45 nAMD patients and was absent in 51 nAMD patients. In addition, the responsiveness to anti-VEGF (Lucentis) therapy was also evaluated in nAMD patients. Forty-four patients were complete responders, 48 were partially responders, and only 4 patients did not respond to the therapy. The plasma levels of C3a, C4a and C5a were significantly higher in nAMD patients compared to controls. Further analysis of nAMD subgroups showed that the levels of C3a, C4a and C5a were significantly increased in patients with CNV but not RAP and PCV. Significantly increased levels of C3a, C4a and C5a were also observed in nAMD patients with subretinal fibrosis but not in those without subretinal fibrosis. Higher levels of C3a were observed in nAMD patients who responded partially to anti-VEGF therapy. CONCLUSIONS:Our results suggest increased systemic complement activation in nAMD patients with CNV but not RAP and PCV. Our results also suggest that higher levels of systemic complement activation may increase the risk of subretinal fibrosis in nAMD patients.
journal_name
Immun Ageingjournal_title
Immunity & ageing : I & Aauthors
Lechner J,Chen M,Hogg RE,Toth L,Silvestri G,Chakravarthy U,Xu Hdoi
10.1186/s12979-016-0060-5subject
Has Abstractpub_date
2016-02-16 00:00:00pages
4issn
1742-4933pii
60journal_volume
13pub_type
杂志文章abstract:BACKGROUND:Neurodegenerative disorders such Alzheimer's disease (AD) are often characterized by senile plaques and neurofibrillary tangle. In addition, reactive astrogliosis, microglia activation and a chronic inflammation are found in AD brain. Activated microglia has been reported to express a large number of beta ch...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-10-6
更新日期:2013-02-21 00:00:00
abstract:BACKGROUND:Systolic blood pressure (SBP) increases steadily with age and bears an independent continuous relationship with the incidence of cardiovascular events. Low-grade inflammation is a suspected pathomechanism causing vascular aging and promote coronary artery disease (CAD). Recent animal studies give evidence th...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/s12979-015-0031-2
更新日期:2015-05-20 00:00:00
abstract:BACKGROUND:Neutrophil dysfunction plays a key role in the development of diseases characterized by inflammation and angiogenesis. Here, we studied the systemic expression of neutrophil markers reflecting activation, adhesion, and resolution of inflammation in patients with neovascular age-related macular degeneration (...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/s12979-017-0100-9
更新日期:2017-07-27 00:00:00
abstract::Progressive increase of mean age and life expectancy in both industrialized and emerging societies parallels an increment of chronic degenerative diseases (CDD) such as cancer, cardiovascular, autoimmune or neurodegenerative diseases among the elderly. CDD are of complex diagnosis, difficult to treat and absorbing an ...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-7-S1-S1
更新日期:2010-12-16 00:00:00
abstract:Background:Peripheral blood mononuclear cells (PBMCs) are implicated in the pathogenesis of age-related macular degeneration (AMD). We here mapped the global gene transcriptome of PBMCs from patients with different clinical subtypes of late AMD. Results:We sampled fresh venous blood from patients with geographic atrop...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/s12979-019-0160-0
更新日期:2019-08-15 00:00:00
abstract:BACKGROUND:Ageing brings about the gradual deterioration of the immune system, also known as immunosenescence. The role of non-coding circular RNA in immunosenescence is under studied. Using circular RNA microarray data, we assembled Comparison groups (C1, C2, C3 and C4) that allowed us to compare the circular RNA expr...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/s12979-015-0042-z
更新日期:2015-10-08 00:00:00
abstract::[This corrects the article DOI: 10.1186/s12979-018-0122-y.]. ...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12979-018-0123-x
更新日期:2018-08-21 00:00:00
abstract:UNLABELLED: BACKGROUND:Respiratory Syncytial Virus (RSV) causes significant disease in the elderly, in part, because immunosenescence impairs protective immune responses to infection in this population. Despite previous and current efforts, there is no RSV vaccine currently licensed in infants or elderly adults. Adjuv...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-9-21
更新日期:2012-10-02 00:00:00
