The Role of CD4 T Cell Memory in Generating Protective Immunity to Novel and Potentially Pandemic Strains of Influenza.

abstract：:Fibroblastic reticular cells (FRCs) are the specialized lymphoid stromal cells initially identified as triggering T-cell recruitment and dynamic motion in secondary lymphoid organs. Interestingly, FRCs also display antigen presentation capacities and support lymphocyte survival. CXCR5+CD4+ follicular T cells are impor...

journal_title：Frontiers in immunology

authors： Misiak J,Jean R,Rodriguez S,Deleurme L,Lamy T,Tarte K,Amé-Thomas P

更新日期：2020-10-02 00:00:00

abstract：:C-reactive protein (CRP) binds to several species of bacterial pathogens including Streptococcus pneumoniae. Experiments in mice have revealed that one of the functions of CRP is to protect against pneumococcal infection by binding to pneumococci and activating the complement system. For protection, however, CRP must ...

journal_title：Frontiers in immunology

authors： Ngwa DN,Singh SK,Gang TB,Agrawal A

更新日期：2020-10-07 00:00:00

abstract：:This article describes the work I did in Bill Paul's lab as a postdoctoral fellow between 1979 and 1983, and to a lesser extent puts that work in the context of other work on B cell activation and antibody responses that was going on in Bill's lab at that time and shortly beforehand, including the discovery of interle...

journal_title：Frontiers in immunology

authors： DeFranco AL

更新日期：2018-04-23 00:00:00

abstract：:While rodent cancer models are essential for early proof-of-concept and mechanistic studies for immune therapies, these models have limitations with regards to predicting the ultimate effectiveness of new immunotherapies in humans. As a unique spontaneous, large animal model of cancer, the value of conducting studies ...

journal_title：Frontiers in immunology

authors： Dow S

更新日期：2020-01-17 00:00:00

abstract：:Neutrophil granulocytes are the most numerous type of leukocyte in humans bearing an enormous, yet largely unexplored therapeutic potential. Scientists have very recently increased their efforts to study and understand these cells which contribute to various types of inflammatory diseases and cancer. The mechanisms th...

journal_title：Frontiers in immunology

authors： Bartneck M,Wang J

更新日期：2019-09-20 00:00:00

abstract：:New approaches are needed to develop more effective interventions to prevent long-term rejection of organ allografts. Computational biology provides a powerful tool to assess the large amount of complex data that is generated in longitudinal studies in this area. This manuscript outlines how our two groups are using m...

journal_title：Frontiers in immunology

authors： Stegall MD,Borrows R

更新日期：2015-08-03 00:00:00

abstract：:Background: The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has posed great threat to human health. T cells play a critical role in antiviral immunity but their numbers and functional state in COVID-19 patients remain largely unclear. Methods: ...

journal_title：Frontiers in immunology

authors： Diao B,Wang C,Tan Y,Chen X,Liu Y,Ning L,Chen L,Li M,Liu Y,Wang G,Yuan Z,Feng Z,Zhang Y,Wu Y,Chen Y

更新日期：2020-05-01 00:00:00

abstract：:Conventional influenza vaccines aim at the induction of virus-neutralizing antibodies that provide with sterilizing immunity. However, influenza vaccination often confers protection from disease but not from infection. The impact of infection-permissive vaccination on the immune response elicited by subsequent influen...

journal_title：Frontiers in immunology

authors： Choi A,Ibañez LI,Strohmeier S,Krammer F,García-Sastre A,Schotsaert M

更新日期：2020-06-09 00:00:00

abstract：:Tuberculosis (TB) is one of the prevalent causes of death worldwide, with 95% of these deaths occurring in developing countries, like India. The causative agent, Mycobacterium tuberculosis (MTb) has the tenacious ability to circumvent the host's immune system for its own advantage. Macrophages are one of the phagocyti...

journal_title：Frontiers in immunology

authors： Ahluwalia PK,Pandey RK,Sehajpal PK,Prajapati VK

更新日期：2017-02-08 00:00:00

abstract：:Multiple sclerosis (MS) is an immune-mediated inflammatory demyelinating disease of the central nervous system. It was previously shown that toll-like receptor (TLR)-2 signaling plays a key role in the murine experimental autoimmune encephalomyelitis (EAE) model of MS, and that TLR2-stimulation of regulatory T cells (...

journal_title：Frontiers in immunology

authors： Hossain MJ,Morandi E,Tanasescu R,Frakich N,Caldano M,Onion D,Faraj TA,Erridge C,Gran B

更新日期：2018-03-14 00:00:00

abstract：:Plasmodium vivax is the most geographically widespread and the dominant human malaria parasite in most countries outside of sub-Saharan Africa and, although it was classically recognized to cause benign infection, severe cases and deaths caused by P. vivax have remarkably been reported. In contrast to Plasmodium falci...

