Abstract:
:Arsenic is ubiquitously present in human lives, including in the environment and organisms, and has divergent effects between different cells and tissues and between different exposure times and doses. These observed effects have been attributed to the nuclear transcription factor kappa B(NF-κB) signaling pathway. Herein, a meta-analysis was performed by independently searching databases including the Cochrane Library, PubMed, Springer, Embase, and China National Knowledge Infrastructure, to analyze effects of arsenic exposure on NF-κB signaling. Compared to controls, in the exposed group, p-IκB levels were found to be 8.13-fold higher (95% CI, 2.40-13.85; Z = 2.78; p = 0.005), IκB levels were 16.19-fold lower (95% CI, -27.44--4.94; Z = 2.78; p = 0.005), and NF-κBp65 levels were 0.77-fold higher (95% CI, 0.13-1.42; Z = 2.34; p = 0.02) for normal cells and tissue, while NF-κBp65 levels were 4.90-fold lower (95% CI, -8.49-1.31; Z = 2.62; p = 0.009), NF-κB activity was 2.45-fold lower (95% CI, -3.66-1.25; Z = 4.00; p < 0.0001), and DNA-binding activity of NF-κB was 9.75-fold lower (95% CI, -18.66-4.54; Z = 2.15; p = 0.03) for abnormal cells and tissue. Short exposure to high arsenic doses activated the NF-κB signaling pathway, while long exposure to low arsenic doses suppressed NF-κB signaling pathway activation. These findings may provide a theoretical basis for injurious and therapeutic mechanisms of divergent effects of arsenic.
journal_name
Int J Environ Res Public Healthauthors
Wei M,Liu J,Xu M,Rui D,Xu S,Feng G,Ding Y,Li S,Guo Sdoi
10.3390/ijerph13020163subject
Has Abstractpub_date
2016-01-26 00:00:00pages
163issue
2eissn
1661-7827issn
1660-4601pii
ijerph13020163journal_volume
13pub_type
杂志文章,meta分析,评审abstract::With the rapid increase of aging workforces, companies worldwide are concerned with improving the health and working status of older workers. Sense of control is an important psychological variable in sociology but has attracted less attention in studies of occupational health and management. This study examined the a...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17010245
更新日期:2019-12-30 00:00:00
abstract::Background: The purpose of this study was to examine the relationship between coaches' interpersonal style and fear of failure in athletes. Methods: A sample of 340 athletes at the Federation Level with a mean age of 18.96 years (SD = 5.69 years.) comprised the sample. Athletes completed questionnaires related to fear...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph16091563
更新日期:2019-05-04 00:00:00
abstract::Very few studies exist of legal interventions (national laws) for essential medicines as part of universal health coverage in middle-income countries, or how the effect of these laws is measured. This study aims to critically assess whether laws related to universal health coverage use five objectives of public health...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17249524
更新日期:2020-12-18 00:00:00
abstract::Total cholesterol (TC) directly correlates with overweight/obesity, but it remains unclear if this association varies by race and ethnicity. We assessed the association as well as the racial/ethnic heterogeneity in this relationship. Data on 63,863 children were assessed using electronic medical records between 2010 a...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph13010019
更新日期:2015-12-23 00:00:00
abstract::This study aimed to assess the impacts of heat waves during the summer of 2015 on mortality in the Czech Republic and to compare them with those of heat waves back to the previous record-breaking summer of 1994. We analyzed daily natural-cause mortality across the country's entire population. A mortality baseline was ...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph14121562
更新日期:2017-12-13 00:00:00
abstract::The panoramic view ultrasound remains uncommon in clinical practice, probably because of its difficulty, high-cost, and lack of research. Morphological changes in muscles have been demonstrated to be related to symptomatology and provide data of interest for clinical assessment. Thus, the aim of this study was to eval...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17197123
更新日期:2020-09-29 00:00:00
abstract::Food insecurity is a major social determinant of health and an assessment of how it may impact college students' mental health is imperative, as well as differential associations by self-identified gender. A cross-sectional survey was used among college students of a mid-size minority-serving institution with a final ...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17114118
更新日期:2020-06-09 00:00:00
abstract::Disparities in healthy food access are well documented in cross-sectional studies in communities across the United States. However, longitudinal studies examining changes in food environments within various neighborhood contexts are scarce. In a sample of 142 census tracts in four low-income, high-minority cities in N...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph16132354
更新日期:2019-07-03 00:00:00