abstract:BACKGROUND:There is strong evidence that an individual's genetic background is an important predisposing factor to longevity. In the present study we analysed the frequency of HLA class I, class II, as well as the TNF-alpha -308 polymorphism that may be related to an increased life span in Mexican Mestizo healthy elder...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-2-13
更新日期:2005-11-03 00:00:00
abstract:BACKGROUND:The age-related weakening of the immune system makes elderly subjects less responsive to influenza vaccination. In the last years, two "enhanced vaccines" were licensed for individuals aged ≥65 years, one being a subunit vaccine (Fluad®) containing the MF59 adjuvant administered intramuscularly (IM-MF59) and...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-11-10
更新日期:2014-05-16 00:00:00
abstract::Alone among herpesviruses, persistent Cytomegalovirus (CMV) markedly alters the numbers and proportions of peripheral immune cells in infected-vs-uninfected people. Because the rate of CMV infection increases with age in most countries, it has been suggested that it drives or at least exacerbates "immunosenescence". T...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-9-23
更新日期:2012-10-31 00:00:00
abstract::The capacity of the remodelling immune responses during stress (named immune plasticity) is fundamental to reach successful ageing. We herein report two pivotal experimental models in order to demonstrate the relevance of the immune plasticity in ageing and successful ageing. These two experimental models will be comp...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-4-7
更新日期:2007-09-29 00:00:00
abstract::Streptococcus pneumoniae is a serious worldwide pathogen and the focus of numerous vaccine development projects. Currently the most widely accepted surrogate marker for evaluating the efficacy of a given vaccine is to utilize ELISA. Measurement of antibody concentration by ELISA without reduction in cross-reactive ant...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-2-10
更新日期:2005-06-27 00:00:00
abstract::The age-related dysregulation and decline of the immune system-collectively termed "immunosenescence"-has been generally associated with an increased susceptibility to infectious pathogens and poor vaccine responses in older adults. While numerous studies have reported on the clinical outcomes of infected or vaccinate...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章,评审
doi:10.1186/s12979-019-0164-9
更新日期:2019-09-13 00:00:00
abstract:BACKGROUND:Multiple myeloma (MM) is a neoplastic disorder of plasma cells interesting mainly the elderly. MM remains an incurable disease, mostly because of the strong interplay between clonal plasma cells (cPCs) and bone marrow (BM) microenvironment. Multiparameter flow cytometry (MFC) allows the simultaneous study of...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/s12979-015-0032-1
更新日期:2015-06-04 00:00:00
abstract::Aging is associated with a decline in immune function (immunosenescence), a situation known to correlate with increased incidence of cancer, infectious and degenerative diseases. Innate, cellular and humoral immunity all exhibit increased deterioration with age. A decrease in functional competence of individual natura...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-2-17
更新日期:2005-11-29 00:00:00
abstract::Concerning allergic diseases, the incidence of allergic symptoms, as well as their severity, seems to decrease with age. The decline of onset of allergic symptoms observed in ageing might result from a decrease of serum total and specific IgE. Atopic disorders are complex diseases that involve interactions among sever...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-2-9
更新日期:2005-05-31 00:00:00
abstract::ABO blood group antigens are expressed either on the surface of red blood cells either on a variety of other cells. Based on the available knowledge of the genes involved in their biosynthesis and their tissue distribution, their polymorphism has been suggested to provide intraspecies diversity allowing to cope with d...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章,评审
doi:10.1186/1742-4933-11-16
更新日期:2014-11-01 00:00:00
abstract:BACKGROUND:Ischemic injury triggers inflammatory cascades and changes in the protein synthesis, neurotransmitters and neuro-hormones in the brain parenchyma that may further amplify the tissue damage. The "Triage® Stroke Panel", a biochemical multimarker assay, detects Brain Natriuretic Peptide (BNP), D-Dimers (DD), Ma...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/s12979-016-0074-z
更新日期:2016-05-31 00:00:00