journal_title：Frontiers in immunology

authors： Totino PR,Lopes SC

更新日期：2017-09-20 00:00:00

abstract：:New biomarkers are needed for discriminating active tuberculosis (TB) from latent TB infection (LTBI), especially in vulnerable groups representing the major diagnostic challenge. This pilot study was carried out to explore the diagnostic potential of selected genes, IFN-γ, IL-17, IL-4, and FoxP3, associated with TB i...

journal_title：Frontiers in immunology

authors： Savolainen LE,Kantele A,Knuuttila A,Pusa L,Karttunen R,Valleala H,Tuuminen T

更新日期：2016-06-14 00:00:00

abstract：:NKG2D is a potent activating immunoreceptor expressed on nearly all cytotoxic lymphocytes promoting their cytotoxicity against self-cells expressing NKG2D ligands (NKG2DLs). NKG2DLs are MHC class I-like glycoproteins that usually are not expressed on "healthy" cells. Rather, their surface expression is induced by vari...

journal_title：Frontiers in immunology

authors： Kim Y,Born C,Bléry M,Steinle A

更新日期：2020-06-04 00:00:00

abstract：:Phloretin (PT), isolated from the apple tree, was previously demonstrated to have antioxidative and anti-inflammatory effects in macrophages and anti-adiposity effects in adipocytes. Inflammatory immune cells generate high levels of reactive oxygen species (ROS) for stimulated severe airway hyperresponsiveness (AHR) a...

journal_title：Frontiers in immunology

authors： Huang WC,Fang LW,Liou CJ

更新日期：2017-02-13 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a disease with a poor prognosis and very few available treatment options. The involvement of the purinergic receptor subtypes P2Y2 and P2X7 in fibrotic lung disease has been demonstrated recently. In this study, we investigated the role of P2Y6 receptors in the pathogenesis of IP...

journal_title：Frontiers in immunology

authors： Müller T,Fay S,Vieira RP,Karmouty-Quintana H,Cicko S,Ayata CK,Zissel G,Goldmann T,Lungarella G,Ferrari D,Di Virgilio F,Robaye B,Boeynaems JM,Lazarowski ER,Blackburn MR,Idzko M

更新日期：2017-08-22 00:00:00

abstract：:Viral infections have a major impact on morbidity and mortality of immunosuppressed solid organ transplant (SOT) patients because of missing or failure of adequate pharmacologic antiviral treatment. Adoptive antiviral T-cell therapy (AVTT), regenerating disturbed endogenous T-cell immunity, emerged as an attractive al...

journal_title：Frontiers in immunology

authors： Amini L,Vollmer T,Wendering DJ,Jurisch A,Landwehr-Kenzel S,Otto NM,Jürchott K,Volk HD,Reinke P,Schmueck-Henneresse M

更新日期：2019-05-28 00:00:00

abstract：:The classical model of cytokine signaling dominates our view of specific gene activation by cytokines such as the interferons (IFNs). The importance of the model extends beyond cytokines and applies to hormones such as growth hormone (GH) and insulin, and growth factors such as epidermal growth factor (EGF) and fibrob...

journal_title：Frontiers in immunology

authors： Johnson HM,Noon-Song EN,Dabelic R,Ahmed CM

更新日期：2013-07-25 00:00:00

abstract：:Fasciola hepatica, also known as the liver fluke, is a trematode that infects livestock and humans causing fasciolosis, a zoonotic disease of increasing importance due to its worldwide distribution and high economic losses. This parasite immunoregulates the host immune system by inducing a strong Th2 and regulatory T ...

journal_title：Frontiers in immunology

authors： Carasi P,Rodríguez E,da Costa V,Frigerio S,Brossard N,Noya V,Robello C,Anegón I,Freire T

更新日期：2017-07-26 00:00:00

abstract：:Adenosine (Ado) is a well-studied neurotransmitter, but it also exerts profound immune regulatory functions. Ado can (i) actively be released by various cells into the tissue environment and can (ii) be produced through the degradation of extracellular ATP by the concerted action of CD39 and CD73. In this sequence of ...

journal_title：Frontiers in immunology

authors： Silva-Vilches C,Ring S,Mahnke K

更新日期：2018-11-09 00:00:00

abstract：:Damage associated molecular patterns (DAMPs) are endogenous molecules originate from damaged cells and tissues with the ability to trigger and/or modify innate immune responses. Upon hemolysis hemoglobin (Hb) is released from red blood cells (RBCs) to the circulation and give a rise to the production of different Hb r...

journal_title：Frontiers in immunology

authors： Bozza MT,Jeney V

更新日期：2020-06-30 00:00:00

abstract：:T follicular helper (Tfh) cells are the subset of CD4 T helper cells that are required for generation and maintenance of germinal center reactions and the generation of long-lived humoral immunity. This specialized T helper subset provides help to cognate B cells via their expression of CD40 ligand, IL-21, IL-4, and o...