abstract::The aim of this study was to analyze the distribution and effectiveness of the different types of smash in professional padel according to the area and direction of the strokes and the gender. Through systematic observation, 1.015 smashes from eight finals (four men's and four women's) of the professional matches were...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17197027
更新日期:2020-09-25 00:00:00
abstract::How staff and students travel to university can impact their physical activity level. An online survey of physical activity and travel behaviour was conducted in early November 2012 to inform planning of physical activity and active travel promotion programs at the University of Sydney, Australia as part of the "Sit L...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph10083563
更新日期:2013-08-09 00:00:00
abstract::Despite increasing research knowledge about the positive well-being effects forests have on citizens, it is still unclear how the quality of forests and individual variables effect the well-being. This research investigated (1) the differences in restorative experiences (components being away, fascination, compatibili...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph18020422
更新日期:2021-01-07 00:00:00
abstract::Impaired muscle recovery (size and strength) following a disuse period commonly occurs in older adults. Many of these individuals are not able to adequately exercise due to pain and logistic barriers. Thus, nutritional and pharmacological therapeutics, that are translatable, are needed to promote muscle recovery follo...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章,评审
doi:10.3390/ijerph17228650
更新日期:2020-11-21 00:00:00
abstract::To analyze the time-frequency characteristics of the particulate matter (PM10) concentration, data series measured at dry bulk ports were used to determine the contribution of various factors during different periods to the PM10 concentration level so as to support the formulation of air quality improvement plans arou...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17165754
更新日期:2020-08-09 00:00:00
abstract::Approximately 33% of normal-length (21⁻35 days) cycles have subclinical ovulatory disturbances and lack sufficient progesterone, although their normal length ensures enough estrogen. Subclinical ovulatory disturbances are related to significant premenopausal spine bone loss (-0.86%/year). Molimina, non-distressing pre...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph15051016
更新日期:2018-05-18 00:00:00
abstract::The main purpose of this paper was to evaluate the relationship between health-related quality of life (HRQoL) and the frequency of physical activity in Spanish children aged 8 to 14 years with attention deficit hyperactivity disorder (ADHD). Sample selection was performed using the data obtained from the children's q...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17082804
更新日期:2020-04-18 00:00:00
abstract::Enclosure is an effective practice for restoring and rehabilitating the degraded grassland ecosystem caused by overgrazing. Shrub species, which are dominant in most desert grasslands in arid and semiarid regions, have some beneficial ecological functions for grassland restoration. However, how the population structur...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph15050946
更新日期:2018-05-09 00:00:00
abstract::In Taiwan, immigrant workers play an important role in fisheries but they are easily ignored by society. The health problems and associated characteristics of immigrant workers in fisheries remain unclear. Descriptive and retrospective analyses were performed. Outpatient data were collected from a primary care clinic ...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph16193702
更新日期:2019-10-01 00:00:00
abstract::Although much research has been conducted on workaholism, its crossover effects remain uninvestigated, especially in the context of organizations. Based on the job demands-resources (JD-R) model of burnout and the conservation of resources (COR) theory, we established a dual-path structural model to examine the effect...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17217742
更新日期:2020-10-23 00:00:00
abstract::The Zika outbreak in Brazil caused congenital impairments and developmental delays, or Congenital Zika Syndrome (CZS). We sought to ascertain whether a family support programme was needed and, if so, could be adapted from the Getting to Know Cerebral Palsy programme (GTKCP) designed for children with cerebral palsy (C...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17103559
更新日期:2020-05-19 00:00:00
abstract::Violence towards animals and violence towards people are often interconnected problems, and as such, this phenomenon has been termed the Link. Violence towards animals is a strong predictor that the abuser may inflict violence on people. However, it must not be assumed this is always the case. Professionals treating a...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17093116
更新日期:2020-04-30 00:00:00
abstract:BACKGROUND:Cigarette smoking is a tough addiction to break. This dependence is the most common dual diagnosis for individuals with schizophrenia. Currently three effective drugs are approved for smoking cessation: nicotine replacement therapy (NRT), varenicline and bupropion. However, some serious side effects of varen...