abstract::In the brain, Oxidative Stress (OS) contribute to structural and functional changes associated with vascular aging, such as endothelial dysfunction, extracellular matrix degradation, resulting in age-related reduced vasodilatation in response to agonists. For this reason, OS is considered a key factor in Alzheimer's D...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/s12979-019-0147-x
更新日期:2019-04-01 00:00:00
abstract:: Nonagenarians are the fastest growing sector of populations across Western European and the developed world. They are some of the oldest members of our societies and survivors of their generation and may help us understand how to age not only longer, but better.The Belfast Longevity Group enlisted the help of 500 com...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-7-6
更新日期:2010-05-27 00:00:00
abstract:BACKGROUND:The immune system gradually deteriorates with age and nutritional status is a major factor in immunosenescence. Of the many nutritional factors implicated in age-related immune dysfunction, vitamin A may be a good candidate, since vitamin A concentrations classically decrease during aging whereas it may poss...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-7-10
更新日期:2010-08-20 00:00:00
abstract:BACKGROUND:Obesity is associated with chronic low-grade inflammation leading to metabolic and cardiovascular diseases, but a subset of obese individuals is considered insulin sensitive (IS). The underlying pathophysiologic mechanisms remain elusive and clinical studies on the relationship between inflammatory markers a...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/s12979-020-00211-y
更新日期:2020-12-21 00:00:00
abstract:: Aging is the sum of the deleterious changes that occur as time goes by. It is the main risk factor for the development of cardiovascular disease, and aging of the vasculature is the event that most often impacts on the health of elderly people. The "free-radical theory of aging" was proposed to explain aging as a con...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-9-26
更新日期:2012-11-15 00:00:00
abstract:BACKGROUND:CD90 (Thy-1) is a small glycoprotein that is particularly abundant on the surface of mouse thymocytes and peripheral T cells, and is often used as a marker in adoptive transfer experiments to distinguish donor and recipient T cells with different CD90 subtypes. We have performed adoptive transfer experiments...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-10-36
更新日期:2013-08-19 00:00:00
abstract::It is now commonly accepted that chronic inflammation associated with obesity during aging induces insulin resistance in the liver. In the present study, we investigated whether the improvement in insulin sensitivity and insulin signaling, mediated by acute exercise, could be associated with modulation of protein-tyro...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-10-8
更新日期:2013-02-25 00:00:00
abstract::Compromised immunity contributes to the decreased ability of the elderly to control infectious disease and to their generally poor response to vaccination. It is controversial as to how far this phenomenon contributes to the well-known age-associated increase in the occurrence of many cancers in the elderly. However, ...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/1742-4933-5-11
更新日期:2008-09-24 00:00:00
abstract:Background:Recent studies show that C-reactive protein (CRP) is not only a biomarker but also a pathogenic mediator contributing to the development of inflammation and ageing-related diseases. However, serum levels of CRP in the healthy ageing population remained unclear, which was investigated in the present study. M...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/s12979-018-0126-7
更新日期:2018-09-08 00:00:00
abstract::Modulation of endogenous cellular defense mechanisms via the vitagene system represents an innovative approach to therapeutic intervention in diseases causing chronic tissue damage, such as in neurodegeneration. The possibility of high-throughoutput screening using proteomic techniques, particularly redox proteomics, ...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章,评审
doi:10.1186/s12979-015-0046-8
更新日期:2015-11-04 00:00:00
abstract:Background:Innate immunity utilizes components of sensory signal transduction such as bitter and sweet taste receptors. In fact, empirical evidence has shown bitter and sweet taste receptors to be an integral component of antimicrobial immune response in upper respiratory tract infections. Since an efficient immune res...
journal_title:Immunity & ageing : I & A
pub_type: 杂志文章
doi:10.1186/s12979-019-0146-y
更新日期:2019-02-23 00:00:00