journal_title：Frontiers in immunology

authors： Hale JS,Ahmed R

更新日期：2015-02-02 00:00:00

abstract：:Atypical hemolytic uremic syndrome (aHUS) is a rare disease characterized by microangiopathic hemolytic anemia, thrombocytopenia and renal failure. It is caused by genetic or acquired defects of the complement alternative pathway. Factor H autoantibodies (anti-FHs) have been reported in 10% of aHUS patients and are as...

journal_title：Frontiers in immunology

authors： Valoti E,Alberti M,Iatropoulos P,Piras R,Mele C,Breno M,Cremaschi A,Bresin E,Donadelli R,Alizzi S,Amoroso A,Benigni A,Remuzzi G,Noris M

更新日期：2019-05-01 00:00:00

abstract：:In addition to their detrimental role in allergic diseases, mast cells (MCs) are well known to be important cells of the innate immune system. In the last decade, they have been shown to contribute significantly to optimal host defense against numerous pathogens including parasites, bacteria, and viruses. The contribu...

journal_title：Frontiers in immunology

authors： Saluja R,Metz M,Maurer M

更新日期：2012-06-13 00:00:00

abstract：:Nephritic factors comprise a heterogeneous group of autoantibodies against neoepitopes generated in the C3 and C5 convertases of the complement system, causing its dysregulation. Classification of these autoantibodies can be clustered according to their stabilization of different convertases either from the classical ...

journal_title：Frontiers in immunology

authors： Corvillo F,Okrój M,Nozal P,Melgosa M,Sánchez-Corral P,López-Trascasa M

更新日期：2019-04-24 00:00:00

abstract：Objective:To examine the utility of the peripheral blood neutrophil-to-lymphocyte ratio (NLR) and monocyte-to-lymphocyte ratio (MLR) as biomarkers of prognosis in seropositive autoimmune encephalitis (AE). Methods:In this multicenter study, we retrospectively analyzed 57 cases of seropositive AE with hospital admissio...

journal_title：Frontiers in immunology

authors： Broadley J,Wesselingh R,Seneviratne U,Kyndt C,Beech P,Buzzard K,Nesbitt C,D'Souza W,Brodtmann A,Kalincik T,Butzkueven H,O'Brien TJ,Monif M,Australian Autoimmune Encephalitis Consortium.

更新日期：2021-01-14 00:00:00

abstract：:The actin cytoskeleton is composed of a dynamic filament meshwork that builds the architecture of the cell to sustain its fundamental properties. This physical structure is characterized by a continuous remodeling, which allows cells to accomplish complex motility steps such as directed migration, crossing of biologic...

journal_title：Frontiers in immunology

authors： Dupré L,Houmadi R,Tang C,Rey-Barroso J

更新日期：2015-11-18 00:00:00

abstract：:The last decade has seen much progress in adjunctive cell therapy for immune disorders. Both corporate and institutional Phase III studies have been run using mesenchymal stromal cells (MSC) for treatment of Graft versus Host Disease (GvHD), and product approval has been achieved for treatment of pediatric GvHD in Can...

journal_title：Frontiers in immunology

authors： Vaes B,Van't Hof W,Deans R,Pinxteren J

更新日期：2012-11-27 00:00:00

abstract：:Background and Objectives: The live non-pathogenic Leishmania tarantolae has recently provided a promising approach as an effective vaccine candidate against experimental leishmaniasis (ILL). Here, we evaluated the immunoprotective potential of the live Iranian Lizard Leishmania mixed with CpG adjuvant against L. majo...

journal_title：Frontiers in immunology

authors： Keshavarzian N,Noroozbeygi M,Haji Molla Hoseini M,Yeganeh F

更新日期：2020-10-23 00:00:00

abstract：:As cutaneous melanoma (CM) currently remains with a bleak prognosis, thorough investigation of new treatment options are of utmost relevance. In the phase II/III randomized clinical trial (CASVAC-0401), the repeated immunization of stages IIB-III CM patients with the irradiated, allogeneic cellular CSF-470 vaccine plu...

journal_title：Frontiers in immunology

authors： Pampena MB,Cartar HC,Cueto GR,Levy EM,Blanco PA,Barrio MM,Mordoh J

更新日期：2018-11-02 00:00:00

abstract：:Developing lymphocytes express the recombination activating genes (RAGs) 1 and 2 products that form a site specific recombinase complex (RAG), introducing double strand DNA breaks (DSBs) at recombination signal sequences (RSSs) flanking the V, D, and J gene segments in the antigen receptor loci. The subsequent steps i...

journal_title：Frontiers in immunology

authors： Bonnet M,Sarmento LM,Martins AC,Sobral D,Silva J,Demengeot J

更新日期：2017-11-10 00:00:00