journal_title:International journal of environmental research and public health
pub_type: 临床试验,杂志文章
doi:10.3390/ijerph10020446
更新日期:2013-01-28 00:00:00
abstract::Multiple studies indicate that PM2.5 is the most deleterious air pollutant for which there are ambient air quality standards. Daily concentrations of PM2.5 in Bangkok, Thailand, continuously exceed the World Health Organization (WHO) and the Thai National Ambient Air Quality Standards (NAAQSs). Bangkok has only recent...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17197298
更新日期:2020-10-06 00:00:00
abstract::Hemodialysis is an effective replacement therapy for chronic renal failure patients. In recent decades, the number of hemodialysis patients has grown rapidly and some measures for preventing blood-borne diseases have been implemented, but hepatitis C virus (HCV) infection remains a significant problem. The meta-analys...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章,meta分析
doi:10.3390/ijerph16081453
更新日期:2019-04-24 00:00:00
abstract::Epidemiological evidence has shown an association between exposure to high temperatures and occupational injuries, an issue gaining importance with environmental change. The aim of this study was to better understand contributing risk factors and preventive actions based on personal experiences. Interviews were conduc...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17030846
更新日期:2020-01-29 00:00:00
abstract::Previous studies have shown that formaldehyde (FA) could cause immunotoxicity by changing the number of T lymphocytes and that cytokines play a pivotal role in the regulation of T lymphocytes. However, the previously used cytokine detection methods are difficult to use in the measurement of several cytokines in a smal...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph111010036
更新日期:2014-09-26 00:00:00
abstract::Aquaculture is a technique to produce food that is under debate, due to its possible consequences for altering the economy, traditional fishing included, or the environment, even with doubts about the health of consumers. This document studies its social acceptance from the point of view of carrying capacity. This ter...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph17186628
更新日期:2020-09-11 00:00:00
abstract::With the introduction of fentanyl to illegal markets in 2013 and an overall rise in rates of synthetic opioid use, opioid-related deaths have increased significantly. A similar trend has been observed for sexually transmitted infections, homicides, and poor mental health outcomes. In this paper, we explore the spatiot...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph18010062
更新日期:2020-12-23 00:00:00
abstract::The last published figures have shown geographical variations in mortality with respect to female breast cancer in European countries. However, national health policies need a dynamic image of the geographical variations within the country. The aim of this paper was to describe the spatial distribution of age-specific...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章
doi:10.3390/ijerph13111162
更新日期:2016-11-22 00:00:00
abstract::The purpose of this study was to determine the effect of stand-biased desks on the physical activity and sedentary behavior of third, fourth and sixth grade students across the school year. Methods: This within classroom crossover design study used teacher-determined allocation for seating within each classroom. Half ...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章,随机对照试验
doi:10.3390/ijerph16060933
更新日期:2019-03-15 00:00:00
abstract::Background: We aimed to review published studies to obtain the best estimate of the risk of depression and anxiety among colorectal cancer (CRC) patients. Methods: We searched the PubMed/Medline database, Web of Science, and Google Scholar on the prevalence of depression or anxiety in CRC patients. A review of 15 stud...
journal_title:International journal of environmental research and public health
pub_type: 杂志文章,评审
doi:10.3390/ijerph16030411
更新日期:2019-01-31 00:00:00